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    ZNF578 zinc finger protein 578 [ Homo sapiens (human) ]

    Gene ID: 147660, updated on 27-Nov-2024

    Summary

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    Official Symbol
    ZNF578provided by HGNC
    Official Full Name
    zinc finger protein 578provided by HGNC
    Primary source
    HGNC:HGNC:26449
    See related
    Ensembl:ENSG00000258405 AllianceGenome:HGNC:26449
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis (RPKM 3.0), thyroid (RPKM 0.7) and 14 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF578 in Genome Data Viewer
    Location:
    19q13.41
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (52453553..52516882)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (55538104..55601470)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (52956806..53020135)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene developmental pluripotency associated 5 pseudogene 1 Neighboring gene zinc finger protein 534 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr19:52956248-52957447 Neighboring gene DUT pseudogene Neighboring gene zinc finger protein 347 pseudogene Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:52986584-52987370 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:52987371-52988156 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:52990721-52991690 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:52996369-52997007 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:52997008-52997645 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:53003665-53004504 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:53029540-53030366 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:53030367-53031194 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:53039321-53039907 Neighboring gene zinc finger protein 808 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:53061637-53062248 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:53062249-53062862 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:53072140-53072749 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15051 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:53073969-53074577 Neighboring gene ribosomal protein L39 pseudogene 34 Neighboring gene zinc finger protein 701 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:53091538-53091757 Neighboring gene zinc finger protein 137, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling. Kouranti I, et al. Int J Mol Sci, 2022 May 5. PMID 35563538, Free PMC Article
    2. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article
    3. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ31384

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 578
    Names
    Putative chemokine-related protein B42

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001099694.2 → NP_001093164.1  zinc finger protein 578

      See identical proteins and their annotated locations for NP_001093164.1

      Status: VALIDATED

      Source sequence(s)
      AC010332, AC022150, AK055946, BC115704, BX955279
      Consensus CDS
      CCDS54310.1
      UniProtKB/Swiss-Prot
      B4DR51, I3L1Y6, Q96N58
      Related
      ENSP00000459216.1, ENST00000421239.7
      Conserved Domains (3) summary
      COG5048
      Location:257 → 582
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:373 → 393
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:24 → 64
      KRAB; KRAB box

    2. NM_001366182.2 → NP_001353111.1  zinc finger protein 578

      Status: VALIDATED

      Source sequence(s)
      AC010332, AC010506, AC022150
      Consensus CDS
      CCDS54310.1
      UniProtKB/Swiss-Prot
      B4DR51, I3L1Y6, Q96N58
      Conserved Domains (3) summary
      COG5048
      Location:257 → 582
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:373 → 393
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:24 → 64
      KRAB; KRAB box

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      52453553..52516882
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047438189.1 → XP_047294145.1  zinc finger protein 578 isoform X1

      UniProtKB/Swiss-Prot
      B4DR51, I3L1Y6, Q96N58

    2. XM_047438194.1 → XP_047294150.1  zinc finger protein 578 isoform X2

    3. XM_047438191.1 → XP_047294147.1  zinc finger protein 578 isoform X1

      UniProtKB/Swiss-Prot
      B4DR51, I3L1Y6, Q96N58

    4. XM_047438190.1 → XP_047294146.1  zinc finger protein 578 isoform X1

      UniProtKB/Swiss-Prot
      B4DR51, I3L1Y6, Q96N58

    5. XM_047438192.1 → XP_047294148.1  zinc finger protein 578 isoform X1

      UniProtKB/Swiss-Prot
      B4DR51, I3L1Y6, Q96N58

    6. XM_047438193.1 → XP_047294149.1  zinc finger protein 578 isoform X1

      UniProtKB/Swiss-Prot
      B4DR51, I3L1Y6, Q96N58

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      55538104..55601470
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054319851.1 → XP_054175826.1  zinc finger protein 578 isoform X1

    2. XM_054319850.1 → XP_054175825.1  zinc finger protein 578 isoform X1

    3. XM_054319853.1 → XP_054175828.1  zinc finger protein 578 isoform X1

    4. XM_054319852.1 → XP_054175827.1  zinc finger protein 578 isoform X1

    5. XM_054319854.1 → XP_054175829.1  zinc finger protein 578 isoform X1

    6. XM_054319855.1 → XP_054175830.1  zinc finger protein 578 isoform X1

    7. XM_054319856.1 → XP_054175831.1  zinc finger protein 578 isoform X2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_152472.1: Suppressed sequence

      Description
      NM_152472.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q1T7F1.1 GenPept UniProtKB/Swiss-Prot:Q1T7F1
    Q96N58.2 GenPept UniProtKB/Swiss-Prot:Q96N58

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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