CORO2B coronin 2B [Homo sapiens (human)] - Gene

Summary

Official Symbol: CORO2Bprovided by HGNC
Official Full Name: coronin 2Bprovided by HGNC
Primary source: HGNC:HGNC:2256
See related: Ensembl:ENSG00000103647 MIM:605002; AllianceGenome:HGNC:2256
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CLIPINC
Summary: Enables talin binding activity and vinculin binding activity. Acts upstream of or within several processes, including negative regulation of cell-substrate adhesion; regulation of actin cytoskeleton organization; and regulation of establishment of protein localization. Located in focal adhesion. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in brain (RPKM 22.9), ovary (RPKM 6.5) and 11 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 15q23

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	15	NC_000015.10 (68518373..68727806)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	15	NC_060939.1 (66341263..66550386)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	15	NC_000015.9 (68810712..69020145)

Chromosome 15 - NC_000015.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Coro2b, a podocyte protein downregulated in human diabetic nephropathy, is involved in the development of protamine sulphate-induced foot process effacement.
Title: Coro2b, a podocyte protein downregulated in human diabetic nephropathy, is involved in the development of protamine sulphate-induced foot process effacement.
CORO2B is a novel podocyte enriched protein influencing cytoskeletal plasticity and stress adaptation.
Title: The WD40-domain containing protein CORO2B is specifically enriched in glomerular podocytes and regulates the ventral actin cytoskeleton.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH48611 (e-PCR)
- UniSTS:26931

D15S1243 (e-PCR)
- UniSTS:77169

A007L06 (e-PCR)
- UniSTS:17278

RH28501 (e-PCR)
- UniSTS:91033

WI-13883 (e-PCR)
- UniSTS:63718

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables actin binding	NAS Non-traceable Author Statement more info	PubMed
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables talin binding	IDA Inferred from Direct Assay more info	PubMed
enables vinculin binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	NAS Non-traceable Author Statement more info	PubMed
involved_in focal adhesion assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of cell-substrate adhesion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of establishment of protein localization	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of stress fiber assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of establishment of protein localization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of actin cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of cellular response to stress	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of glomerular filtration	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in actin cytoskeleton	NAS Non-traceable Author Statement more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in focal adhesion	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: coronin-2B

Names: clipin C; coronin, actin binding protein, 2B; coronin-like protein C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001190456.2 → NP_001177385.1 coronin-2B isoform 2

See identical proteins and their annotated locations for NP_001177385.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream in-frame start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2 and 3 encode the same isoform.

Source sequence(s)

AC090734, AC105014, AI871484, AK289678, DA128408

Consensus CDS

CCDS53952.1

UniProtKB/Swiss-Prot

Q9UQ03

Related

ENSP00000446250.1, ENST00000540068.6

Conserved Domains (2) summary

sd00039
Location:40 → 80

7WD40; WD40 repeat [structural motif]

cl29593
Location:10 → 455

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001190457.2 → NP_001177386.1 coronin-2B isoform 2

See identical proteins and their annotated locations for NP_001177386.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream in-frame start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2 and 3 encode the same isoform.

Source sequence(s)

AC090734, AI871484, AK289678

Consensus CDS

CCDS53952.1

UniProtKB/Swiss-Prot

Q9UQ03

Related

ENSP00000443819.1, ENST00000543950.3

Conserved Domains (2) summary

sd00039
Location:40 → 80

7WD40; WD40 repeat [structural motif]

cl29593
Location:10 → 455

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001324014.1 → NP_001310943.1 coronin-2B isoform 2

Status: VALIDATED

Source sequence(s)

AC090259, AC090734, AC100825, AC105014

Consensus CDS

CCDS53952.1

UniProtKB/Swiss-Prot

Q9UQ03

Conserved Domains (2) summary

sd00039
Location:40 → 80

7WD40; WD40 repeat [structural motif]

cl29593
Location:10 → 455

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001324015.1 → NP_001310944.1 coronin-2B isoform 2

Status: VALIDATED

Source sequence(s)

AC090734, AC105014

Consensus CDS

CCDS53952.1

UniProtKB/Swiss-Prot

Q9UQ03

Conserved Domains (2) summary

sd00039
Location:40 → 80

7WD40; WD40 repeat [structural motif]

cl29593
Location:10 → 455

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_006091.5 → NP_006082.3 coronin-2B isoform 1

See identical proteins and their annotated locations for NP_006082.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AB023142, AC090734, AC105014, BQ184259, HY150896

Consensus CDS

CCDS10229.2

UniProtKB/Swiss-Prot

A8K0W3, O94767, Q8TAN1, Q9UQ03

Related

ENSP00000261861.6, ENST00000261861.10

Conserved Domains (2) summary

sd00039
Location:45 → 85

7WD40; WD40 repeat [structural motif]

cl29593
Location:15 → 460

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...