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    LRRC15 leucine rich repeat containing 15 [ Homo sapiens (human) ]

    Gene ID: 131578, updated on 2-Nov-2024

    Summary

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    Official Symbol
    LRRC15provided by HGNC
    Official Full Name
    leucine rich repeat containing 15provided by HGNC
    Primary source
    HGNC:HGNC:20818
    See related
    Ensembl:ENSG00000172061 MIM:619327; AllianceGenome:HGNC:20818
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LIB
    Summary
    Enables several functions, including fibronectin binding activity; laminin binding activity; and protein sequestering activity. Involved in several processes, including negative regulation of protein localization to plasma membrane; negative regulation of viral entry into host cell; and receptor-mediated virion attachment to host cell. Located in collagen-containing extracellular matrix and plasma membrane. Is active in apical plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in endometrium (RPKM 1.9), gall bladder (RPKM 1.2) and 15 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See LRRC15 in Genome Data Viewer
    Location:
    3q29
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (194355249..194369743, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (197053410..197067898, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (194075978..194090472, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21018 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21019 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21020 Neighboring gene long intergenic non-protein coding RNA 887 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:194033347-194033847 Neighboring gene Sharpr-MPRA regulatory region 2488 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr3:194039992-194041191 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:194057362-194058242 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:194059168-194059834 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:194071533-194072382 Neighboring gene carboxypeptidase N subunit 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:194089931-194090895 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15021 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:194120825-194121378 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:194121379-194121931 Neighboring gene ATPase 13A3 Neighboring gene glycoprotein V platelet Neighboring gene MPRA-validated peak4979 silencer Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:194167532-194168731 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:194170227-194171426 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15022 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15023 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15024 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21022 Neighboring gene ATP13A3 divergent transcript

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. LRRC15 Is a Novel Mesenchymal Protein and Stromal Target for Antibody-Drug Conjugates. Purcell JW, et al. Cancer Res, 2018 Jul 15. PMID 29764866
    2. Leucine-Rich Repeat Containing 15-Mediated Cell Adhesion Is Essential for Integrin Signaling in TGF-β1-Induced PDL Fibroblastic Differentiation. Kim HJ, et al. Stem Cells, 2024 Mar 14. PMID 38051601
    3. The Elusive Coreceptors for the SARS-CoV-2 Spike Protein. Berkowitz RL, et al. Viruses, 2022 Dec 25. PMID 36680105, Free PMC Article
    4. Expression and clinical implications of leucine-rich repeat containing 15 (LRRC15) in osteosarcoma. Cui J, et al. J Orthop Res, 2020 Nov. PMID 32902907
    5. Multi-omics identify falling LRRC15 as a COVID-19 severity marker and persistent pro-thrombotic signals in convalescence. Gisby JS, et al. Nat Commun, 2022 Dec 15. PMID 36522333, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Integrated bioinformatics analysis identified leucine rich repeat containing 15 and secreted phosphoprotein 1 as hub genes for calcific aortic valve disease and osteoarthritis.
      Title: Integrated bioinformatics analysis identified leucine rich repeat containing 15 and secreted phosphoprotein 1 as hub genes for calcific aortic valve disease and osteoarthritis.
    2. Effect of LRRC15 on autophagy in A549 cells.
      Title: Effect of LRRC15 on autophagy in A549 cells.
    3. Leucine-Rich Repeat Containing 15-Mediated Cell Adhesion Is Essential for Integrin Signaling in TGF-beta1-Induced PDL Fibroblastic Differentiation.
      Title: Leucine-Rich Repeat Containing 15-Mediated Cell Adhesion Is Essential for Integrin Signaling in TGF-β1-Induced PDL Fibroblastic Differentiation.
    4. RUNX1 Ameliorates Rheumatoid Arthritis Progression through Epigenetic Inhibition of LRRC15.
      Title: RUNX1 Ameliorates Rheumatoid Arthritis Progression through Epigenetic Inhibition of LRRC15.
    5. Multi-omics identify falling LRRC15 as a COVID-19 severity marker and persistent pro-thrombotic signals in convalescence.
      Title: Multi-omics identify falling LRRC15 as a COVID-19 severity marker and persistent pro-thrombotic signals in convalescence.
    6. Fibroblast-expressed LRRC15 is a receptor for SARS-CoV-2 spike and controls antiviral and antifibrotic transcriptional programs.
      Title: Fibroblast-expressed LRRC15 is a receptor for SARS-CoV-2 spike and controls antiviral and antifibrotic transcriptional programs.
    7. LRRC15 mediates an accessory interaction with the SARS-CoV-2 spike protein.
      Title: LRRC15 mediates an accessory interaction with the SARS-CoV-2 spike protein.
    8. The Elusive Coreceptors for the SARS-CoV-2 Spike Protein.
      Title: The Elusive Coreceptors for the SARS-CoV-2 Spike Protein.
    9. LRRC15 inhibits SARS-CoV-2 cellular entry in trans.
      Title: LRRC15 inhibits SARS-CoV-2 cellular entry in trans.
    10. [Eukaryotic expression and antigen epitope prediction of the LRRC15 protein in excretory secretory antigens of Taenia solium cysticercus].
      Title: [Eukaryotic expression and antigen epitope prediction of the LRRC15 protein in excretory secretory antigens of Taenia solium cysticercus].
    Submit: New GeneRIF Correction See all GeneRIFs (20)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables collagen binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables fibronectin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables laminin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein sequestering activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of viral entry into host cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in receptor-mediated virion attachment to host cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in receptor-mediated virion attachment to host cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with collagen-containing extracellular matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular exosome HDA PubMed 
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    leucine-rich repeat-containing protein 15
    Names
    hLib
    leucine-rich repeat protein induced by beta amyloid
    leucine-rich repeat protein induced by beta-amyloid homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135057.3 → NP_001128529.2  leucine-rich repeat-containing protein 15 isoform a precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC174158, BC101064, BK001325
      Consensus CDS
      CCDS46984.1
      UniProtKB/TrEMBL
      B3KWI4
      Related
      ENSP00000413707.1, ENST00000428839.1
      Conserved Domains (5) summary
      cd00116
      Location:63 → 309
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:109 → 156
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:299 → 340
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:180 → 239
      LRR_8; Leucine rich repeat
      cl15307
      Location:429 → 468
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    2. NM_130830.5 → NP_570843.2  leucine-rich repeat-containing protein 15 isoform b precursor

      See identical proteins and their annotated locations for NP_570843.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks a portion of the 5' coding region, compared to variant 1. The resulting isoform (b) is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      AC174158, AK125112
      Consensus CDS
      CCDS3306.1
      UniProtKB/Swiss-Prot
      Q495Q6, Q7RTN7, Q8TF66
      UniProtKB/TrEMBL
      B3KWI4
      Related
      ENSP00000306276.4, ENST00000347624.4
      Conserved Domains (4) summary
      TIGR00864
      Location:396 → 467
      PCC; polycystin cation channel protein
      COG4886
      Location:220 → 405
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:103 → 150
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:149 → 209
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      194355249..194369743 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      197053410..197067898 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8TF66.2 GenPept UniProtKB/Swiss-Prot:Q8TF66

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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