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    Iqca1 IQ motif containing with AAA domain 1 [ Mus musculus (house mouse) ]

    Gene ID: 74918, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Iqca1provided by MGI
    Official Full Name
    IQ motif containing with AAA domain 1provided by MGI
    Primary source
    MGI:MGI:1922168
    See related
    Ensembl:ENSMUSG00000026301 AllianceGenome:MGI:1922168
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Iqca; 4930465P12Rik; 4930585L22Rik
    Summary
    Predicted to enable ATP binding activity and ATP hydrolysis activity. Predicted to be located in cytoplasm; cytoskeleton; and motile cilium. Is expressed in lung. Orthologous to human IQCA1 (IQ motif containing with AAA domain 1). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in testis adult (RPKM 3.5), lung adult (RPKM 0.8) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Iqca1 in Genome Data Viewer
    Location:
    1 D; 1 45.08 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (89969854..90081158, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (90042132..90153436, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and SOCS box-containing 18 Neighboring gene predicted gene, 41915 Neighboring gene predicted gene, 34616 Neighboring gene STARR-seq mESC enhancer starr_01676 Neighboring gene RIKEN cDNA 4930434B07 gene Neighboring gene STARR-seq mESC enhancer starr_01677 Neighboring gene atypical chemokine receptor 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CRISPR/Cas9-based genome editing in mice uncovers 13 testis- or epididymis-enriched genes individually dispensable for male reproduction†. Sun J, et al. Biol Reprod, 2020 Aug 4. PMID 32588039, Free PMC Article
    2. Identification of FOXJ1 effectors during ciliogenesis in the foetal respiratory epithelium and embryonic left-right organiser of the mouse. Stauber M, et al. Dev Biol, 2017 Mar 15. PMID 27914912
    3. Single-cell transcriptomic analysis of mouse neocortical development. Loo L, et al. Nat Commun, 2019 Jan 11. PMID 30635555, Free PMC Article
    4. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article
    5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in motile cilium IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dynein regulatory complex protein 11
    Names
    IQ and AAA domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368722.1 → NP_001355651.1  dynein regulatory complex protein 11 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC110261, AC124227
      UniProtKB/Swiss-Prot
      Q3UT65, Q9CUL5, Q9D4P1
      Related
      ENSMUSP00000148643.2, ENSMUST00000212394.2
      Conserved Domains (1) summary
      COG0464
      Location:578 → 797
      SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]

    2. NM_029122.3 → NP_083398.2  dynein regulatory complex protein 11 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC110261, AC124227
      Consensus CDS
      CCDS48317.1
      UniProtKB/Swiss-Prot
      Q3UT65, Q9CUL5, Q9D4P1
      UniProtKB/TrEMBL
      E9QMY8
      Related
      ENSMUSP00000108717.3, ENSMUST00000113094.9
      Conserved Domains (2) summary
      COG0464
      Location:569 → 788
      SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
      pfam00004
      Location:571 → 704
      AAA; ATPase family associated with various cellular activities (AAA)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      89969854..90081158 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001033777.1: Suppressed sequence

      Description
      NM_001033777.1: This RefSeq was removed because the CDS is partial.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CUL5.2 GenPept UniProtKB/Swiss-Prot:Q9CUL5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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