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    FBH1 F-box DNA helicase 1 [ Homo sapiens (human) ]

    Gene ID: 84893, updated on 10-Dec-2024

    Summary

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    Official Symbol
    FBH1provided by HGNC
    Official Full Name
    F-box DNA helicase 1provided by HGNC
    Primary source
    HGNC:HGNC:13620
    See related
    Ensembl:ENSG00000134452 MIM:607222; AllianceGenome:HGNC:13620
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Fbx18; hFBH1; FBXO18
    Summary
    This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. It contains an F-box motif and seven conserved helicase motifs, and has both DNA-dependent ATPase and DNA unwinding activities. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in testis (RPKM 14.4), spleen (RPKM 12.3) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See FBH1 in Genome Data Viewer
    Location:
    10p15.1
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (5889572..5937593)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (5890100..5938280)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (5931535..5979556)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene MPRA-validated peak856 silencer Neighboring gene tRNA-Val (anticodon TAC) 3-1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2941 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2942 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2943 Neighboring gene ribosomal protein L12 pseudogene 28 Neighboring gene ankyrin repeat domain 16 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2089 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2090 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2091 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2092 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:5958854-5960053 Neighboring gene MPRA-validated peak859 silencer Neighboring gene uncharacterized LOC105376384 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:5987078-5987636 Neighboring gene uncharacterized LOC107984200 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:6006433-6006934 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:6006935-6007434 Neighboring gene interleukin 15 receptor subunit alpha Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2944 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2945 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2093 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2094 Neighboring gene Sharpr-MPRA regulatory region 4656 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2946 Neighboring gene uncharacterized LOC124902368 Neighboring gene small nucleolar RNA SNORA14 Neighboring gene interleukin 2 receptor subunit alpha

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. FBH1 deficiency sensitizes cells to WEE1 inhibition by promoting mitotic catastrophe. Jennings L, et al. DNA Repair (Amst), 2024 Jan. PMID 38103522,
    2. Rare FBXO18 variations and risk of schizophrenia: Whole-exome sequencing in two parent-affected offspring trios followed by resequencing and case-control studies. Hoya S, et al. Psychiatry Clin Neurosci, 2017 Aug. PMID 28317220
    3. FBH1 protects melanocytes from transformation and is deregulated in melanomas. Jeong YT, et al. Cell Cycle, 2013 Apr 1. PMID 23466708, Free PMC Article
    4. Molecular insight into the PCNA-binding mode of FBH1. Liu J, et al. Structure, 2023 May 4. PMID 36990095, Free PMC Article
    5. The human F-Box DNA helicase FBH1 faces Saccharomyces cerevisiae Srs2 and postreplication repair pathway roles. Chiolo I, et al. Mol Cell Biol, 2007 Nov. PMID 17724085, Free PMC Article

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FBH1 deficiency sensitizes cells to WEE1 inhibition by promoting mitotic catastrophe.
      Title: FBH1 deficiency sensitizes cells to WEE1 inhibition by promoting mitotic catastrophe.
    2. Molecular insight into the PCNA-binding mode of FBH1.
      Title: Molecular insight into the PCNA-binding mode of FBH1.
    3. Report a requirement for PARP2 in stabilizing replication forks that encounter base excision repair (BER) intermediates through Fbh1-dependent regulation of Rad51. Whereas PARP2 is dispensable for tolerance of cells to single stranded breaks or homologous recombination dysfunction, it is redundant with PARP1 in BER.
      Title: PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation.
    4. study does not provide evidence for the contribution of rare non-synonymous FBXO18 variations to the genetic etiol - ogy of schizophrenia in the Japanese population.
      Title: Rare FBXO18 variations and risk of schizophrenia: Whole-exome sequencing in two parent-affected offspring trios followed by resequencing and case-control studies.
    5. FBH1 acts as a negative regulator of RAD51 function in human cells
      Title: FBH1 influences DNA replication fork stability and homologous recombination through ubiquitylation of RAD51.
    6. FBH1 restraining RAD51 DNA binding under unperturbed growth conditions to prevent unwanted or unscheduled DNA recombination.
      Title: FBH1 helicase disrupts RAD51 filaments in vitro and modulates homologous recombination in mammalian cells.
    7. FBH1 inactivation appears to contribute to oncogenic transformation by allowing survival of cells undergoing replicative stress due to external factors such as UV irradiation.
      Title: FBH1 protects melanocytes from transformation and is deregulated in melanomas.
    8. The study reports a mechanism that controls the degradation of FBH1 after DNA damage.
      Title: The helicase FBH1 is tightly regulated by PCNA via CRL4(Cdt2)-mediated proteolysis in human cells.
    9. FBH1 helicase activity is required to eliminate cells with excessive replication stress through the generation of MUS81-induced DNA double-strand breaks.
      Title: FBH1 co-operates with MUS81 in inducing DNA double-strand breaks and cell death following replication stress.
    10. Ubiquitylation affects FBH1 interaction with the RAD51 nucleoprotein filament, but not its translocase and helicase activities.
      Title: Single-molecule sorting reveals how ubiquitylation affects substrate recognition and activities of FBH1 helicase.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies five new breast cancer susceptibility loci.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of F-box protein, helicase 18 (FBXO18) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ14590, MGC131916, MGC141935, MGC141937

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3'-5' DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3'-5' DNA helicase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H2AZ histone chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H3-H4 histone complex chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA clamp loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA helicase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA helicase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables DNA translocase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chromatin extrusion motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cohesin loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables double-stranded DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables forked DNA-dependent helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables four-way junction helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables single-stranded 3'-5' DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA damage response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA duplex unwinding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chromatin looping IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair via homologous recombination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of double-strand break repair via homologous recombination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in replication fork processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in replication fork processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to intra-S DNA damage checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    F-box DNA helicase 1
    Names
    DNA 3'-5' helicase 1
    F-box only protein, helicase, 18
    F-box protein, helicase, 18
    NP_001245381.1
    NP_001245382.1
    NP_116196.3
    NP_835363.1
    XP_016872331.1
    XP_016872333.1
    XP_016872334.1
    XP_024304008.1
    XP_024304009.1
    XP_047281848.1
    XP_047281849.1
    XP_047281850.1
    XP_047281851.1
    XP_047281852.1
    XP_047281853.1
    XP_047281854.1
    XP_047281855.1
    XP_047281856.1
    XP_047281857.1
    XP_047281858.1
    XP_047281859.1
    XP_047281860.1
    XP_047281861.1
    XP_047281862.1
    XP_047281863.1
    XP_054222975.1
    XP_054222976.1
    XP_054222977.1
    XP_054222978.1
    XP_054222979.1
    XP_054222980.1
    XP_054222981.1
    XP_054222982.1
    XP_054222983.1
    XP_054222984.1
    XP_054222985.1
    XP_054222986.1
    XP_054222987.1
    XP_054222988.1
    XP_054222989.1
    XP_054222990.1
    XP_054222991.1
    XP_054222992.1
    XP_054222993.1
    XP_054222994.1
    XP_054222995.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047206.1 RefSeqGene

      Range
      5672..53022
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001258452.2 → NP_001245381.1  F-box DNA helicase 1 isoform 3

      See identical proteins and their annotated locations for NP_001245381.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs at the 5' end and contains an additional in-frame coding exon compared to variant 1, which results in translation initiation from an in-frame downstream AUG, and a shorter isoform (3) with an internal protein segment not found in isoform 1.
      Source sequence(s)
      AF380349, AK122753, CN478453
      Consensus CDS
      CCDS73064.1
      UniProtKB/TrEMBL
      F6UZG9, Q66K33
      Conserved Domains (4) summary
      COG0210
      Location:366 → 875
      UvrD; Superfamily I DNA or RNA helicase [Replication, recombination and repair]
      pfam12937
      Location:138 → 187
      F-box-like; F-box-like
      pfam13538
      Location:814 → 875
      UvrD_C_2; UvrD-like helicase C-terminal domain
      cl21455
      Location:367 → 611
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_001258453.2 → NP_001245382.1  F-box DNA helicase 1 isoform 4

      See identical proteins and their annotated locations for NP_001245382.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs at the 5' end compared to variant 1, resulting in translation initiation from an in-frame downstream AUG, and an isoform (4) with a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      BC110884, CN478453, DB099150
      UniProtKB/TrEMBL
      Q2TAK1, Q66K33
      Conserved Domains (2) summary
      COG0210
      Location:366 → 858
      UvrD; Superfamily I DNA or RNA helicase [Replication, recombination and repair]
      pfam12937
      Location:138 → 185
      F-box-like; F-box-like

    3. NM_032807.5 → NP_116196.3  F-box DNA helicase 1 isoform 1

      See identical proteins and their annotated locations for NP_116196.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AF380349, CN478453
      Consensus CDS
      CCDS7073.1
      UniProtKB/TrEMBL
      Q14DG0
      Related
      ENSP00000369335.5, ENST00000379999.6
      Conserved Domains (4) summary
      COG0210
      Location:491 → 983
      UvrD; Superfamily I DNA or RNA helicase [Replication, recombination and repair]
      pfam12937
      Location:263 → 312
      F-box-like; F-box-like
      pfam13538
      Location:922 → 983
      UvrD_C_2; UvrD-like helicase C-terminal domain
      cl21455
      Location:492 → 736
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    4. NM_178150.3 → NP_835363.1  F-box DNA helicase 1 isoform 2

      See identical proteins and their annotated locations for NP_835363.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs at the 5' end compared to variant 1, resulting in translation initiation from an in-frame downstream AUG, and an isoform (2) with a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      BC113377, CN478453, DB099150
      Consensus CDS
      CCDS7072.1
      UniProtKB/Swiss-Prot
      Q5JVB0, Q5JVB1, Q7Z4Q6, Q7Z4R0, Q8N1P5, Q8N586, Q8NFZ0, Q96E82, Q96K67, Q96SW7, Q9UFB2
      UniProtKB/TrEMBL
      Q14DG0
      Related
      ENSP00000355415.4, ENST00000362091.9
      Conserved Domains (4) summary
      COG0210
      Location:440 → 932
      UvrD; Superfamily I DNA or RNA helicase [Replication, recombination and repair]
      pfam12937
      Location:212 → 261
      F-box-like; F-box-like
      pfam13538
      Location:871 → 932
      UvrD_C_2; UvrD-like helicase C-terminal domain
      cl21455
      Location:441 → 685
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      5889572..5937593
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047425892.1 → XP_047281848.1  F-box DNA helicase 1 isoform X1

      UniProtKB/TrEMBL
      Q14DG0

    2. XM_047425900.1 → XP_047281856.1  F-box DNA helicase 1 isoform X5

      UniProtKB/TrEMBL
      Q14DG0

    3. XM_047425896.1 → XP_047281852.1  F-box DNA helicase 1 isoform X7

      UniProtKB/Swiss-Prot
      Q5JVB0, Q5JVB1, Q7Z4Q6, Q7Z4R0, Q8N1P5, Q8N586, Q8NFZ0, Q96E82, Q96K67, Q96SW7, Q9UFB2
      UniProtKB/TrEMBL
      Q14DG0

    4. XM_047425904.1 → XP_047281860.1  F-box DNA helicase 1 isoform X8

      UniProtKB/TrEMBL
      F6UZG9, Q66K33
      Related
      ENSP00000380439.4, ENST00000397269.7

    5. XM_047425901.1 → XP_047281857.1  F-box DNA helicase 1 isoform X9

      UniProtKB/TrEMBL
      Q2TAK1, Q66K33

    6. XM_047425894.1 → XP_047281850.1  F-box DNA helicase 1 isoform X5

      UniProtKB/TrEMBL
      Q14DG0

    7. XM_047425895.1 → XP_047281851.1  F-box DNA helicase 1 isoform X7

      UniProtKB/Swiss-Prot
      Q5JVB0, Q5JVB1, Q7Z4Q6, Q7Z4R0, Q8N1P5, Q8N586, Q8NFZ0, Q96E82, Q96K67, Q96SW7, Q9UFB2
      UniProtKB/TrEMBL
      Q14DG0

    8. XM_047425898.1 → XP_047281854.1  F-box DNA helicase 1 isoform X8

      UniProtKB/TrEMBL
      F6UZG9, Q66K33

    9. XM_047425902.1 → XP_047281858.1  F-box DNA helicase 1 isoform X9

      UniProtKB/TrEMBL
      Q2TAK1, Q66K33

    10. XM_017016844.3 → XP_016872333.1  F-box DNA helicase 1 isoform X4

      UniProtKB/TrEMBL
      Q14DG0
      Conserved Domains (4) summary
      COG0210
      Location:440 → 949
      UvrD; Superfamily I DNA or RNA helicase [Replication, recombination and repair]
      pfam12937
      Location:212 → 261
      F-box-like; F-box-like
      pfam13538
      Location:888 → 949
      UvrD_C_2; UvrD-like helicase C-terminal domain
      cl21455
      Location:441 → 685
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    11. XM_024448240.2 → XP_024304008.1  F-box DNA helicase 1 isoform X8

      UniProtKB/TrEMBL
      F6UZG9, Q66K33

    12. XM_024448241.2 → XP_024304009.1  F-box DNA helicase 1 isoform X9

      UniProtKB/TrEMBL
      Q2TAK1, Q66K33
      Conserved Domains (2) summary
      COG0210
      Location:366 → 858
      UvrD; Superfamily I DNA or RNA helicase [Replication, recombination and repair]
      pfam12937
      Location:138 → 185
      F-box-like; F-box-like

    13. XM_047425906.1 → XP_047281862.1  F-box DNA helicase 1 isoform X11

    14. XM_047425907.1 → XP_047281863.1  F-box DNA helicase 1 isoform X12

    15. XM_047425897.1 → XP_047281853.1  F-box DNA helicase 1 isoform X8

      UniProtKB/TrEMBL
      F6UZG9, Q66K33

    16. XM_017016842.2 → XP_016872331.1  F-box DNA helicase 1 isoform X3

      UniProtKB/TrEMBL
      Q14DG0

    17. XM_017016845.2 → XP_016872334.1  F-box DNA helicase 1 isoform X6

      UniProtKB/TrEMBL
      Q66K33

    18. XM_047425893.1 → XP_047281849.1  F-box DNA helicase 1 isoform X2

      UniProtKB/TrEMBL
      Q14DG0

    19. XM_047425903.1 → XP_047281859.1  F-box DNA helicase 1 isoform X10

    20. XM_047425905.1 → XP_047281861.1  F-box DNA helicase 1 isoform X8

      UniProtKB/TrEMBL
      F6UZG9, Q66K33

    21. XM_047425899.1 → XP_047281855.1  F-box DNA helicase 1 isoform X8

      UniProtKB/TrEMBL
      F6UZG9, Q66K33

    RNA

    1. XR_007062013.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      5890100..5938280
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054367002.1 → XP_054222977.1  F-box DNA helicase 1 isoform X3

      UniProtKB/TrEMBL
      Q14DG0

    2. XM_054367012.1 → XP_054222987.1  F-box DNA helicase 1 isoform X5

      UniProtKB/TrEMBL
      Q14DG0

    3. XM_054367007.1 → XP_054222982.1  F-box DNA helicase 1 isoform X7

      UniProtKB/Swiss-Prot
      Q5JVB0, Q5JVB1, Q7Z4Q6, Q7Z4R0, Q8N1P5, Q8N586, Q8NFZ0, Q96E82, Q96K67, Q96SW7, Q9UFB2
      UniProtKB/TrEMBL
      Q14DG0

    4. XM_054367017.1 → XP_054222992.1  F-box DNA helicase 1 isoform X8

      UniProtKB/TrEMBL
      F6UZG9, Q66K33

    5. XM_054367013.1 → XP_054222988.1  F-box DNA helicase 1 isoform X9

      UniProtKB/TrEMBL
      Q2TAK1, Q66K33

    6. XM_054367004.1 → XP_054222979.1  F-box DNA helicase 1 isoform X5

      UniProtKB/TrEMBL
      Q14DG0

    7. XM_054367006.1 → XP_054222981.1  F-box DNA helicase 1 isoform X7

      UniProtKB/Swiss-Prot
      Q5JVB0, Q5JVB1, Q7Z4Q6, Q7Z4R0, Q8N1P5, Q8N586, Q8NFZ0, Q96E82, Q96K67, Q96SW7, Q9UFB2
      UniProtKB/TrEMBL
      Q14DG0

    8. XM_054367010.1 → XP_054222985.1  F-box DNA helicase 1 isoform X8

      UniProtKB/TrEMBL
      F6UZG9, Q66K33

    9. XM_054367015.1 → XP_054222990.1  F-box DNA helicase 1 isoform X9

      UniProtKB/TrEMBL
      Q2TAK1, Q66K33

    10. XM_054367003.1 → XP_054222978.1  F-box DNA helicase 1 isoform X4

      UniProtKB/TrEMBL
      Q14DG0

    11. XM_054367008.1 → XP_054222983.1  F-box DNA helicase 1 isoform X8

      UniProtKB/TrEMBL
      F6UZG9, Q66K33

    12. XM_054367014.1 → XP_054222989.1  F-box DNA helicase 1 isoform X9

      UniProtKB/TrEMBL
      Q2TAK1, Q66K33

    13. XM_054367019.1 → XP_054222994.1  F-box DNA helicase 1 isoform X11

    14. XM_054367020.1 → XP_054222995.1  F-box DNA helicase 1 isoform X12

    15. XM_054367009.1 → XP_054222984.1  F-box DNA helicase 1 isoform X8

      UniProtKB/TrEMBL
      F6UZG9, Q66K33

    16. XM_054367005.1 → XP_054222980.1  F-box DNA helicase 1 isoform X6

      UniProtKB/TrEMBL
      Q66K33

    17. XM_054367000.1 → XP_054222975.1  F-box DNA helicase 1 isoform X1

      UniProtKB/TrEMBL
      Q14DG0

    18. XM_054367016.1 → XP_054222991.1  F-box DNA helicase 1 isoform X10

    19. XM_054367001.1 → XP_054222976.1  F-box DNA helicase 1 isoform X2

      UniProtKB/TrEMBL
      Q14DG0

    20. XM_054367018.1 → XP_054222993.1  F-box DNA helicase 1 isoform X8

      UniProtKB/TrEMBL
      F6UZG9, Q66K33

    21. XM_054367011.1 → XP_054222986.1  F-box DNA helicase 1 isoform X8

      UniProtKB/TrEMBL
      F6UZG9, Q66K33

    RNA

    1. XR_008488304.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8NFZ0.2 GenPept UniProtKB/Swiss-Prot:Q8NFZ0

    Gene LinkOut

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