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    SPC24 SPC24 component of NDC80 kinetochore complex [ Homo sapiens (human) ]

    Gene ID: 147841, updated on 9-Dec-2024

    Summary

    Official Symbol
    SPC24provided by HGNC
    Official Full Name
    SPC24 component of NDC80 kinetochore complexprovided by HGNC
    Primary source
    HGNC:HGNC:26913
    See related
    Ensembl:ENSG00000161888 MIM:609394; AllianceGenome:HGNC:26913
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SPBC24
    Summary
    Predicted to contribute to microtubule binding activity. Involved in attachment of spindle microtubules to kinetochore. Located in nucleolus and nucleoplasm. Part of Ndc80 complex. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in bone marrow (RPKM 2.7), lymph node (RPKM 1.3) and 16 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SPC24 in Genome Data Viewer
    Location:
    19p13.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (11145493..11155782, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (11272490..11282805, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (11256169..11266458, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:11200393-11200988 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:11200989-11201582 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr19:11202176-11203375 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:11205098-11206297 Neighboring gene LDLR antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:11212882-11213520 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11215560-11216060 Neighboring gene low density lipoprotein receptor Neighboring gene microRNA 6886 Neighboring gene VISTA enhancer hs1754 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10101 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11276922-11277422 Neighboring gene KN motif and ankyrin repeat domains 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11300095-11300596 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11300597-11301096 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10102 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10103 Neighboring gene DOCK6 antisense RNA 1 Neighboring gene dedicator of cytokinesis 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome wide association study identifies common variants associated with lipid levels in the Chinese population.
    EBI GWAS Catalog
    Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ90806

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    contributes_to microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in attachment of spindle microtubules to kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chromosome segregation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in mitotic spindle assembly checkpoint signaling NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of Ndc80 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of Ndc80 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of Ndc80 complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in kinetochore NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    part_of outer kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    kinetochore protein Spc24
    Names
    SPC24, NDC80 kinetochore complex component, homolog
    hSpc24
    spindle pole body component 24 homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001317031.2NP_001303960.1  kinetochore protein Spc24 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC011485
      UniProtKB/TrEMBL
      K7EJV2
      Related
      ENSP00000465335.1, ENST00000592967.5
      Conserved Domains (1) summary
      pfam08286
      Location:83146
      Spc24; Spc24 subunit of Ndc80
    2. NM_001317032.2NP_001303961.1  kinetochore protein Spc24 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC011485
      UniProtKB/TrEMBL
      K7EJH0
      Related
      ENSP00000465167.1, ENST00000585486.1
      Conserved Domains (1) summary
      pfam08286
      Location:83162
      Spc24; Spc24 subunit of Ndc80
    3. NM_001394314.1NP_001381243.1  kinetochore protein Spc24 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC011485
      UniProtKB/TrEMBL
      K7EMX1
      Related
      ENSP00000466688.1, ENST00000591396.5
      Conserved Domains (1) summary
      COG1269
      Location:4119
      NtpI; Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]
    4. NM_001394315.1NP_001381244.1  kinetochore protein Spc24 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC011485
      UniProtKB/TrEMBL
      K7EJH0
      Conserved Domains (1) summary
      COG1269
      Location:4119
      NtpI; Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]
    5. NM_001394316.1NP_001381245.1  kinetochore protein Spc24 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC011485
      UniProtKB/TrEMBL
      K7EJH0
      Conserved Domains (1) summary
      COG1269
      Location:4119
      NtpI; Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]
    6. NM_001394317.1NP_001381246.1  kinetochore protein Spc24 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC011485
      Conserved Domains (1) summary
      COG1269
      Location:4119
      NtpI; Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]
    7. NM_001394318.1NP_001381247.1  kinetochore protein Spc24 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC011485
      Conserved Domains (1) summary
      COG1269
      Location:4119
      NtpI; Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]
    8. NM_182513.4NP_872319.1  kinetochore protein Spc24 isoform 1

      See identical proteins and their annotated locations for NP_872319.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC011485
      Consensus CDS
      CCDS45974.1
      UniProtKB/Swiss-Prot
      B4DZZ7, C9JGC4, Q8NBT2
      UniProtKB/TrEMBL
      K7EJH0
      Related
      ENSP00000465075.1, ENST00000592540.6
      Conserved Domains (2) summary
      COG1269
      Location:4119
      NtpI; Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]
      pfam08286
      Location:83192
      Spc24; Spc24 subunit of Ndc80

    RNA

    1. NR_172094.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC011485

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      11145493..11155782 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005259753.4XP_005259810.1  kinetochore protein Spc24 isoform X1

      See identical proteins and their annotated locations for XP_005259810.1

      UniProtKB/Swiss-Prot
      Q8NBT2
      Conserved Domains (1) summary
      pfam08286
      Location:50146
      Spc24; Spc24 subunit of Ndc80

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      11272490..11282805 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054319887.1XP_054175862.1  kinetochore protein Spc24 isoform X1