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    ZNF471 zinc finger protein 471 [ Homo sapiens (human) ]

    Gene ID: 57573, updated on 26-Nov-2024

    Summary

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    Official Symbol
    ZNF471provided by HGNC
    Official Full Name
    zinc finger protein 471provided by HGNC
    Primary source
    HGNC:HGNC:23226
    See related
    Ensembl:ENSG00000196263 MIM:620162; AllianceGenome:HGNC:23226
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ERP1; Z1971; Zfp78
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary (RPKM 3.7), endometrium (RPKM 2.7) and 24 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF471 in Genome Data Viewer
    Location:
    19q13.43
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (56507855..56530212)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (59602138..59624646)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (57019224..57041581)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ZNF667 antisense RNA 1 (head to head) Neighboring gene uncharacterized LOC105372471 Neighboring gene uncharacterized LOC124904776 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:57037017-57038216 Neighboring gene ZFP28 divergent transcript Neighboring gene ZFP28 zinc finger protein Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr19:57058653-57059852 Neighboring gene ZNF470 divergent transcript Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:57065620-57066819 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15120 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15121 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15122 Neighboring gene zinc finger protein 470

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The tumor suppressor Zinc finger protein 471 suppresses breast cancer growth and metastasis through inhibiting AKT and Wnt/β-catenin signaling. Tao C, et al. Clin Epigenetics, 2020 Nov 17. PMID 33203470, Free PMC Article
    2. ZNF471 Interacts with BANP to Reduce Tumour Malignancy by Inactivating PI3K/AKT/mTOR Signalling but is Frequently Silenced by Aberrant Promoter Methylation in Renal Cell Carcinoma. Wang X, et al. Int J Biol Sci, 2024. PMID 38169650, Free PMC Article
    3. Suppression of N-Glycosylation of Zinc Finger Protein 471 Affects Proliferation, Invasion, and Docetaxel Sensitivity of Tongue Squamous Cell Carcinoma via Regulation of c-Myc. Liu Y, et al. Am J Pathol, 2024 Jun. PMID 38749608
    4. Zinc-finger protein 471 suppresses gastric cancer through transcriptionally repressing downstream oncogenic PLS3 and TFAP2A. Cao L, et al. Oncogene, 2018 Jun. PMID 29610526, Free PMC Article
    5. Gene promoter-associated CpG island hypermethylation in squamous cell carcinoma of the tongue. Bhat S, et al. Virchows Arch, 2017 Apr. PMID 28255813

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Suppression of N-Glycosylation of Zinc Finger Protein 471 Affects Proliferation, Invasion, and Docetaxel Sensitivity of Tongue Squamous Cell Carcinoma via Regulation of c-Myc.
      Title: Suppression of N-Glycosylation of Zinc Finger Protein 471 Affects Proliferation, Invasion, and Docetaxel Sensitivity of Tongue Squamous Cell Carcinoma via Regulation of c-Myc.
    2. ZNF471 Interacts with BANP to Reduce Tumour Malignancy by Inactivating PI3K/AKT/mTOR Signalling but is Frequently Silenced by Aberrant Promoter Methylation in Renal Cell Carcinoma.
      Title: ZNF471 Interacts with BANP to Reduce Tumour Malignancy by Inactivating PI3K/AKT/mTOR Signalling but is Frequently Silenced by Aberrant Promoter Methylation in Renal Cell Carcinoma.
    3. The tumor suppressor Zinc finger protein 471 suppresses breast cancer growth and metastasis through inhibiting AKT and Wnt/beta-catenin signaling.
      Title: The tumor suppressor Zinc finger protein 471 suppresses breast cancer growth and metastasis through inhibiting AKT and Wnt/β-catenin signaling.
    4. ZNF471 acts as a tumor suppressor in gastric cancer by transcriptionally inhibiting downstream targets TFAP2A and PLS3.
      Title: Zinc-finger protein 471 suppresses gastric cancer through transcriptionally repressing downstream oncogenic PLS3 and TFAP2A.
    5. This is the first study to report hypermethylation of LRPPRC, RAB6C, and ZNF471 in squamous cell carcinoma of the tongue
      Title: Gene promoter-associated CpG island hypermethylation in squamous cell carcinoma of the tongue.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 471
    Names
    EZFIT-related protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001321768.2 → NP_001308697.1  zinc finger protein 471 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC004696, AC005498, AI375847, AL831845, BM991696
      UniProtKB/Swiss-Prot
      Q9BX82
      Conserved Domains (3) summary
      COG5048
      Location:129 → 536
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:443 → 463
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:483 → 507
      zf-H2C2_2; Zinc-finger double domain

    2. NM_020813.4 → NP_065864.2  zinc finger protein 471 isoform 1

      See identical proteins and their annotated locations for NP_065864.2

      Status: VALIDATED

      Source sequence(s)
      AC005498, AI375847, AL831845, BC125221, BM991696
      Consensus CDS
      CCDS12945.1
      UniProtKB/Swiss-Prot
      B4DF32, O75260, Q08AD6, Q08AD7, Q8N3V1, Q9BX82, Q9P2F1
      Related
      ENSP00000309161.4, ENST00000308031.10
      Conserved Domains (5) summary
      smart00349
      Location:14 → 73
      KRAB; krueppel associated box
      COG5048
      Location:203 → 610
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:517 → 537
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:14 → 53
      KRAB; KRAB box
      pfam13465
      Location:557 → 581
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      56507855..56530212
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011527148.2 → XP_011525450.1  zinc finger protein 471 isoform X1

      See identical proteins and their annotated locations for XP_011525450.1

      UniProtKB/Swiss-Prot
      B4DF32, O75260, Q08AD6, Q08AD7, Q8N3V1, Q9BX82, Q9P2F1
      Conserved Domains (5) summary
      smart00349
      Location:14 → 73
      KRAB; krueppel associated box
      COG5048
      Location:203 → 610
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:517 → 537
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:14 → 53
      KRAB; KRAB box
      pfam13465
      Location:557 → 581
      zf-H2C2_2; Zinc-finger double domain

    2. XM_047439129.1 → XP_047295085.1  zinc finger protein 471 isoform X1

      UniProtKB/Swiss-Prot
      B4DF32, O75260, Q08AD6, Q08AD7, Q8N3V1, Q9BX82, Q9P2F1

    3. XM_047439128.1 → XP_047295084.1  zinc finger protein 471 isoform X1

      UniProtKB/Swiss-Prot
      B4DF32, O75260, Q08AD6, Q08AD7, Q8N3V1, Q9BX82, Q9P2F1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      59602138..59624646
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321541.1 → XP_054177516.1  zinc finger protein 471 isoform X1

    2. XM_054321542.1 → XP_054177517.1  zinc finger protein 471 isoform X1

    3. XM_054321543.1 → XP_054177518.1  zinc finger protein 471 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BX82.1 GenPept UniProtKB/Swiss-Prot:Q9BX82

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