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    RPL26L1 ribosomal protein L26 like 1 [ Homo sapiens (human) ]

    Gene ID: 51121, updated on 28-Oct-2024

    Summary

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    Official Symbol
    RPL26L1provided by HGNC
    Official Full Name
    ribosomal protein L26 like 1provided by HGNC
    Primary source
    HGNC:HGNC:17050
    See related
    Ensembl:ENSG00000037241 AllianceGenome:HGNC:17050
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RPL26P1
    Summary
    This gene encodes a protein that shares high sequence similarity with ribosomal protein L26. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Dec 2015]
    Expression
    Ubiquitous expression in testis (RPKM 13.8), kidney (RPKM 5.9) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See RPL26L1 in Genome Data Viewer
    Location:
    5q35.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (172954094..172969771)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (173494364..173509843)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (172385732..172396774)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901135 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:172276540-172277739 Neighboring gene endoplasmic reticulum-golgi intermediate compartment 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:172281789-172282290 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:172285332-172285509 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:172286171-172287171 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:172290019-172290520 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:172304495-172305470 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:172305471-172306446 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23647 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:172328739-172329249 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:172331587-172332786 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23648 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:172341803-172342303 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:172345389-172345890 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:172347219-172347863 Neighboring gene microRNA 10523 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16631 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23649 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:172370360-172370531 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:172382074-172383273 Neighboring gene RPL26L1 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 5956 Neighboring gene inorganic pyrophosphatase 1 pseudogene Neighboring gene ATPase H+ transporting V0 subunit e1 Neighboring gene Sharpr-MPRA regulatory region 12761 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:172444454-172444997 Neighboring gene Sharpr-MPRA regulatory region 4768 Neighboring gene small nucleolar RNA, H/ACA box 74B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Probing nuclear pore complex architecture with proximity-dependent biotinylation. Kim DI, et al. Proc Natl Acad Sci U S A, 2014 Jun 17. PMID 24927568, Free PMC Article
    2. Glutamine Triggers Acetylation-Dependent Degradation of Glutamine Synthetase via the Thalidomide Receptor Cereblon. Nguyen TV, et al. Mol Cell, 2016 Mar 17. PMID 26990986, Free PMC Article
    3. The molecular mechanics of eukaryotic translation. Kapp LD, et al. Annu Rev Biochem, 2004. PMID 15189156
    4. Characterization of gene regulation and protein interaction networks for Matrin 3 encoding mutations linked to amyotrophic lateral sclerosis and myopathy. Iradi MCG, et al. Sci Rep, 2018 Mar 6. PMID 29511296, Free PMC Article
    5. TIMMDC1/C3orf1 functions as a membrane-embedded mitochondrial complex I assembly factor through association with the MCIA complex. Guarani V, et al. Mol Cell Biol, 2014 Mar. PMID 24344204, Free PMC Article

    See all (85) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ46904

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal large subunit biogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular exosome HDA PubMed 

    General protein information

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    Preferred Names
    ribosomal protein uL24-like
    Names
    60S ribosomal protein L26-like 1
    large ribosomal subunit protein uL24-like 1
    ribosomal protein L26 homolog
    ribosomal protein L26 pseudogene 1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001317980.2 → NP_001304909.1  ribosomal protein uL24-like

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, and 4 encode the same protein.
      Source sequence(s)
      AC008429, BC017360, BU193755
      Consensus CDS
      CCDS4382.1
      UniProtKB/Swiss-Prot
      B3KY82, D3DQM0, Q9UNX3
      UniProtKB/TrEMBL
      Q6IBH6
      Related
      ENSP00000428223.1, ENST00000521476.5
      Conserved Domains (2) summary
      PRK05431
      Location:109 → 145
      PRK05431; seryl-tRNA synthetase; Provisional
      pfam16906
      Location:8 → 122
      Ribosomal_L26; Ribosomal proteins L26 eukaryotic, L24P archaeal

    2. NM_001317981.2 → NP_001304910.1  ribosomal protein uL24-like

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
      Source sequence(s)
      BC017360, BI838595
      Consensus CDS
      CCDS4382.1
      UniProtKB/Swiss-Prot
      B3KY82, D3DQM0, Q9UNX3
      UniProtKB/TrEMBL
      Q6IBH6
      Related
      ENSP00000428177.1, ENST00000519974.5
      Conserved Domains (2) summary
      PRK05431
      Location:109 → 145
      PRK05431; seryl-tRNA synthetase; Provisional
      pfam16906
      Location:8 → 122
      Ribosomal_L26; Ribosomal proteins L26 eukaryotic, L24P archaeal

    3. NM_001317982.2 → NP_001304911.1  ribosomal protein uL24-like

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
      Source sequence(s)
      AC008429, BC017360, BQ278240, BU569345
      Consensus CDS
      CCDS4382.1
      UniProtKB/Swiss-Prot
      B3KY82, D3DQM0, Q9UNX3
      UniProtKB/TrEMBL
      Q6IBH6
      Related
      ENSP00000430147.1, ENST00000519239.5
      Conserved Domains (2) summary
      PRK05431
      Location:109 → 145
      PRK05431; seryl-tRNA synthetase; Provisional
      pfam16906
      Location:8 → 122
      Ribosomal_L26; Ribosomal proteins L26 eukaryotic, L24P archaeal

    4. NM_016093.4 → NP_057177.1  ribosomal protein uL24-like

      See identical proteins and their annotated locations for NP_057177.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
      Source sequence(s)
      BC017360, HY015036
      Consensus CDS
      CCDS4382.1
      UniProtKB/Swiss-Prot
      B3KY82, D3DQM0, Q9UNX3
      UniProtKB/TrEMBL
      Q6IBH6
      Related
      ENSP00000265100.2, ENST00000265100.6
      Conserved Domains (2) summary
      PRK05431
      Location:109 → 145
      PRK05431; seryl-tRNA synthetase; Provisional
      pfam16906
      Location:8 → 122
      Ribosomal_L26; Ribosomal proteins L26 eukaryotic, L24P archaeal

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      172954094..172969771
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011534565.3 → XP_011532867.1  ribosomal protein uL24-like isoform X1

      See identical proteins and their annotated locations for XP_011532867.1

      UniProtKB/Swiss-Prot
      B3KY82, D3DQM0, Q9UNX3
      UniProtKB/TrEMBL
      Q6IBH6
      Conserved Domains (2) summary
      PRK05431
      Location:109 → 145
      PRK05431; seryl-tRNA synthetase; Provisional
      pfam16906
      Location:8 → 122
      Ribosomal_L26; Ribosomal proteins L26 eukaryotic, L24P archaeal

    2. XM_017009520.2 → XP_016865009.1  ribosomal protein uL24-like isoform X1

      UniProtKB/Swiss-Prot
      B3KY82, D3DQM0, Q9UNX3
      UniProtKB/TrEMBL
      Q6IBH6
      Conserved Domains (2) summary
      PRK05431
      Location:109 → 145
      PRK05431; seryl-tRNA synthetase; Provisional
      pfam16906
      Location:8 → 122
      Ribosomal_L26; Ribosomal proteins L26 eukaryotic, L24P archaeal

    3. XM_017009519.3 → XP_016865008.1  ribosomal protein uL24-like isoform X1

      UniProtKB/Swiss-Prot
      B3KY82, D3DQM0, Q9UNX3
      UniProtKB/TrEMBL
      Q6IBH6
      Conserved Domains (2) summary
      PRK05431
      Location:109 → 145
      PRK05431; seryl-tRNA synthetase; Provisional
      pfam16906
      Location:8 → 122
      Ribosomal_L26; Ribosomal proteins L26 eukaryotic, L24P archaeal

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      173494364..173509843
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054352711.1 → XP_054208686.1  ribosomal protein uL24-like isoform X1

      UniProtKB/Swiss-Prot
      B3KY82, D3DQM0, Q9UNX3

    2. XM_054352712.1 → XP_054208687.1  ribosomal protein uL24-like isoform X1

      UniProtKB/Swiss-Prot
      B3KY82, D3DQM0, Q9UNX3

    3. XM_054352710.1 → XP_054208685.1  ribosomal protein uL24-like isoform X1

      UniProtKB/Swiss-Prot
      B3KY82, D3DQM0, Q9UNX3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UNX3.1 GenPept UniProtKB/Swiss-Prot:Q9UNX3

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