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    Tecr trans-2,3-enoyl-CoA reductase [ Mus musculus (house mouse) ]

    Gene ID: 106529, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Tecrprovided by MGI
    Official Full Name
    trans-2,3-enoyl-CoA reductaseprovided by MGI
    Primary source
    MGI:MGI:1915408
    See related
    Ensembl:ENSMUSG00000031708 AllianceGenome:MGI:1915408
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SC2; Gpsn2; D17Ertd178e; 2410016D23Rik; A230102P12Rik
    Summary
    Predicted to enable very-long-chain enoyl-CoA reductase activity. Predicted to be involved in fatty acid elongation; sphingolipid metabolic process; and very long-chain fatty acid biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; nervous system; respiratory system; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 14. Orthologous to human TECR (trans-2,3-enoyl-CoA reductase). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 340.9), mammary gland adult (RPKM 233.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tecr in Genome Data Viewer
    Location:
    8 C2; 8 40.22 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (84298327..84321120, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (83571698..83594491, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein S2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_22086 Neighboring gene NADH:ubiquinone oxidoreductase subunit B7 Neighboring gene STARR-positive B cell enhancer ABC_E6666 Neighboring gene RIKEN cDNA D830024N08 gene Neighboring gene predicted gene, 51541 Neighboring gene STARR-positive B cell enhancer ABC_E454 Neighboring gene predicted gene, 42029 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E455 Neighboring gene DnaJ heat shock protein family (Hsp40) member B1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of a mouse synaptic glycoprotein gene in cultured neurons. Yu AC, et al. Neurochem Res, 2005 Oct. PMID 16341590
    2. Identification of two mammalian reductases involved in the two-carbon fatty acyl elongation cascade. Moon YA, et al. J Biol Chem, 2003 Feb 28. PMID 12482854
    3. Very-long-chain fatty acids are crucial to neuronal polarity by providing sphingolipids to lipid rafts. Honda A, et al. Cell Rep, 2023 Oct 31. PMID 37816355
    4. Loss of the selective autophagy receptor p62 impairs murine myeloid leukemia progression and mitophagy. Nguyen TD, et al. Blood, 2019 Jan 10. PMID 30498063
    5. Gene expression profile of the third pharyngeal pouch reveals role of mesenchymal MafB in embryonic thymus development. Sultana DA, et al. Blood, 2009 Mar 26. PMID 19164599, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results describe the sequence and distribution of mouse synaptic glycoprotein homolog 2.
      Title: Identification of a mouse synaptic glycoprotein gene in cultured neurons.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC144249

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables very-long-chain enoyl-CoA reductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables very-long-chain enoyl-CoA reductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid elongation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fatty acid elongation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in sphingolipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sphingolipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sphingolipid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in steroid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in very long-chain fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in very long-chain fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in very long-chain fatty acid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    very-long-chain enoyl-CoA reductase
    Names
    TER
    glycoprotein, synaptic 2
    synaptic glycoprotein SC2
    NP_081455.1
    NP_598879.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027179.1 → NP_081455.1  very-long-chain enoyl-CoA reductase isoform 2

      See identical proteins and their annotated locations for NP_081455.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AK010984, BE994003, BY278351
      Consensus CDS
      CCDS52609.1
      UniProtKB/TrEMBL
      G3UWE1, Q9CWN2
      Related
      ENSMUSP00000131389.2, ENSMUST00000165740.9
      Conserved Domains (2) summary
      PLN02560
      Location:38 → 290
      PLN02560; enoyl-CoA reductase
      cl28922
      Location:3 → 66
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    2. NM_134118.5 → NP_598879.1  very-long-chain enoyl-CoA reductase isoform 1

      See identical proteins and their annotated locations for NP_598879.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK010984, BE994003, BY278351
      Consensus CDS
      CCDS40403.1
      UniProtKB/Swiss-Prot
      Q9CY27
      UniProtKB/TrEMBL
      Q9CWN2
      Related
      ENSMUSP00000019382.10, ENSMUST00000019382.17
      Conserved Domains (1) summary
      PLN02560
      Location:23 → 305
      PLN02560; enoyl-CoA reductase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      84298327..84321120 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CY27.1 GenPept UniProtKB/Swiss-Prot:Q9CY27

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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