PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [Homo sapiens (human)] - Gene

Summary

Official Symbol: PIK3CDprovided by HGNC
Official Full Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit deltaprovided by HGNC
Primary source: HGNC:HGNC:8977
See related: Ensembl:ENSG00000171608 MIM:602839; AllianceGenome:HGNC:8977
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: APDS; PI3K; IMD14; p110D; IMD14A; IMD14B; ROCHIS; P110DELTA
Summary: Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I PI3K found primarily in leukocytes. Like other class I PI3Ks (p110-alpha p110-beta, and p110-gamma), the encoded protein binds p85 adapter proteins and GTP-bound RAS. However, unlike the other class I PI3Ks, this protein phosphorylates itself, not p85 protein.[provided by RefSeq, Jul 2010]
Expression: Broad expression in lymph node (RPKM 21.4), bone marrow (RPKM 20.0) and 22 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1p36.22

Exon count:: 34

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (9627258..9729114)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (9170040..9271897)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (9711789..9789172)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Case report: Deep sequencing and long-read genome sequencing refine prior genetic analyses in families with apparent gonadal mosaicism in PIK3CD-related activated PI3K delta syndrome.
Title: Case report: Deep sequencing and long-read genome sequencing refine prior genetic analyses in families with apparent gonadal mosaicism in PIK3CD-related activated PI3K delta syndrome.
circZNF532 promotes endothelial-to-mesenchymal transition in diabetic retinopathy by recruiting TAF15 to stabilize PIK3CD.
Title: circZNF532 promotes endothelial-to-mesenchymal transition in diabetic retinopathy by recruiting TAF15 to stabilize PIK3CD.
PI3Kdelta Mediates Fibrosis by Patient-Derived Vitreous.
Title: PI3Kδ Mediates Fibrosis by Patient-Derived Vitreous.
STMN1 promotes cell malignancy and bortezomib resistance of multiple myeloma cell lines via PI3K/AKT signaling.
Title: STMN1 promotes cell malignancy and bortezomib resistance of multiple myeloma cell lines via PI3K/AKT signaling.
FAM76B regulates PI3K/Akt/NF-kappaB-mediated M1 macrophage polarization by influencing the stability of PIK3CD mRNA.
Title: FAM76B regulates PI3K/Akt/NF-κB-mediated M1 macrophage polarization by influencing the stability of PIK3CD mRNA.
FOXM1 transcriptional regulation of RacGAP1 activates the PI3K/AKT signaling pathway to promote the proliferation, migration, and invasion of cervical cancer cells.
Title: FOXM1 transcriptional regulation of RacGAP1 activates the PI3K/AKT signaling pathway to promote the proliferation, migration, and invasion of cervical cancer cells.
Upregulation of SEMP1 Contributes to Improving the Biological Functions of Trophoblast via the PI3K/AKT Pathway in Preeclampsia.
Title: Upregulation of SEMP1 Contributes to Improving the Biological Functions of Trophoblast via the PI3K/AKT Pathway in Preeclampsia.
The novel miR-873-5p-YWHAE-PI3K/AKT axis is involved in non-small cell lung cancer progression and chemoresistance by mediating autophagy.
Title: The novel miR-873-5p-YWHAE-PI3K/AKT axis is involved in non-small cell lung cancer progression and chemoresistance by mediating autophagy.
Spinster homolog 2 reduces malignancies of glioblastoma via PTEN/PI3K/AKT pathway.
Title: Spinster homolog 2 reduces malignancies of glioblastoma via PTEN/PI3K/AKT pathway.
Activated phosphoinositide 3-kinase delta syndrome caused by PIK3CD mutations: expanding the phenotype.
Title: Activated phosphoinositide 3-kinase δ syndrome caused by PIK3CD mutations: expanding the phenotype.

Submit: New GeneRIF Correction See all GeneRIFs (144)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Combined immunodeficiency with faciooculoskeletal anomalies MedGen: C2750068 OMIM: 613328 GeneReviews: Not available	Compare labs
Immunodeficiency 14 MedGen: C3714976 OMIM: 615513 GeneReviews: Not available	Compare labs
Immunodeficiency 14b, autosomal recessive MedGen: C5543301 OMIM: 619281 GeneReviews: Not available	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 upregulates the expression of IL-6 and IL-8 via the p38 signaling pathway and the PI3K/Akt signaling pathway in astrocytes	PubMed
	env	HIV-1 gp120-induced PI3-kinase activity and calcium mobilization are inhibited by pertussis toxin and blocking antibodies directed against CCR5 and CXCR4, suggesting that this signaling is mediated through these chemokine receptors	PubMed
	env	CD45 modulates HIV-1 gp120-induced apoptosis by regulating Fas ligand induction and activation of the phosphoinositide 3-kinase/Akt pathway	PubMed
	env	HIV-1 gp120-induced TNF-alpha production by primary human macrophages is mediated by phosphatidylinositol-3 (PI-3) kinase and mitogen-activated protein (MAP) kinase pathways	PubMed
	env	CCR5 activation by gp120 triggers the assembly of endogenous Lyn, PI3K, and Pyk2 and is associated with PI3K and Pyk2 translocation from the cytoplasm to the membrane where they colocalized with Lyn	PubMed
	env	Concomitant activation of Lyn, Pyk2, and class IA PI3K are required for gp120-induced IL-1beta production	PubMed
	env	Insulin-like growth factor-I (IGF-I) and erythropoietin treatment protect against HIV/gp120-mediated neuronal damage in culture and in vivo, in part, through cooperative activation of phosphatidylinositol 3-kinase/Akt/GSK-3beta signaling	PubMed
	env	Pre-treatment of endothelial cells with fibroblast growth factor 2 (FGF2) protects cells from HIV-1 gp120 angiotoxicity; this protection is regulated by crosstalk among the ERK, PI3K-AKT and PKC signaling pathways	PubMed
Envelope surface glycoprotein gp160, precursor	env	HIV-1 gp160 disrupts the association between phospholipase C gamma-1 and phosphoinositide 3 kinase (PI3-kinase), and this effect is dependent on PI3-kinase activity	PubMed
	env	PI3-kinase activation induced by HIV-1 gp160 leads to downregulation of LFA-1-mediated T cell adhesion to B cells	PubMed
Nef	nef	HIV-1 Nef involves the PI3K-PKC pathway for induction of IL6 and CXCL8 (IL8) expression	PubMed
	nef	HIV-1 Nef synergizes with KSHV oncoprotein K1 to activate PI3K/AKT/mTOR signaling pathway, and induces cell proliferation and microtubule formation in endothelial cells	PubMed
	nef	Downregulation of cell surface major histocompatibility complex class I (MHC-I) protein expression by HIV-1 Nef depends on a phosphoinositide 3-kinase (PI3K)-regulated signaling pathway, suggesting an interaction between Nef and PI3K	PubMed
	nef	In the context of Nef-associated kinase complex (NAKC), hnRNP-K interacts with HIV-1 Nef and recruits LCK, PKCdelta, and PI-3 kinase	PubMed
	nef	The presence of HIV-1 Nef in Jurkat cells stimulated with a combination of PMA and anti-CD28 upregulates the levels of PI3K production	PubMed
	nef	The association of phosphatidylinositol (PI) 3-kinase with platelet-derived growth factor (PDGF) activated receptor was downregulated by HIV-1 nef expression	PubMed
Tat	tat	HIV-1 Tat induces phosphorylation of PI3K, AKT, PTEN, and GSK-3beta activating PI3K and AKT and inactivating PTEN and GSK-3beta in vIL-6 expressing cells	PubMed
	tat	HIV-1 Tat-induced upregulation of IDO production requires the activity of IFN-gamma signaling pathway such as JAK and PI3K in human monocyte derived-dendritic cells	PubMed
	tat	PI3K/Akt, TRPC, and GSK3beta signaling pathways are all involved in PDGF-C mediated neuroprotection against HIV-1 Tat in human neuroblastoma cells	PubMed
	tat	Arctigenin regulates the upstream PI3K enzyme from converting PIP2 to PIP3 in Tat-expressing CHME5 cells	PubMed
	tat	Pro-survival effects of intracellular HIV-1 Tat in a microglial cell line is attributed to activation of the PI-3-kinase (PI3K)/Akt pathway via decreasing expression of PTEN, a negative regulator of the PI-3-K pathway	PubMed
	tat	HIV-1 Tat in combination with KSHV kaposin A activates the MEK/ERK, STAT3, and PI3K/Akt signals in NIH3T3 cells	PubMed
	tat	Phosphatidylinositol 3-kinase/Akt signaling pathway is involved in HIV-1 Tat-induced NADPH oxidase stimulation and LTR transactivation	PubMed
	tat	HIV-1 Tat activates phosphatidylinositol 3-kinase (PI3K), leading to the activation of Akt/PKB, decreased levels of cAMP and CREB phosphorylation, and the protection of cells from apoptosis	PubMed
	tat	Phosphatidylinositol 3-kinase inhibits HIV-1 Tat-mediated transactivation of the HIV-1 LTR promoter by affecting the formation of the Tat-associated kinase transactivating complex	PubMed
	tat	HIV-1 Tat induced release of MCP-1 from human lung microvascular endothelial cells involves an interaction between Tat and PI3 kinase	PubMed
	tat	Activation of protein kinase C-epsilon by HIV-1 Tat involves an interaction with PI 3-kinase	PubMed
	tat	HIV-1 Tat-mediated cytopathic changes in human brain micro vascular endothelial cells involves its interaction with phosphatidylinositol 3-kinase (PI3K)	PubMed
Vpr	vpr	HIV-1 Vpr induced upregulation of IL6 involves PI3K/Akt mediated activation of NFKB1 (NF-kappa-B) in astrocytes	PubMed
	vpr	HIV-1 Vpr induced upregulation of CXCL8 (IL8) involves PI3K/Akt mediated activation of NFKB1 (NF-kappa-B) in astrocytes	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-16182 (e-PCR)
- UniSTS:45313

D1S1346 (e-PCR)
- UniSTS:149543

SHGC-146345 (e-PCR)
- UniSTS:175166

RH50479 (e-PCR)
- UniSTS:76863

WI-16324 (e-PCR)
- UniSTS:81471

WI-16255 (e-PCR)
- UniSTS:81472

SHGC-74191 (e-PCR)
- UniSTS:50251

SHGC-74173 (e-PCR)
- UniSTS:27732

D10S16 (e-PCR)
- UniSTS:155756

RH11792 (e-PCR)
- UniSTS:8321

SHGC-111989 (e-PCR)
- UniSTS:168853

NIB2114 (e-PCR)
- UniSTS:41902

A006Z42 (e-PCR)
- UniSTS:65230

PIK3CD_7855 (e-PCR)
- UniSTS:466395

RH63840 (e-PCR)
- UniSTS:60132

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol-3-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-phosphatidylinositol-3-kinase activity	NAS Non-traceable Author Statement more info	PubMed
enables 1-phosphatidylinositol-3-kinase activity	TAS Traceable Author Statement more info	PubMed
enables 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity	IEA Inferred from Electronic Annotation more info
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in B cell activation	TAS Traceable Author Statement more info	PubMed
involved_in B cell chemotaxis	TAS Traceable Author Statement more info	PubMed
involved_in B cell differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in B cell receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in T cell activation	TAS Traceable Author Statement more info	PubMed
involved_in T cell chemotaxis	TAS Traceable Author Statement more info	PubMed
involved_in T cell differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in T cell differentiation	TAS Traceable Author Statement more info	PubMed
involved_in T cell receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in adaptive immune response	TAS Traceable Author Statement more info	PubMed
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in immune response	NAS Non-traceable Author Statement more info	PubMed
involved_in inflammatory response	TAS Traceable Author Statement more info	PubMed
involved_in innate immune response	TAS Traceable Author Statement more info	PubMed
involved_in mast cell chemotaxis	TAS Traceable Author Statement more info	PubMed
involved_in mast cell degranulation	TAS Traceable Author Statement more info	PubMed
involved_in mast cell differentiation	TAS Traceable Author Statement more info	PubMed
involved_in natural killer cell activation	TAS Traceable Author Statement more info	PubMed
involved_in natural killer cell chemotaxis	TAS Traceable Author Statement more info	PubMed
involved_in natural killer cell differentiation	TAS Traceable Author Statement more info	PubMed
involved_in neutrophil chemotaxis	TAS Traceable Author Statement more info	PubMed
involved_in neutrophil extravasation	TAS Traceable Author Statement more info	PubMed
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in phosphatidylinositol-3-phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytokine production	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of endothelial cell migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of endothelial cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of epithelial tube formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neutrophil apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	NAS Non-traceable Author Statement more info	PubMed
involved_in respiratory burst involved in defense response	TAS Traceable Author Statement more info	PubMed
involved_in signal transduction	NAS Non-traceable Author Statement more info	PubMed
involved_in vascular endothelial growth factor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
part_of phosphatidylinositol 3-kinase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of phosphatidylinositol 3-kinase complex	NAS Non-traceable Author Statement more info	PubMed
part_of phosphatidylinositol 3-kinase complex, class IA	IPI Inferred from Physical Interaction more info	PubMed
part_of phosphatidylinositol 3-kinase complex, class IA	NAS Non-traceable Author Statement more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

Names: PI3-kinase p110 subunit delta; PI3Kdelta; phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta short variant 8/20; phosphoinositide-3-kinase C; phosphoinositide-3-kinase, catalytic, delta polypeptide variant p37delta; ptdIns-3-kinase subunit p110-delta

NP_001337163.1

EC 2.7.1.137

EC 2.7.1.153

NP_001337164.1

EC 2.7.1.137

EC 2.7.1.153

NP_005017.3

EC 2.7.1.137

EC 2.7.1.153

XP_006710750.1

EC 2.7.1.137

EC 2.7.1.153

XP_006710752.1

EC 2.7.1.137

EC 2.7.1.153

XP_024303431.1

EC 2.7.1.137

EC 2.7.1.153

XP_024303432.1

EC 2.7.1.137

EC 2.7.1.153

XP_047278506.1

EC 2.7.1.137

EC 2.7.1.153

XP_047278507.1

EC 2.7.1.137

EC 2.7.1.153

XP_047278508.1

EC 2.7.1.137

EC 2.7.1.153

XP_047278509.1

EC 2.7.1.137

EC 2.7.1.153

XP_047278510.1

EC 2.7.1.137

EC 2.7.1.153

XP_047278511.1

EC 2.7.1.137

EC 2.7.1.153

XP_047278512.1

EC 2.7.1.137

EC 2.7.1.153

XP_047278513.1

EC 2.7.1.137

EC 2.7.1.153

XP_047278514.1

EC 2.7.1.137

EC 2.7.1.153

XP_047278515.1

EC 2.7.1.137

EC 2.7.1.153

XP_047278516.1

EC 2.7.1.137

EC 2.7.1.153

XP_047278517.1

EC 2.7.1.137

EC 2.7.1.153

XP_047278518.1

EC 2.7.1.137

EC 2.7.1.153

XP_047278519.1

EC 2.7.1.137

EC 2.7.1.153

XP_047278520.1

EC 2.7.1.137

EC 2.7.1.153

XP_047278521.1

EC 2.7.1.137

EC 2.7.1.153

XP_047278522.1

EC 2.7.1.137

EC 2.7.1.153

XP_047278523.1

EC 2.7.1.137

EC 2.7.1.153

XP_047278524.1

EC 2.7.1.137

EC 2.7.1.153

XP_047278525.1

EC 2.7.1.137

EC 2.7.1.153

XP_047278526.1

EC 2.7.1.137

EC 2.7.1.153

XP_047278527.1

EC 2.7.1.137

EC 2.7.1.153

XP_047278528.1

EC 2.7.1.137

EC 2.7.1.153

XP_047278529.1

EC 2.7.1.137

EC 2.7.1.153

XP_047278530.1

EC 2.7.1.137

EC 2.7.1.153

XP_047278531.1

EC 2.7.1.137

EC 2.7.1.153

XP_047278532.1

EC 2.7.1.137

EC 2.7.1.153

XP_047278533.1

EC 2.7.1.137

EC 2.7.1.153

XP_047278534.1

EC 2.7.1.137

EC 2.7.1.153

XP_047278536.1

EC 2.7.1.137

EC 2.7.1.153

XP_047278545.1

EC 2.7.1.137

EC 2.7.1.153

XP_054193007.1

EC 2.7.1.137

EC 2.7.1.153

XP_054193008.1

EC 2.7.1.137

EC 2.7.1.153

XP_054193009.1

EC 2.7.1.137

EC 2.7.1.153

XP_054193010.1

EC 2.7.1.137

EC 2.7.1.153

XP_054193011.1

EC 2.7.1.137

EC 2.7.1.153

XP_054193012.1

EC 2.7.1.137

EC 2.7.1.153

XP_054193013.1

EC 2.7.1.137

EC 2.7.1.153

XP_054193014.1

EC 2.7.1.137

EC 2.7.1.153

XP_054193015.1

EC 2.7.1.137

EC 2.7.1.153

XP_054193016.1

EC 2.7.1.137

EC 2.7.1.153

XP_054193017.1

EC 2.7.1.137

EC 2.7.1.153

XP_054193018.1

EC 2.7.1.137

EC 2.7.1.153

XP_054193019.1

EC 2.7.1.137

EC 2.7.1.153

XP_054193020.1

EC 2.7.1.137

EC 2.7.1.153

XP_054193021.1

EC 2.7.1.137

EC 2.7.1.153

XP_054193022.1

EC 2.7.1.137

EC 2.7.1.153

XP_054193023.1

EC 2.7.1.137

EC 2.7.1.153

XP_054193024.1

EC 2.7.1.137

EC 2.7.1.153

XP_054193025.1

EC 2.7.1.137

EC 2.7.1.153

XP_054193026.1

EC 2.7.1.137

EC 2.7.1.153

XP_054193027.1

EC 2.7.1.137

EC 2.7.1.153

XP_054193028.1

EC 2.7.1.137

EC 2.7.1.153

XP_054193029.1

EC 2.7.1.137

EC 2.7.1.153

XP_054193030.1

EC 2.7.1.137

EC 2.7.1.153

XP_054193031.1

EC 2.7.1.137

EC 2.7.1.153

XP_054193032.1

EC 2.7.1.137

EC 2.7.1.153

XP_054193033.1

EC 2.7.1.137

EC 2.7.1.153

XP_054193034.1

EC 2.7.1.137

EC 2.7.1.153

XP_054193035.1

EC 2.7.1.137

EC 2.7.1.153

XP_054193036.1

EC 2.7.1.137

EC 2.7.1.153

XP_054193037.1

EC 2.7.1.137

EC 2.7.1.153

XP_054193038.1

EC 2.7.1.137

EC 2.7.1.153

XP_054193039.1

EC 2.7.1.137

EC 2.7.1.153

XP_054193040.1

EC 2.7.1.137

EC 2.7.1.153

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_023434.1 RefSeqGene

Range

5001..82383

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_191

mRNA and Protein(s)

NM_001350234.2 → NP_001337163.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform 2

Status: REVIEWED

Source sequence(s)

AL691449, BC132919, BC150297, CA427830, DA318970, DB216922, U86453, W30913, Y10055

Consensus CDS

CCDS90856.1

UniProtKB/TrEMBL

B2RAH3, B7ZM44, Q1WIR0

Related

ENSP00000513892.1, ENST00000698715.1

Conserved Domains (5) summary

cd08693
Location:314 → 481

C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)

smart00145
Location:505 → 683

PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)

cd05174
Location:675 → 1041

PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta

pfam00794
Location:175 → 281

PI3K_rbd; PI3-kinase family, ras-binding domain

pfam02192
Location:32 → 107

PI3K_p85B; PI3-kinase family, p85-binding domain
NM_001350235.1 → NP_001337164.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform 3

Status: REVIEWED

Source sequence(s)

BC132919, BC150297, CA427830, DA318970, U86453, W30913, Y10055

UniProtKB/TrEMBL

B2RAH3, Q1WIR0

Related

ENSP00000354410.2, ENST00000361110.6

Conserved Domains (5) summary

cd08693
Location:285 → 452

C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)

smart00145
Location:474 → 655

PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)

cd05174
Location:647 → 1013

PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta

pfam00794
Location:175 → 261

PI3K_rbd; PI3-kinase family, ras-binding domain

pfam02192
Location:32 → 107

PI3K_p85B; PI3-kinase family, p85-binding domain
NM_005026.5 → NP_005017.3 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform 1

See identical proteins and their annotated locations for NP_005017.3

Status: REVIEWED

Source sequence(s)

AK314191, AL691449, BC030263, BC132919, BC150297, CA427830, U86453, W30913, Y10055

Consensus CDS

CCDS104.1

UniProtKB/Swiss-Prot

A6NCG0, G1FFP1, O00329, O15445, Q5SR49

UniProtKB/TrEMBL

A0A2K8FKV1, B2RAH3, Q1WIR0

Related

ENSP00000366563.4, ENST00000377346.9

Conserved Domains (5) summary

cd08693
Location:314 → 481

C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)

smart00145
Location:503 → 684

PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)

cd05174
Location:676 → 1042

PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta

pfam00794
Location:175 → 281

PI3K_rbd; PI3-kinase family, ras-binding domain

pfam02192
Location:32 → 107

PI3K_p85B; PI3-kinase family, p85-binding domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

9627258..9729114

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047422557.1 → XP_047278513.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

UniProtKB/Swiss-Prot

A6NCG0, G1FFP1, O00329, O15445, Q5SR49

UniProtKB/TrEMBL

A0A2K8FKV1
XM_047422553.1 → XP_047278509.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

UniProtKB/Swiss-Prot

A6NCG0, G1FFP1, O00329, O15445, Q5SR49

UniProtKB/TrEMBL

A0A2K8FKV1
XM_047422555.1 → XP_047278511.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

UniProtKB/Swiss-Prot

A6NCG0, G1FFP1, O00329, O15445, Q5SR49

UniProtKB/TrEMBL

A0A2K8FKV1
XM_047422551.1 → XP_047278507.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

UniProtKB/Swiss-Prot

A6NCG0, G1FFP1, O00329, O15445, Q5SR49

UniProtKB/TrEMBL

A0A2K8FKV1
XM_047422561.1 → XP_047278517.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2

UniProtKB/TrEMBL

B7ZM44
XM_047422552.1 → XP_047278508.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

UniProtKB/Swiss-Prot

A6NCG0, G1FFP1, O00329, O15445, Q5SR49

UniProtKB/TrEMBL

A0A2K8FKV1
XM_047422576.1 → XP_047278532.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X5

UniProtKB/TrEMBL

A0A8V8TM62
XM_047422562.1 → XP_047278518.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2

UniProtKB/TrEMBL

B7ZM44
XM_047422554.1 → XP_047278510.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

UniProtKB/Swiss-Prot

A6NCG0, G1FFP1, O00329, O15445, Q5SR49

UniProtKB/TrEMBL

A0A2K8FKV1
XM_047422564.1 → XP_047278520.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2

UniProtKB/TrEMBL

B7ZM44
XM_047422568.1 → XP_047278524.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X3
XM_047422573.1 → XP_047278529.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X4
XM_047422574.1 → XP_047278530.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X5

UniProtKB/TrEMBL

A0A8V8TM62
XM_024447663.2 → XP_024303431.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2

UniProtKB/TrEMBL

B2RAH3, B7ZM44, Q1WIR0

Related

ENSP00000513888.1, ENST00000698710.1

Conserved Domains (5) summary

cd08693
Location:314 → 481

C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)

smart00145
Location:505 → 683

PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)

cd05174
Location:675 → 1041

PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta

pfam00794
Location:175 → 281

PI3K_rbd; PI3-kinase family, ras-binding domain

pfam02192
Location:32 → 107

PI3K_p85B; PI3-kinase family, p85-binding domain
XM_047422578.1 → XP_047278534.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X6
XM_024447664.2 → XP_024303432.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X3

UniProtKB/TrEMBL

B2RAH3, Q1WIR0

Conserved Domains (5) summary

cd08693
Location:285 → 452

C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)

smart00145
Location:474 → 655

PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)

cd05174
Location:647 → 1013

PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta

pfam00794
Location:175 → 261

PI3K_rbd; PI3-kinase family, ras-binding domain

pfam02192
Location:32 → 107

PI3K_p85B; PI3-kinase family, p85-binding domain
XM_047422571.1 → XP_047278527.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X4
XM_006710689.3 → XP_006710752.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

See identical proteins and their annotated locations for XP_006710752.1

UniProtKB/Swiss-Prot

A6NCG0, G1FFP1, O00329, O15445, Q5SR49

UniProtKB/TrEMBL

A0A2K8FKV1, B2RAH3, Q1WIR0

Related

ENSP00000513889.1, ENST00000698712.1

Conserved Domains (5) summary

cd08693
Location:314 → 481

C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)

smart00145
Location:503 → 684

PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)

cd05174
Location:676 → 1042

PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta

pfam00794
Location:175 → 281

PI3K_rbd; PI3-kinase family, ras-binding domain

pfam02192
Location:32 → 107

PI3K_p85B; PI3-kinase family, p85-binding domain
XM_047422577.1 → XP_047278533.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X5

UniProtKB/TrEMBL

A0A8V8TM62
XM_047422565.1 → XP_047278521.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2

UniProtKB/TrEMBL

B7ZM44
XM_047422569.1 → XP_047278525.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X3
XM_047422580.1 → XP_047278536.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X7
XM_047422589.1 → XP_047278545.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X8
XM_047422556.1 → XP_047278512.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

UniProtKB/Swiss-Prot

A6NCG0, G1FFP1, O00329, O15445, Q5SR49

UniProtKB/TrEMBL

A0A2K8FKV1
XM_047422550.1 → XP_047278506.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

UniProtKB/Swiss-Prot

A6NCG0, G1FFP1, O00329, O15445, Q5SR49

UniProtKB/TrEMBL

A0A2K8FKV1
XM_047422563.1 → XP_047278519.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2

UniProtKB/TrEMBL

B7ZM44
XM_047422572.1 → XP_047278528.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X4
XM_006710687.3 → XP_006710750.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

See identical proteins and their annotated locations for XP_006710750.1

UniProtKB/Swiss-Prot

A6NCG0, G1FFP1, O00329, O15445, Q5SR49

UniProtKB/TrEMBL

A0A2K8FKV1, B2RAH3, Q1WIR0

Related

ENSP00000513890.1, ENST00000698713.1

Conserved Domains (5) summary

cd08693
Location:314 → 481

C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)

smart00145
Location:503 → 684

PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)

cd05174
Location:676 → 1042

PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta

pfam00794
Location:175 → 281

PI3K_rbd; PI3-kinase family, ras-binding domain

pfam02192
Location:32 → 107

PI3K_p85B; PI3-kinase family, p85-binding domain
XM_047422575.1 → XP_047278531.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X5

UniProtKB/TrEMBL

A0A8V8TM62

Related

ENSP00000513891.1, ENST00000698714.1
XM_047422566.1 → XP_047278522.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X3
XM_047422570.1 → XP_047278526.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X4
XM_047422558.1 → XP_047278514.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

UniProtKB/Swiss-Prot

A6NCG0, G1FFP1, O00329, O15445, Q5SR49

UniProtKB/TrEMBL

A0A2K8FKV1
XM_047422567.1 → XP_047278523.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X3
XM_047422560.1 → XP_047278516.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

UniProtKB/Swiss-Prot

A6NCG0, G1FFP1, O00329, O15445, Q5SR49

UniProtKB/TrEMBL

A0A2K8FKV1
XM_047422559.1 → XP_047278515.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

UniProtKB/Swiss-Prot

A6NCG0, G1FFP1, O00329, O15445, Q5SR49

UniProtKB/TrEMBL

A0A2K8FKV1

Alternate T2T-CHM13v2.0

Genomic

NC_060925.1 Alternate T2T-CHM13v2.0

Range

9170040..9271897

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054337040.1 → XP_054193015.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

UniProtKB/TrEMBL

A7E2E0
XM_054337034.1 → XP_054193009.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

UniProtKB/TrEMBL

A7E2E0
XM_054337037.1 → XP_054193012.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

UniProtKB/TrEMBL

A7E2E0
XM_054337045.1 → XP_054193020.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2
XM_054337033.1 → XP_054193008.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

UniProtKB/TrEMBL

A7E2E0
XM_054337061.1 → XP_054193036.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X5
XM_054337046.1 → XP_054193021.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2
XM_054337036.1 → XP_054193011.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

UniProtKB/TrEMBL

A7E2E0
XM_054337048.1 → XP_054193023.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2
XM_054337053.1 → XP_054193028.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X3
XM_054337058.1 → XP_054193033.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X4
XM_054337059.1 → XP_054193034.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X5
XM_054337044.1 → XP_054193019.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2
XM_054337063.1 → XP_054193038.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X6
XM_054337050.1 → XP_054193025.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X3
XM_054337055.1 → XP_054193030.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X4
XM_054337039.1 → XP_054193014.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

UniProtKB/TrEMBL

A7E2E0
XM_054337062.1 → XP_054193037.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X5
XM_054337049.1 → XP_054193024.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2
XM_054337054.1 → XP_054193029.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X3
XM_054337064.1 → XP_054193039.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X7
XM_054337065.1 → XP_054193040.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X8
XM_054337038.1 → XP_054193013.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

UniProtKB/TrEMBL

A7E2E0
XM_054337032.1 → XP_054193007.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

UniProtKB/TrEMBL

A7E2E0
XM_054337047.1 → XP_054193022.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2
XM_054337056.1 → XP_054193031.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X4
XM_054337035.1 → XP_054193010.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

UniProtKB/TrEMBL

A7E2E0
XM_054337060.1 → XP_054193035.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X5
XM_054337052.1 → XP_054193027.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X3
XM_054337057.1 → XP_054193032.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X4
XM_054337041.1 → XP_054193016.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

UniProtKB/TrEMBL

A7E2E0
XM_054337051.1 → XP_054193026.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X3
XM_054337043.1 → XP_054193018.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

UniProtKB/TrEMBL

A7E2E0
XM_054337042.1 → XP_054193017.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

UniProtKB/TrEMBL

A7E2E0