U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    PTPN20 protein tyrosine phosphatase non-receptor type 20 [ Homo sapiens (human) ]

    Gene ID: 26095, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    PTPN20provided by HGNC
    Official Full Name
    protein tyrosine phosphatase non-receptor type 20provided by HGNC
    Primary source
    HGNC:HGNC:23423
    See related
    Ensembl:ENSG00000204179 MIM:610630; AllianceGenome:HGNC:23423
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CT126; PTPN20A; PTPN20B; bA42B19.1; bA142I17.1
    Summary
    The product of this gene belongs to the family of classical tyrosine-specific protein tyrosine phosphatases. Many protein tyrosine phosphatases have been shown to regulate fundamental cellular processes. The encoded protein appears to be targeted to sites of actin polymerization. A pseudogene of this gene has been defined on chromosome 10. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
    Expression
    Broad expression in testis (RPKM 2.2), adrenal (RPKM 1.4) and 18 other tissues See more
    Orthologs
    mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See PTPN20 in Genome Data Viewer
    Location:
    10q11.22
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (46911428..47003653)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (47800189..47916646)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (48737040..48827934, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene FERM and PDZ domain containing 2 pseudogene Neighboring gene FERM and PDZ domain containing 2B (pseudogene) Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:48600992-48602191 Neighboring gene NANOG hESC enhancer GRCh37_chr10:48563688-48564189 Neighboring gene uncharacterized LOC105378291 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:48510376-48510765 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2353 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:48473688-48474887 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:48460575-48461276 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:48456799-48457326 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:48456269-48456798 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:48428532-48429032 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:48426933-48427433 Neighboring gene growth differentiation factor 10

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Identification of PTPN20 as an innate immunity-related gene in gastric cancer with Helicobacter pylori infection. Ma L, et al. Front Immunol, 2023. PMID 37359510, Free PMC Article
    2. Protein tyrosine phosphatase hPTPN20a is targeted to sites of actin polymerization. Fodero-Tavoletti MT, et al. Biochem J, 2005 Jul 15. PMID 15790311, Free PMC Article
    3. Pair-wise regulation of convergence and extension cell movements by four phosphatases via RhoA. van Eekelen M, et al. PLoS One, 2012. PMID 22545146, Free PMC Article
    4. The DNA sequence and comparative analysis of human chromosome 10. Deloukas P, et al. Nature, 2004 May 27. PMID 15164054
    5. A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. Yao Z, et al. Mol Cell, 2017 Jan 19. PMID 28065597, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of PTPN20 as an innate immunity-related gene in gastric cancer with Helicobacter pylori infection.
      Title: Identification of PTPN20 as an innate immunity-related gene in gastric cancer with Helicobacter pylori infection.
    2. identification of hPTPN20a as a novel and widely expressed phosphatase with a dynamic subcellular distribution that is targeted to sites of actin polymerization
      Title: Protein tyrosine phosphatase hPTPN20a is targeted to sites of actin polymerization.
    Submit: New GeneRIF Correction

    Phenotypes

    Go to the top of the page Help

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • KIAA0187, MGC142033, DKFZp566K0524, DKFZp781P23155

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    NOT enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in centriolar satellite IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasmic side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    tyrosine-protein phosphatase non-receptor type 20
    Names
    protein tyrosine phosphatase, non-receptor type 20A
    protein tyrosine phosphatase, non-receptor type 20B
    NP_001035816.1
    NP_001035817.1
    NP_001035818.1
    NP_001035819.1
    NP_001035820.1
    NP_001035821.1
    NP_001035822.1
    NP_001035823.1
    NP_001035824.1
    NP_001307610.1
    NP_001307611.1
    NP_001307612.1
    NP_001307613.1
    NP_001307614.1
    NP_001307615.1
    NP_001307617.1
    NP_001307618.1
    NP_001307619.1
    NP_001307620.1
    NP_001339450.1
    NP_001339451.1
    NP_001339452.1
    NP_001339453.1
    NP_001339454.1
    NP_001339455.1
    NP_001339456.1
    NP_001339457.1
    NP_001339458.1
    NP_001339459.1
    NP_001339460.1
    NP_001339461.1
    NP_001339462.1
    NP_001339463.1
    NP_001339464.1
    NP_001339465.1
    NP_001339466.1
    NP_001339467.1
    NP_001339468.1
    NP_001339469.1
    NP_001339470.1
    NP_001339471.1
    NP_001339472.1
    NP_001339473.1
    NP_001339474.1
    NP_001339475.1
    NP_001339476.1
    NP_001339477.1
    NP_001339478.1
    NP_001339479.1
    NP_001339480.1
    NP_001339481.1
    NP_001339482.1
    NP_001339483.1
    NP_001339484.1
    NP_056420.3
    XP_011537907.1
    XP_011537908.1
    XP_011537909.1
    XP_011537912.1
    XP_016871534.1
    XP_047280959.1
    XP_047280960.1
    XP_047280961.1
    XP_047280962.1
    XP_047280963.1
    XP_047280964.1
    XP_047280965.1
    XP_047280966.1
    XP_047280968.1
    XP_047280969.1
    XP_047280970.1
    XP_047280971.1
    XP_047280972.1
    XP_047280973.1
    XP_047280974.1
    XP_047280975.1
    XP_047280976.1
    XP_047280978.1
    XP_047280979.1
    XP_047280980.1
    XP_047280981.1
    XP_047280982.1
    XP_047280983.1
    XP_047280984.1
    XP_047280985.1
    XP_047280986.1
    XP_047280987.1
    XP_047280989.1
    XP_047280990.1
    XP_054221455.1
    XP_054221456.1
    XP_054221457.1
    XP_054221458.1
    XP_054221459.1
    XP_054221460.1
    XP_054221461.1
    XP_054221462.1
    XP_054221463.1
    XP_054221464.1
    XP_054221465.1
    XP_054221466.1
    XP_054221467.1
    XP_054221468.1
    XP_054221469.1
    XP_054221470.1
    XP_054221471.1
    XP_054221472.1
    XP_054221473.1
    XP_054221474.1
    XP_054221475.1
    XP_054221476.1
    XP_054221477.1
    XP_054221478.1
    XP_054221479.1
    XP_054221480.1
    XP_054221481.1
    XP_054221482.1
    XP_054221483.1
    XP_054221484.1
    XP_054221485.1
    XP_054221486.1
    XP_054221487.1
    XP_054221488.1
    XP_054221489.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042357.5 → NP_001035816.1  tyrosine-protein phosphatase non-receptor type 20 isoform 1

      See identical proteins and their annotated locations for NP_001035816.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AL050040, AL358791, AY704146, BC036539, BC093750, BX648913
      Consensus CDS
      CCDS73110.1
      UniProtKB/Swiss-Prot
      A6NNH8, B7ZKV3, Q4JDG6, Q4JDK1, Q4JDK5, Q4JDK6, Q4JDK8, Q4JDK9, Q4JDL0, Q4JDL1, Q4JDL3, Q4JDL4, Q4JDL5, Q4JDL6, Q4JDL7, Q4JDL8, Q5RJ33, Q5T1G3
      UniProtKB/TrEMBL
      Q5T1G2
      Related
      ENSP00000363459.3, ENST00000374339.5
      Conserved Domains (2) summary
      smart00194
      Location:159 → 411
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:185 → 411
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    2. NM_001042358.5 → NP_001035817.1  tyrosine-protein phosphatase non-receptor type 20 isoform 3

      See identical proteins and their annotated locations for NP_001035817.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and in the 5' coding region, compared to variant 1. The resulting protein (isoform 3) contains a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AL358791, AY704141, AY753191, BC036539
      Consensus CDS
      CCDS73105.1
      UniProtKB/TrEMBL
      Q5T1G2
      Related
      ENSP00000424283.1, ENST00000511769.5
      Conserved Domains (1) summary
      smart00194
      Location:150 → 402
      PTPc; Protein tyrosine phosphatase, catalytic domain

    3. NM_001042359.4 → NP_001035818.1  tyrosine-protein phosphatase non-receptor type 20 isoform 4

      See identical proteins and their annotated locations for NP_001035818.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and in the 5' coding region, compared to variant 1. It also lacks an in-frame segment of the coding region, compared to variant 1. The resulting protein (isoform 4) is shorter and contains a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AL358791, AY704141, AY753191, BC036539
      Consensus CDS
      CCDS73107.1
      UniProtKB/Swiss-Prot
      Q4JDL3
      Related
      ENSP00000425912.1, ENST00000513156.5
      Conserved Domains (1) summary
      pfam00102
      Location:142 → 260
      Y_phosphatase; Protein-tyrosine phosphatase

    4. NM_001042360.4 → NP_001035819.1  tyrosine-protein phosphatase non-receptor type 20 isoform 5

      See identical proteins and their annotated locations for NP_001035819.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and in the 5' coding region, compared to variant 1. The resulting protein (isoform 5) contains a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AL358791, AY704141, AY753191, BC036539
      Consensus CDS
      CCDS73109.1
      UniProtKB/Swiss-Prot
      Q4JDL3
      Related
      ENSP00000379077.2, ENST00000395727.6
      Conserved Domains (1) summary
      cl28904
      Location:16 → 222
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    5. NM_001042361.5 → NP_001035820.1  tyrosine-protein phosphatase non-receptor type 20 isoform 6

      See identical proteins and their annotated locations for NP_001035820.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) has multiple coding region differences, compared to variant 1, one of which results in a frameshift. The resulting protein (isoform 6) contains distinct N- and C-termini, compared to isoform 1.
      Source sequence(s)
      AL358791, AY704141, AY753191, BC036539
      Consensus CDS
      CCDS73106.1
      UniProtKB/Swiss-Prot
      Q4JDL3
      Related
      ENSP00000425362.1, ENST00000509774.5
      Conserved Domains (1) summary
      cl27757
      Location:150 → 188
      Y_phosphatase; Protein-tyrosine phosphatase

    6. NM_001042362.4 → NP_001035821.1  tyrosine-protein phosphatase non-receptor type 20 isoform 7

      See identical proteins and their annotated locations for NP_001035821.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) has multiple coding region differences, compared to variant 1, one of which results in a frameshift. The resulting protein (isoform 7) contains distinct N- and C-termini, compared to isoform 1.
      Source sequence(s)
      AL358791, AY704141, AY753191, BC036539
      Consensus CDS
      CCDS73108.1
      UniProtKB/Swiss-Prot
      Q4JDL3
      Related
      ENSP00000427676.1, ENST00000503851.5

    7. NM_001042363.5 → NP_001035822.1  tyrosine-protein phosphatase non-receptor type 20 isoform 8

      See identical proteins and their annotated locations for NP_001035822.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start site compared to variant 1. The encoded isoform (8) has a shorter N-terminus compared to isoform 1. Variants 8, 11, and 12 all encode the same isoform (8).
      Source sequence(s)
      AL050040, AL358791, AY704141, BC036539, BX648913
      Consensus CDS
      CCDS73114.1
      UniProtKB/TrEMBL
      Q5T1G2
      Related
      ENSP00000363335.2, ENST00000374218.6
      Conserved Domains (1) summary
      smart00194
      Location:78 → 330
      PTPc; Protein tyrosine phosphatase, catalytic domain

    8. NM_001042364.5 → NP_001035823.1  tyrosine-protein phosphatase non-receptor type 20 isoform 9

      See identical proteins and their annotated locations for NP_001035823.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR and has multiple coding region differences, compared to variant 1, one of which results in a frameshift. These differences cause translation initiation at a downstream AUG and a protein (isoform 9) with a distinct C-terminus, compared to isoform 1. Variants 9, 32, and 33 all encode the same isoform (9).
      Source sequence(s)
      AL050040, AL358791, BC036539, BX648913
      Consensus CDS
      CCDS73115.1
      UniProtKB/TrEMBL
      Q5T1G4
      Related
      ENSP00000379075.3, ENST00000395725.7
      Conserved Domains (1) summary
      smart00194
      Location:78 → 116
      PTPc; Protein tyrosine phosphatase, catalytic domain

    9. NM_001042365.4 → NP_001035824.1  tyrosine-protein phosphatase non-receptor type 20 isoform 10

      See identical proteins and their annotated locations for NP_001035824.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) differs in the 5' UTR and has multiple coding region differences, compared to variant 1, one of which results in a frameshift. These differences cause translation initiation at a downstream AUG and a protein (isoform 10) with a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AL050040, AL358791, BC036539, BX648913
      Consensus CDS
      CCDS73116.1
      UniProtKB/TrEMBL
      G8JLF9, Q4JDK3, Q5H9Q9
      Related
      ENSP00000363462.3, ENST00000374342.6

    10. NM_001320681.2 → NP_001307610.1  tyrosine-protein phosphatase non-receptor type 20 isoform 8

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start site compared to variant 1. The encoded isoform (8) has a shorter N-terminus compared to isoform 1. Variants 8, 11, and 12 all encode the same isoform (8).
      Source sequence(s)
      AL050040, AL358791, AY704141, BC036539, BX648913
      Consensus CDS
      CCDS73114.1
      UniProtKB/TrEMBL
      Q5T1G2
      Related
      ENSP00000379071.2, ENST00000395721.6
      Conserved Domains (1) summary
      smart00194
      Location:78 → 330
      PTPc; Protein tyrosine phosphatase, catalytic domain

    11. NM_001320682.2 → NP_001307611.1  tyrosine-protein phosphatase non-receptor type 20 isoform 11

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13) differs in the 5' UTR and lacks portions of the 5' and 3' coding regions, resulting in a frameshift compared to variant 1. The encoded isoform (11) is shorter than isoform 1. Variants 13-15, 47, and 48 all encode the same isoform (11).
      Source sequence(s)
      AL358791, BC036539, BC143394, CR933668
      UniProtKB/Swiss-Prot
      Q4JDL3
      UniProtKB/TrEMBL
      Q5H9Q9
      Conserved Domains (1) summary
      cl28904
      Location:51 → 86
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    12. NM_001320683.2 → NP_001307612.1  tyrosine-protein phosphatase non-receptor type 20 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17) differs in the 5' UTR and lacks two alternate exons in the coding region, resulting in a frameshift compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus compared to isoform 1. Both variants 2 and 17 encode the same isoform (2).
      Source sequence(s)
      AL358791, AY704147, AY753191, BC036539, BC093750
      Consensus CDS
      CCDS73111.1
      UniProtKB/Swiss-Prot
      Q4JDL3
      Related
      ENSP00000425012.1, ENST00000509599.5
      Conserved Domains (1) summary
      smart00194
      Location:159 → 197
      PTPc; Protein tyrosine phosphatase, catalytic domain

    13. NM_001320684.2 → NP_001307613.1  tyrosine-protein phosphatase non-receptor type 20 isoform 13

      Status: REVIEWED

      Description
      Transcript Variant: This variant (18) differs in the 5' UTR and lacks three alternate in-frame exons in the coding region compared to variant 1. The encoded isoform (13) is shorter than isoform 1.
      Source sequence(s)
      AL358791, AY704148, AY753191, BC036539, BC143394
      Consensus CDS
      CCDS81454.1
      UniProtKB/Swiss-Prot
      Q4JDL3
      Related
      ENSP00000420995.1, ENST00000502705.5
      Conserved Domains (1) summary
      cl21483
      Location:158 → 197
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    14. NM_001320685.2 → NP_001307614.1  tyrosine-protein phosphatase non-receptor type 20 isoform 14

      Status: REVIEWED

      Description
      Transcript Variant: This variant (19) differs in the 5' UTR and lacks one alternate exon in the 5' coding region, resulting in a frameshift compared to variant 1. The encoded isoform (14) is shorter and has a distinct N-terminus compared to isoform 1. Variants 19 and 21 both encode the same isoform (14).
      Source sequence(s)
      AL358791, AY704150, AY753191, BC036539, BX005072
      UniProtKB/TrEMBL
      Q5T1G2
      Conserved Domains (1) summary
      smart00194
      Location:131 → 383
      PTPc; Protein tyrosine phosphatase, catalytic domain

    15. NM_001320686.2 → NP_001307615.1  tyrosine-protein phosphatase non-receptor type 20 isoform 8

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start site compared to variant 1. The encoded isoform (8) has a shorter N-terminus compared to isoform 1. Variants 8, 11, and 12 all encode the same isoform (8).
      Source sequence(s)
      AL358791, AY704152, AY753191, BC036539
      Consensus CDS
      CCDS73114.1
      UniProtKB/TrEMBL
      Q5T1G2
      Related
      ENSP00000426355.1, ENST00000505814.5
      Conserved Domains (1) summary
      smart00194
      Location:78 → 330
      PTPc; Protein tyrosine phosphatase, catalytic domain

    16. NM_001320688.2 → NP_001307617.1  tyrosine-protein phosphatase non-receptor type 20 isoform 15

      Status: REVIEWED

      Description
      Transcript Variant: This variant (20) differs in the 5' UTR and has multiple coding region differences compared to variant 1. The encoded isoform (15) is shorter than isoform 1.
      Source sequence(s)
      AL358791, AY704153, AY753191, BC036539
      Consensus CDS
      CCDS81456.1
      UniProtKB/Swiss-Prot
      Q4JDL3
      Related
      ENSP00000422839.1, ENST00000513266.5
      Conserved Domains (1) summary
      pfam00102
      Location:70 → 188
      Y_phosphatase; Protein-tyrosine phosphatase

    17. NM_001320689.2 → NP_001307618.1  tyrosine-protein phosphatase non-receptor type 20 isoform 11

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14) differs in the 5' UTR and lacks portions of the 5' and 3' coding regions, resulting in a frameshift compared to variant 1. The encoded isoform (11) is shorter than isoform 1. Variants 13-15, 47, and 48 all encode the same isoform (11).
      Source sequence(s)
      AL358791, AY704156, AY753191, BC036539
      UniProtKB/Swiss-Prot
      Q4JDL3
      UniProtKB/TrEMBL
      Q4JDK3
      Conserved Domains (1) summary
      cl28904
      Location:51 → 86
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    18. NM_001320690.2 → NP_001307619.1  tyrosine-protein phosphatase non-receptor type 20 isoform 11

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15) differs in the 5' UTR and lacks portions of the 5' and 3' coding regions, resulting in a frameshift compared to variant 1. The encoded isoform (11) is shorter than isoform 1. Variants 13-15, 47, and 48 all encode the same isoform (11).
      Source sequence(s)
      AL358791, AY704157, AY753191, BC036539
      UniProtKB/Swiss-Prot
      Q4JDL3
      UniProtKB/TrEMBL
      Q4JDK3
      Conserved Domains (1) summary
      cl28904
      Location:51 → 86
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    19. NM_001320691.2 → NP_001307620.1  tyrosine-protein phosphatase non-receptor type 20 isoform 12

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16) differs in the 5' UTR, lacks a portion of the coding region and initiates translation at a downstream start site compared to variant 1. The encoded isoform (12) has a shorter N-terminus compared to isoform 1. Variants 16 and 25-30 all encode the same isoform (12).
      Source sequence(s)
      AL358791, AY704158, AY753191, BC036539
      UniProtKB/Swiss-Prot
      Q4JDL3
      Conserved Domains (1) summary
      cd00047
      Location:1 → 170
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    20. NM_001352521.2 → NP_001339450.1  tyrosine-protein phosphatase non-receptor type 20 isoform 14

      Status: REVIEWED

      Description
      Transcript Variant: This variant (21), as well as variant 19, encodes isoform 14.
      Source sequence(s)
      AL358791, BX005072
      UniProtKB/TrEMBL
      Q5T1G2
      Conserved Domains (1) summary
      smart00194
      Location:131 → 383
      PTPc; Protein tyrosine phosphatase, catalytic domain

    21. NM_001352522.2 → NP_001339451.1  tyrosine-protein phosphatase non-receptor type 20 isoform 16

      Status: REVIEWED

      Source sequence(s)
      AL358791, BX005072
      Conserved Domains (1) summary
      smart00194
      Location:78 → 258
      PTPc; Protein tyrosine phosphatase, catalytic domain

    22. NM_001352523.2 → NP_001339452.1  tyrosine-protein phosphatase non-receptor type 20 isoform 17

      Status: REVIEWED

      Source sequence(s)
      AL358791, BX005072
      Conserved Domains (1) summary
      cl27757
      Location:131 → 169
      Y_phosphatase; Protein-tyrosine phosphatase

    23. NM_001352524.2 → NP_001339453.1  tyrosine-protein phosphatase non-receptor type 20 isoform 30

      Status: REVIEWED

      Source sequence(s)
      AL358791, BX005072
      Conserved Domains (1) summary
      cl27757
      Location:150 → 188
      Y_phosphatase; Protein-tyrosine phosphatase

    24. NM_001352525.2 → NP_001339454.1  tyrosine-protein phosphatase non-receptor type 20 isoform 12

      Status: REVIEWED

      Description
      Transcript Variant: This variant (25), as well as variants 16 and 26-30, encodes isoform 12.
      Source sequence(s)
      AL358791, BX005072
      Conserved Domains (1) summary
      cd00047
      Location:1 → 170
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    25. NM_001352526.2 → NP_001339455.1  tyrosine-protein phosphatase non-receptor type 20 isoform 12

      Status: REVIEWED

      Description
      Transcript Variant: This variant (26), as well as variants 16, 25, and 27-30, encodes isoform 12.
      Source sequence(s)
      AL358791, BX005072
      Conserved Domains (1) summary
      cd00047
      Location:1 → 170
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    26. NM_001352527.2 → NP_001339456.1  tyrosine-protein phosphatase non-receptor type 20 isoform 12

      Status: REVIEWED

      Description
      Transcript Variant: This variant (27), as well as variants 16, 25, 26, and 28-30, encodes isoform 12.
      Source sequence(s)
      AL358791, BX005072
      Conserved Domains (1) summary
      cd00047
      Location:1 → 170
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    27. NM_001352528.2 → NP_001339457.1  tyrosine-protein phosphatase non-receptor type 20 isoform 12

      Status: REVIEWED

      Description
      Transcript Variant: This variant (28), as well as variants 16, 25-27, 29, and 30, encodes isoform 12.
      Source sequence(s)
      AL358791, BX005072
      Conserved Domains (1) summary
      cd00047
      Location:1 → 170
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    28. NM_001352529.2 → NP_001339458.1  tyrosine-protein phosphatase non-receptor type 20 isoform 12

      Status: REVIEWED

      Description
      Transcript Variant: This variant (29), as well as variants 16, 25-28, and 30, encodes isoform 12.
      Source sequence(s)
      AL358791, BX005072
      Conserved Domains (1) summary
      cd00047
      Location:1 → 170
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    29. NM_001352530.2 → NP_001339459.1  tyrosine-protein phosphatase non-receptor type 20 isoform 12

      Status: REVIEWED

      Description
      Transcript Variant: This variant (30), as well as variants 16 and 25-29, encodes isoform 12.
      Source sequence(s)
      AL358791, BX005072
      Conserved Domains (1) summary
      cd00047
      Location:1 → 170
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    30. NM_001352531.2 → NP_001339460.1  tyrosine-protein phosphatase non-receptor type 20 isoform 31

      Status: REVIEWED

      Source sequence(s)
      AL358791, BX005072
      Consensus CDS
      CCDS86087.1
      Related
      ENSP00000421404.1, ENST00000502254.5

    31. NM_001352532.2 → NP_001339461.1  tyrosine-protein phosphatase non-receptor type 20 isoform 9

      Status: REVIEWED

      Description
      Transcript Variant: This variant (32), as well as variants 9 and 33, encodes isoform 9.
      Source sequence(s)
      AL358791, BX005072
      Consensus CDS
      CCDS73115.1
      UniProtKB/TrEMBL
      Q5T1G4
      Conserved Domains (1) summary
      smart00194
      Location:78 → 116
      PTPc; Protein tyrosine phosphatase, catalytic domain

    32. NM_001352533.2 → NP_001339462.1  tyrosine-protein phosphatase non-receptor type 20 isoform 9

      Status: REVIEWED

      Description
      Transcript Variant: This variant (33), as well as variants 9 and 32, encodes isoform 9.
      Source sequence(s)
      AL358791, BX005072
      Consensus CDS
      CCDS73115.1
      UniProtKB/TrEMBL
      Q5T1G4
      Related
      ENSP00000423819.1, ENST00000509900.5
      Conserved Domains (1) summary
      smart00194
      Location:78 → 116
      PTPc; Protein tyrosine phosphatase, catalytic domain

    33. NM_001352534.2 → NP_001339463.1  tyrosine-protein phosphatase non-receptor type 20 isoform 18

      Status: REVIEWED

      Source sequence(s)
      AL358791, BX005072
      Conserved Domains (1) summary
      cl27757
      Location:131 → 169
      Y_phosphatase; Protein-tyrosine phosphatase

    34. NM_001352535.2 → NP_001339464.1  tyrosine-protein phosphatase non-receptor type 20 isoform 19

      Status: REVIEWED

      Source sequence(s)
      AL358791, BX005072

    35. NM_001352536.2 → NP_001339465.1  tyrosine-protein phosphatase non-receptor type 20 isoform 20

      Status: REVIEWED

      Description
      Transcript Variant: This variant (36), as well as variants 37-39, encodes isoform 20.
      Source sequence(s)
      AL358791, BX005072
      Conserved Domains (1) summary
      cl28904
      Location:78 → 119
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    36. NM_001352537.2 → NP_001339466.1  tyrosine-protein phosphatase non-receptor type 20 isoform 20

      Status: REVIEWED

      Description
      Transcript Variant: This variant (37), as well as variants 36, 38, and 39, encodes isoform 20.
      Source sequence(s)
      AL358791, BX005072
      Conserved Domains (1) summary
      cl28904
      Location:78 → 119
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    37. NM_001352538.2 → NP_001339467.1  tyrosine-protein phosphatase non-receptor type 20 isoform 20

      Status: REVIEWED

      Description
      Transcript Variant: This variant (38), as well as variants 36, 37, and 39, encodes isoform 20.
      Source sequence(s)
      AL358791, BX005072
      Conserved Domains (1) summary
      cl28904
      Location:78 → 119
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    38. NM_001352539.2 → NP_001339468.1  tyrosine-protein phosphatase non-receptor type 20 isoform 20

      Status: REVIEWED

      Description
      Transcript Variant: This variant (39), as well as variants 36-38, encodes isoform 20.
      Source sequence(s)
      AL358791, BX005072
      Conserved Domains (1) summary
      cl28904
      Location:78 → 119
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    39. NM_001352540.2 → NP_001339469.1  tyrosine-protein phosphatase non-receptor type 20 isoform 29

      Status: REVIEWED

      Source sequence(s)
      AL358791, BX005072
      Conserved Domains (1) summary
      cl27757
      Location:78 → 105
      Y_phosphatase; Protein-tyrosine phosphatase

    40. NM_001352541.2 → NP_001339470.1  tyrosine-protein phosphatase non-receptor type 20 isoform 21

      Status: REVIEWED

      Description
      Transcript Variant: This variant (41), as well as variant 42, encodes isoform 21.
      Source sequence(s)
      AL358791, BX005072

    41. NM_001352542.2 → NP_001339471.1  tyrosine-protein phosphatase non-receptor type 20 isoform 21

      Status: REVIEWED

      Description
      Transcript Variant: This variant (42), as well as variant 41, encodes isoform 21.
      Source sequence(s)
      AL358791, BX005072

    42. NM_001352543.2 → NP_001339472.1  tyrosine-protein phosphatase non-receptor type 20 isoform 22

      Status: REVIEWED

      Description
      Transcript Variant: This variant (43), as well as variant 44, encodes isoform 22.
      Source sequence(s)
      AL358791, BX005072
      Conserved Domains (1) summary
      cl27757
      Location:1 → 98
      Y_phosphatase; Protein-tyrosine phosphatase

    43. NM_001352544.2 → NP_001339473.1  tyrosine-protein phosphatase non-receptor type 20 isoform 22

      Status: REVIEWED

      Description
      Transcript Variant: This variant (44), as well as variant 43, encodes isoform 22.
      Source sequence(s)
      AL358791, BX005072
      Conserved Domains (1) summary
      cl27757
      Location:1 → 98
      Y_phosphatase; Protein-tyrosine phosphatase

    44. NM_001352545.2 → NP_001339474.1  tyrosine-protein phosphatase non-receptor type 20 isoform 23

      Status: REVIEWED

      Source sequence(s)
      AL358791, BX005072
      Conserved Domains (1) summary
      cl27757
      Location:57 → 95
      Y_phosphatase; Protein-tyrosine phosphatase

    45. NM_001352546.2 → NP_001339475.1  tyrosine-protein phosphatase non-receptor type 20 isoform 24

      Status: REVIEWED

      Source sequence(s)
      AL358791, BX005072
      Conserved Domains (1) summary
      cl27757
      Location:48 → 86
      Y_phosphatase; Protein-tyrosine phosphatase

    46. NM_001352547.2 → NP_001339476.1  tyrosine-protein phosphatase non-receptor type 20 isoform 11

      Status: REVIEWED

      Description
      Transcript Variant: This variant (47), as well as variants 13-15 and 48, encodes isoform 11.
      Source sequence(s)
      AL358791, BX005072
      Conserved Domains (1) summary
      cl28904
      Location:51 → 86
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    47. NM_001352548.2 → NP_001339477.1  tyrosine-protein phosphatase non-receptor type 20 isoform 11

      Status: REVIEWED

      Description
      Transcript Variant: This variant (48), as well as variants 13-15 and 47, encodes isoform 11.
      Source sequence(s)
      AL358791, BX005072
      Conserved Domains (1) summary
      cl28904
      Location:51 → 86
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    48. NM_001352549.2 → NP_001339478.1  tyrosine-protein phosphatase non-receptor type 20 isoform 25

      Status: REVIEWED

      Description
      Transcript Variant: This variant (49), as well as variant 50, encodes isoform 25.
      Source sequence(s)
      AL358791, BX005072
      Conserved Domains (1) summary
      cl28904
      Location:51 → 72
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    49. NM_001352550.2 → NP_001339479.1  tyrosine-protein phosphatase non-receptor type 20 isoform 25

      Status: REVIEWED

      Description
      Transcript Variant: This variant (50), as well as variant 49, encodes isoform 25.
      Source sequence(s)
      AL358791, BX005072
      Conserved Domains (1) summary
      cl28904
      Location:51 → 72
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    50. NM_001352551.2 → NP_001339480.1  tyrosine-protein phosphatase non-receptor type 20 isoform 26

      Status: REVIEWED

      Source sequence(s)
      AL358791, BX005072
      Conserved Domains (1) summary
      cl27757
      Location:41 → 73
      Y_phosphatase; Protein-tyrosine phosphatase

    51. NM_001352552.2 → NP_001339481.1  tyrosine-protein phosphatase non-receptor type 20 isoform 27

      Status: REVIEWED

      Description
      Transcript Variant: This variant (52), as well as variants 53 and 54, encodes isoform 27.
      Source sequence(s)
      AL358791, BX005072
      Conserved Domains (1) summary
      cl28904
      Location:1 → 66
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    52. NM_001352553.2 → NP_001339482.1  tyrosine-protein phosphatase non-receptor type 20 isoform 27

      Status: REVIEWED

      Description
      Transcript Variant: This variant (53), as well as variants 52 and 54, encodes isoform 27.
      Source sequence(s)
      AL358791, BX005072
      Conserved Domains (1) summary
      cl28904
      Location:1 → 66
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    53. NM_001352554.2 → NP_001339483.1  tyrosine-protein phosphatase non-receptor type 20 isoform 27

      Status: REVIEWED

      Description
      Transcript Variant: This variant (54), as well as variants 52 and 53, encodes isoform 27.
      Source sequence(s)
      AL358791, BX005072
      Conserved Domains (1) summary
      cl28904
      Location:1 → 66
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    54. NM_001352555.2 → NP_001339484.1  tyrosine-protein phosphatase non-receptor type 20 isoform 28

      Status: REVIEWED

      Source sequence(s)
      AL358791, BX005072
      UniProtKB/TrEMBL
      Q5H9Q9

    55. NM_015605.9 → NP_056420.3  tyrosine-protein phosphatase non-receptor type 20 isoform 2

      See identical proteins and their annotated locations for NP_056420.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks two alternate exons in the coding region, resulting in a frameshift compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus compared to isoform 1. Both variants 2 and 17 encode the same isoform (2).
      Source sequence(s)
      AL050040, AL358791, AY704146, BC036539, BC093750, BX648913
      Consensus CDS
      CCDS73111.1
      UniProtKB/Swiss-Prot
      Q4JDL3
      UniProtKB/TrEMBL
      Q9Y406
      Related
      ENSP00000363466.3, ENST00000374346.7
      Conserved Domains (1) summary
      smart00194
      Location:159 → 197
      PTPc; Protein tyrosine phosphatase, catalytic domain

    RNA

    1. NR_148022.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL358791, BX005072

    2. NR_148023.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL358791, BX005072

    3. NR_148024.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL358791, BX005072

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      46911428..47003653
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047425027.1 → XP_047280983.1  tyrosine-protein phosphatase non-receptor type 20 isoform X23

    2. XM_047425033.1 → XP_047280989.1  tyrosine-protein phosphatase non-receptor type 20 isoform X27

    3. XM_047425013.1 → XP_047280969.1  tyrosine-protein phosphatase non-receptor type 20 isoform X12

    4. XM_047425034.1 → XP_047280990.1  tyrosine-protein phosphatase non-receptor type 20 isoform X27

    5. XM_047425031.1 → XP_047280987.1  tyrosine-protein phosphatase non-receptor type 20 isoform X26

      UniProtKB/TrEMBL
      G8JLF9, Q4JDK3
      Related
      ENSP00000379072.4, ENST00000395722.7

    6. XM_011539610.3 → XP_011537912.1  tyrosine-protein phosphatase non-receptor type 20 isoform X7

      See identical proteins and their annotated locations for XP_011537912.1

      UniProtKB/TrEMBL
      Q5T1G2
      Conserved Domains (1) summary
      smart00194
      Location:78 → 330
      PTPc; Protein tyrosine phosphatase, catalytic domain

    7. XM_047425010.1 → XP_047280966.1  tyrosine-protein phosphatase non-receptor type 20 isoform X10

    8. XM_047425028.1 → XP_047280984.1  tyrosine-protein phosphatase non-receptor type 20 isoform X23

    9. XM_047425012.1 → XP_047280968.1  tyrosine-protein phosphatase non-receptor type 20 isoform X11

    10. XM_011539605.3 → XP_011537907.1  tyrosine-protein phosphatase non-receptor type 20 isoform X1

      See identical proteins and their annotated locations for XP_011537907.1

      UniProtKB/Swiss-Prot
      A6NNH8, B7ZKV3, Q4JDG6, Q4JDK1, Q4JDK5, Q4JDK6, Q4JDK8, Q4JDK9, Q4JDL0, Q4JDL1, Q4JDL3, Q4JDL4, Q4JDL5, Q4JDL6, Q4JDL7, Q4JDL8, Q5RJ33, Q5T1G3
      UniProtKB/TrEMBL
      Q5T1G2
      Conserved Domains (2) summary
      smart00194
      Location:159 → 411
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:185 → 411
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    11. XM_047425018.1 → XP_047280974.1  tyrosine-protein phosphatase non-receptor type 20 isoform X17

    12. XM_011539607.3 → XP_011537909.1  tyrosine-protein phosphatase non-receptor type 20 isoform X1

      See identical proteins and their annotated locations for XP_011537909.1

      UniProtKB/Swiss-Prot
      A6NNH8, B7ZKV3, Q4JDG6, Q4JDK1, Q4JDK5, Q4JDK6, Q4JDK8, Q4JDK9, Q4JDL0, Q4JDL1, Q4JDL3, Q4JDL4, Q4JDL5, Q4JDL6, Q4JDL7, Q4JDL8, Q5RJ33, Q5T1G3
      UniProtKB/TrEMBL
      Q5T1G2
      Conserved Domains (2) summary
      smart00194
      Location:159 → 411
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:185 → 411
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    13. XM_047425025.1 → XP_047280981.1  tyrosine-protein phosphatase non-receptor type 20 isoform X21

    14. XM_047425004.1 → XP_047280960.1  tyrosine-protein phosphatase non-receptor type 20 isoform X3

    15. XM_047425008.1 → XP_047280964.1  tyrosine-protein phosphatase non-receptor type 20 isoform X8

    16. XM_047425007.1 → XP_047280963.1  tyrosine-protein phosphatase non-receptor type 20 isoform X7

    17. XM_047425030.1 → XP_047280986.1  tyrosine-protein phosphatase non-receptor type 20 isoform X25

    18. XM_047425029.1 → XP_047280985.1  tyrosine-protein phosphatase non-receptor type 20 isoform X24

    19. XM_047425003.1 → XP_047280959.1  tyrosine-protein phosphatase non-receptor type 20 isoform X2

    20. XM_011539606.4 → XP_011537908.1  tyrosine-protein phosphatase non-receptor type 20 isoform X1

      See identical proteins and their annotated locations for XP_011537908.1

      UniProtKB/Swiss-Prot
      A6NNH8, B7ZKV3, Q4JDG6, Q4JDK1, Q4JDK5, Q4JDK6, Q4JDK8, Q4JDK9, Q4JDL0, Q4JDL1, Q4JDL3, Q4JDL4, Q4JDL5, Q4JDL6, Q4JDL7, Q4JDL8, Q5RJ33, Q5T1G3
      UniProtKB/TrEMBL
      Q5T1G2
      Conserved Domains (2) summary
      smart00194
      Location:159 → 411
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:185 → 411
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    21. XM_047425006.1 → XP_047280962.1  tyrosine-protein phosphatase non-receptor type 20 isoform X6

    22. XM_047425017.1 → XP_047280973.1  tyrosine-protein phosphatase non-receptor type 20 isoform X16

    23. XM_047425015.1 → XP_047280971.1  tyrosine-protein phosphatase non-receptor type 20 isoform X14

    24. XM_047425026.1 → XP_047280982.1  tyrosine-protein phosphatase non-receptor type 20 isoform X22

    25. XM_047425005.1 → XP_047280961.1  tyrosine-protein phosphatase non-receptor type 20 isoform X4

    26. XM_047425024.1 → XP_047280980.1  tyrosine-protein phosphatase non-receptor type 20 isoform X20

    27. XM_047425019.1 → XP_047280975.1  tyrosine-protein phosphatase non-receptor type 20 isoform X18

    28. XM_047425014.1 → XP_047280970.1  tyrosine-protein phosphatase non-receptor type 20 isoform X13

    29. XM_047425016.1 → XP_047280972.1  tyrosine-protein phosphatase non-receptor type 20 isoform X15

    30. XM_047425009.1 → XP_047280965.1  tyrosine-protein phosphatase non-receptor type 20 isoform X9

    31. XM_047425020.1 → XP_047280976.1  tyrosine-protein phosphatase non-receptor type 20 isoform X19

    32. XM_017016045.2 → XP_016871534.1  tyrosine-protein phosphatase non-receptor type 20 isoform X5

    33. XM_047425023.1 → XP_047280979.1  tyrosine-protein phosphatase non-receptor type 20 isoform X19

    34. XM_047425022.1 → XP_047280978.1  tyrosine-protein phosphatase non-receptor type 20 isoform X19

    RNA

    1. XR_007061954.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      47800189..47916646
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054365480.1 → XP_054221455.1  tyrosine-protein phosphatase non-receptor type 20 isoform X28

    2. XM_054365488.1 → XP_054221463.1  tyrosine-protein phosphatase non-receptor type 20 isoform X34

    3. XM_054365509.1 → XP_054221484.1  tyrosine-protein phosphatase non-receptor type 20 isoform X23

    4. XM_054365513.1 → XP_054221488.1  tyrosine-protein phosphatase non-receptor type 20 isoform X27

    5. XM_054365489.1 → XP_054221464.1  tyrosine-protein phosphatase non-receptor type 20 isoform X34

    6. XM_054365499.1 → XP_054221474.1  tyrosine-protein phosphatase non-receptor type 20 isoform X12

    7. XM_054365514.1 → XP_054221489.1  tyrosine-protein phosphatase non-receptor type 20 isoform X27

    8. XM_054365512.1 → XP_054221487.1  tyrosine-protein phosphatase non-receptor type 20 isoform X26

      UniProtKB/TrEMBL
      G8JLF9, Q4JDK3

    9. XM_054365491.1 → XP_054221466.1  tyrosine-protein phosphatase non-receptor type 20 isoform X34

    10. XM_054365494.1 → XP_054221469.1  tyrosine-protein phosphatase non-receptor type 20 isoform X7

    11. XM_054365497.1 → XP_054221472.1  tyrosine-protein phosphatase non-receptor type 20 isoform X10

    12. XM_054365510.1 → XP_054221485.1  tyrosine-protein phosphatase non-receptor type 20 isoform X23

    13. XM_054365498.1 → XP_054221473.1  tyrosine-protein phosphatase non-receptor type 20 isoform X11

    14. XM_054365481.1 → XP_054221456.1  tyrosine-protein phosphatase non-receptor type 20 isoform X28

    15. XM_054365483.1 → XP_054221458.1  tyrosine-protein phosphatase non-receptor type 20 isoform X30

    16. XM_054365505.1 → XP_054221480.1  tyrosine-protein phosphatase non-receptor type 20 isoform X17

    17. XM_054365492.1 → XP_054221467.1  tyrosine-protein phosphatase non-receptor type 20 isoform X35

    18. XM_054365484.1 → XP_054221459.1  tyrosine-protein phosphatase non-receptor type 20 isoform X31

    19. XM_054365490.1 → XP_054221465.1  tyrosine-protein phosphatase non-receptor type 20 isoform X34

    20. XM_054365511.1 → XP_054221486.1  tyrosine-protein phosphatase non-receptor type 20 isoform X25

    21. XM_054365482.1 → XP_054221457.1  tyrosine-protein phosphatase non-receptor type 20 isoform X29

    22. XM_054365487.1 → XP_054221462.1  tyrosine-protein phosphatase non-receptor type 20 isoform X33

    23. XM_054365486.1 → XP_054221461.1  tyrosine-protein phosphatase non-receptor type 20 isoform X1

      UniProtKB/Swiss-Prot
      A6NNH8, B7ZKV3, Q4JDG6, Q4JDK1, Q4JDK5, Q4JDK6, Q4JDK8, Q4JDK9, Q4JDL0, Q4JDL1, Q4JDL3, Q4JDL4, Q4JDL5, Q4JDL6, Q4JDL7, Q4JDL8, Q5RJ33, Q5T1G3

    24. XM_054365493.1 → XP_054221468.1  tyrosine-protein phosphatase non-receptor type 20 isoform X6

    25. XM_054365503.1 → XP_054221478.1  tyrosine-protein phosphatase non-receptor type 20 isoform X16

    26. XM_054365501.1 → XP_054221476.1  tyrosine-protein phosphatase non-receptor type 20 isoform X14

    27. XM_054365508.1 → XP_054221483.1  tyrosine-protein phosphatase non-receptor type 20 isoform X22

    28. XM_054365485.1 → XP_054221460.1  tyrosine-protein phosphatase non-receptor type 20 isoform X32

    29. XM_054365507.1 → XP_054221482.1  tyrosine-protein phosphatase non-receptor type 20 isoform X20

    30. XM_054365504.1 → XP_054221479.1  tyrosine-protein phosphatase non-receptor type 20 isoform X37

    31. XM_054365496.1 → XP_054221471.1  tyrosine-protein phosphatase non-receptor type 20 isoform X36

    32. XM_054365500.1 → XP_054221475.1  tyrosine-protein phosphatase non-receptor type 20 isoform X13

    33. XM_054365502.1 → XP_054221477.1  tyrosine-protein phosphatase non-receptor type 20 isoform X15

    34. XM_054365495.1 → XP_054221470.1  tyrosine-protein phosphatase non-receptor type 20 isoform X9

    35. XM_054365506.1 → XP_054221481.1  tyrosine-protein phosphatase non-receptor type 20 isoform X19

    RNA

    1. XR_008488193.1 RNA Sequence

    2. XR_008488194.1 RNA Sequence

    3. XR_008488195.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001042387.1: Suppressed sequence

      Description
      NM_001042387.1: This RefSeq was permanently suppressed because it is a redundant RefSeq for this protein tyrosine phosphatase family member.

    2. NM_001042389.1: Suppressed sequence

      Description
      NM_001042389.1: This RefSeq was permanently suppressed because it is a redundant RefSeq for this protein tyrosine phosphatase family member.

    3. NM_001042390.1: Suppressed sequence

      Description
      NM_001042390.1: This RefSeq was permanently suppressed because it is a redundant RefSeq for this protein tyrosine phosphatase family member.

    4. NM_001042391.1: Suppressed sequence

      Description
      NM_001042391.1: This RefSeq was permanently suppressed because it is a redundant RefSeq for this protein tyrosine phosphatase family member.

    5. NM_001042392.1: Suppressed sequence

      Description
      NM_001042392.1: This RefSeq was permanently suppressed because it is a redundant RefSeq for this protein tyrosine phosphatase family member.

    6. NM_001042393.1: Suppressed sequence

      Description
      NM_001042393.1: This RefSeq was permanently suppressed because it is a redundant RefSeq for this protein tyrosine phosphatase family member.

    7. NM_001042394.1: Suppressed sequence

      Description
      NM_001042394.1: This RefSeq was permanently suppressed because it is a redundant RefSeq for this protein tyrosine phosphatase family member.

    8. NM_001042395.1: Suppressed sequence

      Description
      NM_001042395.1: This RefSeq was permanently suppressed because it is a redundant RefSeq for this protein tyrosine phosphatase family member.

    9. NM_001042396.1: Suppressed sequence

      Description
      NM_001042396.1: This RefSeq was permanently suppressed because it is a redundant RefSeq for this protein tyrosine phosphatase family member.

    10. NM_001042397.1: Suppressed sequence

      Description
      NM_001042397.1: This RefSeq was permanently suppressed because it is a redundant RefSeq for this protein tyrosine phosphatase family member.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4JDL3.1 GenPept UniProtKB/Swiss-Prot:Q4JDL3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous