EP300 E1A binding protein p300 [Homo sapiens (human)] - Gene

Summary

Official Symbol: EP300provided by HGNC
Official Full Name: E1A binding protein p300provided by HGNC
Primary source: HGNC:HGNC:3373
See related: Ensembl:ENSG00000100393 MIM:602700; AllianceGenome:HGNC:3373
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: p300; KAT3B; MKHK2; RSTS2
Summary: This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in bone marrow (RPKM 27.3), testis (RPKM 17.5) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 22q13.2

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	22	NC_000022.11 (41092592..41180077)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	22	NC_060946.1 (41567504..41655012)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	22	NC_000022.10 (41488596..41576081)

Chromosome 22 - NC_000022.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NAP1L1 Promotes Endometrial Cancer Progression via EP300-Mediated DDX5 Promoter Acetylation.
Title: NAP1L1 Promotes Endometrial Cancer Progression via EP300-Mediated DDX5 Promoter Acetylation.
CREB-binding protein/P300 bromodomain inhibition reduces neutrophil accumulation and activates antitumor immunity in triple-negative breast cancer.
Title: CREB-binding protein/P300 bromodomain inhibition reduces neutrophil accumulation and activates antitumor immunity in triple-negative breast cancer.
AR coactivators, CBP/p300, are critical mediators of DNA repair in prostate cancer.
Title: AR coactivators, CBP/p300, are critical mediators of DNA repair in prostate cancer.
KIF15 promotes human glioblastoma progression under the synergistic transactivation of REST and P300.
Title: KIF15 promotes human glioblastoma progression under the synergistic transactivation of REST and P300.
EP300 promotes tumor stemness via epigenetic activation of CRISP3 leading to lobaplatin resistance in triple-negative breast cancer.
Title: EP300 promotes tumor stemness via epigenetic activation of CRISP3 leading to lobaplatin resistance in triple-negative breast cancer.
P300 Participates in Ionizing Radiation-Mediated Activation of Cathepsin L by Mutant p53.
Title: P300 Participates in Ionizing Radiation-Mediated Activation of Cathepsin L by Mutant p53.
P300 reduces TUBB4B expression to facilitate the biological process of migration and invasion of non-small cell lung cancer cells.
Title: P300 reduces TUBB4B expression to facilitate the biological process of migration and invasion of non-small cell lung cancer cells.
EP300 through upregulating the expression of vimentin to promote the progression of chordoma.
Title: EP300 through upregulating the expression of vimentin to promote the progression of chordoma.
P300 in schizophrenia: Then and now.
Title: P300 in schizophrenia: Then and now.
EP300-ZNF384 transactivates IL3RA to promote the progression of B-cell acute lymphoblastic leukemia.
Title: EP300-ZNF384 transactivates IL3RA to promote the progression of B-cell acute lymphoblastic leukemia.

Submit: New GeneRIF Correction See all GeneRIFs (464)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Colorectal cancer MedGen: C0346629 OMIM: 114500 GeneReviews: Lynch Syndrome	Compare labs
Menke-Hennekam syndrome 2 MedGen: C5193035 OMIM: 618333 GeneReviews: Not available	Compare labs
Rubinstein-Taybi syndrome due to CREBBP mutations MedGen: C4551859 OMIM: 180849 GeneReviews: Rubinstein-Taybi Syndrome	Compare labs
Rubinstein-Taybi syndrome due to EP300 haploinsufficiency MedGen: C3150941 OMIM: 613684 GeneReviews: Rubinstein-Taybi Syndrome	Compare labs

Copy number response

Description
Copy number response Triplosensitivity No evidence available (Last evaluated 2013-03-14) ClinGen Genome Curation Page Haploinsufficency Sufficient evidence for dosage pathogenicity (Last evaluated 2013-03-14) ClinGen Genome Curation PagePubMed

EBI GWAS Catalog

Description
A genome-wide association study on a southern European population identifies a new Crohn's disease susceptibility locus at RBX1-EP300. EBI GWAS Catalog EBI GWAS CatalogPubMed
Biological insights from 108 schizophrenia-associated genetic loci. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of E1A binding protein p300 (EP300) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 and p300 synergistically increase TGF-beta, ATF-2 and activating protein-1 (AP-1) expression leading to tubular cell apoptosis; in addition, HIV-1 gp120 treatment causes phosphorylation of Smad2 and downregulation of c-Jun	PubMed
	env	HIV-1 gp120-induced apoptosis in human proximal renal tubular cells is significantly enhanced by p300, and Smad7 and an anti-TGF-beta antibody inhibit this effect of p300	PubMed
Tat	tat	HIV-1 Tat interaction with p300 and other histone acetyl transferases is preferentially important for Tat-mediated transactivation of integrated, but not unintegrated, HIV-1 LTR promoter	PubMed
	tat	Acetylation of HIV-1 Tat by p300 at Lys50 regulates Tat binding to cyclin T1 and HIV-1 TAR RNA, as well as Tat-mediated transactivation of the HIV-1 LTR promoter, by allowing Tat to dissociate from TAR RNA	PubMed
	tat	HIV-1 Tat is acetylated by p300 on Lys50 and Lys51	PubMed
	tat	HIV-1 Tat-induced upregulation and phosphorylation of STAT3 expression results in increased GFAP, Egr-1, and p300 transcription and protein expression in both Tat-expressing astrocytes, and HIV-infected astrocytes	PubMed
	tat	HIV-1 Tat-induced upregulation of p300 occurs at the transcriptional level through the cis-acting elements of early growth response 1 (egr-1) within its promoter	PubMed
	tat	HIV-1 Tat, NAP-1, and p300 synergistically activate HIV-1 transcription	PubMed
	tat	Tat stimulates NF-kappaB-inducing kinase IKKalpha translocation from the cytoplasm to the nucleus in monocytes, which leads to IKKalpha and CBP/p300 recruitment to the IL-10 promoter and histone H3 phosphorylation (Ser 10) and acetylation (Lys 14)	PubMed
	tat	HIV-1 Tat-mediated upregulation of adenovirus E1a-associated 300 kDa protein p300 regulates increased GFAP expression in astrocytes	PubMed
	tat	HIV-1 Tat interaction with p300 increases the histone acetyl transferase (HAT) activity of p300 on histone H4, indicating Tat modulates HAT activity of co-activators to derepress the HIV-1 chromatin structure and aid in activated transcription	PubMed
	tat	HIV-1 Tat forms a ternary complex with p300 and P/CAF	PubMed
	tat	Binding of HIV-1 Tat to p300 induces a conformational change in the CBP/p300 complex such that it can acquire and bind better to basal transcription factors, indicating Tat helps CBP/p300 recruit new partners to the transcription machinery	PubMed
	tat	HIV-1 Tat recruits CBP/p300 to the chromosomally integrated HIV-1 LTR promoter	PubMed
	tat	Acetylation of the p50 subunit of NFkappaB by CBP/p300 is regulated by HIV-1 Tat	PubMed
	tat	INI-1 and BRG-1 synergize with the p300 acetyltransferase to activate the HIV promoter; this synergism depends on the acetyltransferase activity of p300 and on HIV-1 Tat amino acids Lys(50) and Lys(51), suggesting a regulation of Tat by these proteins	PubMed
	tat	HIV-1 Tat binds to the minimal histone acetyltransferase domain (amino acids 1253-1710) and E1a binding domain (amino acids 1542-1710) of p300, an effect mediated by the basic domain (amino acids 48-57) of Tat	PubMed
	tat	HIV-1 Tat induces the polyubiquitination and degradation of Tip60 through p300/CBP-associated E4-type ubiquitin-ligase activity, which results in a dramatic impairment of the Tip60-dependent apoptotic cell response to DNA damage	PubMed
Vpr	vpr	HIV-1 Vpr and p300/HAT colocalizes with CENP-A and CENP-H proteins in the centromere and arm region of chromosome	PubMed
	vpr	HIV-1 Vpr actively recruits p300/HAT to a range of chromatine regions including the centromere, resulting in the displacement of HP1-alpha	PubMed
	vpr	Data suggests that HIV-1 Vpr, Rel A, and p300 act in concert to activate HIV transcription	PubMed
	vpr	Adenovirus E1A protein represses activation by Vpr by competing for binding to p300, suggesting that p300 is required for activation of HIV transcription by Vpr	PubMed
	vpr	Transcription Factor IIH (TFIIH) and p300 act cooperatively to enhance Vpr effects on glucocorticoid receptor transactivation	PubMed
	vpr	The C-terminus of HIV-1 Vpr (amino acids 64-84) mediates the binding of Vpr to p300 (amino acids 2045-2191)	PubMed
	vpr	HIV-1 Vpr transactivation of HIV transcription and of the glucocorticoid receptor pathway is mediated by direct binding to the p300 co-activator	PubMed
integrase	gag-pol	The interaction between HIV-1 IN and KAP1 is highly favored by HAT/p300-mediated IN acetylation	PubMed
	gag-pol	HAT/p300 acetylates lysine's 264, 266, and 273 of HIV-1 IN	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU048745 (e-PCR)
- UniSTS:145195

RH46342 (e-PCR)
- UniSTS:48221

RH136048 (e-PCR)
- UniSTS:210043

STS-U01877 (e-PCR)
- UniSTS:43913

D22S1541 (e-PCR)
- UniSTS:67472

A009U19 (e-PCR)
- UniSTS:43409

RH65941 (e-PCR)
- UniSTS:21415

PMC113761P2 (e-PCR)
- UniSTS:270253

G32842 (e-PCR)
- UniSTS:117421

EP300_8165 (e-PCR)
- UniSTS:467671

STS-N57495 (e-PCR)
- UniSTS:71650

WI-18189 (e-PCR)
- UniSTS:65508

SGC38348 (e-PCR)
- UniSTS:73462

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables NF-kappaB binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables STAT family protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables acetylation-dependent protein binding	IDA Inferred from Direct Assay more info	PubMed
enables acetyltransferase activity	EXP Inferred from Experiment more info	PubMed
enables acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables acetyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables acyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables beta-catenin binding	IPI Inferred from Physical Interaction more info	PubMed
enables chromatin DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables damaged DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables histone H2AK5 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AK9 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H2B acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H2BK12 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BK5 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3 acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H3K122 acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H3K14 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K18 acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H3K23 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K27 acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H3K27 acetyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables histone H3K36 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K4 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K56 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K9 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4 acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H4 acetyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables histone H4K12 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4K16 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4K16 propionyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4K5 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4K8 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone acetyltransferase activity	TAS Traceable Author Statement more info	PubMed
enables histone butyryltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone crotonyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone lactyltransferase (CoA-dependent) activity	IDA Inferred from Direct Assay more info	PubMed
enables lysine N-acetyltransferase activity, acting on acetyl phosphate as donor	IDA Inferred from Direct Assay more info	PubMed
enables nuclear androgen receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables p53 binding	IEA Inferred from Electronic Annotation more info
enables peptide 2-hydroxyisobutyryltransferase activity	IEA Inferred from Electronic Annotation more info
enables peptide N-acetyltransferase activity	TAS Traceable Author Statement more info
enables peptide butyryltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables peptide-lysine-N-acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables peptide-lysine-N-acetyltransferase activity	TAS Traceable Author Statement more info
enables pre-mRNA intronic binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein propionyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables tau protein binding	NAS Non-traceable Author Statement more info	PubMed
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription coactivator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transcription coactivator activity	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	TAS Traceable Author Statement more info	PubMed
enables transcription coactivator binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coregulator binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in B cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in N-terminal peptidyl-lysine acetylation	IDA Inferred from Direct Assay more info	PubMed
involved_in animal organ morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in behavioral defense response	IEA Inferred from Electronic Annotation more info
involved_in canonical NF-kappaB signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to L-leucine	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to UV	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to nutrient levels	IDA Inferred from Direct Assay more info	PubMed
involved_in circadian rhythm	ISS Inferred from Sequence or Structural Similarity more info
involved_in face morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in fat cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in heart development	IEA Inferred from Electronic Annotation more info
involved_in internal peptidyl-lysine acetylation	IDA Inferred from Direct Assay more info	PubMed
involved_in internal protein amino acid acetylation	IDA Inferred from Direct Assay more info	PubMed
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IDA Inferred from Direct Assay more info	PubMed
involved_in learning or memory	IEA Inferred from Electronic Annotation more info
involved_in lung development	IEA Inferred from Electronic Annotation more info
involved_in megakaryocyte development	IEA Inferred from Electronic Annotation more info
involved_in multicellular organism growth	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of autophagy	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of gluconeogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of protein-containing complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in nervous system development	TAS Traceable Author Statement more info	PubMed
involved_in peptidyl-lysine acetylation	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-lysine butyrylation	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-lysine crotonylation	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-lysine propionylation	IDA Inferred from Direct Assay more info	PubMed
involved_in platelet formation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation by host of viral transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of T-helper 17 cell lineage commitment	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of TORC1 signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of TORC2 signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of neuron projection development	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein import into nucleus	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of receptor signaling pathway via JAK-STAT	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transforming growth factor beta receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein acetylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein destabilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein stabilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of androgen receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of autophagy	TAS Traceable Author Statement more info	PubMed
involved_in regulation of cellular response to heat	TAS Traceable Author Statement more info
involved_in regulation of glycolytic process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of mitochondrion organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of signal transduction by p53 class mediator	TAS Traceable Author Statement more info
involved_in regulation of tubulin deacetylation	IDA Inferred from Direct Assay more info	PubMed
involved_in response to estrogen	IDA Inferred from Direct Assay more info	PubMed
involved_in response to hypoxia	IDA Inferred from Direct Assay more info	PubMed
involved_in skeletal muscle tissue development	IEA Inferred from Electronic Annotation more info
involved_in somitogenesis	IEA Inferred from Electronic Annotation more info
involved_in stimulatory C-type lectin receptor signaling pathway	TAS Traceable Author Statement more info
involved_in swimming	IEA Inferred from Electronic Annotation more info
involved_in thigmotaxis	IEA Inferred from Electronic Annotation more info
involved_in transcription initiation-coupled chromatin remodeling	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in chromatin	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
part_of histone acetyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of protein-DNA complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: histone acetyltransferase p300

Names: E1A-associated protein p300; E1A-binding protein, 300kD; histone butyryltransferase p300; histone crotonyltransferase p300; p300 HAT; protein 2-hydroxyisobutyryltransferase p300; protein lactyltransferas p300; protein propionyltransferase p300

NP_001349772.1

EC 2.3.1.48

NP_001420.2

EC 2.3.1.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_009817.1 RefSeqGene

Range

4983..92468

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_1422

mRNA and Protein(s)

NM_001362843.2 → NP_001349772.1 histone acetyltransferase p300 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region, compared to variant 1, which results in a shorter protein (isoform 2) compared to isoform 1.

Source sequence(s)

AL035658, AL080243, AL096765

Consensus CDS

CCDS93173.1

UniProtKB/TrEMBL

A0A669KB12

Related

ENSP00000501078.1, ENST00000674155.1

Conserved Domains (11) summary

cd05495
Location:1025 → 1132

Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...

smart00551
Location:1703 → 1781

ZnF_TAZ; TAZ zinc finger, present in p300 and CBP

cd02337
Location:1642 → 1682

ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...

cd15802
Location:1144 → 1216

RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases

cd15646
Location:1217 → 1251

PHD_p300; PHD finger found in histone acetyltransferase p300

pfam02172
Location:566 → 646

KIX; KIX domain

pfam02135
Location:347 → 414

zf-TAZ; TAZ zinc finger

pfam08214
Location:1280 → 1586

HAT_KAT11; Histone acetylation protein

pfam09030
Location:1979 → 2071

Creb_binding; Creb binding

pfam09606
Location:1958 → 2382

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cl25526
Location:935 → 1038

TonB_N; TonB N-terminal region
NM_001429.4 → NP_001420.2 histone acetyltransferase p300 isoform 1

See identical proteins and their annotated locations for NP_001420.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AL035658, AL080243, BC053889, CN278277, CN278282, DB047746, N57495, U01877

Consensus CDS

CCDS14010.1

UniProtKB/Swiss-Prot

B1AKC2, Q09472

Related

ENSP00000263253.7, ENST00000263253.9

Conserved Domains (11) summary

cd05495
Location:1051 → 1158

Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...

smart00551
Location:1729 → 1807

ZnF_TAZ; TAZ zinc finger, present in p300 and CBP

COG0810
Location:961 → 1064

TonB; Periplasmic protein TonB, links inner and outer membranes [Cell wall/membrane/envelope biogenesis]

cd02337
Location:1668 → 1708

ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...

cd15802
Location:1170 → 1242

RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases

cd15646
Location:1243 → 1277

PHD_p300; PHD finger found in histone acetyltransferase p300

pfam09606
Location:1984 → 2408

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam02135
Location:347 → 414

zf-TAZ; TAZ zinc finger

pfam02172
Location:566 → 646

KIX; KIX domain

pfam08214
Location:1306 → 1517

HAT_KAT11; Histone acetylation protein

pfam09030
Location:2005 → 2098

Creb_binding; Creb binding