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    WDR64 WD repeat domain 64 [ Homo sapiens (human) ]

    Gene ID: 128025, updated on 27-Nov-2024

    Summary

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    Official Symbol
    WDR64provided by HGNC
    Official Full Name
    WD repeat domain 64provided by HGNC
    Primary source
    HGNC:HGNC:26570
    See related
    Ensembl:ENSG00000162843 AllianceGenome:HGNC:26570
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Biased expression in testis (RPKM 1.6) and placenta (RPKM 0.1) See more
    Orthologs
    mouse all
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    Genomic context

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    See WDR64 in Genome Data Viewer
    Location:
    1q43
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (241652281..241802777)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (241063753..241214784)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (241815583..241966079)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene kynurenine 3-monooxygenase Neighboring gene opsin 3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:241802798-241803368 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:241803369-241803938 Neighboring gene uncharacterized LOC124904603 Neighboring gene CHM like Rab escort protein Neighboring gene CRISPRi-validated cis-regulatory element chr1.12743 Neighboring gene uncharacterized LOC105373231 Neighboring gene ribosomal protein L6 pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Radiation pharmacogenomics: a genome-wide association approach to identify radiation response biomarkers using human lymphoblastoid cell lines. Niu N, et al. Genome Res, 2010 Nov. PMID 20923822, Free PMC Article
    2. Follow-up examination of linkage and association to chromosome 1q43 in multiple sclerosis. McCauley JL, et al. Genes Immun, 2009 Oct. PMID 19626040, Free PMC Article
    3. A genome-wide association study of behavioral disinhibition. McGue M, et al. Behav Genet, 2013 Sep. PMID 23942779, Free PMC Article
    4. TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile. Dendoncker K, et al. Proc Natl Acad Sci U S A, 2019 Jun 25. PMID 31182584, Free PMC Article
    5. Physical and functional interactome atlas of human receptor tyrosine kinases. Salokas K, et al. EMBO Rep, 2022 Jun 7. PMID 35384245, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    2. Observational study of gene-disease association. (HuGE Navigator)
      Title: Follow-up examination of linkage and association to chromosome 1q43 in multiple sclerosis.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association study of behavioral disinhibition.
    EBI GWAS Catalog
    Radiation pharmacogenomics: a genome-wide association approach to identify radiation response biomarkers using human lymphoblastoid cell lines.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ32978

    General protein information

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    Preferred Names
    WD repeat-containing protein 64

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001367482.1 → NP_001354411.1  WD repeat-containing protein 64

      Status: VALIDATED

      Source sequence(s)
      AL365366, BX248405, BX322532
      Consensus CDS
      CCDS91185.1
      UniProtKB/Swiss-Prot
      B1ANS9, B1ANT0, Q7Z573, Q96LY9
      UniProtKB/TrEMBL
      A0A0C4DG52
      Related
      ENSP00000402446.4, ENST00000437684.7

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      241652281..241802777
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011544087.3 → XP_011542389.1  WD repeat-containing protein 64 isoform X3

      Conserved Domains (3) summary
      COG2319
      Location:91 → 538
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:468 → 505
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:284 → 538
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. XM_011544091.2 → XP_011542393.1  WD repeat-containing protein 64 isoform X4

      Conserved Domains (3) summary
      COG2319
      Location:91 → 538
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:468 → 505
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:284 → 538
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. XM_011544092.3 → XP_011542394.1  WD repeat-containing protein 64 isoform X5

      Conserved Domains (3) summary
      COG2319
      Location:91 → 538
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:468 → 505
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:284 → 538
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    4. XM_017000315.2 → XP_016855804.1  WD repeat-containing protein 64 isoform X1

      UniProtKB/Swiss-Prot
      B1ANS9, B1ANT0, Q7Z573, Q96LY9

    5. XM_011544086.4 → XP_011542388.1  WD repeat-containing protein 64 isoform X2

      See identical proteins and their annotated locations for XP_011542388.1

      UniProtKB/Swiss-Prot
      B1ANS9, B1ANT0, Q7Z573, Q96LY9
      Conserved Domains (3) summary
      COG2319
      Location:85 → 545
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:307 → 344
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:123 → 377
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    6. XM_047445900.1 → XP_047301856.1  WD repeat-containing protein 64 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      241063753..241214784
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054334409.1 → XP_054190384.1  WD repeat-containing protein 64 isoform X3

    2. XM_054334410.1 → XP_054190385.1  WD repeat-containing protein 64 isoform X4

    3. XM_054334411.1 → XP_054190386.1  WD repeat-containing protein 64 isoform X5

    4. XM_054334406.1 → XP_054190381.1  WD repeat-containing protein 64 isoform X1

    5. XM_054334408.1 → XP_054190383.1  WD repeat-containing protein 64 isoform X2

    6. XM_054334407.1 → XP_054190382.1  WD repeat-containing protein 64 isoform X2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_144625.4: Suppressed sequence

      Description
      NM_144625.4: This RefSeq was removed because currently there is insufficient support for the transcript and protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B1ANS9.1 GenPept UniProtKB/Swiss-Prot:B1ANS9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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