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    SPC24 SPC24 component of NDC80 kinetochore complex [ Homo sapiens (human) ]

    Gene ID: 147841, updated on 3-Nov-2024

    Summary

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    Official Symbol
    SPC24provided by HGNC
    Official Full Name
    SPC24 component of NDC80 kinetochore complexprovided by HGNC
    Primary source
    HGNC:HGNC:26913
    See related
    Ensembl:ENSG00000161888 MIM:609394; AllianceGenome:HGNC:26913
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SPBC24
    Summary
    Predicted to contribute to microtubule binding activity. Involved in attachment of spindle microtubules to kinetochore. Located in nucleolus and nucleoplasm. Part of Ndc80 complex. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in bone marrow (RPKM 2.7), lymph node (RPKM 1.3) and 16 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SPC24 in Genome Data Viewer
    Location:
    19p13.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (11145493..11155782, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (11272490..11282805, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (11256169..11266458, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:11200393-11200988 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:11200989-11201582 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr19:11202176-11203375 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:11205098-11206297 Neighboring gene LDLR antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:11212882-11213520 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11215560-11216060 Neighboring gene low density lipoprotein receptor Neighboring gene microRNA 6886 Neighboring gene VISTA enhancer hs1754 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10101 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11276922-11277422 Neighboring gene KN motif and ankyrin repeat domains 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11300095-11300596 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11300597-11301096 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10102 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10103 Neighboring gene DOCK6 antisense RNA 1 Neighboring gene dedicator of cytokinesis 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. SPC24 is critical for anaplastic thyroid cancer progression. Yin H, et al. Oncotarget, 2017 Mar 28. PMID 28423533, Free PMC Article
    2. LINC02154 promotes the proliferation and metastasis of hepatocellular carcinoma by enhancing SPC24 promoter activity and activating the PI3K-AKT signaling pathway. Yue H, et al. Cell Oncol (Dordr), 2022 Jun. PMID 35543858
    3. A novel prognostic biomarker SPC24 up-regulated in hepatocellular carcinoma. Zhu P, et al. Oncotarget, 2015 Dec 1. PMID 26515591, Free PMC Article
    4. Polo-like kinase 1 creates the tension-sensing 3F3/2 phosphoepitope and modulates the association of spindle-checkpoint proteins at kinetochores. Ahonen LJ, et al. Curr Biol, 2005 Jun 21. PMID 15964272
    5. SPC24 Regulates breast cancer progression by PI3K/AKT signaling. Zhou J, et al. Gene, 2018 Oct 30. PMID 30180968

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LINC02154 promotes the proliferation and metastasis of hepatocellular carcinoma by enhancing SPC24 promoter activity and activating the PI3K-AKT signaling pathway.
      Title: LINC02154 promotes the proliferation and metastasis of hepatocellular carcinoma by enhancing SPC24 promoter activity and activating the PI3K-AKT signaling pathway.
    2. hsa-miR-7-5p suppresses proliferation, migration and promotes apoptosis in hepatocellular carcinoma cell lines by inhibiting SPC24 expression.
      Title: hsa-miR-7-5p suppresses proliferation, migration and promotes apoptosis in hepatocellular carcinoma cell lines by inhibiting SPC24 expression.
    3. SPC24 is up-regulated in human breast cancer.SPC24 regulates PI3K/AKT kinase pathway in breast cancer.
      Title: SPC24 Regulates breast cancer progression by PI3K/AKT signaling.
    4. our data demonstrates that SPC24 can serve as a promising prognostic biomarker of anaplastic thyroid cancer cells
      Title: SPC24 is critical for anaplastic thyroid cancer progression.
    5. Data indicate that kinetochore protein Spc24 (SPC24) may be a promising molecular target for hepatocellular carcinoma (HCC) therapy.
      Title: A novel prognostic biomarker SPC24 up-regulated in hepatocellular carcinoma.
    6. the Spc24, Spc25, Nuf2, and Ndc80/Hec1 complex is a faithful copy of the endogenous Ndc80 complex
      Title: Architecture of the human ndc80-hec1 complex, a critical constituent of the outer kinetochore.
    7. hSPC24 is a component of the human NDC80 kinetochore complex
      Title: Identification of two novel components of the human NDC80 kinetochore complex.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome wide association study identifies common variants associated with lipid levels in the Chinese population.
    EBI GWAS Catalog
    Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ90806

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    contributes_to microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in attachment of spindle microtubules to kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromosome segregation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in mitotic spindle assembly checkpoint signaling NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Ndc80 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Ndc80 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Ndc80 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in kinetochore NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    part_of outer kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    kinetochore protein Spc24
    Names
    SPC24, NDC80 kinetochore complex component, homolog
    hSpc24
    spindle pole body component 24 homolog

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001317031.2 → NP_001303960.1  kinetochore protein Spc24 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC011485
      UniProtKB/TrEMBL
      K7EJV2
      Related
      ENSP00000465335.1, ENST00000592967.5
      Conserved Domains (1) summary
      pfam08286
      Location:83 → 146
      Spc24; Spc24 subunit of Ndc80

    2. NM_001317032.2 → NP_001303961.1  kinetochore protein Spc24 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC011485
      UniProtKB/TrEMBL
      K7EJH0
      Related
      ENSP00000465167.1, ENST00000585486.1
      Conserved Domains (1) summary
      pfam08286
      Location:83 → 162
      Spc24; Spc24 subunit of Ndc80

    3. NM_001394314.1 → NP_001381243.1  kinetochore protein Spc24 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC011485
      UniProtKB/TrEMBL
      K7EMX1
      Related
      ENSP00000466688.1, ENST00000591396.5
      Conserved Domains (1) summary
      COG1269
      Location:4 → 119
      NtpI; Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]

    4. NM_001394315.1 → NP_001381244.1  kinetochore protein Spc24 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC011485
      UniProtKB/TrEMBL
      K7EJH0
      Conserved Domains (1) summary
      COG1269
      Location:4 → 119
      NtpI; Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]

    5. NM_001394316.1 → NP_001381245.1  kinetochore protein Spc24 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC011485
      UniProtKB/TrEMBL
      K7EJH0
      Conserved Domains (1) summary
      COG1269
      Location:4 → 119
      NtpI; Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]

    6. NM_001394317.1 → NP_001381246.1  kinetochore protein Spc24 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC011485
      Conserved Domains (1) summary
      COG1269
      Location:4 → 119
      NtpI; Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]

    7. NM_001394318.1 → NP_001381247.1  kinetochore protein Spc24 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC011485
      Conserved Domains (1) summary
      COG1269
      Location:4 → 119
      NtpI; Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]

    8. NM_182513.4 → NP_872319.1  kinetochore protein Spc24 isoform 1

      See identical proteins and their annotated locations for NP_872319.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC011485
      Consensus CDS
      CCDS45974.1
      UniProtKB/Swiss-Prot
      B4DZZ7, C9JGC4, Q8NBT2
      UniProtKB/TrEMBL
      K7EJH0
      Related
      ENSP00000465075.1, ENST00000592540.6
      Conserved Domains (2) summary
      COG1269
      Location:4 → 119
      NtpI; Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]
      pfam08286
      Location:83 → 192
      Spc24; Spc24 subunit of Ndc80

    RNA

    1. NR_172094.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC011485

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      11145493..11155782 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005259753.4 → XP_005259810.1  kinetochore protein Spc24 isoform X1

      See identical proteins and their annotated locations for XP_005259810.1

      UniProtKB/Swiss-Prot
      Q8NBT2
      Conserved Domains (1) summary
      pfam08286
      Location:50 → 146
      Spc24; Spc24 subunit of Ndc80

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      11272490..11282805 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054319887.1 → XP_054175862.1  kinetochore protein Spc24 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8NBT2.3 GenPept UniProtKB/Swiss-Prot:Q8NBT2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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