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    STRN4 striatin 4 [ Homo sapiens (human) ]

    Gene ID: 29888, updated on 3-Dec-2024

    Summary

    Official Symbol
    STRN4provided by HGNC
    Official Full Name
    striatin 4provided by HGNC
    Primary source
    HGNC:HGNC:15721
    See related
    Ensembl:ENSG00000090372 MIM:614767; AllianceGenome:HGNC:15721
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZIN; PPP2R6C; zinedin
    Summary
    Enables armadillo repeat domain binding activity; protein phosphatase 2A binding activity; and protein-macromolecule adaptor activity. Involved in negative regulation of hippo signaling. Part of FAR/SIN/STRIPAK complex. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis (RPKM 42.4), spleen (RPKM 16.0) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See STRN4 in Genome Data Viewer
    Location:
    19q13.32
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (46719511..46746450, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (49545101..49572026, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (47222768..47249707, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene protein kinase D2 Neighboring gene RNA, 7SL, cytoplasmic 364, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47200828-47201328 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:47213106-47213924 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10822 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14846 Neighboring gene uncharacterized LOC107987269 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10823 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10824 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14847 Neighboring gene microRNA 320e Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47228602-47229146 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47230777-47231320 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47231865-47232408 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr19:47233845-47235044 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10825 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10826 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10827 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10828 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10829 Neighboring gene fukutin related protein Neighboring gene Sharpr-MPRA regulatory region 2893 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr19:47287225-47288424 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:47288509-47289110 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:47289111-47289712 Neighboring gene solute carrier family 1 member 5 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10830 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10831 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:47291519-47292120 Neighboring gene heterogeneous nuclear ribonucleoprotein M pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ35594

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables armadillo repeat domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calmodulin binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein phosphatase 2A binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein phosphatase 2A binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein-containing complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein-macromolecule adaptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of hippo signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of modification of postsynaptic structure IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of FAR/SIN/STRIPAK complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of FAR/SIN/STRIPAK complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in GABA-ergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in dendritic spine IEA
    Inferred from Electronic Annotation
    more info
     
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    striatin-4
    Names
    protein phosphatase 2 regulatory subunit B'''gamma
    striatin, calmodulin binding protein 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039877.2NP_001034966.1  striatin-4 isoform 2

      See identical proteins and their annotated locations for NP_001034966.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (2).
      Source sequence(s)
      AB209003, AF212940, DA510367
      Consensus CDS
      CCDS42581.1
      UniProtKB/TrEMBL
      Q59GV6
      Related
      ENSP00000375777.1, ENST00000391910.7
      Conserved Domains (4) summary
      COG2319
      Location:423753
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:437759
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam08232
      Location:64189
      Striatin; Striatin family
      sd00039
      Location:450496
      7WD40; WD40 repeat [structural motif]
    2. NM_013403.3NP_037535.2  striatin-4 isoform 1

      See identical proteins and their annotated locations for NP_037535.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses an alternate splice site in the central coding region, compared to variant 2. The resulting isoform (1) lacks an internal 7-aa segment, compared to isoform 2.
      Source sequence(s)
      AF212940, BC034604, DA510367
      Consensus CDS
      CCDS12690.1
      UniProtKB/Swiss-Prot
      A0A024R0V2, B4DQH7, F8VYA6, Q8NE53, Q9NRL3
      UniProtKB/TrEMBL
      Q59GV6
      Related
      ENSP00000263280.4, ENST00000263280.11
      Conserved Domains (4) summary
      COG2319
      Location:416746
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:430752
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam08232
      Location:64189
      Striatin; Striatin family
      sd00039
      Location:443489
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      46719511..46746450 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006723172.3XP_006723235.1  striatin-4 isoform X2

      UniProtKB/TrEMBL
      Q59GV6
      Conserved Domains (4) summary
      COG2319
      Location:431761
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:445767
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam08232
      Location:64204
      Striatin; Striatin family
      sd00039
      Location:458504
      7WD40; WD40 repeat [structural motif]
    2. XM_006723171.3XP_006723234.1  striatin-4 isoform X1

      UniProtKB/TrEMBL
      Q59GV6
      Conserved Domains (4) summary
      COG2319
      Location:438768
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:452774
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam08232
      Location:64204
      Striatin; Striatin family
      sd00039
      Location:465511
      7WD40; WD40 repeat [structural motif]
    3. XM_047438714.1XP_047294670.1  striatin-4 isoform X5

      UniProtKB/TrEMBL
      B4DMU7, F5GYK2
      Related
      ENSP00000440901.1, ENST00000539396.5
    4. XM_047438713.1XP_047294669.1  striatin-4 isoform X4

      UniProtKB/TrEMBL
      B4DMU7
    5. XM_047438712.1XP_047294668.1  striatin-4 isoform X3

      UniProtKB/TrEMBL
      B4DMU7
    6. XM_047438715.1XP_047294671.1  striatin-4 isoform X6

      UniProtKB/TrEMBL
      B4DMU7
    7. XM_011526878.2XP_011525180.1  striatin-4 isoform X7

      Conserved Domains (1) summary
      pfam08232
      Location:64204
      Striatin; Striatin family
    8. XM_017026719.2XP_016882208.1  striatin-4 isoform X8

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      49545101..49572026 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320764.1XP_054176739.1  striatin-4 isoform X2

      UniProtKB/TrEMBL
      Q59GV6
    2. XM_054320763.1XP_054176738.1  striatin-4 isoform X1

      UniProtKB/TrEMBL
      Q59GV6
    3. XM_054320767.1XP_054176742.1  striatin-4 isoform X5

      UniProtKB/TrEMBL
      B4DMU7, F5GYK2
    4. XM_054320766.1XP_054176741.1  striatin-4 isoform X4

      UniProtKB/TrEMBL
      B4DMU7
    5. XM_054320765.1XP_054176740.1  striatin-4 isoform X3

      UniProtKB/TrEMBL
      B4DMU7
    6. XM_054320768.1XP_054176743.1  striatin-4 isoform X6

      UniProtKB/TrEMBL
      B4DMU7
    7. XM_054320769.1XP_054176744.1  striatin-4 isoform X7

    8. XM_054320770.1XP_054176745.1  striatin-4 isoform X8