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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_052978.2 RefSeqGene
- Range
-
5401..37562
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
NM_001206796.3 → NP_001193725.1 pyruvate kinase PKM isoform c
See identical proteins and their annotated locations for NP_001193725.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (c).
- Source sequence(s)
-
AC020779
- Consensus CDS
-
CCDS92037.1
- UniProtKB/TrEMBL
- A0A804F729, B4DRT3
- Related
- ENSP00000455901.2, ENST00000565154.6
- Conserved Domains (2) summary
-
- cd00288
Location:116 → 604
- Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...
- TIGR01064
Location:117 → 601
- pyruv_kin; pyruvate kinase
-
NM_001206797.3 → NP_001193726.1 pyruvate kinase PKM isoform d
See identical proteins and their annotated locations for NP_001193726.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence, lacks an alternate in-frame segment, and has an alternate in-frame coding exon compared to variant 4. The resulting isoform (d) is shorter at the N-terminus, lacks an alternate internal segment, and has a different internal segment compared to isoform c.
- Source sequence(s)
-
AC020779
- Consensus CDS
-
CCDS73752.1
- UniProtKB/TrEMBL
- B4DNK4, B4DRT3
- Related
- ENSP00000373745.4, ENST00000389093.7
- Conserved Domains (1) summary
-
- cd00288
Location:42 → 456
- Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...
-
NM_001206798.3 → NP_001193727.1 pyruvate kinase PKM isoform e
See identical proteins and their annotated locations for NP_001193727.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence, lacks an alternate exon, and has an alternate in-frame coding exon compared to variant 4. The resulting isoform (e) has a shorter and distinct N-terminus, lacks an alternate internal segment, and has a different internal segment compared to isoform c.
- Source sequence(s)
-
AC020779
- UniProtKB/TrEMBL
-
B4DRT3
- Conserved Domains (2) summary
-
- cd00288
Location:68 → 515
- Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...
- TIGR01064
Location:68 → 512
- pyruv_kin; pyruvate kinase
-
NM_001206799.2 → NP_001193728.1 pyruvate kinase PKM isoform f
See identical proteins and their annotated locations for NP_001193728.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (f) has a shorter and distinct N-terminus compared to isoform c.
- Source sequence(s)
-
AC020779, AK294315, AK309781, BC000481, BC035198
- UniProtKB/TrEMBL
-
B4DRT3
- Conserved Domains (2) summary
-
- cd00288
Location:47 → 535
- Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...
- TIGR01064
Location:48 → 532
- pyruv_kin; pyruvate kinase
-
NM_001316318.2 → NP_001303247.1 pyruvate kinase PKM isoform g
Status: REVIEWED
- Description
- Transcript Variant: This variant (8) lacks an alternate in-frame exon in the 5' end of the coding sequence compared to variant 4. The resulting isoform (g) has the same N- and C-termini but is shorter compared to isoform c.
- Source sequence(s)
-
AC020779
- Consensus CDS
-
CCDS92035.1
- UniProtKB/TrEMBL
- A0A804F6T5, B4DRT3
- Related
- ENSP00000455736.2, ENST00000565184.6
- Conserved Domains (2) summary
-
- cd00288
Location:77 → 565
- Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...
- TIGR01064
Location:78 → 562
- pyruv_kin; pyruvate kinase
-
NM_001411081.1 → NP_001398010.1 pyruvate kinase PKM isoform h
Status: REVIEWED
- Source sequence(s)
-
AC020779
- Consensus CDS
-
CCDS92036.1
- UniProtKB/TrEMBL
- A0A8V8TNX9, B4DRT3
- Related
- ENSP00000513903.1, ENST00000698741.1
-
NM_002654.6 → NP_002645.3 pyruvate kinase PKM isoform a
See identical proteins and their annotated locations for NP_002645.3
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) differs in the 5' UTR and coding sequence and has an alternate in-frame coding exon compared to variant 4. The resulting isoform (a, also called M2) is shorter at the N-terminus and has a different internal segment compared to isoform c.
- Source sequence(s)
-
AC020779
- Consensus CDS
-
CCDS32284.1
- UniProtKB/Swiss-Prot
- A6NFK3, B2R5N8, B3KRY0, B4DFX8, B4DUU6, P14618, P14786, Q53GK4, Q96E76, Q9BWB5, Q9UCV6, Q9UPF2
- UniProtKB/TrEMBL
- B4DRT3, V9HWB8
- Related
- ENSP00000334983.5, ENST00000335181.10
- Conserved Domains (1) summary
-
- cd00288
Location:42 → 530
- Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...
-
NM_182470.4 → NP_872270.1 pyruvate kinase PKM isoform b
See identical proteins and their annotated locations for NP_872270.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (b, also called M1) is shorter at the N-terminus compared to isoform c.
- Source sequence(s)
-
AC020779
- Consensus CDS
-
CCDS32285.1
- UniProtKB/TrEMBL
-
B4DRT3
- Related
- ENSP00000320171.6, ENST00000319622.10
- Conserved Domains (1) summary
-
- cd00288
Location:42 → 530
- Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...
-
NM_182471.4 → NP_872271.1 pyruvate kinase PKM isoform b
See identical proteins and their annotated locations for NP_872271.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (b, also called M1) is shorter at the N-terminus compared to isoform c.
- Source sequence(s)
-
AC020779
- Consensus CDS
-
CCDS32285.1
- UniProtKB/TrEMBL
-
B4DRT3
- Related
- ENSP00000456970.1, ENST00000568459.5
- Conserved Domains (1) summary
-
- cd00288
Location:42 → 530
- Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000015.10 Reference GRCh38.p14 Primary Assembly
- Range
-
72199029..72231591 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_005254445.6 → XP_005254502.1 pyruvate kinase PKM isoform X7
See identical proteins and their annotated locations for XP_005254502.1
- UniProtKB/Swiss-Prot
- A6NFK3, B2R5N8, B3KRY0, B4DFX8, B4DUU6, P14618, P14786, Q53GK4, Q96E76, Q9BWB5, Q9UCV6, Q9UPF2
- UniProtKB/TrEMBL
- B4DRT3, V9HWB8
- Conserved Domains (1) summary
-
- cd00288
Location:42 → 530
- Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...
-
XM_011521670.2 → XP_011519972.1 pyruvate kinase PKM isoform X4
See identical proteins and their annotated locations for XP_011519972.1
- UniProtKB/TrEMBL
-
B4DRT3
- Conserved Domains (1) summary
-
- cd00288
Location:77 → 565
- Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...
-
XM_047432666.1 → XP_047288622.1 pyruvate kinase PKM isoform X7
- UniProtKB/Swiss-Prot
- A6NFK3, B2R5N8, B3KRY0, B4DFX8, B4DUU6, P14618, P14786, Q53GK4, Q96E76, Q9BWB5, Q9UCV6, Q9UPF2
- UniProtKB/TrEMBL
- B4DRT3, V9HWB8
-
XM_047432664.1 → XP_047288620.1 pyruvate kinase PKM isoform X5
- UniProtKB/TrEMBL
-
B4DRT3
-
XM_047432665.1 → XP_047288621.1 pyruvate kinase PKM isoform X6
- UniProtKB/TrEMBL
-
B4DRT3
-
XM_005254443.2 → XP_005254500.1 pyruvate kinase PKM isoform X3
- UniProtKB/TrEMBL
-
B4DRT3
- Conserved Domains (2) summary
-
- cd00288
Location:102 → 590
- Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...
- TIGR01064
Location:103 → 587
- pyruv_kin; pyruvate kinase
-
XM_047432662.1 → XP_047288618.1 pyruvate kinase PKM isoform X1
- UniProtKB/TrEMBL
-
B4DRT3
-
XM_047432663.1 → XP_047288619.1 pyruvate kinase PKM isoform X2
- UniProtKB/TrEMBL
-
B4DRT3
Alternate T2T-CHM13v2.0
Genomic
-
NC_060939.1 Alternate T2T-CHM13v2.0
- Range
-
70015755..70047883 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_054378186.1 → XP_054234161.1 pyruvate kinase PKM isoform X4
- UniProtKB/TrEMBL
-
B4DRT3
-
XM_054378187.1 → XP_054234162.1 pyruvate kinase PKM isoform X5
- UniProtKB/TrEMBL
-
B4DRT3
-
XM_054378188.1 → XP_054234163.1 pyruvate kinase PKM isoform X6
- UniProtKB/TrEMBL
-
B4DRT3
-
XM_054378185.1 → XP_054234160.1 pyruvate kinase PKM isoform X3
- UniProtKB/TrEMBL
-
B4DRT3