CTSB cathepsin B [Homo sapiens (human)] - Gene

Summary

Official Symbol: CTSBprovided by HGNC
Official Full Name: cathepsin Bprovided by HGNC
Primary source: HGNC:HGNC:2527
See related: Ensembl:ENSG00000164733 MIM:116810; AllianceGenome:HGNC:2527
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: KWE; APPS; CPSB; RECEUP
Summary: This gene encodes a member of the C1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cathepsin B light and heavy chains, which can dimerize to form the double chain form of the enzyme. This enzyme is a lysosomal cysteine protease with both endopeptidase and exopeptidase activity that may play a role in protein turnover. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer's disease, the most common cause of dementia. Overexpression of the encoded protein has been associated with esophageal adenocarcinoma and other tumors. Both Cathepsin B and Cathepsin L are involved in the cleavage of the spike protein from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) upon its entry to the human host cell. Multiple pseudogenes of this gene have been identified. [provided by RefSeq, Sep 2020]
Annotation information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in SARS-CoV-2 infection.
Expression: Broad expression in thyroid (RPKM 602.1), appendix (RPKM 198.7) and 21 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 8p23.1

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	8	NC_000008.11 (11842524..11868087, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	8	NC_060932.1 (7872212..7897789)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	8	NC_000008.10 (11700033..11725596, complement)

Chromosome 8 - NC_000008.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Significance of Cathepsin B in Mediating Radiation Resistance in Colon Carcinoma Cell Line (Caco-2).
Title: The Significance of Cathepsin B in Mediating Radiation Resistance in Colon Carcinoma Cell Line (Caco-2).
The Relationship Between Exercise, Cathepsin B, and Cognitive Functions: Systematic Review.
Title: The Relationship Between Exercise, Cathepsin B, and Cognitive Functions: Systematic Review.
Correlation Analysis of CTSB Promoter Polymorphism and Function in Patients with Dilated Cardiomyopathy.
Title: Correlation Analysis of CTSB Promoter Polymorphism and Function in Patients with Dilated Cardiomyopathy.
Cathepsin B maturation plays a critical role in leptin-induced hepatic cancer cell growth through activation of NLRP3 inflammasomes.
Title: Cathepsin B maturation plays a critical role in leptin-induced hepatic cancer cell growth through activation of NLRP3 inflammasomes.
Research progress of cathepsin B in brain aging and Alzheimer's diseases.
Title: Research progress of cathepsin B in brain aging and Alzheimer's diseases.
Association of AXIN1 rs12921862 C/A and rs1805105 G/A and CTSB rs12898 G/A polymorphisms with papillary thyroid carcinoma: A case-control study.
Title: Association of AXIN1 rs12921862 C/A and rs1805105 G/A and CTSB rs12898 G/A polymorphisms with papillary thyroid carcinoma: A case-control study.
Increased glucose metabolism in TAMs fuels O-GlcNAcylation of lysosomal Cathepsin B to promote cancer metastasis and chemoresistance.
Title: Increased glucose metabolism in TAMs fuels O-GlcNAcylation of lysosomal Cathepsin B to promote cancer metastasis and chemoresistance.
Cathepsin B-A Neuronal Death Mediator in Alzheimer's Disease Leading to Neurodegeneration.
Title: Cathepsin B-A Neuronal Death Mediator in Alzheimer's Disease Leading to Neurodegeneration.
Endoplasmic reticulum stress promoted acinar cell necroptosis in acute pancreatitis through cathepsinB-mediated AP-1 activation.
Title: Endoplasmic reticulum stress promoted acinar cell necroptosis in acute pancreatitis through cathepsinB-mediated AP-1 activation.
Cathepsin B p.Gly284Val Variant in Parkinson's Disease Pathogenesis.
Title: Cathepsin B p.Gly284Val Variant in Parkinson's Disease Pathogenesis.

Submit: New GeneRIF Correction See all GeneRIFs (252)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Keratolytic winter erythema MedGen: C0406756 OMIM: 148370 GeneReviews: Not available	Compare labs

Copy number response

Description
Copy number response Haploinsufficency No evidence available (Last evaluated 2012-02-08) ClinGen Genome Curation Page Triplosensitivity No evidence available (Last evaluated 2012-02-08) ClinGen Genome Curation Page

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
HIV-1 infection upregulates cathepsin B, cystatin B, and cystatin C in the frontal white matter of patients with HIV-Associated Neurocognitive Disorders	PubMed
HIV-1 infection in macrophages decreases Cathepsin B and MMP9 interactions	PubMed
HIV-1 infection upregulates cathepsin B (CTSB) in microglia and CHME-5 cells	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 upregulates the expression of cathepsin B (CTSB) in human B cells	PubMed
	env	HIV-1 gp120-treated vaginal epithelial cells show downregulation of cathepsin B (CTSB) expression as compared to untreated control	PubMed
Pr55(Gag)	gag	Macrophages and HEK293T cells deficient in cathepsin B (CTSB) fail to release HIV-1 Gag pseudoparticles into the extracellular environment	PubMed
Vpr	vpr	A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of cathepsin B (CTSB) expression by HIV-1 Vpr in Vpr transduced macrophages	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH102692 (e-PCR)
- UniSTS:97026

G54083 (e-PCR)
- UniSTS:109320

D11S2921 (e-PCR)
- UniSTS:152074

GDB:434012 (e-PCR)
- UniSTS:157204

D10S275 (e-PCR)
- UniSTS:147992

RH103511 (e-PCR)
- UniSTS:97836

D8S2279 (e-PCR)
- UniSTS:473907

D10S16 (e-PCR)
- UniSTS:155756

D1S1423 (e-PCR)
- UniSTS:149619

D1S1425 (e-PCR)
- UniSTS:149621

D8S2052 (e-PCR)
- UniSTS:35702

CTSB_430 (e-PCR)
- UniSTS:277134

D16S325 (e-PCR)
- UniSTS:147089

SHGC-58122 (e-PCR)
- UniSTS:55199

D8S1946 (e-PCR)
- UniSTS:47016

RH75619 (e-PCR)
- UniSTS:90043

RH11588 (e-PCR)
- UniSTS:16834

G61996 (e-PCR)
- UniSTS:139215

D3S1673 (e-PCR)
- UniSTS:148450

STS-M14221 (e-PCR)
- UniSTS:51967

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables collagen binding	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type peptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables peptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables proteoglycan binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to thyroid hormone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in collagen catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in decidualization	IEA Inferred from Electronic Annotation more info
involved_in epithelial cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in proteolysis	IDA Inferred from Direct Assay more info	PubMed
involved_in proteolysis involved in protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis involved in protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of apoptotic process	TAS Traceable Author Statement more info	PubMed
involved_in regulation of catalytic activity	IEA Inferred from Electronic Annotation more info
involved_in symbiont entry into host cell	IEA Inferred from Electronic Annotation more info
involved_in thyroid hormone generation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
colocalizes_with collagen-containing extracellular matrix	HDA more info	PubMed
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in endolysosome lumen	TAS Traceable Author Statement more info
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	HDA more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in ficolin-1-rich granule lumen	TAS Traceable Author Statement more info
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosome	IDA Inferred from Direct Assay more info	PubMed
located_in melanosome	IEA Inferred from Electronic Annotation more info
part_of peptidase inhibitor complex	IPI Inferred from Physical Interaction more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cathepsin B

Names: APP secretase; amyloid precursor protein secretase; cathepsin B1; cysteine protease; epididymis secretory sperm binding protein; keratolytic winter erythema (Oudtshoorn skin disease)

NP_001304166.1

EC 3.4.22.1

NP_001371643.1

EC 3.4.22.1

NP_001371652.1

EC 3.4.22.1

NP_001371653.1

EC 3.4.22.1

NP_001371654.1

EC 3.4.22.1

NP_001371655.1

EC 3.4.22.1

NP_001371656.1

EC 3.4.22.1

NP_001371657.1

EC 3.4.22.1

NP_001899.1

EC 3.4.22.1

NP_680090.1

EC 3.4.22.1

NP_680091.1

EC 3.4.22.1

NP_680092.1

EC 3.4.22.1

NP_680093.1

EC 3.4.22.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_009217.2 RefSeqGene

Range

5051..30614

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001317237.2 → NP_001304166.1 cathepsin B isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (6) differs in the 5' UTR, lacks an exon in its 5' coding region and uses an alternate translation start site compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus, and lacks a predicted signal peptide compared to isoform 1.

Source sequence(s)

AA516096, AC069185, AK130184, BX647765, DC386022

UniProtKB/TrEMBL

Q5HYG5

Related

ENSP00000504808.1, ENST00000678629.1

Conserved Domains (1) summary

cd02620
Location:25 → 204

Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
NM_001384714.1 → NP_001371643.1 cathepsin B isoform 1 preproprotein

Status: REVIEWED

Description

Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Both variants 1 and 7 encode the same protein.

Source sequence(s)

AC025857, AC069185

Consensus CDS

CCDS5986.1

UniProtKB/Swiss-Prot

B3KQR5, B3KRR5, P07858, Q503A6, Q96D87

UniProtKB/TrEMBL

A0A024R374, A0A7P0NGZ6, A8K2H4

Related

ENSP00000503674.1, ENST00000678145.1

Conserved Domains (2) summary

cd02620
Location:81 → 328

Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...

pfam08127
Location:26 → 65

Propeptide_C1; Peptidase family C1 propeptide
NM_001384723.1 → NP_001371652.1 cathepsin B isoform 1 preproprotein

Status: REVIEWED

Description

Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. Both variants 1 and 8 encode the same protein.

Source sequence(s)

AC025857, AC069185

Consensus CDS

CCDS5986.1

UniProtKB/Swiss-Prot

B3KQR5, B3KRR5, P07858, Q503A6, Q96D87

UniProtKB/TrEMBL

A0A024R374, A0A7P0NGZ6, A8K2H4

Related

ENSP00000503435.1, ENST00000677819.1

Conserved Domains (2) summary

cd02620
Location:81 → 328

Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...

pfam08127
Location:26 → 65

Propeptide_C1; Peptidase family C1 propeptide
NM_001384724.1 → NP_001371653.1 cathepsin B isoform 1 preproprotein

Status: REVIEWED

Description

Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 1. Both variants 1 and 9 encode the same protein.

Source sequence(s)

AC025857, AC069185

Consensus CDS

CCDS5986.1

UniProtKB/Swiss-Prot

B3KQR5, B3KRR5, P07858, Q503A6, Q96D87

UniProtKB/TrEMBL

A0A024R374, A0A7P0NGZ6, A8K2H4

Related

ENSP00000504797.1, ENST00000677650.1

Conserved Domains (2) summary

cd02620
Location:81 → 328

Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...

pfam08127
Location:26 → 65

Propeptide_C1; Peptidase family C1 propeptide
NM_001384725.1 → NP_001371654.1 cathepsin B isoform 1 preproprotein

Status: REVIEWED

Description

Transcript Variant: This variant (10) differs in the 5' UTR compared to variant 1. Both variants 1 and 10 encode the same protein.

Source sequence(s)

AC025857, AC069185

Consensus CDS

CCDS5986.1

UniProtKB/Swiss-Prot

B3KQR5, B3KRR5, P07858, Q503A6, Q96D87

UniProtKB/TrEMBL

A0A024R374, A0A7P0NGZ6, A8K2H4

Related

ENSP00000503513.1, ENST00000678357.1

Conserved Domains (2) summary

cd02620
Location:81 → 328

Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...

pfam08127
Location:26 → 65

Propeptide_C1; Peptidase family C1 propeptide
NM_001384726.1 → NP_001371655.1 cathepsin B isoform 1 preproprotein

Status: REVIEWED

Description

Transcript Variant: This variant (11) differs in the 5' UTR compared to variant 1. Both variants 1 and 11 encode the same protein.

Source sequence(s)

AC025857, AC069185

Consensus CDS

CCDS5986.1

UniProtKB/Swiss-Prot

B3KQR5, B3KRR5, P07858, Q503A6, Q96D87

UniProtKB/TrEMBL

A0A024R374, A0A7P0NGZ6, A8K2H4

Related

ENSP00000434217.1, ENST00000534510.6

Conserved Domains (2) summary

cd02620
Location:81 → 328

Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...

pfam08127
Location:26 → 65

Propeptide_C1; Peptidase family C1 propeptide
NM_001384727.1 → NP_001371656.1 cathepsin B isoform 1 preproprotein

Status: REVIEWED

Description

Transcript Variant: This variant (12) differs in the 5' UTR compared to variant 1. Both variants 1 and 12 encode the same protein.

Source sequence(s)

AC025857, AC069185

Consensus CDS

CCDS5986.1

UniProtKB/Swiss-Prot

B3KQR5, B3KRR5, P07858, Q503A6, Q96D87

UniProtKB/TrEMBL

A0A024R374, A0A7P0NGZ6, A8K2H4

Related

ENSP00000503174.1, ENST00000677418.1

Conserved Domains (2) summary

cd02620
Location:81 → 328

Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...

pfam08127
Location:26 → 65

Propeptide_C1; Peptidase family C1 propeptide
NM_001384728.1 → NP_001371657.1 cathepsin B isoform 1 preproprotein

Status: REVIEWED

Description

Transcript Variant: This variant (13) differs in the 5' UTR compared to variant 1. Both variants 1 and 13 encode the same protein.

Source sequence(s)

AC025857, AC069185

Consensus CDS

CCDS5986.1

UniProtKB/Swiss-Prot

B3KQR5, B3KRR5, P07858, Q503A6, Q96D87

UniProtKB/TrEMBL

A0A024R374, A0A7P0NGZ6, A8K2H4

Related

ENSP00000503487.1, ENST00000678929.1

Conserved Domains (2) summary

cd02620
Location:81 → 328

Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...

pfam08127
Location:26 → 65

Propeptide_C1; Peptidase family C1 propeptide
NM_001908.5 → NP_001899.1 cathepsin B isoform 1 preproprotein

See identical proteins and their annotated locations for NP_001899.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes isoform (1). Variants 1-5, and 7-13 encode the same isoform (1).

Source sequence(s)

AA516096, AC069185, AK130184, DC386022

Consensus CDS

CCDS5986.1

UniProtKB/Swiss-Prot

B3KQR5, B3KRR5, P07858, Q503A6, Q96D87

UniProtKB/TrEMBL

A0A024R374, A0A7P0NGZ6, A8K2H4

Related

ENSP00000345672.5, ENST00000353047.11

Conserved Domains (2) summary

cd02620
Location:81 → 328

Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...

pfam08127
Location:26 → 65

Propeptide_C1; Peptidase family C1 propeptide
NM_147780.4 → NP_680090.1 cathepsin B isoform 1 preproprotein

See identical proteins and their annotated locations for NP_680090.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-5 encode the same isoform (1).

Source sequence(s)

AA516096, AC069185, AK130184, BG770805, DC386022

Consensus CDS

CCDS5986.1

UniProtKB/Swiss-Prot

B3KQR5, B3KRR5, P07858, Q503A6, Q96D87

UniProtKB/TrEMBL

A0A024R374, A0A7P0NGZ6, A8K2H4

Related

ENSP00000503078.1, ENST00000677544.1

Conserved Domains (2) summary

cd02620
Location:81 → 328

Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...

pfam08127
Location:26 → 65

Propeptide_C1; Peptidase family C1 propeptide
NM_147781.4 → NP_680091.1 cathepsin B isoform 1 preproprotein

See identical proteins and their annotated locations for NP_680091.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-5 encode the same isoform (1).

Source sequence(s)

AA516096, AC069185, AK130184, AL543654, DC386022

Consensus CDS

CCDS5986.1

UniProtKB/Swiss-Prot

B3KQR5, B3KRR5, P07858, Q503A6, Q96D87

UniProtKB/TrEMBL

A0A024R374, A0A7P0NGZ6, A8K2H4

Related

ENSP00000342070.3, ENST00000345125.8

Conserved Domains (2) summary

cd02620
Location:81 → 328

Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...

pfam08127
Location:26 → 65

Propeptide_C1; Peptidase family C1 propeptide
NM_147782.4 → NP_680092.1 cathepsin B isoform 1 preproprotein

See identical proteins and their annotated locations for NP_680092.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-5 encode the same isoform (1).

Source sequence(s)

AA516096, AC069185, AK130184, BG770805, DC386022

Consensus CDS

CCDS5986.1

UniProtKB/Swiss-Prot

B3KQR5, B3KRR5, P07858, Q503A6, Q96D87

UniProtKB/TrEMBL

A0A024R374, A0A7P0NGZ6, A8K2H4

Related

ENSP00000503280.1, ENST00000678242.1

Conserved Domains (2) summary

cd02620
Location:81 → 328

Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...

pfam08127
Location:26 → 65

Propeptide_C1; Peptidase family C1 propeptide
NM_147783.4 → NP_680093.1 cathepsin B isoform 1 preproprotein

See identical proteins and their annotated locations for NP_680093.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1-5 encode the same isoform (1).

Source sequence(s)

AA516096, AC069185, AK092070, AK130184

Consensus CDS

CCDS5986.1

UniProtKB/Swiss-Prot

B3KQR5, B3KRR5, P07858, Q503A6, Q96D87

UniProtKB/TrEMBL

A0A024R374, A0A7P0NGZ6, A8K2H4

Related

ENSP00000503858.1, ENST00000679051.1

Conserved Domains (2) summary

cd02620
Location:81 → 328

Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...

pfam08127
Location:26 → 65

Propeptide_C1; Peptidase family C1 propeptide