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    CNTNAP4 contactin associated protein family member 4 [ Homo sapiens (human) ]

    Gene ID: 85445, updated on 3-Dec-2024

    Summary

    Official Symbol
    CNTNAP4provided by HGNC
    Official Full Name
    contactin associated protein family member 4provided by HGNC
    Primary source
    HGNC:HGNC:18747
    See related
    Ensembl:ENSG00000152910 MIM:610518; AllianceGenome:HGNC:18747
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CASPR4
    Summary
    This gene encodes a member of the neurexin protein family. Members of this family function in the vertebrate nervous system as cell adhesion molecules and receptors. This protein contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, and thrombospondin N-terminal-like domains. This protein may also play a role in proper neurotransmission in the dopaminergic and GABAergic systems and mutations in this gene may be associated with certain psychiatric illnesses. A polymorphism in an intron of this gene may be associated with longevity. [provided by RefSeq, Apr 2016]
    Expression
    Biased expression in brain (RPKM 7.4) and adrenal (RPKM 0.3) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CNTNAP4 in Genome Data Viewer
    Location:
    16q23.1
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (76277401..76560757)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (82333540..82616946)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (76311299..76594654)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371349 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7729 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr16:76257277-76258016 Neighboring gene ribosomal protein L18 pseudogene 13 Neighboring gene RN7SK pseudogene 233 Neighboring gene long intergenic non-protein coding RNA 2125 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_44671 Neighboring gene NANOG hESC enhancer GRCh37_chr16:76716883-76717434 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_44716 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr16:76749983-76751182 Neighboring gene uncharacterized LOC105376774

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.
    EBI GWAS Catalog
    Genome-wide association study of d-amphetamine response in healthy volunteers identifies putative associations, including cadherin 13 (CDH13).
    EBI GWAS Catalog
    Genome-wide SNP associations with rubella-specific cytokine responses in measles-mumps-rubella vaccine recipients.
    EBI GWAS Catalog
    Investigation of single nucleotide polymorphisms and biological pathways associated with response to TNFα inhibitors in patients with rheumatoid arthritis.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA1763

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of grooming behavior ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of synaptic transmission, GABAergic ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of synaptic transmission, dopaminergic ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in presynaptic membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    contactin-associated protein-like 4
    Names
    cell recognition molecule Caspr4
    contactin associated protein like 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001322178.2NP_001309107.1  contactin-associated protein-like 4 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC010528, AC106741, AC108125, FO681478
      UniProtKB/TrEMBL
      A0A0A0MR20
      Conserved Domains (9) summary
      smart00231
      Location:55177
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00054
      Location:912946
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00057
      Location:54176
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cd00110
      Location:744888
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:503534
      EGF; EGF-like domain
      pfam02210
      Location:212341
      Laminin_G_2; Laminin G domain
      cl00085
      Location:542589
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
      cl02436
      Location:554637
      COLFI; Fibrillar collagen C-terminal domain
      cl22861
      Location:371429
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    2. NM_001322179.2NP_001309108.1  contactin-associated protein-like 4 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC010528, AC106741, AC108125, FO681478
      UniProtKB/TrEMBL
      A0A0A0MR20
      Conserved Domains (7) summary
      smart00231
      Location:55177
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00057
      Location:54176
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cd00110
      Location:371521
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:553584
      EGF; EGF-like domain
      pfam02210
      Location:212341
      Laminin_G_2; Laminin G domain
      cl00085
      Location:592639
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
      cl02436
      Location:604687
      COLFI; Fibrillar collagen C-terminal domain
    3. NM_001322180.2NP_001309109.1  contactin-associated protein-like 4 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC010528, AC106741, AC108125, FO681478
      UniProtKB/TrEMBL
      A0A0A0MR20
      Conserved Domains (8) summary
      smart00231
      Location:348
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00054
      Location:833867
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00057
      Location:347
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cd00110
      Location:665809
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:424455
      EGF; EGF-like domain
      pfam02210
      Location:83212
      Laminin_G_2; Laminin G domain
      cl00085
      Location:463510
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
      cl02436
      Location:475558
      COLFI; Fibrillar collagen C-terminal domain
    4. NM_001322181.2NP_001309110.1  contactin-associated protein-like 4 isoform 6 precursor

      Status: REVIEWED

      Source sequence(s)
      AC010528, AC106741, AC108125, FO681478
      UniProtKB/TrEMBL
      A0A0A0MR20
      Conserved Domains (8) summary
      smart00231
      Location:55176
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00054
      Location:961995
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00057
      Location:54175
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cd00110
      Location:793937
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:552583
      EGF; EGF-like domain
      pfam02210
      Location:211340
      Laminin_G_2; Laminin G domain
      cl00085
      Location:591638
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
      cl02436
      Location:603686
      COLFI; Fibrillar collagen C-terminal domain
    5. NM_001322187.2NP_001309116.1  contactin-associated protein-like 4 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC010528, AC106741, AC108125, FO681478
      Conserved Domains (7) summary
      cd00054
      Location:490524
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00110
      Location:322466
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:81112
      EGF; EGF-like domain
      pfam02210
      Location:574704
      Laminin_G_2; Laminin G domain
      cl00085
      Location:120167
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
      cl02436
      Location:132215
      COLFI; Fibrillar collagen C-terminal domain
      cl22861
      Location:252
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    6. NM_001322188.2NP_001309117.1  contactin-associated protein-like 4 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC010528, AC106741, AC108125, FO681478
      UniProtKB/TrEMBL
      A0A0A0MR20
      Conserved Domains (8) summary
      smart00231
      Location:55177
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00054
      Location:962996
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00057
      Location:54176
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cd00110
      Location:794938
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:553584
      EGF; EGF-like domain
      pfam02210
      Location:212341
      Laminin_G_2; Laminin G domain
      cl00085
      Location:592639
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
      cl02436
      Location:604687
      COLFI; Fibrillar collagen C-terminal domain
    7. NM_001322189.2NP_001309118.1  contactin-associated protein-like 4 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC010528, AC106741, AC108125, FO681478
      UniProtKB/TrEMBL
      A0A0A0MR20
      Conserved Domains (8) summary
      smart00231
      Location:389
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00054
      Location:874908
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00057
      Location:188
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cd00110
      Location:706850
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:465496
      EGF; EGF-like domain
      pfam02210
      Location:124253
      Laminin_G_2; Laminin G domain
      cl00085
      Location:504551
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
      cl02436
      Location:516599
      COLFI; Fibrillar collagen C-terminal domain
    8. NM_001322190.2NP_001309119.1  contactin-associated protein-like 4 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AB100092, AC106741, AC108125, FO681478
      Consensus CDS
      CCDS82015.1
      UniProtKB/TrEMBL
      A0A087WTA1, F5H107
      Related
      ENSP00000477698.1, ENST00000622250.4
      Conserved Domains (8) summary
      smart00231
      Location:55177
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00054
      Location:914948
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00057
      Location:54176
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cd00110
      Location:746890
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:505536
      EGF; EGF-like domain
      pfam02210
      Location:9981128
      Laminin_G_2; Laminin G domain
      cl00085
      Location:544591
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
      cl02436
      Location:556639
      COLFI; Fibrillar collagen C-terminal domain
    9. NM_001322191.2NP_001309120.1  contactin-associated protein-like 4 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC010528, AC106741, AC108125, FO681478
      Conserved Domains (7) summary
      cd00054
      Location:653687
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00110
      Location:485629
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:244275
      EGF; EGF-like domain
      pfam02210
      Location:737867
      Laminin_G_2; Laminin G domain
      cl00085
      Location:283330
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
      cl02436
      Location:295378
      COLFI; Fibrillar collagen C-terminal domain
      cl22861
      Location:132
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    10. NM_033401.5NP_207837.2  contactin-associated protein-like 4 isoform 1 precursor

      See identical proteins and their annotated locations for NP_207837.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AB051550, AC106741, AC108125, BM544789, Z44514
      Consensus CDS
      CCDS73915.1
      UniProtKB/Swiss-Prot
      E9PFZ6, Q86YZ7, Q9C0A0
      UniProtKB/TrEMBL
      A0A0A0MR20
      Related
      ENSP00000479811.1, ENST00000611870.5
      Conserved Domains (7) summary
      cd00054
      Location:962996
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00057
      Location:54176
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cd00110
      Location:794938
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:553584
      EGF; EGF-like domain
      pfam02210
      Location:212341
      Laminin_G_2; Laminin G domain
      cl00085
      Location:592639
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
      cl02436
      Location:604687
      COLFI; Fibrillar collagen C-terminal domain
    11. NM_138994.5NP_620481.2  contactin-associated protein-like 4 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate exon in the 5' UTR and CDS and lacks several coding exons, compared to variant 1. It encodes a shorter protein (isoform 2) which has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AB100093, AC106741, AC108125, DA319383, DB050637, DT217898
      Consensus CDS
      CCDS10924.2
      UniProtKB/TrEMBL
      F5H107
      Related
      ENSP00000418741.1, ENST00000478060.5
      Conserved Domains (8) summary
      smart00231
      Location:30152
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00054
      Location:889923
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00057
      Location:29151
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cd00110
      Location:721865
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:480511
      EGF; EGF-like domain
      pfam02210
      Location:9731103
      Laminin_G_2; Laminin G domain
      cl00085
      Location:519566
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
      cl02436
      Location:531614
      COLFI; Fibrillar collagen C-terminal domain

    RNA

    1. NR_136210.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC010528, AC106741, AC108125, FO681478
    2. NR_136213.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC010528, AC106741, AC108125, FO681478
    3. NR_136216.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC010528, AC106741, AC108125, FO681478

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      76277401..76560757
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047434819.1XP_047290775.1  contactin-associated protein-like 4 isoform X2

      UniProtKB/TrEMBL
      Q96M80
    2. XM_011523403.3XP_011521705.1  contactin-associated protein-like 4 isoform X1

      UniProtKB/TrEMBL
      A0A0A0MR20
      Related
      ENSP00000417628.1, ENST00000476707.1
      Conserved Domains (8) summary
      smart00231
      Location:30152
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00054
      Location:937971
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00057
      Location:29151
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cd00110
      Location:769913
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:528559
      EGF; EGF-like domain
      pfam02210
      Location:187316
      Laminin_G_2; Laminin G domain
      cl00085
      Location:567614
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
      cl02436
      Location:579662
      COLFI; Fibrillar collagen C-terminal domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      82333540..82616946
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054314225.1XP_054170200.1  contactin-associated protein-like 4 isoform X2

      UniProtKB/TrEMBL
      Q96M80
    2. XM_054314224.1XP_054170199.1  contactin-associated protein-like 4 isoform X3

      UniProtKB/TrEMBL
      A0A0A0MR20