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    BOD1L2 biorientation of chromosomes in cell division 1 like 2 [ Homo sapiens (human) ]

    Gene ID: 284257, updated on 10-Dec-2024

    Summary

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    Official Symbol
    BOD1L2provided by HGNC
    Official Full Name
    biorientation of chromosomes in cell division 1 like 2provided by HGNC
    Primary source
    HGNC:HGNC:28505
    See related
    Ensembl:ENSG00000228075 AllianceGenome:HGNC:28505
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BOD1P; FAM44C
    Summary
    Predicted to be involved in cell division. Predicted to be located in centrosome; cytoplasm; and kinetochore. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See BOD1L2 in Genome Data Viewer
    Location:
    18q21.31
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (57147087..57150410)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (57349948..57353271)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (54814318..54817641)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372136 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13366 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:54728921-54729810 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr18:54731909-54732444 Neighboring gene long intergenic non-protein coding RNA, regulator of reprogramming Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr18:54738769-54739482 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr18:54739483-54740196 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:54743705-54744654 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr18:54744655-54745604 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:54745605-54746553 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:54814487-54815082 Neighboring gene long intergenic non-protein coding RNA 2565 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr18:54877070-54878269 Neighboring gene RNA, U6 small nuclear 737, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Bod1, a novel kinetochore protein required for chromosome biorientation. Porter IM, et al. J Cell Biol, 2007 Oct 22. PMID 17938248, Free PMC Article
    2. A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition. Benslimane Y, et al. Aging Cell, 2021 Apr. PMID 33660365, Free PMC Article
    3. Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity. Kim JJ, et al. Genes Dev, 2019 Dec 1. PMID 31753913, Free PMC Article
    4. The BioPlex Network: A Systematic Exploration of the Human Interactome. Huttlin EL, et al. Cell, 2015 Jul 16. PMID 26186194, Free PMC Article
    5. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC33608

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    biorientation of chromosomes in cell division protein 1-like 2
    Names
    biorientation of chromosomes in cell division 1 pseudogene
    biorientation of chromosomes in cell division protein 1 pseudogene
    family with sequence similarity 44, member C
    putative biorientation of chromosomes in cell division protein 1 pseudogene
    putative biorientation of chromosomes in cell division protein 1-like 2
    putative protein FAM44C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001257964.2 → NP_001244893.1  biorientation of chromosomes in cell division protein 1-like 2

      See identical proteins and their annotated locations for NP_001244893.1

      Status: VALIDATED

      Source sequence(s)
      AC100775
      Consensus CDS
      CCDS59322.1
      UniProtKB/Swiss-Prot
      B3KXU4, Q8IYS8, Q8WW13
      UniProtKB/TrEMBL
      B4DX39
      Related
      ENSP00000467843.1, ENST00000585477.2
      Conserved Domains (1) summary
      pfam05205
      Location:42 → 135
      COMPASS-Shg1; COMPASS (Complex proteins associated with Set1p) component shg1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

      Range
      57147087..57150410
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060942.1 Alternate T2T-CHM13v2.0

      Range
      57349948..57353271
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NG_005659.3: Suppressed sequence

      Description
      NG_005659.3: This RefSeq was permanently suppressed because it is now thought that this gene represents a transcribed pseudogene.

    2. NG_026335.1: Suppressed sequence

      Description
      NG_026335.1: This RefSeq was permanently suppressed because it is now thought that this pseudogene is transcribed.

    3. NM_175906.2: Suppressed sequence

      Description
      NM_175906.2: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.

    4. NR_033372.1: Suppressed sequence

      Description
      NR_033372.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IYS8.2 GenPept UniProtKB/Swiss-Prot:Q8IYS8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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