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    PPP2R2A protein phosphatase 2 regulatory subunit Balpha [ Homo sapiens (human) ]

    Gene ID: 5520, updated on 3-Nov-2024

    Summary

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    Official Symbol
    PPP2R2Aprovided by HGNC
    Official Full Name
    protein phosphatase 2 regulatory subunit Balphaprovided by HGNC
    Primary source
    HGNC:HGNC:9304
    See related
    Ensembl:ENSG00000221914 MIM:604941; AllianceGenome:HGNC:9304
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    B55A; PR52A; PR55A; B55ALPHA; PR55alpha
    Summary
    The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]
    Expression
    Ubiquitous expression in esophagus (RPKM 15.8), placenta (RPKM 12.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PPP2R2A in Genome Data Viewer
    Location:
    8p21.2
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (26291508..26372680)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (26567415..26649239)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (26149024..26230196)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379336 Neighboring gene MPRA-validated peak6960 silencer Neighboring gene RNA, 5S ribosomal pseudogene 258 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:26008986-26009594 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:26035468-26035634 Neighboring gene MPRA-validated peak6961 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19037 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:26087585-26088201 Neighboring gene matrix metallopeptidase 12 (macrophage elastase) pseudogene Neighboring gene Sharpr-MPRA regulatory region 858 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19038 Neighboring gene Sharpr-MPRA regulatory region 13890 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:26192157-26192656 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:26239047-26240246 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27126 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19039 Neighboring gene Sharpr-MPRA regulatory region 12075 Neighboring gene GATA motif-containing MPRA enhancer 260 Neighboring gene SDA1 domain containing 1 pseudogene 1 Neighboring gene BCL2 interacting protein 3 like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Protein phosphatase 2A regulatory subunit B55α functions in mouse oocyte maturation and early embryonic development. Liang S, et al. Oncotarget, 2017 Apr 18. PMID 28439046, Free PMC Article
    2. Loss of PPP2R2A inhibits homologous recombination DNA repair and predicts tumor sensitivity to PARP inhibition. Kalev P, et al. Cancer Res, 2012 Dec 15. PMID 23087057
    3. Evaluation of PPP2R2A as a prostate cancer susceptibility gene: a comprehensive germline and somatic study. Cheng Y, et al. Cancer Genet, 2011 Jul. PMID 21872824, Free PMC Article
    4. The protein phosphatase 2A regulatory subunit B55α is a modulator of signaling and microRNA expression in acute myeloid leukemia cells. Ruvolo PP, et al. Biochim Biophys Acta, 2014 Sep. PMID 24858343, Free PMC Article
    5. miR-892a regulated PPP2R2A expression and promoted cell proliferation of human colorectal cancer cells. Liang WL, et al. Biomed Pharmacother, 2015 May. PMID 26054685

    See all (241) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FAM122A ensures cell cycle interphase progression and checkpoint control by inhibiting B55alpha/PP2A through helical motifs.
      Title: FAM122A ensures cell cycle interphase progression and checkpoint control by inhibiting B55α/PP2A through helical motifs.
    2. PR55alpha-controlled protein phosphatase 2A inhibits p16 expression and blocks cellular senescence induction by gamma-irradiation.
      Title: PR55α-controlled protein phosphatase 2A inhibits p16 expression and blocks cellular senescence induction by γ-irradiation.
    3. PP2A-B55alpha controls keratinocyte adhesion through dephosphorylation of the Desmoplakin C-terminus.
      Title: PP2A-B55alpha controls keratinocyte adhesion through dephosphorylation of the Desmoplakin C-terminus.
    4. PP2A/B55alpha substrate recruitment as defined by the retinoblastoma-related protein p107.
      Title: PP2A/B55α substrate recruitment as defined by the retinoblastoma-related protein p107.
    5. LncRNA-HCG18 regulates the viability, apoptosis, migration, invasion and epithelial-mesenchymal transition of papillary thyroid cancer cells via regulating the miR-106a-5p/PPP2R2A axis.
      Title: LncRNA-HCG18 regulates the viability, apoptosis, migration, invasion and epithelial-mesenchymal transition of papillary thyroid cancer cells via regulating the miR-106a-5p/PPP2R2A axis.
    6. B55alpha/PP2A Limits Endothelial Cell Apoptosis During Vascular Remodeling: A Complementary Approach To Disrupt Pathological Vessels?
      Title: B55α/PP2A Limits Endothelial Cell Apoptosis During Vascular Remodeling: A Complementary Approach To Disrupt Pathological Vessels?
    7. AMOTL2 inhibits JUN Thr239 dephosphorylation by binding PPP2R2A to suppress the proliferation in non-small cell lung cancer cells.
      Title: AMOTL2 inhibits JUN Thr239 dephosphorylation by binding PPP2R2A to suppress the proliferation in non-small cell lung cancer cells.
    8. microRNA-665 is down-regulated in gastric cancer and inhibits proliferation, invasion, and EMT by targeting PPP2R2A.
      Title: microRNA-665 is down-regulated in gastric cancer and inhibits proliferation, invasion, and EMT by targeting PPP2R2A.
    9. 14-3-3 proteins protect AMPK-phosphorylated ten-eleven translocation-2 (TET2) from PP2A-mediated dephosphorylation.
      Title: 14-3-3 proteins protect AMPK-phosphorylated ten-eleven translocation-2 (TET2) from PP2A-mediated dephosphorylation.
    10. Long noncoding RNA GMAN promotes hepatocellular carcinoma progression by interacting with eIF4B.
      Title: Long noncoding RNA GMAN promotes hepatocellular carcinoma progression by interacting with eIF4B.
    Submit: New GeneRIF Correction See all GeneRIFs (53)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of protein phosphatase 2, regulatory subunit B, alpha (PPP2R2A) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Rev rev HIV-1 Rev interacting protein, protein phosphatase 2, regulatory subunit B, alpha (PPP2R2A), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed
    Tat tat HIV-1 Tat upregulates the total levels of PP2A protein and downregulates the inactive form of phosphorylated PP2A, which leads to inhibit hTERT activity directly or indirectly in CD4+ T cells PubMed
    tat Protein phosphatase-2A (PP2A) and protein phosphatase-1 (PP1) regulate HIV-1 Tat-activated transcription through dephosphorylation of CDK9 PubMed
    tat An increase in the amount of PP2A core enzyme with a concomitant decrease in the amount of PP2A holoenzyme inhibits HIV-1 Tat-stimulated transcription from the HIV-1 LTR promoter, indicating a role for PP2A in the modulation of HIV-1 gene expression PubMed
    Vpr vpr Amino-acid peptide sequence (residues 77-92) of HIV-1 Vpr binds to PP2A1. The sequence from HIV-1 89.6 strain is a cell penetrating and death domain PubMed
    vpr HIV-1 Vpr cell death causing peptide (amino acid residues 71-96) can activate the expression of PP2A when applied extracellularly to CD4+ T cells as well as cause the activation of PP2A from brain, liver, and adipose tissues PubMed
    vpr HIV-1 Vpr was found to upregulate PP2A in fission yeast PubMed
    vpr HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A PubMed
    nucleocapsid gag HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ26613, FLJ41727, MGC52248, DKFZp686N05117

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein phosphatase regulator activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein dephosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein dephosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to morphine IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    part_of protein phosphatase type 2A complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein phosphatase type 2A complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
    Names
    protein phosphatase 2, regulatory subunit B, alpha
    NP_001171062.1
    NP_002708.1
    XP_005273616.1
    XP_011542867.1
    XP_024302954.1
    XP_024302955.1
    XP_047277889.1
    XP_047277890.1
    XP_047277891.1
    XP_047277892.1
    XP_054216733.1
    XP_054216734.1
    XP_054216735.1
    XP_054216736.1
    XP_054216737.1
    XP_054216738.1
    XP_054216739.1
    XP_054216740.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177591.2 → NP_001171062.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform 2

      See identical proteins and their annotated locations for NP_001171062.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' terminal exon and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is longer than isoform 1.
      Source sequence(s)
      AC022911, AI814790, AK303981, BC041071
      Consensus CDS
      CCDS55213.1
      UniProtKB/TrEMBL
      Q56VW8
      Related
      ENSP00000325074.7, ENST00000315985.7
      Conserved Domains (2) summary
      COG5170
      Location:17 → 452
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      sd00039
      Location:41 → 89
      7WD40; WD40 repeat [structural motif]

    2. NM_002717.4 → NP_002708.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform 1

      See identical proteins and their annotated locations for NP_002708.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the shorter isoform (1).
      Source sequence(s)
      AC022911, AI814790, AK314823, BC041071, DB451813
      Consensus CDS
      CCDS34867.1
      UniProtKB/Swiss-Prot
      B2RBU8, B4E1T7, P50409, P63151, Q00007
      UniProtKB/TrEMBL
      A0A140VJT0, Q56VW8
      Related
      ENSP00000370113.3, ENST00000380737.8
      Conserved Domains (2) summary
      COG5170
      Location:7 → 442
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      sd00039
      Location:31 → 79
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      26291508..26372680
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005273559.2 → XP_005273616.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X2

      See identical proteins and their annotated locations for XP_005273616.1

      UniProtKB/TrEMBL
      Q56VW8
      Conserved Domains (2) summary
      COG5170
      Location:7 → 441
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      sd00039
      Location:30 → 78
      7WD40; WD40 repeat [structural motif]

    2. XM_011544565.2 → XP_011542867.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1

      See identical proteins and their annotated locations for XP_011542867.1

      UniProtKB/TrEMBL
      Q56VW8
      Conserved Domains (2) summary
      COG5170
      Location:17 → 451
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      sd00039
      Location:40 → 88
      7WD40; WD40 repeat [structural motif]

    3. XM_047421936.1 → XP_047277892.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X5

    4. XM_024447186.2 → XP_024302954.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X3

      UniProtKB/TrEMBL
      Q56VW8
      Conserved Domains (2) summary
      COG5170
      Location:5 → 422
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      sd00039
      Location:11 → 59
      7WD40; WD40 repeat [structural motif]

    5. XM_024447187.2 → XP_024302955.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X4

      UniProtKB/TrEMBL
      A0A590UJJ1, A0A590UJY3
      Related
      ENSP00000499441.1, ENST00000660435.1
      Conserved Domains (2) summary
      COG5170
      Location:2 → 283
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      sd00039
      Location:21 → 57
      7WD40; WD40 repeat [structural motif]

    6. XM_047421935.1 → XP_047277891.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X4

      UniProtKB/TrEMBL
      A0A590UJJ1

    7. XM_047421933.1 → XP_047277889.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X4

      UniProtKB/TrEMBL
      A0A590UJJ1

    8. XM_047421934.1 → XP_047277890.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X4

      UniProtKB/TrEMBL
      A0A590UJJ1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      26567415..26649239
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054360759.1 → XP_054216734.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X2

    2. XM_054360761.1 → XP_054216736.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X4

      UniProtKB/TrEMBL
      A0A590UJJ1

    3. XM_054360758.1 → XP_054216733.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1

    4. XM_054360765.1 → XP_054216740.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X5

    5. XM_054360764.1 → XP_054216739.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X4

      UniProtKB/TrEMBL
      A0A590UJJ1

    6. XM_054360762.1 → XP_054216737.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X4

      UniProtKB/TrEMBL
      A0A590UJJ1

    7. XM_054360760.1 → XP_054216735.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X3

    8. XM_054360763.1 → XP_054216738.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X4

      UniProtKB/TrEMBL
      A0A590UJJ1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P63151.1 GenPept UniProtKB/Swiss-Prot:P63151

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