DDX11 DEAD/H-box helicase 11 [Homo sapiens (human)] - Gene

Summary

Official Symbol: DDX11provided by HGNC
Official Full Name: DEAD/H-box helicase 11provided by HGNC
Primary source: HGNC:HGNC:2736
See related: Ensembl:ENSG00000013573 MIM:601150; AllianceGenome:HGNC:2736
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CHL1; KRG2; WABS; CHLR1
Summary: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an enzyme that possesses both ATPase and DNA helicase activities. This gene is a homolog of the yeast CHL1 gene, and may function to maintain chromosome transmission fidelity and genome stability. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in bone marrow (RPKM 6.8), lymph node (RPKM 4.6) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 12p11.21

Exon count:: 33

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (31073860..31104799)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (30948354..30979293)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (31226794..31257733)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DEAD/H-box helicase 11 is transcriptionally activated by Yin Yang-1 and accelerates oral squamous cell carcinoma progression.
Title: DEAD/H-box helicase 11 is transcriptionally activated by Yin Yang-1 and accelerates oral squamous cell carcinoma progression.
Mapping of DDX11 genetic interactions defines sister chromatid cohesion as the major dependency.
Title: Mapping of DDX11 genetic interactions defines sister chromatid cohesion as the major dependency.
Mutations in DEAD/H-box helicase 11 correlate with increased relapse risk in adults with acute myeloid leukaemia with normal cytogenetics.
Title: Mutations in DEAD/H-box helicase 11 correlate with increased relapse risk in adults with acute myeloid leukaemia with normal cytogenetics.
Finding underlying genetic mechanisms of two patients with autism spectrum disorder carrying familial apparently balanced chromosomal translocations.
Title: Finding underlying genetic mechanisms of two patients with autism spectrum disorder carrying familial apparently balanced chromosomal translocations.
Expression of DDX11 and DNM1L at the 12p11 Locus Modulates Systemic Lupus Erythematosus Susceptibility.
Title: Expression of DDX11 and DNM1L at the 12p11 Locus Modulates Systemic Lupus Erythematosus Susceptibility.
Timeless couples G-quadruplex detection with processing by DDX11 helicase during DNA replication.
Title: Timeless couples G-quadruplex detection with processing by DDX11 helicase during DNA replication.
E2F1 mediated DDX11 transcriptional activation promotes hepatocellular carcinoma progression through PI3K/AKT/mTOR pathway.
Title: E2F1 mediated DDX11 transcriptional activation promotes hepatocellular carcinoma progression through PI3K/AKT/mTOR pathway.
The long non-coding RNA DDX11-AS1 facilitates cell progression and oxaliplatin resistance via regulating miR-326/IRS1 axis in gastric cancer.
Title: The long non-coding RNA DDX11-AS1 facilitates cell progression and oxaliplatin resistance via regulating miR-326/IRS1 axis in gastric cancer.
The iron-sulfur helicase DDX11 promotes the generation of single-stranded DNA for CHK1 activation.
Title: The iron-sulfur helicase DDX11 promotes the generation of single-stranded DNA for CHK1 activation.
DDX11-AS1exacerbates bladder cancer progression by enhancing CDK6 expression via suppressing miR-499b-5p.
Title: DDX11-AS1exacerbates bladder cancer progression by enhancing CDK6 expression via suppressing miR-499b-5p.

Submit: New GeneRIF Correction See all GeneRIFs (36)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Warsaw breakage syndrome MedGen: C3150658 OMIM: 613398 GeneReviews: Warsaw Syndrome	not available

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	DDX11 is downregulated in HIV-1 Tat and NC cotransfection of HEK 293T cells	PubMed
nucleocapsid	gag	DDX11 is downregulated in HIV-1 Tat and NC cotransfection of HEK 293T cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ECD03348 (e-PCR)
- UniSTS:284433

RH65252 (e-PCR)
- UniSTS:87705

RH80562 (e-PCR)
- UniSTS:87778

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 4 iron, 4 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables 5'-3' DNA helicase activity	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent H2AZ histone chaperone activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent H3-H4 histone complex chaperone activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent activity, acting on DNA	IDA Inferred from Direct Assay more info	PubMed
enables ATP-dependent activity, acting on DNA	IMP Inferred from Mutant Phenotype more info	PubMed
enables ATP-dependent activity, acting on RNA	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA clamp loader activity	IEA Inferred from Electronic Annotation more info
enables DNA helicase activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA helicase activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA replication origin binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables G-quadruplex DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables chromatin extrusion motor activity	IEA Inferred from Electronic Annotation more info
enables cohesin loader activity	IEA Inferred from Electronic Annotation more info
enables double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables double-stranded DNA helicase activity	IEA Inferred from Electronic Annotation more info
enables forked DNA-dependent helicase activity	IEA Inferred from Electronic Annotation more info
enables four-way junction helicase activity	IEA Inferred from Electronic Annotation more info
enables helicase activity	IDA Inferred from Direct Assay more info	PubMed
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables single-stranded 3'-5' DNA helicase activity	IEA Inferred from Electronic Annotation more info
enables single-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables single-stranded RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables triplex DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA damage response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA duplex unwinding	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA duplex unwinding	IDA Inferred from Direct Assay more info	PubMed
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in G-quadruplex DNA unwinding	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to bleomycin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to cisplatin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to hydroxyurea	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin looping	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in establishment of sister chromatid cohesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of protein binding	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleolar chromatin organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of chromatin binding	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of double-strand break repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of endodeoxyribonuclease activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of sister chromatid cohesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription of nucleolar large rRNA by RNA polymerase I	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in replication fork processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sister chromatid cohesion	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of Ctf18 RFC-like complex	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	HDA more info	PubMed
located_in midbody	IDA Inferred from Direct Assay more info	PubMed
NOT part_of mitotic cohesin complex	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
colocalizes_with nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in spindle pole	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ATP-dependent DNA helicase DDX11

Names: CHL1-like helicase homolog; CHL1-related helicase gene-1; CHL1-related protein 1; DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 (CHL1-like helicase homolog, S. cerevisiae); DEAD/H box protein 11; DNA 5'-3' helicase DDX11; KRG-2; hCHLR1; keratinocyte growth factor-regulated gene 2 protein; probable ATP-dependent DNA helicase DDX11; probable ATP-dependent RNA helicase DDX11

NP_001244073.1

EC 5.6.2.3

NP_001244074.1

EC 5.6.2.3

NP_001400621.1

EC 5.6.2.3

NP_001400622.1

EC 5.6.2.3

NP_001400623.1

EC 5.6.2.3

NP_001400624.1

EC 5.6.2.3

NP_001400625.1

EC 5.6.2.3

NP_001400626.1

EC 5.6.2.3

NP_001400627.1

EC 5.6.2.3

NP_001400628.1

EC 5.6.2.3

NP_001400629.1

EC 5.6.2.3

NP_001400631.1

EC 5.6.2.3

NP_001400632.1

EC 5.6.2.3

NP_001400633.1

EC 5.6.2.3

NP_001400634.1

EC 5.6.2.3

NP_001400635.1

EC 5.6.2.3

NP_004390.3

EC 5.6.2.3

NP_085911.2

EC 5.6.2.3

NP_689651.1

EC 5.6.2.3

XP_005253388.1

EC 5.6.2.3

XP_005253390.1

EC 5.6.2.3

XP_006719113.1

EC 5.6.2.3

XP_011518894.1

EC 5.6.2.3

XP_011518897.1

EC 5.6.2.3

XP_011518899.2

EC 5.6.2.3

XP_016874408.1

EC 5.6.2.3

XP_016874409.2

EC 5.6.2.3

XP_016874410.2

EC 5.6.2.3

XP_016874411.1

EC 5.6.2.3

XP_016874414.1

EC 5.6.2.3

XP_016874415.2

EC 5.6.2.3

XP_016874416.2

EC 5.6.2.3

XP_016874417.2

EC 5.6.2.3

XP_016874418.2

EC 5.6.2.3

XP_016874419.2

EC 5.6.2.3

XP_016874424.1

EC 5.6.2.3

XP_016874425.1

EC 5.6.2.3

XP_016874426.1

EC 5.6.2.3

XP_016874427.2

EC 5.6.2.3

XP_016874428.2

EC 5.6.2.3

XP_047284403.1

EC 5.6.2.3

XP_047284404.1

EC 5.6.2.3

XP_047284405.1

EC 5.6.2.3

XP_047284407.1

EC 5.6.2.3

XP_047284408.1

EC 5.6.2.3

XP_047284409.1

EC 5.6.2.3

XP_047284410.1

EC 5.6.2.3

XP_047284411.1

EC 5.6.2.3

XP_047284412.1

EC 5.6.2.3

XP_047284413.1

EC 5.6.2.3

XP_047284414.1

EC 5.6.2.3

XP_047284415.1

EC 5.6.2.3

XP_047284416.1

EC 5.6.2.3

XP_047284417.1

EC 5.6.2.3

XP_047284418.1

EC 5.6.2.3

XP_047284419.1

EC 5.6.2.3

XP_047284420.1

EC 5.6.2.3

XP_047284421.1

EC 5.6.2.3

XP_054227284.1

EC 5.6.2.3

XP_054227285.1

EC 5.6.2.3

XP_054227286.1

EC 5.6.2.3

XP_054227287.1

EC 5.6.2.3

XP_054227288.1

EC 5.6.2.3

XP_054227289.1

EC 5.6.2.3

XP_054227290.1

EC 5.6.2.3

XP_054227291.1

EC 5.6.2.3

XP_054227292.1

EC 5.6.2.3

XP_054227293.1

EC 5.6.2.3

XP_054227294.1

EC 5.6.2.3

XP_054227295.1

EC 5.6.2.3

XP_054227296.1

EC 5.6.2.3

XP_054227297.1

EC 5.6.2.3

XP_054227298.1

EC 5.6.2.3

XP_054227299.1

EC 5.6.2.3

XP_054227300.1

EC 5.6.2.3

XP_054227301.1

EC 5.6.2.3

XP_054227302.1

EC 5.6.2.3

XP_054227303.1

EC 5.6.2.3

XP_054227304.1

EC 5.6.2.3

XP_054227305.1

EC 5.6.2.3

XP_054227306.1

EC 5.6.2.3

XP_054227307.1

EC 5.6.2.3

XP_054227308.1

EC 5.6.2.3

XP_054227309.1

EC 5.6.2.3

XP_054227310.1

EC 5.6.2.3

XP_054227311.1

EC 5.6.2.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_023352.1 RefSeqGene

Range

5016..35955

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001257144.2 → NP_001244073.1 ATP-dependent DNA helicase DDX11 isoform 3

See identical proteins and their annotated locations for NP_001244073.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 3. Variants 3, 4, 9 and 10 all encode the same isoform (3).

Source sequence(s)

AC008013, BC050522

Consensus CDS

CCDS44856.1

UniProtKB/Swiss-Prot

Q13333, Q86VQ4, Q86W62, Q92498, Q92770, Q92998, Q92999, Q96FC9

UniProtKB/TrEMBL

Q2NKM7

Related

ENSP00000440402.1, ENST00000545668.5

Conserved Domains (1) summary

cl26947
Location:227 → 822

HBB; Helical and beta-bridge domain
NM_001257145.2 → NP_001244074.1 ATP-dependent DNA helicase DDX11 isoform 4

See identical proteins and their annotated locations for NP_001244074.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) differs in the 5' UTR and coding region, and uses a downstream AUG compared to variant 3. The resulting protein (isoform 4) has shorter N- and C-termini compared to isoform 3. Variants 5, 11, and 12 all encode the same isoform (4).

Source sequence(s)

AC008013, BC050069

Consensus CDS

CCDS58224.1

UniProtKB/TrEMBL

Q2NKM7

Related

ENSP00000228264.6, ENST00000228264.10

Conserved Domains (3) summary

smart00488
Location:1 → 411

DEXDc2; DEAD-like helicases superfamily

TIGR00604
Location:201 → 867

rad3; DNA repair helicase (rad3)

pfam13307
Location:666 → 853

Helicase_C_2; Helicase C-terminal domain
NM_001413692.1 → NP_001400621.1 ATP-dependent DNA helicase DDX11 isoform 1

Status: REVIEWED

Source sequence(s)

AC008013
NM_001413693.1 → NP_001400622.1 ATP-dependent DNA helicase DDX11 isoform 1

Status: REVIEWED

Source sequence(s)

AC008013
NM_001413694.1 → NP_001400623.1 ATP-dependent DNA helicase DDX11 isoform 1

Status: REVIEWED

Source sequence(s)

AC008013
NM_001413695.1 → NP_001400624.1 ATP-dependent DNA helicase DDX11 isoform 3

Status: REVIEWED

Source sequence(s)

AC008013

UniProtKB/Swiss-Prot

Q13333, Q86VQ4, Q86W62, Q92498, Q92770, Q92998, Q92999, Q96FC9
NM_001413696.1 → NP_001400625.1 ATP-dependent DNA helicase DDX11 isoform 3

Status: REVIEWED

Source sequence(s)

AC008013

UniProtKB/Swiss-Prot

Q13333, Q86VQ4, Q86W62, Q92498, Q92770, Q92998, Q92999, Q96FC9
NM_001413697.1 → NP_001400626.1 ATP-dependent DNA helicase DDX11 isoform 4

Status: REVIEWED

Source sequence(s)

AC008013
NM_001413698.1 → NP_001400627.1 ATP-dependent DNA helicase DDX11 isoform 4

Status: REVIEWED

Source sequence(s)

AC008013
NM_001413699.1 → NP_001400628.1 ATP-dependent DNA helicase DDX11 isoform 5

Status: REVIEWED

Source sequence(s)

AC008013
NM_001413700.1 → NP_001400629.1 ATP-dependent DNA helicase DDX11 isoform 6

Status: REVIEWED

Source sequence(s)

AC008013
NM_001413702.1 → NP_001400631.1 ATP-dependent DNA helicase DDX11 isoform 7

Status: REVIEWED

Source sequence(s)

AC008013
NM_001413703.1 → NP_001400632.1 ATP-dependent DNA helicase DDX11 isoform 7

Status: REVIEWED

Source sequence(s)

AC008013
NM_001413704.1 → NP_001400633.1 ATP-dependent DNA helicase DDX11 isoform 8

Status: REVIEWED

Source sequence(s)

AC008013
NM_001413705.1 → NP_001400634.1 ATP-dependent DNA helicase DDX11 isoform 9

Status: REVIEWED

Source sequence(s)

AC008013
NM_001413706.1 → NP_001400635.1 ATP-dependent DNA helicase DDX11 isoform 10

Status: REVIEWED

Source sequence(s)

AC008013
NM_004399.3 → NP_004390.3 ATP-dependent DNA helicase DDX11 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon and uses an alternate splice junction compared to variant 3, that results in a frameshift. The resulting isoform (2) lacks an internal segment and has a distinct C-terminus compared to isoform 3.

Source sequence(s)

AC008013, BC011264, BC111733, X99583

Consensus CDS

CCDS8721.1

UniProtKB/TrEMBL

Q2NKM7

Related

ENSP00000309965.5, ENST00000350437.8

Conserved Domains (3) summary

smart00488
Location:11 → 437

DEXDc2; DEAD-like helicases superfamily

smart00491
Location:680 → 817

HELICc2; helicase superfamily c-terminal domain

TIGR00604
Location:227 → 843

rad3; DNA repair helicase (rad3)
NM_030653.4 → NP_085911.2 ATP-dependent DNA helicase DDX11 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (1) uses an alternate splice junction at a coding exon compared to variant 3, that results in a frameshift. The resulting isoform (1) is shorter and has a distinct C-terminus compared to isoform 3. Variants 1 and 6-8 all encode the same isoform (1).

Source sequence(s)

AC008013, BC011264, BC111733

Consensus CDS

CCDS41767.1

UniProtKB/TrEMBL

Q2NKM7

Related

ENSP00000443426.1, ENST00000542838.6

Conserved Domains (3) summary

smart00488
Location:11 → 437

DEXDc2; DEAD-like helicases superfamily

TIGR00604
Location:227 → 893

rad3; DNA repair helicase (rad3)

pfam13307
Location:692 → 879

Helicase_C_2; Helicase C-terminal domain
NM_152438.2 → NP_689651.1 ATP-dependent DNA helicase DDX11 isoform 3

See identical proteins and their annotated locations for NP_689651.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) encodes the longest isoform (3). Variants 3, 4, 9 and 10 all encode the same isoform (3).

Source sequence(s)

AC008013, BC011264, BC111733

Consensus CDS

CCDS44856.1

UniProtKB/Swiss-Prot

Q13333, Q86VQ4, Q86W62, Q92498, Q92770, Q92998, Q92999, Q96FC9

UniProtKB/TrEMBL

Q2NKM7

Conserved Domains (1) summary

cl26947
Location:227 → 822

HBB; Helical and beta-bridge domain

RNA

NR_182200.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC008013
NR_182201.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC008013
NR_182202.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC008013

Related

ENST00000435753.6
NR_182203.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC008013

Related

ENST00000539049.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000012.12 Reference GRCh38.p14 Primary Assembly

Range

31073860..31104799

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017018922.2 → XP_016874411.1 ATP-dependent DNA helicase DDX11 isoform X5
XM_017018925.2 → XP_016874414.1 ATP-dependent DNA helicase DDX11 isoform X5
XM_017018919.3 → XP_016874408.1 ATP-dependent DNA helicase DDX11 isoform X1
XM_006719050.5 → XP_006719113.1 ATP-dependent DNA helicase DDX11 isoform X14

UniProtKB/TrEMBL

Q2NKM7

Conserved Domains (3) summary

smart00488
Location:47 → 473

DEXDc2; DEAD-like helicases superfamily

TIGR00604
Location:263 → 929

rad3; DNA repair helicase (rad3)

pfam13307
Location:728 → 915

Helicase_C_2; Helicase C-terminal domain
XM_005253333.5 → XP_005253390.1 ATP-dependent DNA helicase DDX11 isoform X16

UniProtKB/TrEMBL

Q2NKM7

Conserved Domains (3) summary

smart00488
Location:47 → 473

DEXDc2; DEAD-like helicases superfamily

TIGR00604
Location:263 → 929

rad3; DNA repair helicase (rad3)

pfam13307
Location:728 → 915

Helicase_C_2; Helicase C-terminal domain
XM_011520592.4 → XP_011518894.1 ATP-dependent DNA helicase DDX11 isoform X8

See identical proteins and their annotated locations for XP_011518894.1

Conserved Domains (2) summary

smart00488
Location:47 → 473

DEXDc2; DEAD-like helicases superfamily

smart00491
Location:746 → 860

HELICc2; helicase superfamily c-terminal domain
XM_005253331.5 → XP_005253388.1 ATP-dependent DNA helicase DDX11 isoform X12

UniProtKB/TrEMBL

Q2NKM7

Conserved Domains (2) summary

smart00488
Location:47 → 473

DEXDc2; DEAD-like helicases superfamily

smart00491
Location:746 → 860

HELICc2; helicase superfamily c-terminal domain
XM_011520595.4 → XP_011518897.1 ATP-dependent DNA helicase DDX11 isoform X22

UniProtKB/TrEMBL

Q2NKM7

Conserved Domains (3) summary

smart00488
Location:47 → 473

DEXDc2; DEAD-like helicases superfamily

smart00491
Location:716 → 853

HELICc2; helicase superfamily c-terminal domain

TIGR00604
Location:263 → 879

rad3; DNA repair helicase (rad3)
XM_047428447.1 → XP_047284403.1 ATP-dependent DNA helicase DDX11 isoform X2
XM_047428452.1 → XP_047284408.1 ATP-dependent DNA helicase DDX11 isoform X15
XM_047428454.1 → XP_047284410.1 ATP-dependent DNA helicase DDX11 isoform X17
XM_047428448.1 → XP_047284404.1 ATP-dependent DNA helicase DDX11 isoform X10
XM_047428461.1 → XP_047284417.1 ATP-dependent DNA helicase DDX11 isoform X24
XM_047428451.1 → XP_047284407.1 ATP-dependent DNA helicase DDX11 isoform X14
XM_047428453.1 → XP_047284409.1 ATP-dependent DNA helicase DDX11 isoform X16
XM_047428449.1 → XP_047284405.1 ATP-dependent DNA helicase DDX11 isoform X12
XM_047428459.1 → XP_047284415.1 ATP-dependent DNA helicase DDX11 isoform X22
XM_017018928.3 → XP_016874417.2 ATP-dependent DNA helicase DDX11 isoform X9
XM_017018930.3 → XP_016874419.2 ATP-dependent DNA helicase DDX11 isoform X13
XM_017018921.3 → XP_016874410.2 ATP-dependent DNA helicase DDX11 isoform X4
XM_047428455.1 → XP_047284411.1 ATP-dependent DNA helicase DDX11 isoform X18
XM_017018929.3 → XP_016874418.2 ATP-dependent DNA helicase DDX11 isoform X11
XM_017018920.3 → XP_016874409.2 ATP-dependent DNA helicase DDX11 isoform X3
XM_047428457.1 → XP_047284413.1 ATP-dependent DNA helicase DDX11 isoform X20
XM_017018926.3 → XP_016874415.2 ATP-dependent DNA helicase DDX11 isoform X6
XM_017018927.3 → XP_016874416.2 ATP-dependent DNA helicase DDX11 isoform X7
XM_047428460.1 → XP_047284416.1 ATP-dependent DNA helicase DDX11 isoform X23
XM_047428456.1 → XP_047284412.1 ATP-dependent DNA helicase DDX11 isoform X19
XM_047428458.1 → XP_047284414.1 ATP-dependent DNA helicase DDX11 isoform X21
XM_017018938.3 → XP_016874427.2 ATP-dependent DNA helicase DDX11 isoform X28
XM_017018939.3 → XP_016874428.2 ATP-dependent DNA helicase DDX11 isoform X29
XM_047428463.1 → XP_047284419.1 ATP-dependent DNA helicase DDX11 isoform X27
XM_047428464.1 → XP_047284420.1 ATP-dependent DNA helicase DDX11 isoform X30
XM_011520597.4 → XP_011518899.2 ATP-dependent DNA helicase DDX11 isoform X31
XM_017018935.1 → XP_016874424.1 ATP-dependent DNA helicase DDX11 isoform X26
XM_047428462.1 → XP_047284418.1 ATP-dependent DNA helicase DDX11 isoform X25
XM_017018936.1 → XP_016874425.1 ATP-dependent DNA helicase DDX11 isoform X26
XM_047428465.1 → XP_047284421.1 ATP-dependent DNA helicase DDX11 isoform X32
XM_017018937.2 → XP_016874426.1 ATP-dependent DNA helicase DDX11 isoform X26

RNA

XR_001748610.3 RNA Sequence
XR_007063056.1 RNA Sequence
XR_007063057.1 RNA Sequence
XR_007063058.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

NC_060936.1 Alternate T2T-CHM13v2.0

Range

30948354..30979293

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054371328.1 → XP_054227303.1 ATP-dependent DNA helicase DDX11 isoform X34
XM_054371309.1 → XP_054227284.1 ATP-dependent DNA helicase DDX11 isoform X8
XM_054371311.1 → XP_054227286.1 ATP-dependent DNA helicase DDX11 isoform X10
XM_054371310.1 → XP_054227285.1 ATP-dependent DNA helicase DDX11 isoform X8
XM_054371317.1 → XP_054227292.1 ATP-dependent DNA helicase DDX11 isoform X14
XM_054371319.1 → XP_054227294.1 ATP-dependent DNA helicase DDX11 isoform X15
XM_054371325.1 → XP_054227300.1 ATP-dependent DNA helicase DDX11 isoform X24
XM_054371318.1 → XP_054227293.1 ATP-dependent DNA helicase DDX11 isoform X14
XM_054371313.1 → XP_054227288.1 ATP-dependent DNA helicase DDX11 isoform X12
XM_054371314.1 → XP_054227289.1 ATP-dependent DNA helicase DDX11 isoform X12
XM_054371321.1 → XP_054227296.1 ATP-dependent DNA helicase DDX11 isoform X16
XM_054371323.1 → XP_054227298.1 ATP-dependent DNA helicase DDX11 isoform X17
XM_054371322.1 → XP_054227297.1 ATP-dependent DNA helicase DDX11 isoform X16
XM_054371315.1 → XP_054227290.1 ATP-dependent DNA helicase DDX11 isoform X34
XM_054371330.1 → XP_054227305.1 ATP-dependent DNA helicase DDX11 isoform X41
XM_054371320.1 → XP_054227295.1 ATP-dependent DNA helicase DDX11 isoform X36
XM_054371312.1 → XP_054227287.1 ATP-dependent DNA helicase DDX11 isoform X33
XM_054371316.1 → XP_054227291.1 ATP-dependent DNA helicase DDX11 isoform X35
XM_054371331.1 → XP_054227306.1 ATP-dependent DNA helicase DDX11 isoform X42
XM_054371324.1 → XP_054227299.1 ATP-dependent DNA helicase DDX11 isoform X37
XM_054371326.1 → XP_054227301.1 ATP-dependent DNA helicase DDX11 isoform X38
XM_054371327.1 → XP_054227302.1 ATP-dependent DNA helicase DDX11 isoform X39
XM_054371335.1 → XP_054227310.1 ATP-dependent DNA helicase DDX11 isoform X44
XM_054371332.1 → XP_054227307.1 ATP-dependent DNA helicase DDX11 isoform X43
XM_054371329.1 → XP_054227304.1 ATP-dependent DNA helicase DDX11 isoform X40
XM_054371336.1 → XP_054227311.1 ATP-dependent DNA helicase DDX11 isoform X32
XM_054371334.1 → XP_054227309.1 ATP-dependent DNA helicase DDX11 isoform X43
XM_054371333.1 → XP_054227308.1 ATP-dependent DNA helicase DDX11 isoform X43

RNA

XR_008488549.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_030655.2: Suppressed sequence

Description

NM_030655.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.