PRKCZ protein kinase C zeta [Homo sapiens (human)] - Gene

Summary

Official Symbol: PRKCZprovided by HGNC
Official Full Name: protein kinase C zetaprovided by HGNC
Primary source: HGNC:HGNC:9412
See related: Ensembl:ENSG00000067606 MIM:176982; AllianceGenome:HGNC:9412
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PKC2; PKC-ZETA
Summary: Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Expression: Broad expression in brain (RPKM 11.4), placenta (RPKM 8.8) and 22 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1p36.33

Exon count:: 35

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (2048504..2185395)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (1484023..1620370)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (1981850..2116834)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genetic polymorphism in untranslated regions of PRKCZ influences mRNA structure, stability and binding sites.
Title: Genetic polymorphism in untranslated regions of PRKCZ influences mRNA structure, stability and binding sites.
PKCzeta phosphorylates VASP to mediate chemotaxis in breast cancer cells.
Title: PKCζ phosphorylates VASP to mediate chemotaxis in breast cancer cells.
PKCzeta activation promotes maturation of cord blood T cells towards a Th1 IFN-gamma propensity.
Title: PKCζ activation promotes maturation of cord blood T cells towards a Th1 IFN-γ propensity.
PKC-zeta mediated reduction of the extracellular vesicles-associated TGF-beta1 overcomes radiotherapy resistance in breast cancer.
Title: PKC-ζ mediated reduction of the extracellular vesicles-associated TGF-β1 overcomes radiotherapy resistance in breast cancer.
Methylation-mediated silencing of protein kinase C zeta induces apoptosis avoidance through ATM/CHK2 inactivation in dedifferentiated chondrosarcoma.
Title: Methylation-mediated silencing of protein kinase C zeta induces apoptosis avoidance through ATM/CHK2 inactivation in dedifferentiated chondrosarcoma.
Human placenta and trophoblasts simultaneously express three isoforms of atypical protein kinase-c.
Title: Human placenta and trophoblasts simultaneously express three isoforms of atypical protein kinase-c.
Cord Blood T Cells Expressing High and Low PKCzeta Levels Develop into Cells with a Propensity to Display Th1 and Th9 Cytokine Profiles, Respectively.
Title: Cord Blood T Cells Expressing High and Low PKCζ Levels Develop into Cells with a Propensity to Display Th1 and Th9 Cytokine Profiles, Respectively.
A polybasic domain in aPKC mediates Par6-dependent control of membrane targeting and kinase activity.
Title: A polybasic domain in aPKC mediates Par6-dependent control of membrane targeting and kinase activity.
Mitochondrial nucleoid remodeling and biogenesis are regulated by the p53-p21(WAF1)-PKCzeta pathway in p16(INK4a)-silenced cells.
Title: Mitochondrial nucleoid remodeling and biogenesis are regulated by the p53-p21(WAF1)-PKCζ pathway in p16(INK4a)-silenced cells.
Bone metastatic breast cancer cells display downregulation of PKC-zeta with enhanced glutamine metabolism.
Title: Bone metastatic breast cancer cells display downregulation of PKC-ζ with enhanced glutamine metabolism.

Submit: New GeneRIF Correction See all GeneRIFs (179)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia. EBI GWAS Catalog EBI GWAS CatalogPubMed
Hundreds of variants clustered in genomic loci and biological pathways affect human height. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 activates forward trafficking and surface clustering of NMDA receptors in membrane microdomains by a PKA-dependent phosphorylation of the NR1 C-terminal Ser897, followed by a PKC-dependent phosphorylation of Ser896	PubMed
	env	Down modulation of the interaction between HIV-1 gp120 and CD4 by TPA is blocked by protein kinase C (PKC) inhibitors, suggesting PKC may play an important role in HIV-1 infection	PubMed
	env	c-FLIPL inhibits Bax activation via modulating PKC expression at the transcriptional level involving AP-2 during gp120 treatment	PubMed
	env	Induction of apoptosis in cell cultures through binding of HIV-1 gp120 or gp160 to CXCR4 involves protein kinase C, basic fibroblast growth factor, caspase-3, and the pro-apoptotic molecule Bax	PubMed
	env	Pre-treatment of endothelial cells with fibroblast growth factor 2 (FGF2) protects cells from HIV-1 gp120 angiotoxicity; this protection is regulated by crosstalk among the ERK, PI3K-AKT and PKC signaling pathways	PubMed
	env	HIV-1 gp120 increases the levels of calcium-dependent and -independent PKC isozymes; the most striking change is observed in PKC-zeta isozyme levels	PubMed
	env	A specific interaction between CD4 and HIV-1 gp120 is required for phosphorylation of CD4, which could involve protein kinase C	PubMed
	env	IL-16 induces rapid translocation of PKC from the cytosol to the membrane in CD4+ cells; PKC inhibitors completely block IL-16-induced lymphocyte migration as well as the motile response induced by HIV-1 gp120 and anti-CD4 antibody binding to CD4	PubMed
Envelope surface glycoprotein gp160, precursor	env	HIV-1 gp160-induced AP-1 complex formation is dependent upon protein tyrosine phosphorylation and is abolished by inhibitors of protein kinase C, but it is unaffected by calcium channel blockers or cyclosporine A	PubMed
Envelope transmembrane glycoprotein gp41	env	A synthetic peptide corresponding to cytoplasmic domain residues 828-848 of HIV-1 gp41 inhibits pKC-catalysed phosphorylation of a protein substrate	PubMed
	env	A synthetic peptide containing residues 581-597 from HIV-1 gp41 inhibits protein kinase C (pkC)-mediated phosphorylation of the CD3 gamma-chain in intact cells and directly inhibits partially purified pkC	PubMed
Pr55(Gag)	gag	The phosphorylation of HIV-1 Gag by PRKCI regulates HIV-1 Vpr incorporation into virions and HIV-1 replication in macrophages	PubMed
	gag	Immunoprecipation analysis demonstrates that PRKCZ binds HIV-1 Gag and phosphorylates Gag at position serine 487 in the p6 domain of Gag	PubMed
	gag	The amplified luminescent proximity homogeneous assay (AlphaScreen) identifies the interaction of HIV-1 Gag with PRKCZ	PubMed
Tat	tat	HIV-1 Tat increases CXCL12-induced internalization of CXCR4, and the Tat-mediated CXCR4 internalization requires activity of protein kinase C (zeta)	PubMed
	tat	Phospholipase C/protein kinase C signaling pathway-dependent phosphorylation of p44/42 and JNK MAP kinases participates partially in IL-1beta induction by TAT	PubMed
	tat	Protein kinase C is required for HIV-1 Tat-mediated transactivation of the viral LTR promoter, indicating protein kinase C regulates the process of HIV-1 transactivation and may play a role in the transition of HIV from latency to productive growth	PubMed
	tat	Protein kinase C phosphorylates HIV-1 Tat on serine residue 46	PubMed
	tat	HIV-1 Tat activates protein kinase C, resulting in the induction of TNF-alpha, IL-6 and IL-10 expression and the secretion of MCP-1	PubMed
Vpr	vpr	The phosphorylation of HIV-1 Gag at Ser487 by PRKCZ regulates HIV-1 Vpr incorporation into virions and HIV-1 replication in macrophages	PubMed
matrix	gag	Protein kinase C (PKC) phosphorylates HIV-1 Matrix on serine residue 111 resulting in a shift in localization of Matrix from the cytosol to the cellular membrane, suggesting a myristoyl-protein switch regulated by PKC phosphorylation	PubMed
retropepsin	gag-pol	Phosphorylation of human recombinant vimentin by PKC inhibits the proteolytic processing of the vimentin head domain by HIV-1 protease	PubMed
reverse transcriptase	gag-pol	HIV-1 RT heterodimer expressed in bacteria can be phosphorylated in vitro by several purified mammalian protein kinases including auto-activated protein kinase (PK), CKII, cytosolic protamine kinase (CPK), myelin basic protein kinase 1 (MBPK1), and PRKC	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-147428 (e-PCR)
- UniSTS:172805

PMC156606P1 (e-PCR)
- UniSTS:271408

SHGC-33169 (e-PCR)
- UniSTS:82233

SHGC-74107 (e-PCR)
- UniSTS:78499

SHGC-74092 (e-PCR)
- UniSTS:18341

G60196 (e-PCR)
- UniSTS:137455

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 14-3-3 protein binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables diacylglycerol-dependent serine/threonine kinase activity	EXP Inferred from Experiment more info	PubMed
enables diacylglycerol-dependent serine/threonine kinase activity	TAS Traceable Author Statement more info
enables insulin receptor substrate binding	IC Inferred by Curator more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phospholipase binding	IEA Inferred from Electronic Annotation more info
enables potassium channel regulator activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell migration	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cellular response to insulin stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to insulin stimulus	IEA Inferred from Electronic Annotation more info
involved_in establishment of cell polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of cell polarity	ISS Inferred from Sequence or Structural Similarity more info
involved_in establishment or maintenance of epithelial cell apical/basal polarity	ISS Inferred from Sequence or Structural Similarity more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in long-term memory	IEA Inferred from Electronic Annotation more info
involved_in long-term synaptic potentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in membrane depolarization	IEA Inferred from Electronic Annotation more info
involved_in membrane hyperpolarization	IEA Inferred from Electronic Annotation more info
involved_in microtubule cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of peptidyl-tyrosine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein-containing complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron projection extension	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-serine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of NF-kappaB transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of T-helper 2 cell cytokine production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of T-helper 2 cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell-matrix adhesion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of excitatory postsynaptic potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of insulin receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of interleukin-10 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of interleukin-13 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of interleukin-4 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of interleukin-5 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein kinase C signaling	IEA Inferred from Electronic Annotation more info
involved_in protein localization to plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in vesicle transport along microtubule	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of PAR polarity complex	ISS Inferred from Sequence or Structural Similarity more info
located_in Schaffer collateral - CA1 synapse	IEA Inferred from Electronic Annotation more info
located_in apical cortex	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in axon hillock	IEA Inferred from Electronic Annotation more info
located_in bicellular tight junction	IEA Inferred from Electronic Annotation more info
located_in cell junction	TAS Traceable Author Statement more info
located_in cell leading edge	IEA Inferred from Electronic Annotation more info
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	TAS Traceable Author Statement more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	HDA more info	PubMed
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
located_in membrane	TAS Traceable Author Statement more info	PubMed
located_in microtubule organizing center	IEA Inferred from Electronic Annotation more info
located_in myelin sheath abaxonal region	IEA Inferred from Electronic Annotation more info
located_in nuclear envelope	IEA Inferred from Electronic Annotation more info
located_in nuclear matrix	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info
located_in stress fiber	IEA Inferred from Electronic Annotation more info
located_in tight junction	NAS Non-traceable Author Statement more info	PubMed
located_in vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protein kinase C zeta type

Names: nPKC-zeta

NP_001028753.1

EC 2.7.11.13

NP_001028754.1

EC 2.7.11.13

NP_001229803.1

EC 2.7.11.13

NP_001337732.1

EC 2.7.11.13

NP_001337733.1

EC 2.7.11.13

NP_001337734.1

EC 2.7.11.13

NP_001337735.1

EC 2.7.11.13

NP_002735.3

EC 2.7.11.13

XP_011540075.1

EC 2.7.11.13

XP_011540076.1

EC 2.7.11.13

XP_011540077.1

EC 2.7.11.13

XP_011540078.1

EC 2.7.11.13

XP_016857278.1

EC 2.7.11.13

XP_016857279.1

EC 2.7.11.13

XP_016857281.1

EC 2.7.11.13

XP_016857282.1

EC 2.7.11.13

XP_016857286.1

EC 2.7.11.13

XP_016857291.1

EC 2.7.11.13

XP_016857292.1

EC 2.7.11.13

XP_024304159.1

EC 2.7.11.13

XP_024304164.1

EC 2.7.11.13

XP_024304165.1

EC 2.7.11.13

XP_047281211.1

EC 2.7.11.13

XP_047281216.1

EC 2.7.11.13

XP_047281218.1

EC 2.7.11.13

XP_047281229.1

EC 2.7.11.13

XP_047281239.1

EC 2.7.11.13

XP_047281260.1

EC 2.7.11.13

XP_047281263.1

EC 2.7.11.13

XP_047281279.1

EC 2.7.11.13

XP_047281296.1

EC 2.7.11.13

XP_047281304.1

EC 2.7.11.13

XP_054193655.1

EC 2.7.11.13

XP_054193656.1

EC 2.7.11.13

XP_054193657.1

EC 2.7.11.13

XP_054193658.1

EC 2.7.11.13

XP_054193659.1

EC 2.7.11.13

XP_054193660.1

EC 2.7.11.13

XP_054193661.1

EC 2.7.11.13

XP_054193662.1

EC 2.7.11.13

XP_054193663.1

EC 2.7.11.13

XP_054193664.1

EC 2.7.11.13

XP_054193665.1

EC 2.7.11.13

XP_054193666.1

EC 2.7.11.13

XP_054193667.1

EC 2.7.11.13

XP_054193668.1

EC 2.7.11.13

XP_054193669.1

EC 2.7.11.13

XP_054193670.1

EC 2.7.11.13

XP_054193671.1

EC 2.7.11.13

XP_054193672.1

EC 2.7.11.13

XP_054193673.1

EC 2.7.11.13

XP_054193674.1

EC 2.7.11.13

XP_054193675.1

EC 2.7.11.13

XP_054193676.1

EC 2.7.11.13

XP_054193677.1

EC 2.7.11.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029616.1 RefSeqGene

Range

4942..139926

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001033581.3 → NP_001028753.1 protein kinase C zeta type isoform 2

See identical proteins and their annotated locations for NP_001028753.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation from a downstream ATG and an isoform (2) with a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode the same isoform (2).

Source sequence(s)

BC008058, CB152283

Consensus CDS

CCDS41229.1

UniProtKB/TrEMBL

B3KUN5

Related

ENSP00000383712.2, ENST00000400921.6

Conserved Domains (1) summary

cl21453
Location:53 → 409

PKc_like; Protein Kinases, catalytic domain
NM_001033582.3 → NP_001028754.1 protein kinase C zeta type isoform 2

See identical proteins and their annotated locations for NP_001028754.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation from a downstream ATG and an isoform (3) with a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode the same isoform (2).

Source sequence(s)

AL542576, AU134793, BC008058

Consensus CDS

CCDS41229.1

UniProtKB/TrEMBL

B3KUN5

Conserved Domains (1) summary

cl21453
Location:53 → 409

PKc_like; Protein Kinases, catalytic domain
NM_001242874.3 → NP_001229803.1 protein kinase C zeta type isoform 3

See identical proteins and their annotated locations for NP_001229803.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.

Source sequence(s)

AK294782, AL590822, BC008058, DC312466

Consensus CDS

CCDS55563.1

UniProtKB/TrEMBL

B3KUN5

Related

ENSP00000426412.1, ENST00000461106.6

Conserved Domains (2) summary

cd21095
Location:25 → 79

C1_aPKC_zeta; protein kinase C conserved region 1 (C1 domain) found in the atypical protein kinase C (aPKC) zeta type

cl21453
Location:132 → 488

PKc_like; Protein Kinases, catalytic domain
NM_001350803.2 → NP_001337732.1 protein kinase C zeta type isoform 4

Status: REVIEWED

Source sequence(s)

AI186591, BC008058, BQ084132, CB152283, DA392984

UniProtKB/TrEMBL

B3KUN5

Conserved Domains (1) summary

cl21453
Location:53 → 417

PKc_like; Protein Kinases, catalytic domain
NM_001350804.2 → NP_001337733.1 protein kinase C zeta type isoform 4

Status: REVIEWED

Source sequence(s)

AI186591, AL645703, BC008058, BQ084132, CB152283

UniProtKB/TrEMBL

B3KUN5

Conserved Domains (1) summary

cl21453
Location:53 → 417

PKc_like; Protein Kinases, catalytic domain
NM_001350805.2 → NP_001337734.1 protein kinase C zeta type isoform 5

Status: REVIEWED

Source sequence(s)

AI186591, AL590822, BC008058, DC328654

UniProtKB/TrEMBL

B3KUN5

Conserved Domains (1) summary

cl21453
Location:1 → 355

PKc_like; Protein Kinases, catalytic domain
NM_001350806.2 → NP_001337735.1 protein kinase C zeta type isoform 5

Status: REVIEWED

Source sequence(s)

AI186591, AL590822, BC008058, DC314278

UniProtKB/TrEMBL

B3KUN5

Conserved Domains (1) summary

cl21453
Location:1 → 355

PKc_like; Protein Kinases, catalytic domain
NM_002744.6 → NP_002735.3 protein kinase C zeta type isoform 1

See identical proteins and their annotated locations for NP_002735.3

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AL391845, BC008058, BC014270

Consensus CDS

CCDS37.1

UniProtKB/Swiss-Prot

A8K4N0, A8MU64, B7Z2J7, E9PCW2, Q05513, Q15207, Q5SYT5, Q969S4

Related

ENSP00000367830.3, ENST00000378567.8

Conserved Domains (3) summary

cd06404
Location:16 → 98

PB1_aPKC; PB1 domain is an essential modular domain of the atypical protein kinase C (aPKC) which in complex with Par6 and Par3 proteins is crucial for establishment of apical-basal polarity of animal cells. PB1 domain is a modular domain mediating specific ...

cd05617
Location:236 → 592

STKc_aPKC_zeta; Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C zeta

pfam00130
Location:131 → 181

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

RNA

NR_146911.2 RNA Sequence

Status: REVIEWED

Source sequence(s)

BC008058, CB152283, HY218327

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

2048504..2185395

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047425255.1 → XP_047281211.1 protein kinase C zeta type isoform X4
XM_017001790.2 → XP_016857279.1 protein kinase C zeta type isoform X2
XM_017001789.2 → XP_016857278.1 protein kinase C zeta type isoform X1
XM_011541773.2 → XP_011540075.1 protein kinase C zeta type isoform X3

Conserved Domains (4) summary

cd06404
Location:16 → 98

PB1_aPKC; PB1 domain is an essential modular domain of the atypical protein kinase C (aPKC) which in complex with Par6 and Par3 proteins is crucial for establishment of apical-basal polarity of animal cells. PB1 domain is a modular domain mediating specific ...

smart00220
Location:252 → 518

S_TKc; Serine/Threonine protein kinases, catalytic domain

pfam00130
Location:131 → 181

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

cl21453
Location:236 → 529

PKc_like; Protein Kinases, catalytic domain
XM_011541775.4 → XP_011540077.1 protein kinase C zeta type isoform X13

Conserved Domains (3) summary

cd06404
Location:16 → 98

PB1_aPKC; PB1 domain is an essential modular domain of the atypical protein kinase C (aPKC) which in complex with Par6 and Par3 proteins is crucial for establishment of apical-basal polarity of animal cells. PB1 domain is a modular domain mediating specific ...

pfam00130
Location:131 → 181

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

cl21453
Location:236 → 325

PKc_like; Protein Kinases, catalytic domain
XM_017001803.3 → XP_016857292.1 protein kinase C zeta type isoform X18
XM_047425262.1 → XP_047281218.1 protein kinase C zeta type isoform X6
XM_047425260.1 → XP_047281216.1 protein kinase C zeta type isoform X5
XM_017001792.2 → XP_016857281.1 protein kinase C zeta type isoform X10

UniProtKB/TrEMBL

E9PBE1

Conserved Domains (1) summary

cl21453
Location:53 → 354

PKc_like; Protein Kinases, catalytic domain
XM_011541776.2 → XP_011540078.1 protein kinase C zeta type isoform X14

See identical proteins and their annotated locations for XP_011540078.1

UniProtKB/TrEMBL

E9PBE1

Conserved Domains (1) summary

cl21453
Location:53 → 346

PKc_like; Protein Kinases, catalytic domain
XM_011541774.2 → XP_011540076.1 protein kinase C zeta type isoform X8

Conserved Domains (3) summary

smart00220
Location:148 → 414

S_TKc; Serine/Threonine protein kinases, catalytic domain

pfam00130
Location:27 → 77

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

cl21453
Location:132 → 425

PKc_like; Protein Kinases, catalytic domain
XM_047425283.1 → XP_047281239.1 protein kinase C zeta type isoform X9
XM_047425323.1 → XP_047281279.1 protein kinase C zeta type isoform X11
XM_024448391.2 → XP_024304159.1 protein kinase C zeta type isoform X10

UniProtKB/TrEMBL

E9PBE1

Conserved Domains (1) summary

cl21453
Location:53 → 354

PKc_like; Protein Kinases, catalytic domain
XM_024448396.2 → XP_024304164.1 protein kinase C zeta type isoform X14

UniProtKB/TrEMBL

E9PBE1

Conserved Domains (1) summary

cl21453
Location:53 → 346

PKc_like; Protein Kinases, catalytic domain
XM_047425348.1 → XP_047281304.1 protein kinase C zeta type isoform X15

Related

ENSP00000424398.1, ENST00000478770.6
XM_047425304.1 → XP_047281260.1 protein kinase C zeta type isoform X10
XM_047425340.1 → XP_047281296.1 protein kinase C zeta type isoform X14
XM_047425273.1 → XP_047281229.1 protein kinase C zeta type isoform X7
XM_017001793.2 → XP_016857282.1 protein kinase C zeta type isoform X10

UniProtKB/TrEMBL

E9PBE1

Conserved Domains (1) summary

cl21453
Location:53 → 354

PKc_like; Protein Kinases, catalytic domain
XM_047425307.1 → XP_047281263.1 protein kinase C zeta type isoform X10
XM_017001797.2 → XP_016857286.1 protein kinase C zeta type isoform X12

UniProtKB/TrEMBL

E9PBE1
XM_024448397.2 → XP_024304165.1 protein kinase C zeta type isoform X16

Conserved Domains (1) summary

cl21453
Location:1 → 300

PKc_like; Protein Kinases, catalytic domain
XM_017001802.2 → XP_016857291.1 protein kinase C zeta type isoform X17

UniProtKB/TrEMBL

E9PBE1