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    RRM2 ribonucleotide reductase regulatory subunit M2 [ Homo sapiens (human) ]

    Gene ID: 6241, updated on 10-Dec-2024

    Summary

    Official Symbol
    RRM2provided by HGNC
    Official Full Name
    ribonucleotide reductase regulatory subunit M2provided by HGNC
    Primary source
    HGNC:HGNC:10452
    See related
    Ensembl:ENSG00000171848 MIM:180390; AllianceGenome:HGNC:10452
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    R2; RR2; RR2M; C2orf48
    Summary
    This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Sep 2009]
    Expression
    Biased expression in bone marrow (RPKM 28.1), lymph node (RPKM 20.5) and 13 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See RRM2 in Genome Data Viewer
    Location:
    2p25.1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (10122568..10211010)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (10151280..10239549)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (10262695..10351136)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:10197717-10198660 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:10198661-10199603 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10200462-10201324 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10201325-10202185 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10203342-10203940 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10203941-10204538 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10204790-10205668 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10205669-10206546 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10211417-10211918 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11154 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11155 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11156 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11157 Neighboring gene cystin 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15296 Neighboring gene uncharacterized LOC124900536 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:10231300-10231817 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15297 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:10259653-10260596 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:10260597-10261539 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:10261588-10262143 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:10262327-10262827 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr2:10273128-10273791 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11159 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10282796-10283457 Neighboring gene small nucleolar RNA SNORA2/SNORA34 family Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10303055-10303660 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10303661-10304265 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10309414-10310044 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10311305-10311934 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10311935-10312564 Neighboring gene uncharacterized LOC105373424 Neighboring gene microRNA 4261 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10357075-10357867 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10366095-10366704 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:10393383-10394004 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10395247-10395866 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10411801-10412301 Neighboring gene uncharacterized LOC124907731 Neighboring gene RNA, 7SL, cytoplasmic 66, pseudogene

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Pol gag-pol HIV-1 Pol is identified to have a physical interaction with ribonucleotide reductase M2 (RRM2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ25102, MGC121034, MGC121036

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    part_of ribonucleoside-diphosphate reductase complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 

    General protein information

    Preferred Names
    ribonucleoside-diphosphate reductase subunit M2
    Names
    ribonucleotide reductase M2 polypeptide
    ribonucleotide reductase small chain
    ribonucleotide reductase small subunit
    uncharacterized protein C2orf48
    NP_001025.1
    NP_001159403.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034.4NP_001025.1  ribonucleoside-diphosphate reductase subunit M2 isoform 2

      See identical proteins and their annotated locations for NP_001025.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternative downstream promoter, and it thus has a shorter 5' UTR and uses a downstream translational start codon, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      AC104794, AC118058, BM994533, X59618
      Consensus CDS
      CCDS1669.1
      UniProtKB/Swiss-Prot
      B2R9B5, J3KP43, P31350, Q5WRU7
      UniProtKB/TrEMBL
      A0A286YFD6
      Related
      ENSP00000302955.4, ENST00000304567.10
      Conserved Domains (1) summary
      PLN02492
      Location:70389
      PLN02492; ribonucleoside-diphosphate reductase
    2. NM_001165931.1NP_001159403.1  ribonucleoside-diphosphate reductase subunit M2 isoform 1

      See identical proteins and their annotated locations for NP_001159403.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC104794, AC118058, BM994533, DA477511, X59618
      Consensus CDS
      CCDS54334.1
      Related
      ENSP00000353770.2, ENST00000360566.6
      Conserved Domains (1) summary
      PLN02492
      Location:130449
      PLN02492; ribonucleoside-diphosphate reductase

    RNA

    1. NR_164157.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC007240, AC104794

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      10122568..10211010
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      10151280..10239549
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_161344.1: Suppressed sequence

      Description
      NR_161344.1: This RefSeq was removed because currently there is insufficient support for the transcript.