SRRT serrate, RNA effector molecule [Homo sapiens (human)] - Gene

Summary

Official Symbol: SRRTprovided by HGNC
Official Full Name: serrate, RNA effector moleculeprovided by HGNC
Primary source: HGNC:HGNC:24101
See related: Ensembl:ENSG00000087087 MIM:614469; AllianceGenome:HGNC:24101
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ARS2; ASR2; serrate
Summary: Enables mRNA cap binding complex binding activity and protein-macromolecule adaptor activity. Involved in primary miRNA processing. Located in nucleoplasm. Part of ribonucleoprotein complex. [provided by Alliance of Genome Resources, Oct 2024]
Expression: Broad expression in testis (RPKM 66.3), bone marrow (RPKM 37.2) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 7q22.1

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (100875103..100888664)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (102115207..102128766)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (100472725..100486285)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ARS2/SRRT: at the nexus of RNA polymerase II transcription, transcript maturation and quality control.
Title: ARS2/SRRT: at the nexus of RNA polymerase II transcription, transcript maturation and quality control.
Mapping domains of ARS2 critical for its RNA decay capacity.
Title: Mapping domains of ARS2 critical for its RNA decay capacity.
ARS2/MAGL signaling in glioblastoma stem cells promotes self-renewal and M2-like polarization of tumor-associated macrophages.
Title: ARS2/MAGL signaling in glioblastoma stem cells promotes self-renewal and M2-like polarization of tumor-associated macrophages.
In the present study, the authors demonstrate that ARS2 regulates both the 3=-end processing and stability of NEAT1.
Title: ARS2 Regulates Nuclear Paraspeckle Formation through 3'-End Processing and Stability of NEAT1 Long Noncoding RNA.
Overexpression of Ars2 promoted cell proliferation and colony formation in glioblastoma cells, whereas the depletion of Ars2 inhibited cell proliferation, colony formation, and tumor growth. Knockdown of Ars2 reduced the expression levels of miR-6798-3p.
Title: Ars2 promotes cell proliferation and tumorigenicity in glioblastoma through regulating miR-6798-3p.
Depletion of Ars2 reduced the level of miR-6734-3p by inhibiting the interaction of Ars2 with either CBC complex or Drosha, leading to p27 up-regulation-mediated G1 cell cycle arrest, and culminating in inhibition of cell proliferation and leukemogenesis in AML
Title: Depletion of Ars2 inhibits cell proliferation and leukemogenesis in acute myeloid leukemia by modulating the miR-6734-3p/p27 axis.
Deletion of Ars2 from adult mice resulted in defective hematopoiesis in bone marrow and thymus.Ars2 was required for survival of developing thymocytes and for limiting differentiation of bone marrow resident long-term hematopoietic stem cells. Ars2 knockout led to rapid thymic involution and loss of the ability of mice to regenerate peripheral blood after myeloablation.
Title: The RNA binding protein Ars2 supports hematopoiesis at multiple levels.
Ars2 deficiency inhibited the activation of the MAPK/ERK pathway, leading to cell cycle arrest in the G1 phase, resulting in suppression of glioblastoma cell proliferation.
Title: Knockdown of arsenic resistance protein 2 inhibits human glioblastoma cell proliferation through the MAPK/ERK pathway.
Study present the human ARS2 crystal structure, which exhibits similarities and metazoan-specific differences to the plant homologue SERRATE, most notably an additional RRM domain. RRM domain is required to bind RNA, whereas a basic patch in the C-terminal leg of ARS2 mediates the interaction with FLASH.
Title: Structural analysis of human ARS2 as a platform for co-transcriptional RNA sorting.
define two mutually exclusive complexes CBC-NELF-E and CBC-ARS2-PHAX, which likely act in respectively earlier and later phases of transcription
Title: Structural basis for mutually exclusive co-transcriptional nuclear cap-binding complexes with either NELF-E or ARS2.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association analysis identifies multiple loci related to resting heart rate. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of serrate RNA effector molecule homolog (SRRT) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

GDB:4585581 (e-PCR)
- UniSTS:76804

GDB:4585149 (e-PCR)
- UniSTS:82221

A002D09 (e-PCR)
- UniSTS:57698

WI-20788 (e-PCR)
- UniSTS:78436

SHGC-30159 (e-PCR)
- UniSTS:37246

RH18532 (e-PCR)
- UniSTS:20428

GDB:4585547 (e-PCR)
- UniSTS:78827

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables RNA binding	HDA more info	PubMed
enables mRNA cap binding complex binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-macromolecule adaptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in neuronal stem cell population maintenance	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of neurogenesis	IEA Inferred from Electronic Annotation more info
involved_in primary miRNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in primary miRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to arsenic-containing substance	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nuclear body	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	TAS Traceable Author Statement more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
part_of ribonucleoprotein complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: serrate RNA effector molecule homolog

Names: arsenate resistance protein 2; arsenate resistance protein ARS2; arsenite resistance protein; arsenite-resistance protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001128852.2 → NP_001122324.1 serrate RNA effector molecule homolog isoform c

See identical proteins and their annotated locations for NP_001122324.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate in-frame splice junction at the end of a 5' exon compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is 1 aa shorter compared to isoform a.

Source sequence(s)

AC011895, AL096723, DA611314

Consensus CDS

CCDS47666.1

UniProtKB/Swiss-Prot

Q9BXP5

Related

ENSP00000481173.1, ENST00000614484.4

Conserved Domains (2) summary

pfam04959
Location:645 → 850

ARS2; Arsenite-resistance protein 2

pfam12066
Location:153 → 262

DUF3546; Domain of unknown function (DUF3546)
NM_001128853.2 → NP_001122325.1 serrate RNA effector molecule homolog isoform d

See identical proteins and their annotated locations for NP_001122325.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) uses an alternate in-frame splice junction at the end of a 3' exon compared to variant 1. The resulting isoform (d) has the same N- and C-termini but is 4 aa shorter compared to isoform a.

Source sequence(s)

AF248955, BC109117, DA611314

Consensus CDS

CCDS47665.1

UniProtKB/Swiss-Prot

Q9BXP5

Related

ENSP00000478341.1, ENST00000618262.4

Conserved Domains (2) summary

pfam04959
Location:646 → 847

ARS2; Arsenite-resistance protein 2

pfam12066
Location:153 → 262

DUF3546; Domain of unknown function (DUF3546)
NM_001128854.2 → NP_001122326.1 serrate RNA effector molecule homolog isoform e

See identical proteins and their annotated locations for NP_001122326.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) uses alternate in-frame splice junctions at the ends of a 5' and 3' exon compared to variant 1. The resulting isoform (e) has the same N- and C-termini but is 5 aa shorter compared to isoform a.

Source sequence(s)

AF248955, BC109117, DA611314

Consensus CDS

CCDS47667.1

UniProtKB/Swiss-Prot

Q9BXP5

Related

ENSP00000483556.1, ENST00000618411.4

Conserved Domains (2) summary

pfam04959
Location:645 → 846

ARS2; Arsenite-resistance protein 2

pfam12066
Location:153 → 262

DUF3546; Domain of unknown function (DUF3546)
NM_015908.6 → NP_056992.4 serrate RNA effector molecule homolog isoform a

See identical proteins and their annotated locations for NP_056992.4

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).

Source sequence(s)

AC011895, AF248955, BC109116, DA611314

Consensus CDS

CCDS34709.1

UniProtKB/Swiss-Prot

A4D2E5, A4D2E6, A6NK22, B4DJL4, B4DZA6, O95808, Q32MI4, Q6NT74, Q8TDQ5, Q9BWP6, Q9BXP4, Q9BXP5, Q9Y4S4

Related

ENSP00000480421.1, ENST00000611405.5

Conserved Domains (2) summary

pfam04959
Location:646 → 851

ARS2; Arsenite-resistance protein 2

pfam12066
Location:153 → 262

DUF3546; Domain of unknown function (DUF3546)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000007.14 Reference GRCh38.p14 Primary Assembly

Range

100875103..100888664

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005250407.3 → XP_005250464.1 serrate RNA effector molecule homolog isoform X3

Conserved Domains (2) summary

pfam04959
Location:653 → 854

ARS2; Arsenite-resistance protein 2

pfam12066
Location:160 → 269

DUF3546; Domain of unknown function (DUF3546)
XM_005250408.2 → XP_005250465.1 serrate RNA effector molecule homolog isoform X4

Conserved Domains (2) summary

pfam04959
Location:652 → 853

ARS2; Arsenite-resistance protein 2

pfam12066
Location:160 → 269

DUF3546; Domain of unknown function (DUF3546)
XM_005250405.3 → XP_005250462.1 serrate RNA effector molecule homolog isoform X1

Conserved Domains (2) summary

pfam04959
Location:653 → 858

ARS2; Arsenite-resistance protein 2

pfam12066
Location:160 → 269

DUF3546; Domain of unknown function (DUF3546)
XM_005250406.3 → XP_005250463.1 serrate RNA effector molecule homolog isoform X2

Conserved Domains (2) summary

pfam04959
Location:652 → 857

ARS2; Arsenite-resistance protein 2

pfam12066
Location:160 → 269

DUF3546; Domain of unknown function (DUF3546)
XM_047420459.1 → XP_047276415.1 serrate RNA effector molecule homolog isoform X5
XM_047420460.1 → XP_047276416.1 serrate RNA effector molecule homolog isoform X6

Alternate T2T-CHM13v2.0

Genomic

NC_060931.1 Alternate T2T-CHM13v2.0

Range

102115207..102128766

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054358372.1 → XP_054214347.1 serrate RNA effector molecule homolog isoform X3
XM_054358373.1 → XP_054214348.1 serrate RNA effector molecule homolog isoform X4
XM_054358370.1 → XP_054214345.1 serrate RNA effector molecule homolog isoform X1
XM_054358371.1 → XP_054214346.1 serrate RNA effector molecule homolog isoform X2
XM_054358374.1 → XP_054214349.1 serrate RNA effector molecule homolog isoform X5
XM_054358375.1 → XP_054214350.1 serrate RNA effector molecule homolog isoform X6

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_182800.2: Suppressed sequence

Description

NM_182800.2: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript, and it is a nonsense-mediated mRNA decay (NMD) candidate.