EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit [Homo sapiens (human)] - Gene

Summary

Official Symbol: EZH2provided by HGNC
Official Full Name: enhancer of zeste 2 polycomb repressive complex 2 subunitprovided by HGNC
Primary source: HGNC:HGNC:3527
See related: Ensembl:ENSG00000106462 MIM:601573; AllianceGenome:HGNC:3527
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: WVS; ENX1; KMT6; WVS2; ENX-1; EZH2b; KMT6A
Summary: This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Feb 2011]
Expression: Broad expression in bone marrow (RPKM 9.3), testis (RPKM 8.6) and 14 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 7q36.1

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (148807383..148884291, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (149989157..150066070, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (148504475..148581383, complement)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Homeobox B9 promotes the invasion and metastasis of hepatocellular carcinoma cells via the EZH2-MIR203A-SNAI2 axis.
Title: Homeobox B9 promotes the invasion and metastasis of hepatocellular carcinoma cells via the EZH2-MIR203A-SNAI2 axis.
EZH2 specifically regulates ISL1 during embryonic urinary tract formation.
Title: EZH2 specifically regulates ISL1 during embryonic urinary tract formation.
EZH2 represses mesenchymal genes and upholds the epithelial state of breast carcinoma cells.
Title: EZH2 represses mesenchymal genes and upholds the epithelial state of breast carcinoma cells.
LncRNA CARMN facilitates odontogenic differentiation of dental pulp cells by impairing EZH2.
Title: LncRNA CARMN facilitates odontogenic differentiation of dental pulp cells by impairing EZH2.
MTF2 facilitates the advancement of osteosarcoma through mediating EZH2/SFRP1/Wnt signaling.
Title: MTF2 facilitates the advancement of osteosarcoma through mediating EZH2/SFRP1/Wnt signaling.
TXNIP mediated by EZH2 regulated osteogenic differentiation in hBmscs and MC3T3-E1 cells through the modulation of oxidative stress and PI3K/AKT/Nrf2 pathway.
Title: TXNIP mediated by EZH2 regulated osteogenic differentiation in hBmscs and MC3T3-E1 cells through the modulation of oxidative stress and PI3K/AKT/Nrf2 pathway.
A novel EZH2/NXPH4/CDKN2A axis is involved in regulating the proliferation and migration of non-small cell lung cancer cells.
Title: A novel EZH2/NXPH4/CDKN2A axis is involved in regulating the proliferation and migration of non-small cell lung cancer cells.
LINC01348 suppresses hepatocellular carcinoma metastasis through inhibition of SF3B3-mediated EZH2 pre-mRNA splicing.
Title: LINC01348 suppresses hepatocellular carcinoma metastasis through inhibition of SF3B3-mediated EZH2 pre-mRNA splicing.
PRMT6 facilitates EZH2 protein stability by inhibiting TRAF6-mediated ubiquitination degradation to promote glioblastoma cell invasion and migration.
Title: PRMT6 facilitates EZH2 protein stability by inhibiting TRAF6-mediated ubiquitination degradation to promote glioblastoma cell invasion and migration.
TRIM37 interacts with EZH2 to epigenetically suppress PTCH1 and regulate stemness in glioma stem cells through sonic hedgehog pathway.
Title: TRIM37 interacts with EZH2 to epigenetically suppress PTCH1 and regulate stemness in glioma stem cells through sonic hedgehog pathway.

Submit: New GeneRIF Correction See all GeneRIFs (1347)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Weaver syndrome MedGen: C0265210 OMIM: 277590 GeneReviews: EZH2-Related Overgrowth	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Screening in Jurkat T-cells with a short-hairpin-RNA (shRNA) library identifies enhancer of zeste homolog 2 (EZH2) is important for HIV-1 replication	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	HIV-1 Tat induces EZH2 phophorylation in an Akt1 dependent manner	PubMed
	tat	HIV-1 Tat decreases EZH2 levels on the HIV-1 LTR	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH120228 (e-PCR)
- UniSTS:132686

SHGC-132531 (e-PCR)
- UniSTS:173390

D7S688 (e-PCR)
- UniSTS:4729

EZH2_7791 (e-PCR)
- UniSTS:468410

RH123504 (e-PCR)
- UniSTS:135879

D7S688 (e-PCR)
- UniSTS:71399

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	EXP Inferred from Experiment more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II core promoter sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables chromatin DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables histone H3 methyltransferase activity	TAS Traceable Author Statement more info
enables histone H3K27 methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone H3K27 methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H3K27 methyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables histone H3K27 methyltransferase activity	TAS Traceable Author Statement more info	PubMed
enables histone H3K27 trimethyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone binding	IDA Inferred from Direct Assay more info	PubMed
enables histone methyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables lncRNA binding	IEA Inferred from Electronic Annotation more info
enables nucleosome binding	IDA Inferred from Direct Assay more info	PubMed
enables primary miRNA binding	IEA Inferred from Electronic Annotation more info
enables promoter-specific chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-lysine N-methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-lysine N-methyltransferase activity	TAS Traceable Author Statement more info
enables ribonucleoprotein complex binding	IEA Inferred from Electronic Annotation more info
enables transcription corepressor activity	ISS Inferred from Sequence or Structural Similarity more info
enables transcription corepressor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in B cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in DNA methylation-dependent constitutive heterochromatin formation	IEA Inferred from Electronic Annotation more info
involved_in G1 to G0 transition	IEA Inferred from Electronic Annotation more info
involved_in G1/S transition of mitotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in cardiac muscle hypertrophy in response to stress	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hydrogen peroxide	IEA Inferred from Electronic Annotation more info
involved_in cellular response to trichostatin A	IEA Inferred from Electronic Annotation more info
involved_in cerebellar cortex development	IEA Inferred from Electronic Annotation more info
involved_in chromatin organization	TAS Traceable Author Statement more info
involved_in facultative heterochromatin formation	IEA Inferred from Electronic Annotation more info
involved_in hepatocyte homeostasis	IEA Inferred from Electronic Annotation more info
involved_in heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in hippocampus development	IEA Inferred from Electronic Annotation more info
involved_in keratinocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in liver regeneration	IEA Inferred from Electronic Annotation more info
involved_in methylation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of G1/S transition of mitotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cytokine production involved in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of gene expression, epigenetic	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of gene expression, epigenetic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression, epigenetic	TAS Traceable Author Statement more info
involved_in negative regulation of keratinocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of retinoic acid receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of stem cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of striated muscle cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription elongation by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of GTPase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of MAP kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell cycle G1/S phase transition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of dendrite development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of epithelial to mesenchymal transition	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization to chromatin	IEA Inferred from Electronic Annotation more info
involved_in protein modification process	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	TAS Traceable Author Statement more info
involved_in regulation of circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of gliogenesis	IEA Inferred from Electronic Annotation more info
involved_in regulation of kidney development	IEA Inferred from Electronic Annotation more info
involved_in regulatory ncRNA-mediated heterochromatin formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to estradiol	IEA Inferred from Electronic Annotation more info
involved_in response to tetrachloromethane	IEA Inferred from Electronic Annotation more info
involved_in rhythmic process	IEA Inferred from Electronic Annotation more info
involved_in skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration	IEA Inferred from Electronic Annotation more info
involved_in stem cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in subtelomeric heterochromatin formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in synaptic transmission, GABAergic	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of ESC/E(Z) complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ESC/E(Z) complex	IDA Inferred from Direct Assay more info	PubMed
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
part_of chromatin silencing complex	IEA Inferred from Electronic Annotation more info
is_active_in chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome, telomeric region	IGI Inferred from Genetic Interaction more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in pericentric heterochromatin	IEA Inferred from Electronic Annotation more info
located_in pronucleus	IEA Inferred from Electronic Annotation more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: histone-lysine N-methyltransferase EZH2

Names: enhancer of zeste homolog 2; lysine N-methyltransferase 6

NP_001190176.1

EC 2.1.1.356

NP_001190177.1

EC 2.1.1.356

NP_001190178.1

EC 2.1.1.356

NP_004447.2

EC 2.1.1.356

NP_694543.1

EC 2.1.1.356

XP_005250019.1

EC 2.1.1.356

XP_005250020.1

EC 2.1.1.356

XP_005250021.1

EC 2.1.1.356

XP_011514185.1

EC 2.1.1.356

XP_011514187.1

EC 2.1.1.356

XP_011514189.1

EC 2.1.1.356

XP_011514191.1

EC 2.1.1.356

XP_011514192.1

EC 2.1.1.356

XP_011514194.1

EC 2.1.1.356

XP_011514195.1

EC 2.1.1.356

XP_011514196.1

EC 2.1.1.356

XP_011514197.1

EC 2.1.1.356

XP_011514198.1

EC 2.1.1.356

XP_011514201.1

EC 2.1.1.356

XP_011514203.1

EC 2.1.1.356

XP_016867306.1

EC 2.1.1.356

XP_016867308.1

EC 2.1.1.356

XP_016867309.1

EC 2.1.1.356

XP_047275945.1

EC 2.1.1.356

XP_047275946.1

EC 2.1.1.356

XP_047275947.1

EC 2.1.1.356

XP_047275948.1

EC 2.1.1.356

XP_047275949.1

EC 2.1.1.356

XP_047275950.1

EC 2.1.1.356

XP_047275951.1

EC 2.1.1.356

XP_047275952.1

EC 2.1.1.356

XP_047275953.1

EC 2.1.1.356

XP_047275954.1

EC 2.1.1.356

XP_047275955.1

EC 2.1.1.356

XP_047275956.1

EC 2.1.1.356

XP_047275957.1

EC 2.1.1.356

XP_047275958.1

EC 2.1.1.356

XP_047275960.1

EC 2.1.1.356

XP_047275961.1

EC 2.1.1.356

XP_047275962.1

EC 2.1.1.356

XP_047275963.1

EC 2.1.1.356

XP_047275964.1

EC 2.1.1.356

XP_047275965.1

EC 2.1.1.356

XP_054213455.1

EC 2.1.1.356

XP_054213456.1

EC 2.1.1.356

XP_054213457.1

EC 2.1.1.356

XP_054213458.1

EC 2.1.1.356

XP_054213459.1

EC 2.1.1.356

XP_054213460.1

EC 2.1.1.356

XP_054213461.1

EC 2.1.1.356

XP_054213462.1

EC 2.1.1.356

XP_054213463.1

EC 2.1.1.356

XP_054213464.1

EC 2.1.1.356

XP_054213465.1

EC 2.1.1.356

XP_054213466.1

EC 2.1.1.356

XP_054213467.1

EC 2.1.1.356

XP_054213468.1

EC 2.1.1.356

XP_054213469.1

EC 2.1.1.356

XP_054213470.1

EC 2.1.1.356

XP_054213471.1

EC 2.1.1.356

XP_054213472.1

EC 2.1.1.356

XP_054213473.1

EC 2.1.1.356

XP_054213474.1

EC 2.1.1.356

XP_054213475.1

EC 2.1.1.356

XP_054213476.1

EC 2.1.1.356

XP_054213477.1

EC 2.1.1.356

XP_054213478.1

EC 2.1.1.356

XP_054213479.1

EC 2.1.1.356

XP_054213480.1

EC 2.1.1.356

XP_054213481.1

EC 2.1.1.356

XP_054213482.1

EC 2.1.1.356

XP_054213483.1

EC 2.1.1.356

XP_054213484.1

EC 2.1.1.356

XP_054213485.1

EC 2.1.1.356

XP_054213486.1

EC 2.1.1.356

XP_054213487.1

EC 2.1.1.356

XP_054213488.1

EC 2.1.1.356

XP_054213489.1

EC 2.1.1.356

XP_054213490.1

EC 2.1.1.356

XP_054213491.1

EC 2.1.1.356

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_032043.1 RefSeqGene

Range

5001..81978

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_531

mRNA and Protein(s)

NM_001203247.2 → NP_001190176.1 histone-lysine N-methyltransferase EZH2 isoform c

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an in-frame segment in the coding region, as compared to variant 1. The resulting isoform (c) lacks one internal segment, as compared to isoform a.

Source sequence(s)

BC010858, BU953788, CN283479, U61145

Consensus CDS

CCDS56516.1

UniProtKB/Swiss-Prot

B2RAQ1, B3KS30, B7Z1D6, B7Z7L6, Q15755, Q15910, Q75MG3, Q92857, Q96FI6

UniProtKB/TrEMBL

Q75MP9

Related

ENSP00000419711.1, ENST00000460911.5

Conserved Domains (4) summary

cd19218
Location:609 → 728

SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins

pfam11616
Location:39 → 68

EZH2_WD-Binding; WD repeat binding protein EZH2

pfam18118
Location:158 → 249

PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain

pfam18264
Location:559 → 590

preSET_CXC; CXC domain
NM_001203248.2 → NP_001190177.1 histone-lysine N-methyltransferase EZH2 isoform d

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks two in-frame segments in the coding region, as compared to variant 1. The resulting isoform (d) lacks two internal segments, as compared to isoform a.

Source sequence(s)

AK293239, BC010858, BU953788, CN283479

Consensus CDS

CCDS56518.1

UniProtKB/TrEMBL

Q75MP9

Related

ENSP00000419856.1, ENST00000483967.5

Conserved Domains (4) summary

cd19218
Location:600 → 719

SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins

pfam11616
Location:39 → 68

EZH2_WD-Binding; WD repeat binding protein EZH2

pfam18118
Location:149 → 240

PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain

pfam18264
Location:550 → 581

preSET_CXC; CXC domain
NM_001203249.2 → NP_001190178.1 histone-lysine N-methyltransferase EZH2 isoform e

Status: REVIEWED

Description

Transcript Variant: This variant (5) has an alternate 5' UTR exon and lacks an in-frame exon and two in-frame segments in the coding region, as compared to variant 1. The resulting isoform (e) lacks three internal segments, as compared to isoform a.

Source sequence(s)

AK302216, BC010858, BU953788

Consensus CDS

CCDS56517.1

UniProtKB/TrEMBL

Q75MP9

Related

ENSP00000419050.1, ENST00000476773.5

Conserved Domains (4) summary

cd19218
Location:558 → 677

SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins

pfam11616
Location:39 → 68

EZH2_WD-Binding; WD repeat binding protein EZH2

pfam18118
Location:149 → 240

PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain

pfam18264
Location:508 → 539

preSET_CXC; CXC domain
NM_004456.5 → NP_004447.2 histone-lysine N-methyltransferase EZH2 isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (a).

Source sequence(s)

BC010858, BU953788, CN283479

Consensus CDS

CCDS5891.1

UniProtKB/TrEMBL

A0A090N8E9, Q75MQ0

Related

ENSP00000320147.2, ENST00000320356.7

Conserved Domains (4) summary

cd19218
Location:614 → 733

SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins

pfam11616
Location:39 → 68

EZH2_WD-Binding; WD repeat binding protein EZH2

pfam18118
Location:158 → 249

PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain

pfam18264
Location:564 → 595

preSET_CXC; CXC domain
NM_152998.3 → NP_694543.1 histone-lysine N-methyltransferase EZH2 isoform b

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an in-frame exon and an in-frame segment in the coding region, as compared to variant 1. The resulting isoform (b) lacks two internal segments, as compared to isoform a.

Source sequence(s)

AK314291, BC010858, BU953788, CN283479

Consensus CDS

CCDS5892.1

UniProtKB/TrEMBL

Q75MP9, S4S3R8

Related

ENSP00000223193.2, ENST00000350995.6

Conserved Domains (4) summary

cd19218
Location:570 → 689

SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins

pfam11616
Location:39 → 68

EZH2_WD-Binding; WD repeat binding protein EZH2

pfam18118
Location:119 → 210

PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain

pfam18264
Location:520 → 551

preSET_CXC; CXC domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000007.14 Reference GRCh38.p14 Primary Assembly

Range

148807383..148884291 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047420002.1 → XP_047275958.1 histone-lysine N-methyltransferase EZH2 isoform X22

UniProtKB/TrEMBL

Q75MP9
XM_017011820.3 → XP_016867309.1 histone-lysine N-methyltransferase EZH2 isoform X20

UniProtKB/TrEMBL

Q75MQ0

Conserved Domains (4) summary

cd19218
Location:566 → 685

SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins

pfam11616
Location:39 → 68

EZH2_WD-Binding; WD repeat binding protein EZH2

pfam18118
Location:110 → 201

PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain

pfam18264
Location:516 → 547

preSET_CXC; CXC domain
XM_011515887.4 → XP_011514189.1 histone-lysine N-methyltransferase EZH2 isoform X7

UniProtKB/TrEMBL

Q75MQ0

Conserved Domains (4) summary

cd19218
Location:605 → 724

SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins

pfam11616
Location:39 → 68

EZH2_WD-Binding; WD repeat binding protein EZH2

pfam18118
Location:149 → 240

PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain

pfam18264
Location:555 → 586

preSET_CXC; CXC domain
XM_047420004.1 → XP_047275960.1 histone-lysine N-methyltransferase EZH2 isoform X24

UniProtKB/TrEMBL

F2YMM1, Q75MP9
XM_011515894.3 → XP_011514196.1 histone-lysine N-methyltransferase EZH2 isoform X14

UniProtKB/TrEMBL

Q75MQ0

Conserved Domains (4) summary

cd19218
Location:575 → 694

SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins

pfam11616
Location:39 → 68

EZH2_WD-Binding; WD repeat binding protein EZH2

pfam18118
Location:119 → 210

PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain

pfam18264
Location:525 → 556

preSET_CXC; CXC domain
XM_047420001.1 → XP_047275957.1 histone-lysine N-methyltransferase EZH2 isoform X19

UniProtKB/TrEMBL

Q75MP9
XM_047419999.1 → XP_047275955.1 histone-lysine N-methyltransferase EZH2 isoform X17

UniProtKB/TrEMBL

Q75MQ0
XM_047419990.1 → XP_047275946.1 histone-lysine N-methyltransferase EZH2 isoform X2

UniProtKB/TrEMBL

Q75MP9
XM_047419997.1 → XP_047275953.1 histone-lysine N-methyltransferase EZH2 isoform X9

UniProtKB/TrEMBL

Q75MP9
XM_047419992.1 → XP_047275948.1 histone-lysine N-methyltransferase EZH2 isoform X4

UniProtKB/Swiss-Prot

B2RAQ1, B3KS30, B7Z1D6, B7Z7L6, Q15755, Q15910, Q75MG3, Q92857, Q96FI6

UniProtKB/TrEMBL

Q75MP9
XM_047419993.1 → XP_047275949.1 histone-lysine N-methyltransferase EZH2 isoform X5

UniProtKB/TrEMBL

Q75MP9
XM_047419998.1 → XP_047275954.1 histone-lysine N-methyltransferase EZH2 isoform X13

UniProtKB/TrEMBL

Q75MP9
XM_011515883.3 → XP_011514185.1 histone-lysine N-methyltransferase EZH2 isoform X1

UniProtKB/TrEMBL

Q75MQ0

Conserved Domains (2) summary

smart00317
Location:625 → 746

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

pfam11616
Location:47 → 75

EZH2_WD-Binding; WD repeat binding protein EZH2
XM_047419994.1 → XP_047275950.1 histone-lysine N-methyltransferase EZH2 isoform X5

UniProtKB/TrEMBL

Q75MP9
XM_005249962.5 → XP_005250019.1 histone-lysine N-methyltransferase EZH2 isoform X2

UniProtKB/TrEMBL

Q75MP9

Conserved Domains (4) summary

cd19218
Location:617 → 736

SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins

pfam11616
Location:47 → 76

EZH2_WD-Binding; WD repeat binding protein EZH2

pfam18118
Location:166 → 257

PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain

pfam18264
Location:567 → 598

preSET_CXC; CXC domain
XM_047419989.1 → XP_047275945.1 histone-lysine N-methyltransferase EZH2 isoform X1

UniProtKB/TrEMBL

Q75MQ0
XM_047419991.1 → XP_047275947.1 histone-lysine N-methyltransferase EZH2 isoform X30

UniProtKB/TrEMBL

A0A090N8E9, Q75MQ0
XM_047420000.1 → XP_047275956.1 histone-lysine N-methyltransferase EZH2 isoform X18

UniProtKB/TrEMBL

Q75MP9
XM_011515895.3 → XP_011514197.1 histone-lysine N-methyltransferase EZH2 isoform X16

UniProtKB/TrEMBL

Q75MQ0

Conserved Domains (2) summary

smart00317
Location:577 → 698

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

pfam11616
Location:47 → 75

EZH2_WD-Binding; WD repeat binding protein EZH2
XM_005249964.5 → XP_005250021.1 histone-lysine N-methyltransferase EZH2 isoform X21

UniProtKB/TrEMBL

Q75MP9

Conserved Domains (2) summary

smart00317
Location:569 → 690

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

pfam11616
Location:47 → 75

EZH2_WD-Binding; WD repeat binding protein EZH2
XM_005249963.5 → XP_005250020.1 histone-lysine N-methyltransferase EZH2 isoform X5

UniProtKB/TrEMBL

Q75MP9

Conserved Domains (4) summary

cd19218
Location:608 → 727

SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins

pfam11616
Location:47 → 76

EZH2_WD-Binding; WD repeat binding protein EZH2

pfam18118
Location:157 → 248

PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain

pfam18264
Location:558 → 589

preSET_CXC; CXC domain
XM_011515885.3 → XP_011514187.1 histone-lysine N-methyltransferase EZH2 isoform X3

UniProtKB/TrEMBL

Q75MQ0

Conserved Domains (4) summary

cd19218
Location:613 → 732

SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins

pfam11616
Location:47 → 76

EZH2_WD-Binding; WD repeat binding protein EZH2

pfam18118
Location:157 → 248

PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain

pfam18264
Location:563 → 594

preSET_CXC; CXC domain
XM_011515896.3 → XP_011514198.1 histone-lysine N-methyltransferase EZH2 isoform X23

UniProtKB/TrEMBL

Q75MP9

Conserved Domains (2) summary

smart00317
Location:539 → 660

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

pfam11616
Location:47 → 75

EZH2_WD-Binding; WD repeat binding protein EZH2
XM_011515893.3 → XP_011514195.1 histone-lysine N-methyltransferase EZH2 isoform X13

UniProtKB/TrEMBL

Q75MP9

Conserved Domains (2) summary

smart00317
Location:581 → 702

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

pfam11616
Location:47 → 75

EZH2_WD-Binding; WD repeat binding protein EZH2
XM_011515890.3 → XP_011514192.1 histone-lysine N-methyltransferase EZH2 isoform X11

UniProtKB/TrEMBL

Q75MQ0

Conserved Domains (2) summary

smart00317
Location:586 → 707

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

pfam11616
Location:47 → 75

EZH2_WD-Binding; WD repeat binding protein EZH2
XM_017011819.2 → XP_016867308.1 histone-lysine N-methyltransferase EZH2 isoform X15

UniProtKB/TrEMBL

Q75MP9

Conserved Domains (2) summary

smart00317
Location:578 → 699

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

pfam11616
Location:47 → 75

EZH2_WD-Binding; WD repeat binding protein EZH2
XM_011515892.3 → XP_011514194.1 histone-lysine N-methyltransferase EZH2 isoform X12

UniProtKB/TrEMBL

Q75MQ0

Conserved Domains (2) summary

smart00317
Location:583 → 704

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

pfam11616
Location:47 → 75

EZH2_WD-Binding; WD repeat binding protein EZH2
XM_017011817.3 → XP_016867306.1 histone-lysine N-methyltransferase EZH2 isoform X1

UniProtKB/TrEMBL

Q75MQ0

Conserved Domains (2) summary

smart00317
Location:625 → 746

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

pfam11616
Location:47 → 75

EZH2_WD-Binding; WD repeat binding protein EZH2
XM_011515889.3 → XP_011514191.1 histone-lysine N-methyltransferase EZH2 isoform X10

UniProtKB/TrEMBL

Q75MQ0

Conserved Domains (3) summary

cd19218
Location:592 → 711

SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins

pfam18118
Location:136 → 227

PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain

pfam18264
Location:542 → 573

preSET_CXC; CXC domain
XM_047419996.1 → XP_047275952.1 histone-lysine N-methyltransferase EZH2 isoform X8

UniProtKB/TrEMBL

Q75MP9
XM_047419995.1 → XP_047275951.1 histone-lysine N-methyltransferase EZH2 isoform X6

UniProtKB/TrEMBL

Q75MQ0
XM_047420005.1 → XP_047275961.1 histone-lysine N-methyltransferase EZH2 isoform X25

UniProtKB/TrEMBL

Q75MQ0
XM_047420006.1 → XP_047275962.1 histone-lysine N-methyltransferase EZH2 isoform X25

UniProtKB/TrEMBL

Q75MQ0
XM_011515901.4 → XP_011514203.1 histone-lysine N-methyltransferase EZH2 isoform X28

UniProtKB/TrEMBL

B7Z8K5

Conserved Domains (1) summary

pfam11616
Location:47 → 75

EZH2_WD-Binding; WD repeat binding protein EZH2
XM_047420008.1 → XP_047275964.1 histone-lysine N-methyltransferase EZH2 isoform X28

UniProtKB/TrEMBL

B7Z8K5
XM_047420007.1 → XP_047275963.1 histone-lysine N-methyltransferase EZH2 isoform X27
XM_011515899.4 → XP_011514201.1 histone-lysine N-methyltransferase EZH2 isoform X26

Conserved Domains (1) summary

pfam11616
Location:47 → 75

EZH2_WD-Binding; WD repeat binding protein EZH2
XM_047420009.1 → XP_047275965.1 histone-lysine N-methyltransferase EZH2 isoform X29

UniProtKB/TrEMBL

B7Z8K5

Alternate T2T-CHM13v2.0

Genomic

NC_060931.1 Alternate T2T-CHM13v2.0

Range

149989157..150066070 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054357507.1 → XP_054213482.1 histone-lysine N-methyltransferase EZH2 isoform X22

UniProtKB/TrEMBL

Q75MP9
XM_054357505.1 → XP_054213480.1 histone-lysine N-methyltransferase EZH2 isoform X20

UniProtKB/TrEMBL

Q75MQ0
XM_054357491.1 → XP_054213466.1 histone-lysine N-methyltransferase EZH2 isoform X7

UniProtKB/TrEMBL

Q75MQ0
XM_054357509.1 → XP_054213484.1 histone-lysine N-methyltransferase EZH2 isoform X24

UniProtKB/TrEMBL

F2YMM1, Q75MP9
XM_054357499.1 → XP_054213474.1 histone-lysine N-methyltransferase EZH2 isoform X14

UniProtKB/TrEMBL

Q75MQ0
XM_054357504.1 → XP_054213479.1 histone-lysine N-methyltransferase EZH2 isoform X19

UniProtKB/TrEMBL

Q75MP9
XM_054357502.1 → XP_054213477.1 histone-lysine N-methyltransferase EZH2 isoform X17

UniProtKB/TrEMBL

Q75MQ0
XM_054357484.1 → XP_054213459.1 histone-lysine N-methyltransferase EZH2 isoform X2

UniProtKB/TrEMBL

Q75MP9
XM_054357493.1 → XP_054213468.1 histone-lysine N-methyltransferase EZH2 isoform X9

UniProtKB/TrEMBL

Q75MP9
XM_054357486.1 → XP_054213461.1 histone-lysine N-methyltransferase EZH2 isoform X4

UniProtKB/Swiss-Prot

B2RAQ1, B3KS30, B7Z1D6, B7Z7L6, Q15755, Q15910, Q75MG3, Q92857, Q96FI6

UniProtKB/TrEMBL

Q75MP9
XM_054357488.1 → XP_054213463.1 histone-lysine N-methyltransferase EZH2 isoform X5

UniProtKB/TrEMBL

Q75MP9
XM_054357498.1 → XP_054213473.1 histone-lysine N-methyltransferase EZH2 isoform X13

UniProtKB/TrEMBL

Q75MP9
XM_054357482.1 → XP_054213457.1 histone-lysine N-methyltransferase EZH2 isoform X1

UniProtKB/TrEMBL

Q75MQ0
XM_054357489.1 → XP_054213464.1 histone-lysine N-methyltransferase EZH2 isoform X5

UniProtKB/TrEMBL

Q75MP9
XM_054357483.1 → XP_054213458.1 histone-lysine N-methyltransferase EZH2 isoform X2

UniProtKB/TrEMBL

Q75MP9
XM_054357481.1 → XP_054213456.1 histone-lysine N-methyltransferase EZH2 isoform X1

UniProtKB/TrEMBL

Q75MQ0
XM_054357496.1 → XP_054213471.1 histone-lysine N-methyltransferase EZH2 isoform X12

UniProtKB/TrEMBL

Q75MQ0
XM_054357501.1 → XP_054213476.1 histone-lysine N-methyltransferase EZH2 isoform X16

UniProtKB/TrEMBL

Q75MQ0
XM_054357506.1 → XP_054213481.1 histone-lysine N-methyltransferase EZH2 isoform X21

UniProtKB/TrEMBL

Q75MP9
XM_054357485.1 → XP_054213460.1 histone-lysine N-methyltransferase EZH2 isoform X3

UniProtKB/TrEMBL

Q75MQ0
XM_054357508.1 → XP_054213483.1 histone-lysine N-methyltransferase EZH2 isoform X23

UniProtKB/TrEMBL

Q75MP9
XM_054357495.1 → XP_054213470.1 histone-lysine N-methyltransferase EZH2 isoform X11

UniProtKB/TrEMBL

Q75MQ0
XM_054357500.1 → XP_054213475.1 histone-lysine N-methyltransferase EZH2 isoform X15

UniProtKB/TrEMBL

Q75MP9
XM_054357480.1 → XP_054213455.1 histone-lysine N-methyltransferase EZH2 isoform X1

UniProtKB/TrEMBL

Q75MQ0
XM_054357503.1 → XP_054213478.1 histone-lysine N-methyltransferase EZH2 isoform X18

UniProtKB/TrEMBL

Q75MP9
XM_054357487.1 → XP_054213462.1 histone-lysine N-methyltransferase EZH2 isoform X5

UniProtKB/TrEMBL

Q75MP9
XM_054357497.1 → XP_054213472.1 histone-lysine N-methyltransferase EZH2 isoform X13

UniProtKB/TrEMBL

Q75MP9
XM_054357494.1 → XP_054213469.1 histone-lysine N-methyltransferase EZH2 isoform X10

UniProtKB/TrEMBL

Q75MQ0
XM_054357492.1 → XP_054213467.1 histone-lysine N-methyltransferase EZH2 isoform X8

UniProtKB/TrEMBL

Q75MP9
XM_054357490.1 → XP_054213465.1 histone-lysine N-methyltransferase EZH2 isoform X6

UniProtKB/TrEMBL

Q75MQ0
XM_054357510.1 → XP_054213485.1 histone-lysine N-methyltransferase EZH2 isoform X25

UniProtKB/TrEMBL

Q75MQ0
XM_054357511.1 → XP_054213486.1 histone-lysine N-methyltransferase EZH2 isoform X25

UniProtKB/TrEMBL

Q75MQ0
XM_054357515.1 → XP_054213490.1 histone-lysine N-methyltransferase EZH2 isoform X28

UniProtKB/TrEMBL

B7Z8K5
XM_054357514.1 → XP_054213489.1 histone-lysine N-methyltransferase EZH2 isoform X28

UniProtKB/TrEMBL

B7Z8K5
XM_054357513.1 → XP_054213488.1 histone-lysine N-methyltransferase EZH2 isoform X27
XM_054357512.1 → XP_054213487.1 histone-lysine N-methyltransferase EZH2 isoform X26
XM_054357516.1 → XP_054213491.1 histone-lysine N-methyltransferase EZH2 isoform X29

UniProtKB/TrEMBL

B7Z8K5