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    SRRT serrate, RNA effector molecule [ Homo sapiens (human) ]

    Gene ID: 51593, updated on 9-Dec-2024

    Summary

    Official Symbol
    SRRTprovided by HGNC
    Official Full Name
    serrate, RNA effector moleculeprovided by HGNC
    Primary source
    HGNC:HGNC:24101
    See related
    Ensembl:ENSG00000087087 MIM:614469; AllianceGenome:HGNC:24101
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARS2; ASR2; serrate
    Summary
    Enables mRNA cap binding complex binding activity and protein-macromolecule adaptor activity. Involved in primary miRNA processing. Located in nucleoplasm. Part of ribonucleoprotein complex. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis (RPKM 66.3), bone marrow (RPKM 37.2) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SRRT in Genome Data Viewer
    Location:
    7q22.1
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (100875103..100888664)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (102115207..102128766)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (100472725..100486285)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene solute carrier family 12 member 9 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:100434739-100435658 Neighboring gene SLC12A9 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26388 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26389 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18463 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:100456152-100456652 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:100456653-100457153 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:100457811-100458310 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:100458529-100459030 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18464 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18465 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26390 Neighboring gene microRNA 6875 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:100471610-100472274 Neighboring gene thyroid hormone receptor interactor 6 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:100472275-100472939 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18466 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:100478564-100479401 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:100483425-100484158 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18467 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr7:100487829-100488562 and GRCh37_chr7:100488563-100489295 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:100489576-100490315 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:100490316-100491054 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:100493326-100493946 Neighboring gene UFM1 specific peptidase 1 Neighboring gene acetylcholinesterase (Yt blood group)

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association analysis identifies multiple loci related to resting heart rate.
    EBI GWAS Catalog
    Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of serrate RNA effector molecule homolog (SRRT) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC126427

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables RNA binding HDA PubMed 
    enables mRNA cap binding complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-macromolecule adaptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuronal stem cell population maintenance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of neurogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in primary miRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in primary miRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to arsenic-containing substance NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in nuclear body IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    serrate RNA effector molecule homolog
    Names
    arsenate resistance protein 2
    arsenate resistance protein ARS2
    arsenite resistance protein
    arsenite-resistance protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001128852.2NP_001122324.1  serrate RNA effector molecule homolog isoform c

      See identical proteins and their annotated locations for NP_001122324.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice junction at the end of a 5' exon compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is 1 aa shorter compared to isoform a.
      Source sequence(s)
      AC011895, AL096723, DA611314
      Consensus CDS
      CCDS47666.1
      UniProtKB/Swiss-Prot
      Q9BXP5
      Related
      ENSP00000481173.1, ENST00000614484.4
      Conserved Domains (2) summary
      pfam04959
      Location:645850
      ARS2; Arsenite-resistance protein 2
      pfam12066
      Location:153262
      DUF3546; Domain of unknown function (DUF3546)
    2. NM_001128853.2NP_001122325.1  serrate RNA effector molecule homolog isoform d

      See identical proteins and their annotated locations for NP_001122325.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice junction at the end of a 3' exon compared to variant 1. The resulting isoform (d) has the same N- and C-termini but is 4 aa shorter compared to isoform a.
      Source sequence(s)
      AF248955, BC109117, DA611314
      Consensus CDS
      CCDS47665.1
      UniProtKB/Swiss-Prot
      Q9BXP5
      Related
      ENSP00000478341.1, ENST00000618262.4
      Conserved Domains (2) summary
      pfam04959
      Location:646847
      ARS2; Arsenite-resistance protein 2
      pfam12066
      Location:153262
      DUF3546; Domain of unknown function (DUF3546)
    3. NM_001128854.2NP_001122326.1  serrate RNA effector molecule homolog isoform e

      See identical proteins and their annotated locations for NP_001122326.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses alternate in-frame splice junctions at the ends of a 5' and 3' exon compared to variant 1. The resulting isoform (e) has the same N- and C-termini but is 5 aa shorter compared to isoform a.
      Source sequence(s)
      AF248955, BC109117, DA611314
      Consensus CDS
      CCDS47667.1
      UniProtKB/Swiss-Prot
      Q9BXP5
      Related
      ENSP00000483556.1, ENST00000618411.4
      Conserved Domains (2) summary
      pfam04959
      Location:645846
      ARS2; Arsenite-resistance protein 2
      pfam12066
      Location:153262
      DUF3546; Domain of unknown function (DUF3546)
    4. NM_015908.6NP_056992.4  serrate RNA effector molecule homolog isoform a

      See identical proteins and their annotated locations for NP_056992.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AC011895, AF248955, BC109116, DA611314
      Consensus CDS
      CCDS34709.1
      UniProtKB/Swiss-Prot
      A4D2E5, A4D2E6, A6NK22, B4DJL4, B4DZA6, O95808, Q32MI4, Q6NT74, Q8TDQ5, Q9BWP6, Q9BXP4, Q9BXP5, Q9Y4S4
      Related
      ENSP00000480421.1, ENST00000611405.5
      Conserved Domains (2) summary
      pfam04959
      Location:646851
      ARS2; Arsenite-resistance protein 2
      pfam12066
      Location:153262
      DUF3546; Domain of unknown function (DUF3546)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      100875103..100888664
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005250407.3XP_005250464.1  serrate RNA effector molecule homolog isoform X3

      Conserved Domains (2) summary
      pfam04959
      Location:653854
      ARS2; Arsenite-resistance protein 2
      pfam12066
      Location:160269
      DUF3546; Domain of unknown function (DUF3546)
    2. XM_005250408.2XP_005250465.1  serrate RNA effector molecule homolog isoform X4

      Conserved Domains (2) summary
      pfam04959
      Location:652853
      ARS2; Arsenite-resistance protein 2
      pfam12066
      Location:160269
      DUF3546; Domain of unknown function (DUF3546)
    3. XM_005250405.3XP_005250462.1  serrate RNA effector molecule homolog isoform X1

      Conserved Domains (2) summary
      pfam04959
      Location:653858
      ARS2; Arsenite-resistance protein 2
      pfam12066
      Location:160269
      DUF3546; Domain of unknown function (DUF3546)
    4. XM_005250406.3XP_005250463.1  serrate RNA effector molecule homolog isoform X2

      Conserved Domains (2) summary
      pfam04959
      Location:652857
      ARS2; Arsenite-resistance protein 2
      pfam12066
      Location:160269
      DUF3546; Domain of unknown function (DUF3546)
    5. XM_047420459.1XP_047276415.1  serrate RNA effector molecule homolog isoform X5

    6. XM_047420460.1XP_047276416.1  serrate RNA effector molecule homolog isoform X6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      102115207..102128766
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054358372.1XP_054214347.1  serrate RNA effector molecule homolog isoform X3

    2. XM_054358373.1XP_054214348.1  serrate RNA effector molecule homolog isoform X4

    3. XM_054358370.1XP_054214345.1  serrate RNA effector molecule homolog isoform X1

    4. XM_054358371.1XP_054214346.1  serrate RNA effector molecule homolog isoform X2

    5. XM_054358374.1XP_054214349.1  serrate RNA effector molecule homolog isoform X5

    6. XM_054358375.1XP_054214350.1  serrate RNA effector molecule homolog isoform X6

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_182800.2: Suppressed sequence

      Description
      NM_182800.2: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript, and it is a nonsense-mediated mRNA decay (NMD) candidate.