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    immt inner membrane protein, mitochondrial (mitofilin) [ Danio rerio (zebrafish) ]

    Gene ID: 327206, updated on 2-Nov-2024

    Summary

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    Official Symbol
    immtprovided by ZNC
    Official Full Name
    inner membrane protein, mitochondrial (mitofilin)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-5417
    See related
    Ensembl:ENSDARG00000102874 AllianceGenome:ZFIN:ZDB-GENE-030131-5417
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    mic60; zgc:64180; wu:fd16e04; wu:fi69g11
    Summary
    Predicted to be involved in cristae formation. Predicted to be located in mitochondrial inner membrane. Predicted to be part of MICOS complex. Is expressed in eye; immature eye; midbrain; myotome; and pectoral fin musculature. Orthologous to human IMMT (inner membrane mitochondrial protein). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See immt in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (16093916..16123580)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (15788345..15818017)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene MAX dimerization protein 3 Neighboring gene ring finger protein 103 Neighboring gene pentatricopeptide repeat domain 3 Neighboring gene RNA polymerase I subunit A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The zebrafish orthologue of the human hepatocerebral disease gene MPV17 plays pleiotropic roles in mitochondria. Martorano L, et al. Dis Model Mech, 2019 Mar 14. PMID 30833296, Free PMC Article
    2. Intrinsic myocardial defects underlie an Rbfox-deficient zebrafish model of hypoplastic left heart syndrome. Huang M, et al. Nat Commun, 2022 Oct 5. PMID 36198703, Free PMC Article
    3. Decellularized zebrafish cardiac extracellular matrix induces mammalian heart regeneration. Chen WC, et al. Sci Adv, 2016 Nov. PMID 28138518, Free PMC Article
    4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in cristae formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of MICOS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    MICOS complex subunit MIC60

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001401.1 → NP_001001401.1  MICOS complex subunit MIC60

      See identical proteins and their annotated locations for NP_001001401.1

      Status: PROVISIONAL

      Source sequence(s)
      BC057438
      UniProtKB/TrEMBL
      A0A8M1MZK8, Q6PFS4
      Related
      ENSDARP00000133453.1, ENSDART00000159181.2
      Conserved Domains (3) summary
      pfam09731
      Location:39 → 747
      Mitofilin; Mitochondrial inner membrane protein
      cd16269
      Location:490 → 505
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:418 → 522
      GBP_C; Guanylate-binding protein, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      16093916..16123580
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005157191.4 → XP_005157248.1  MICOS complex subunit MIC60 isoform X1

      UniProtKB/TrEMBL
      A0A8M2B3A8
      Conserved Domains (3) summary
      pfam09731
      Location:39 → 712
      Mitofilin; Mitochondrial inner membrane protein
      cd16269
      Location:455 → 470
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:383 → 487
      GBP_C; Guanylate-binding protein, C-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version

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