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    CYGB cytoglobin [ Homo sapiens (human) ]

    Gene ID: 114757, updated on 27-Nov-2024

    Summary

    Official Symbol
    CYGBprovided by HGNC
    Official Full Name
    cytoglobinprovided by HGNC
    Primary source
    HGNC:HGNC:16505
    See related
    Ensembl:ENSG00000161544 MIM:608759; AllianceGenome:HGNC:16505
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HGB; NOD; STAP
    Summary
    This gene encodes a globin protein found in vertebrate cells. The encoded protein is described as a hexacoordinate hemoglobin which binds ligand differently from the pentacoordinate hemoglobins involved in oxygen transport, and may be involved in protection during oxidative stress. This gene is located on chromosome 17 in the same region as a retinal gene which is mutated in progressive rod-cone degeneration, but in the opposite orientation. [provided by RefSeq, Jan 2012]
    Expression
    Ubiquitous expression in fat (RPKM 16.5), urinary bladder (RPKM 7.0) and 23 other tissues See more
    Orthologs
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    Genomic context

    See CYGB in Genome Data Viewer
    Location:
    17q25.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (76527356..76551193, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (77424099..77449394, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (74523438..74533791, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr17:74449240-74449408 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12808 Neighboring gene aralkylamine N-acetyltransferase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74469380-74469890 Neighboring gene rhomboid 5 homolog 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9018 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9019 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9020 Neighboring gene Sharpr-MPRA regulatory region 10531 Neighboring gene MPRA-validated peak3008 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74487839-74488704 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74496763-74497432 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12809 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:74506318-74506528 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74508911-74509513 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:74518115-74518272 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12810 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74525989-74526722 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74526723-74527456 Neighboring gene photoreceptor disc component Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74543392-74543895 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12811 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74553466-74554266 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74554267-74555068 Neighboring gene small nucleolar RNA, C/D box 1C Neighboring gene small nucleolar RNA host gene 16 Neighboring gene small nucleolar RNA, C/D box 1B

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr Treatment of human primary astrocytes with HIV-1 Vpr downregulates expression of eleven genes, BNIP3, CYGB, DUOX2, DUSP1, FOXM1, GAPDH, HPRT1, MT3, MTL5, PTGS2, and SCARA3 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables carbon monoxide binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables catalase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables fatty acid peroxidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nitric oxide dioxygenase activity, heme protein as donor IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables nitrite reductase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables oxygen binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables oxygen carrier activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables peroxidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables superoxide dismutase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in fatty acid oxidation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of collagen biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of fibroblast migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of hepatic stellate cell activation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nitric oxide catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in oxygen transport NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in removal of superoxide radicals IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to oxidative stress ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    cytoglobin
    Names
    histoglobin
    nitric oxygen dioxygenase CYGB
    nitrite reductase CYGB
    pseudoperoxidase CYGB
    stellate cell activation-associated protein
    superoxide dismutase CYGB
    NP_599030.1
    XP_005257062.1
    XP_016879605.1
    XP_054170909.1
    XP_054170910.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_134268.5NP_599030.1  cytoglobin

      See identical proteins and their annotated locations for NP_599030.1

      Status: VALIDATED

      Source sequence(s)
      AI470692, AK098057, BQ881744
      Consensus CDS
      CCDS11746.1
      UniProtKB/Swiss-Prot
      Q541Y7, Q8N2X5, Q8WWM9
      UniProtKB/TrEMBL
      A0A1K0FUB6
      Related
      ENSP00000293230.4, ENST00000293230.10
      Conserved Domains (1) summary
      cd08924
      Location:22171
      Cygb; Cytoglobin and related globins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      76527356..76551193 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017024116.2XP_016879605.1  cytoglobin isoform X2

      UniProtKB/TrEMBL
      K7EIM9
      Conserved Domains (1) summary
      cl21461
      Location:1106
      Globin_like; Globin-like proteins
    2. XM_005257005.4XP_005257062.1  cytoglobin isoform X1

      Conserved Domains (1) summary
      cd08924
      Location:22171
      Cygb; Cytoglobin and related globins

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      77424099..77449394 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054314935.1XP_054170910.1  cytoglobin isoform X2

    2. XM_054314934.1XP_054170909.1  cytoglobin isoform X1