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    UNKL unk like zinc finger [ Homo sapiens (human) ]

    Gene ID: 64718, updated on 10-Dec-2024

    Summary

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    Official Symbol
    UNKLprovided by HGNC
    Official Full Name
    unk like zinc fingerprovided by HGNC
    Primary source
    HGNC:HGNC:14184
    See related
    Ensembl:ENSG00000059145 MIM:617463; AllianceGenome:HGNC:14184
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZC3H5L; C16orf28; ZC3HDC5L
    Summary
    This gene encodes a RING finger protein that may function in Rac signaling. It can bind to Brg/Brm-associated factor 60b and can promote its ubiquitination. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jun 2013]
    Expression
    Ubiquitous expression in ovary (RPKM 4.2), endometrium (RPKM 4.2) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See UNKL in Genome Data Viewer
    Location:
    16p13.3
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (1363205..1414704, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (1379337..1429329, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (1413206..1464705, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10221 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:1382600-1382800 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6970 Neighboring gene ribosomal protein S20 pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:1388370-1389219 Neighboring gene BAI1 associated protein 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:1392110-1392658 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6971 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10222 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6972 Neighboring gene TSR3 ribosome maturation factor Neighboring gene N-acetylglucosamine-1-phosphate transferase subunit gamma Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:1425173-1425672 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6973 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6975 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6974 Neighboring gene tight junction protein 1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6976 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:1458173-1458350 Neighboring gene uncharacterized LOC101929440 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6979 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:1463606-1464180 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:1464181-1464755 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:1464756-1465330 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:1465331-1465904 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:1470039-1470894 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:1470895-1471748 Neighboring gene uncharacterized LOC105371044 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6984 Neighboring gene ubiquinol-cytochrome c reductase complex assembly factor 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. The SWI/SNF protein BAF60b is ubiquitinated through a signalling process involving Rac GTPase and the RING finger protein Unkempt. Lorès P, et al. FEBS J, 2010 Mar. PMID 20148946
    2. The embryonically active gene, unkempt, of Drosophila encodes a Cys3His finger protein. Mohler J, et al. Genetics, 1992 Jun. PMID 1339381, Free PMC Article
    3. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. Daniels RJ, et al. Hum Mol Genet, 2001 Feb 15. PMID 11157797
    4. The sequence and analysis of duplication-rich human chromosome 16. Martin J, et al. Nature, 2004 Dec 23. PMID 15616553
    5. Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system. Ebstein F, et al. Int J Biochem Cell Biol, 2009 May. PMID 19028597

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Characterizes the related Drosophila gene and protein.
      Title: The embryonically active gene, unkempt, of Drosophila encodes a Cys3His finger protein.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC5179, FLJ12623, FLJ23360, KIAA0734

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative E3 ubiquitin-protein ligase UNKL
    Names
    RING finger protein unkempt-like
    unkempt family zinc finger-like
    unkempt homolog-like
    zinc finger CCCH domain-containing protein 5-like

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033129.1 RefSeqGene

      Range
      5001..56500
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001037125.4 → NP_001032202.1  putative E3 ubiquitin-protein ligase UNKL isoform 2

      See identical proteins and their annotated locations for NP_001032202.1

      Status: REVIEWED

      Source sequence(s)
      AL031721, AL032819
      Consensus CDS
      CCDS32359.1
      UniProtKB/Swiss-Prot
      Q9H9P5
      Related
      ENSP00000301712.5, ENST00000301712.5
      Conserved Domains (1) summary
      pfam18384
      Location:25 → 60
      zf_CCCH_5; Unkempt Zinc finger domain 1 (Znf1)

    2. NM_001193388.4 → NP_001180317.2  putative E3 ubiquitin-protein ligase UNKL isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL031709, AL031721, AL032819
      UniProtKB/Swiss-Prot
      B0QYN6, B1GXI8, Q96EV1, Q96RZ1, Q9BWL5, Q9H5K0, Q9H9P5, Q9UJJ8
      UniProtKB/TrEMBL
      E9PDK2
      Related
      ENSP00000422852.3, ENST00000508903.7
      Conserved Domains (4) summary
      pfam18384
      Location:25 → 60
      zf_CCCH_5; Unkempt Zinc finger domain 1 (Znf1)
      pfam00642
      Location:286 → 312
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam13868
      Location:569 → 649
      TPH; Trichohyalin-plectin-homology domain
      cl17238
      Location:640 → 683
      RING_Ubox; RING finger (Really Interesting New Gene) domain and U-box domain superfamily

    3. NM_001193389.2 → NP_001180318.1  putative E3 ubiquitin-protein ligase UNKL isoform 4

      See identical proteins and their annotated locations for NP_001180318.1

      Status: REVIEWED

      Source sequence(s)
      AL031709, AL031721
      Consensus CDS
      CCDS53980.1
      UniProtKB/Swiss-Prot
      Q9H9P5
      Related
      ENSP00000501444.1, ENST00000674376.1
      Conserved Domains (1) summary
      pfam13920
      Location:139 → 176
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

    4. NM_001276414.2 → NP_001263343.1  putative E3 ubiquitin-protein ligase UNKL isoform 5

      See identical proteins and their annotated locations for NP_001263343.1

      Status: REVIEWED

      Source sequence(s)
      AL031709, AL031721
      Consensus CDS
      CCDS61787.1
      UniProtKB/Swiss-Prot
      Q9H9P5
      Related
      ENSP00000248104.7, ENST00000248104.11
      Conserved Domains (1) summary
      pfam13920
      Location:186 → 223
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

    5. NM_001367622.1 → NP_001354551.1  putative E3 ubiquitin-protein ligase UNKL isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL031709, AL031721

    6. NM_001370526.1 → NP_001357455.1  putative E3 ubiquitin-protein ligase UNKL isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL031709, AL031721
      Conserved Domains (1) summary
      pfam03962
      Location:75 → 143
      Mnd1; Mnd1 family

    7. NM_001372107.1 → NP_001359036.1  putative E3 ubiquitin-protein ligase UNKL isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL031709, AL031721, AL032819
      Consensus CDS
      CCDS92080.1
      UniProtKB/Swiss-Prot
      B0QYN6, B1GXI8, Q96EV1, Q96RZ1, Q9BWL5, Q9H5K0, Q9H9P5, Q9UJJ8
      UniProtKB/TrEMBL
      A0A0A0MRZ1
      Related
      ENSP00000373873.6, ENST00000389221.9
      Conserved Domains (5) summary
      pfam04012
      Location:569 → 699
      PspA_IM30; PspA/IM30 family
      cd16772
      Location:690 → 727
      RING-HC_UNKL; RING finger, HC subclass, found in RING finger protein unkempt-like (UNKL) and similar proteins
      pfam00642
      Location:286 → 311
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam02161
      Location:442 → 534
      Prog_receptor; Progesterone receptor
      pfam18384
      Location:25 → 60
      zf_CCCH_5; Unkempt Zinc finger domain 1 (Znf1)

    RNA

    1. NR_160278.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL031709, AL031721, AL032819

    2. NR_160279.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL031709, AL031721

    3. NR_160280.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL031709, AL031721

    4. NR_163466.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL031709, AL031721
      Related
      ENST00000403703.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      1363205..1414704 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047434489.1 → XP_047290445.1  putative E3 ubiquitin-protein ligase UNKL isoform X5

      UniProtKB/Swiss-Prot
      B0QYN6, B1GXI8, Q96EV1, Q96RZ1, Q9BWL5, Q9H5K0, Q9H9P5, Q9UJJ8

    2. XM_047434488.1 → XP_047290444.1  putative E3 ubiquitin-protein ligase UNKL isoform X4

      UniProtKB/Swiss-Prot
      B0QYN6, B1GXI8, Q96EV1, Q96RZ1, Q9BWL5, Q9H5K0, Q9H9P5, Q9UJJ8

    3. XM_011522612.2 → XP_011520914.1  putative E3 ubiquitin-protein ligase UNKL isoform X3

      UniProtKB/Swiss-Prot
      B0QYN6, B1GXI8, Q96EV1, Q96RZ1, Q9BWL5, Q9H5K0, Q9H9P5, Q9UJJ8
      Conserved Domains (3) summary
      pfam00642
      Location:236 → 262
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam13863
      Location:519 → 593
      DUF4200; Domain of unknown function (DUF4200)
      pfam13920
      Location:640 → 677
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

    4. XM_047434491.1 → XP_047290447.1  putative E3 ubiquitin-protein ligase UNKL isoform X6

    5. XM_011522611.2 → XP_011520913.1  putative E3 ubiquitin-protein ligase UNKL isoform X2

      UniProtKB/Swiss-Prot
      B0QYN6, B1GXI8, Q96EV1, Q96RZ1, Q9BWL5, Q9H5K0, Q9H9P5, Q9UJJ8
      Conserved Domains (3) summary
      pfam00642
      Location:306 → 332
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam11825
      Location:482 → 553
      Nuc_recep-AF1; Nuclear/hormone receptor activator site AF-1
      pfam13920
      Location:660 → 697
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

    6. XM_011522610.2 → XP_011520912.1  putative E3 ubiquitin-protein ligase UNKL isoform X1

      UniProtKB/Swiss-Prot
      B0QYN6, B1GXI8, Q96EV1, Q96RZ1, Q9BWL5, Q9H5K0, Q9H9P5, Q9UJJ8
      Conserved Domains (4) summary
      pfam00642
      Location:306 → 332
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam11825
      Location:482 → 553
      Nuc_recep-AF1; Nuclear/hormone receptor activator site AF-1
      pfam13863
      Location:589 → 663
      DUF4200; Domain of unknown function (DUF4200)
      pfam13920
      Location:710 → 747
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

    7. XM_047434490.1 → XP_047290446.1  putative E3 ubiquitin-protein ligase UNKL isoform X6

    8. XM_047434495.1 → XP_047290451.1  putative E3 ubiquitin-protein ligase UNKL isoform X9

    9. XM_047434493.1 → XP_047290449.1  putative E3 ubiquitin-protein ligase UNKL isoform X8

    10. XM_047434494.1 → XP_047290450.1  putative E3 ubiquitin-protein ligase UNKL isoform X9

    11. XM_047434492.1 → XP_047290448.1  putative E3 ubiquitin-protein ligase UNKL isoform X8

    12. XM_017023569.2 → XP_016879058.1  putative E3 ubiquitin-protein ligase UNKL isoform X8

      UniProtKB/Swiss-Prot
      Q9H9P5
      Conserved Domains (1) summary
      pfam13920
      Location:189 → 226
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

    13. XM_011522613.2 → XP_011520915.1  putative E3 ubiquitin-protein ligase UNKL isoform X7

      Conserved Domains (1) summary
      pfam00642
      Location:306 → 332
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)

    RNA

    1. XR_007064900.1 RNA Sequence

    2. XR_007064899.1 RNA Sequence

    3. XR_007064898.1 RNA Sequence

    4. XR_007064897.1 RNA Sequence

    5. XR_007064896.1 RNA Sequence

    6. XR_932901.2 RNA Sequence

    7. XR_007064901.1 RNA Sequence

    8. XR_007064903.1 RNA Sequence

    9. XR_007064902.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      1379337..1429329 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054313698.1 → XP_054169673.1  putative E3 ubiquitin-protein ligase UNKL isoform X5

      UniProtKB/Swiss-Prot
      B0QYN6, B1GXI8, Q96EV1, Q96RZ1, Q9BWL5, Q9H5K0, Q9H9P5, Q9UJJ8

    2. XM_054313697.1 → XP_054169672.1  putative E3 ubiquitin-protein ligase UNKL isoform X4

      UniProtKB/Swiss-Prot
      B0QYN6, B1GXI8, Q96EV1, Q96RZ1, Q9BWL5, Q9H5K0, Q9H9P5, Q9UJJ8

    3. XM_054313696.1 → XP_054169671.1  putative E3 ubiquitin-protein ligase UNKL isoform X3

      UniProtKB/Swiss-Prot
      B0QYN6, B1GXI8, Q96EV1, Q96RZ1, Q9BWL5, Q9H5K0, Q9H9P5, Q9UJJ8

    4. XM_054313702.1 → XP_054169677.1  putative E3 ubiquitin-protein ligase UNKL isoform X11

    5. XM_054313701.1 → XP_054169676.1  putative E3 ubiquitin-protein ligase UNKL isoform X6

    6. XM_054313699.1 → XP_054169674.1  putative E3 ubiquitin-protein ligase UNKL isoform X10

    7. XM_054313695.1 → XP_054169670.1  putative E3 ubiquitin-protein ligase UNKL isoform X2

      UniProtKB/Swiss-Prot
      B0QYN6, B1GXI8, Q96EV1, Q96RZ1, Q9BWL5, Q9H5K0, Q9H9P5, Q9UJJ8

    8. XM_054313694.1 → XP_054169669.1  putative E3 ubiquitin-protein ligase UNKL isoform X1

      UniProtKB/Swiss-Prot
      B0QYN6, B1GXI8, Q96EV1, Q96RZ1, Q9BWL5, Q9H5K0, Q9H9P5, Q9UJJ8

    9. XM_054313700.1 → XP_054169675.1  putative E3 ubiquitin-protein ligase UNKL isoform X6

    10. XM_054313707.1 → XP_054169682.1  putative E3 ubiquitin-protein ligase UNKL isoform X9

    11. XM_054313706.1 → XP_054169681.1  putative E3 ubiquitin-protein ligase UNKL isoform X8

    12. XM_054313708.1 → XP_054169683.1  putative E3 ubiquitin-protein ligase UNKL isoform X9

    13. XM_054313705.1 → XP_054169680.1  putative E3 ubiquitin-protein ligase UNKL isoform X8

    14. XM_054313704.1 → XP_054169679.1  putative E3 ubiquitin-protein ligase UNKL isoform X8

    15. XM_054313703.1 → XP_054169678.1  putative E3 ubiquitin-protein ligase UNKL isoform X7

    RNA

    1. XR_008484720.1 RNA Sequence

    2. XR_008484719.1 RNA Sequence

    3. XR_008484718.1 RNA Sequence

    4. XR_008484723.1 RNA Sequence

    5. XR_008484721.1 RNA Sequence

    6. XR_008484717.1 RNA Sequence

    7. XR_008484716.1 RNA Sequence

    8. XR_008484715.1 RNA Sequence

    9. XR_008484722.1 RNA Sequence

    10. XR_008484725.1 RNA Sequence

    11. XR_008484724.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_024023.1: Suppressed sequence

      Description
      NM_024023.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H9P5.3 GenPept UniProtKB/Swiss-Prot:Q9H9P5

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    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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