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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_029817.1 RefSeqGene
- Range
-
5011..220130
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
NM_003128.3 → NP_003119.2 spectrin beta chain, non-erythrocytic 1 isoform 1
See identical proteins and their annotated locations for NP_003119.2
Status: REVIEWED
- Description
- Transcript Variant: This variant (1), also known as long or sigma-1, represents the longer transcript and encodes the longer isoform (1).
- Source sequence(s)
-
AB209748, AC093110, BM679686, BP218428, BP312037
- Consensus CDS
-
CCDS33198.1
- UniProtKB/Swiss-Prot
- B2RP63, O60837, Q01082, Q16057, Q53R99, Q59ER3, Q8IX99
- UniProtKB/TrEMBL
- B2ZZ89, D6W5B9, K9MS24
- Related
- ENSP00000349259.4, ENST00000356805.9
- Conserved Domains (6) summary
-
- COG5069
Location:48 → 530
- SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
- cd00176
Location:530 → 743
- SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
- cd10571
Location:2200 → 2305
- PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain
- pfam00435
Location:2017 → 2075
- Spectrin; Spectrin repeat
- cd21248
Location:173 → 277
- CH_SPTB_like_rpt2; second calponin homology (CH) domain found in the beta-I spectrin-like subfamily
- cd21316
Location:3 → 156
- CH_SPTBN1_rpt1; first calponin homology (CH) domain found in spectrin beta chain, non-erythrocytic 1 (SPTBN1) and similar proteins
-
NM_178313.3 → NP_842565.2 spectrin beta chain, non-erythrocytic 1 isoform 2
See identical proteins and their annotated locations for NP_842565.2
Status: REVIEWED
- Description
- Transcript Variant: This variant (2), also known as short or sigma-2, differs in the 5' UTR, 3' UTR, and coding region (compared to variant 1). The resulting protein (isoform 2) maintains the reading frame but has shorter and distinct sequences at both the N- and C-termini, compared to isoform 1.
- Source sequence(s)
-
AC092839, AC093110, AF327441, AK025071, CR980403
- Consensus CDS
-
CCDS33199.1
- UniProtKB/TrEMBL
-
K9MS24
- Related
- ENSP00000334156.5, ENST00000333896.5
- Conserved Domains (3) summary
-
- COG5069
Location:34 → 517
- SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
- cd00176
Location:517 → 730
- SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
- pfam00435
Location:2004 → 2062
- Spectrin; Spectrin repeat
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000002.12 Reference GRCh38.p14 Primary Assembly
- Range
-
54456327..54671446
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_017004781.2 → XP_016860270.1 spectrin beta chain, non-erythrocytic 1 isoform X1
- UniProtKB/Swiss-Prot
- B2RP63, O60837, Q01082, Q16057, Q53R99, Q59ER3, Q8IX99
- UniProtKB/TrEMBL
- B2ZZ89, D6W5B9, K9MS24
- Conserved Domains (6) summary
-
- COG5069
Location:48 → 530
- SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
- cd00176
Location:530 → 743
- SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
- cd10571
Location:2200 → 2305
- PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain
- pfam00435
Location:2017 → 2075
- Spectrin; Spectrin repeat
- cd21248
Location:173 → 277
- CH_SPTB_like_rpt2; second calponin homology (CH) domain found in the beta-I spectrin-like subfamily
- cd21316
Location:3 → 156
- CH_SPTBN1_rpt1; first calponin homology (CH) domain found in spectrin beta chain, non-erythrocytic 1 (SPTBN1) and similar proteins
-
XM_017004779.2 → XP_016860268.1 spectrin beta chain, non-erythrocytic 1 isoform X1
- UniProtKB/Swiss-Prot
- B2RP63, O60837, Q01082, Q16057, Q53R99, Q59ER3, Q8IX99
- UniProtKB/TrEMBL
- B2ZZ89, D6W5B9, K9MS24
- Conserved Domains (6) summary
-
- COG5069
Location:48 → 530
- SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
- cd00176
Location:530 → 743
- SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
- cd10571
Location:2200 → 2305
- PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain
- pfam00435
Location:2017 → 2075
- Spectrin; Spectrin repeat
- cd21248
Location:173 → 277
- CH_SPTB_like_rpt2; second calponin homology (CH) domain found in the beta-I spectrin-like subfamily
- cd21316
Location:3 → 156
- CH_SPTBN1_rpt1; first calponin homology (CH) domain found in spectrin beta chain, non-erythrocytic 1 (SPTBN1) and similar proteins
-
XM_005264517.3 → XP_005264574.1 spectrin beta chain, non-erythrocytic 1 isoform X1
See identical proteins and their annotated locations for XP_005264574.1
- UniProtKB/Swiss-Prot
- B2RP63, O60837, Q01082, Q16057, Q53R99, Q59ER3, Q8IX99
- UniProtKB/TrEMBL
- B2ZZ89, D6W5B9, K9MS24
- Conserved Domains (6) summary
-
- COG5069
Location:48 → 530
- SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
- cd00176
Location:530 → 743
- SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
- cd10571
Location:2200 → 2305
- PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain
- pfam00435
Location:2017 → 2075
- Spectrin; Spectrin repeat
- cd21248
Location:173 → 277
- CH_SPTB_like_rpt2; second calponin homology (CH) domain found in the beta-I spectrin-like subfamily
- cd21316
Location:3 → 156
- CH_SPTBN1_rpt1; first calponin homology (CH) domain found in spectrin beta chain, non-erythrocytic 1 (SPTBN1) and similar proteins
-
XM_006712087.4 → XP_006712150.1 spectrin beta chain, non-erythrocytic 1 isoform X1
See identical proteins and their annotated locations for XP_006712150.1
- UniProtKB/Swiss-Prot
- B2RP63, O60837, Q01082, Q16057, Q53R99, Q59ER3, Q8IX99
- UniProtKB/TrEMBL
- B2ZZ89, D6W5B9, K9MS24
- Conserved Domains (6) summary
-
- COG5069
Location:48 → 530
- SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
- cd00176
Location:530 → 743
- SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
- cd10571
Location:2200 → 2305
- PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain
- pfam00435
Location:2017 → 2075
- Spectrin; Spectrin repeat
- cd21248
Location:173 → 277
- CH_SPTB_like_rpt2; second calponin homology (CH) domain found in the beta-I spectrin-like subfamily
- cd21316
Location:3 → 156
- CH_SPTBN1_rpt1; first calponin homology (CH) domain found in spectrin beta chain, non-erythrocytic 1 (SPTBN1) and similar proteins
-
XM_047445595.1 → XP_047301551.1 spectrin beta chain, non-erythrocytic 1 isoform X1
- UniProtKB/Swiss-Prot
- B2RP63, O60837, Q01082, Q16057, Q53R99, Q59ER3, Q8IX99
- UniProtKB/TrEMBL
- B2ZZ89, D6W5B9, K9MS24
-
XM_047445593.1 → XP_047301549.1 spectrin beta chain, non-erythrocytic 1 isoform X1
- UniProtKB/Swiss-Prot
- B2RP63, O60837, Q01082, Q16057, Q53R99, Q59ER3, Q8IX99
- UniProtKB/TrEMBL
- B2ZZ89, D6W5B9, K9MS24
-
XM_047445591.1 → XP_047301547.1 spectrin beta chain, non-erythrocytic 1 isoform X1
- UniProtKB/Swiss-Prot
- B2RP63, O60837, Q01082, Q16057, Q53R99, Q59ER3, Q8IX99
- UniProtKB/TrEMBL
- B2ZZ89, D6W5B9, K9MS24
-
XM_017004780.2 → XP_016860269.1 spectrin beta chain, non-erythrocytic 1 isoform X1
- UniProtKB/Swiss-Prot
- B2RP63, O60837, Q01082, Q16057, Q53R99, Q59ER3, Q8IX99
- UniProtKB/TrEMBL
- B2ZZ89, D6W5B9, K9MS24
- Conserved Domains (6) summary
-
- COG5069
Location:48 → 530
- SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
- cd00176
Location:530 → 743
- SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
- cd10571
Location:2200 → 2305
- PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain
- pfam00435
Location:2017 → 2075
- Spectrin; Spectrin repeat
- cd21248
Location:173 → 277
- CH_SPTB_like_rpt2; second calponin homology (CH) domain found in the beta-I spectrin-like subfamily
- cd21316
Location:3 → 156
- CH_SPTBN1_rpt1; first calponin homology (CH) domain found in spectrin beta chain, non-erythrocytic 1 (SPTBN1) and similar proteins
-
XM_047445594.1 → XP_047301550.1 spectrin beta chain, non-erythrocytic 1 isoform X1
- UniProtKB/Swiss-Prot
- B2RP63, O60837, Q01082, Q16057, Q53R99, Q59ER3, Q8IX99
- UniProtKB/TrEMBL
- B2ZZ89, D6W5B9, K9MS24
-
XM_047445592.1 → XP_047301548.1 spectrin beta chain, non-erythrocytic 1 isoform X1
- UniProtKB/Swiss-Prot
- B2RP63, O60837, Q01082, Q16057, Q53R99, Q59ER3, Q8IX99
- UniProtKB/TrEMBL
- B2ZZ89, D6W5B9, K9MS24
-
XM_005264518.3 → XP_005264575.1 spectrin beta chain, non-erythrocytic 1 isoform X2
See identical proteins and their annotated locations for XP_005264575.1
- UniProtKB/TrEMBL
-
K9MS24
- Conserved Domains (5) summary
-
- cd00014
Location:161 → 264
- CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
- cd00176
Location:517 → 730
- SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
- cd10571
Location:2187 → 2292
- PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain
- pfam00169
Location:2187 → 2294
- PH; PH domain
- pfam00435
Location:409 → 512
- Spectrin; Spectrin repeat
Alternate T2T-CHM13v2.0
Genomic
-
NC_060926.1 Alternate T2T-CHM13v2.0
- Range
-
54450519..54665452
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_054343538.1 → XP_054199513.1 spectrin beta chain, non-erythrocytic 1 isoform X1
- UniProtKB/Swiss-Prot
- B2RP63, O60837, Q01082, Q16057, Q53R99, Q59ER3, Q8IX99
- UniProtKB/TrEMBL
- B2ZZ89, D6W5B9, K9MS24
-
XM_054343539.1 → XP_054199514.1 spectrin beta chain, non-erythrocytic 1 isoform X1
- UniProtKB/Swiss-Prot
- B2RP63, O60837, Q01082, Q16057, Q53R99, Q59ER3, Q8IX99
- UniProtKB/TrEMBL
- B2ZZ89, D6W5B9, K9MS24
-
XM_054343543.1 → XP_054199518.1 spectrin beta chain, non-erythrocytic 1 isoform X1
- UniProtKB/Swiss-Prot
- B2RP63, O60837, Q01082, Q16057, Q53R99, Q59ER3, Q8IX99
- UniProtKB/TrEMBL
- B2ZZ89, D6W5B9, K9MS24
-
XM_054343540.1 → XP_054199515.1 spectrin beta chain, non-erythrocytic 1 isoform X1
- UniProtKB/Swiss-Prot
- B2RP63, O60837, Q01082, Q16057, Q53R99, Q59ER3, Q8IX99
- UniProtKB/TrEMBL
- B2ZZ89, D6W5B9, K9MS24
-
XM_054343547.1 → XP_054199522.1 spectrin beta chain, non-erythrocytic 1 isoform X1
- UniProtKB/Swiss-Prot
- B2RP63, O60837, Q01082, Q16057, Q53R99, Q59ER3, Q8IX99
- UniProtKB/TrEMBL
- B2ZZ89, D6W5B9, K9MS24
-
XM_054343542.1 → XP_054199517.1 spectrin beta chain, non-erythrocytic 1 isoform X1
- UniProtKB/Swiss-Prot
- B2RP63, O60837, Q01082, Q16057, Q53R99, Q59ER3, Q8IX99
- UniProtKB/TrEMBL
- B2ZZ89, D6W5B9, K9MS24
-
XM_054343545.1 → XP_054199520.1 spectrin beta chain, non-erythrocytic 1 isoform X1
- UniProtKB/Swiss-Prot
- B2RP63, O60837, Q01082, Q16057, Q53R99, Q59ER3, Q8IX99
- UniProtKB/TrEMBL
- B2ZZ89, D6W5B9, K9MS24
-
XM_054343541.1 → XP_054199516.1 spectrin beta chain, non-erythrocytic 1 isoform X1
- UniProtKB/Swiss-Prot
- B2RP63, O60837, Q01082, Q16057, Q53R99, Q59ER3, Q8IX99
- UniProtKB/TrEMBL
- B2ZZ89, D6W5B9, K9MS24
-
XM_054343546.1 → XP_054199521.1 spectrin beta chain, non-erythrocytic 1 isoform X1
- UniProtKB/Swiss-Prot
- B2RP63, O60837, Q01082, Q16057, Q53R99, Q59ER3, Q8IX99
- UniProtKB/TrEMBL
- B2ZZ89, D6W5B9, K9MS24
-
XM_054343544.1 → XP_054199519.1 spectrin beta chain, non-erythrocytic 1 isoform X1
- UniProtKB/Swiss-Prot
- B2RP63, O60837, Q01082, Q16057, Q53R99, Q59ER3, Q8IX99
- UniProtKB/TrEMBL
- B2ZZ89, D6W5B9, K9MS24
-
XM_054343548.1 → XP_054199523.1 spectrin beta chain, non-erythrocytic 1 isoform X2
- UniProtKB/TrEMBL
-
K9MS24