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    urb2 URB2 ribosome biogenesis homolog [ Danio rerio (zebrafish) ]

    Gene ID: 570267, updated on 2-Nov-2024

    Summary

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    Official Symbol
    urb2provided by ZNC
    Official Full Name
    URB2 ribosome biogenesis homologprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-2621
    See related
    Ensembl:ENSDARG00000003217 AllianceGenome:ZFIN:ZDB-GENE-030131-2621
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fc13e02; wu:fc13e02; si:dkey-162b3.2
    Summary
    Involved in regulation of signal transduction by p53 class mediator. Acts upstream of or within regulation of hematopoietic stem cell differentiation. Predicted to be located in nucleus. Predicted to be active in nucleolus. Is expressed in caudal hematopoietic tissue. Orthologous to human URB2 (URB2 ribosome biogenesis homolog). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See urb2 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (24234330..24262839, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (24103882..24130159, complement)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene piggyBac transposable element derived 5 Neighboring gene UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 Neighboring gene ATP-binding cassette, sub-family B (MDR/TAP), member 10 Neighboring gene actin alpha 1, skeletal muscle b Neighboring gene centriole, cilia and spindle-associated protein b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. mTORC1 mediates the expansion of hematopoietic stem and progenitor cells through ribosome biogenesis protein Urb2 in zebrafish. Huang W, et al. Stem Cell Reports, 2024 Sep 10. PMID 39178846, Free PMC Article
    2. Ribosome biogenesis protein Urb2 regulates hematopoietic stem cells development via P53 pathway in zebrafish. Cai P, et al. Biochem Biophys Res Commun, 2018 Mar 4. PMID 29470984
    3. Genetic compensation triggered by actin mutation prevents the muscle damage caused by loss of actin protein. Sztal TE, et al. PLoS Genet, 2018 Feb. PMID 29420541, Free PMC Article
    4. Mammalian Target of Rapamycin Complex 1 Signaling Is Required for the Dedifferentiation From Biliary Cell to Bipotential Progenitor Cell in Zebrafish Liver Regeneration. He J, et al. Hepatology, 2019 Dec. PMID 31136010
    5. A new evolutionary model for the vertebrate actin family including two novel groups. Witjes L, et al. Mol Phylogenet Evol, 2019 Dec. PMID 31560986

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. mTORC1 mediates the expansion of hematopoietic stem and progenitor cells through ribosome biogenesis protein Urb2 in zebrafish.
      Title: mTORC1 mediates the expansion of hematopoietic stem and progenitor cells through ribosome biogenesis protein Urb2 in zebrafish.
    2. Loss of Urb2 disrupts definitive hematopoiesis in zebrafish.
      Title: Ribosome biogenesis protein Urb2 regulates hematopoietic stem cells development via P53 pathway in zebrafish.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0133

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of hematopoietic stem cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of signal transduction by p53 class mediator IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosome biogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    unhealthy ribosome biogenesis protein 2 homolog
    Names
    URB2 ribosome biogenesis 2 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001123301.2 → NP_001116773.2  unhealthy ribosome biogenesis protein 2 homolog isoform 1

      See identical proteins and their annotated locations for NP_001116773.2

      Status: PROVISIONAL

      Source sequence(s)
      CR762497
      UniProtKB/Swiss-Prot
      B0V0U5
      Related
      ENSDARP00000121235.1, ENSDART00000138747.3
      Conserved Domains (1) summary
      pfam10441
      Location:1291 → 1484
      Urb2; Urb2/Npa2 family

    2. NM_001123393.1 → NP_001116865.1  unhealthy ribosome biogenesis protein 2 homolog isoform 2

      Status: PROVISIONAL

      Source sequence(s)
      CR762497
      UniProtKB/TrEMBL
      A0A8N7UYV9, B0V0U6, F1QES6
      Related
      ENSDARP00000123082.1, ENSDART00000146524.2
      Conserved Domains (1) summary
      pfam10441
      Location:122 → 315
      Urb2; Urb2/Npa2 family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      24234330..24262839 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068212915.1 → XP_068069016.1  unhealthy ribosome biogenesis protein 2 homolog isoform X1

      Related
      ENSDARP00000144441.2, ENSDART00000176800.2

    2. XM_005156878.5 → XP_005156935.1  unhealthy ribosome biogenesis protein 2 homolog isoform X2

      See identical proteins and their annotated locations for XP_005156935.1

      UniProtKB/Swiss-Prot
      B0V0U5
      Conserved Domains (1) summary
      pfam10441
      Location:1291 → 1484
      Urb2; Urb2/Npa2 family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B0V0U5.1 GenPept UniProtKB/Swiss-Prot:B0V0U5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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