U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ZNF484 zinc finger protein 484 [ Homo sapiens (human) ]

    Gene ID: 83744, updated on 10-Dec-2024

    Summary

    Official Symbol
    ZNF484provided by HGNC
    Official Full Name
    zinc finger protein 484provided by HGNC
    Primary source
    HGNC:HGNC:23385
    See related
    Ensembl:ENSG00000127081 AllianceGenome:HGNC:23385
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BA526D8.4
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis (RPKM 2.5), brain (RPKM 1.4) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ZNF484 in Genome Data Viewer
    Location:
    9q22.31
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (92844182..92878038, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (105004630..105044436, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (95606464..95640320, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 19, pseudogene Neighboring gene zinc finger protein 41 pseudogene Neighboring gene eukaryotic translation elongation factor 1 delta pseudogene 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:95640075-95640610 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:95644899-95645416 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:95645417-95645933 Neighboring gene SPATA31 subfamily B member 2, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:95653403-95653903 Neighboring gene sorting nexin 18 pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    zinc finger protein 484
    Names
    KRAB box containing C2H2 type zinc finger bA526D8.4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007101.4NP_001007102.1  zinc finger protein 484 isoform b

      See identical proteins and their annotated locations for NP_001007102.1

      Status: VALIDATED

      Source sequence(s)
      AL136981
      Consensus CDS
      CCDS35067.1
      UniProtKB/Swiss-Prot
      Q5JVG2
      Related
      ENSP00000364646.3, ENST00000332591.6
      Conserved Domains (3) summary
      COG5048
      Location:374775
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:658678
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl02581
      Location:131
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    2. NM_001261458.3NP_001248387.1  zinc finger protein 484 isoform c

      See identical proteins and their annotated locations for NP_001248387.1

      Status: VALIDATED

      Source sequence(s)
      AL136981
      Consensus CDS
      CCDS59136.1
      UniProtKB/Swiss-Prot
      Q5JVG2
      Related
      ENSP00000378881.3, ENST00000395505.6
      Conserved Domains (6) summary
      smart00349
      Location:1069
      KRAB; krueppel associated box
      COG5048
      Location:412813
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:696716
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:722744
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:1049
      KRAB; KRAB box
      pfam13465
      Location:736759
      zf-H2C2_2; Zinc-finger double domain
    3. NM_001261459.3NP_001248388.1  zinc finger protein 484 isoform b

      See identical proteins and their annotated locations for NP_001248388.1

      Status: VALIDATED

      Source sequence(s)
      AL136981
      Consensus CDS
      CCDS35067.1
      UniProtKB/Swiss-Prot
      Q5JVG2
      Related
      ENSP00000378882.4, ENST00000395506.7
      Conserved Domains (3) summary
      COG5048
      Location:374775
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:658678
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl02581
      Location:131
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    4. NM_001261460.3NP_001248389.1  zinc finger protein 484 isoform b

      See identical proteins and their annotated locations for NP_001248389.1

      Status: VALIDATED

      Source sequence(s)
      AL136981
      Consensus CDS
      CCDS35067.1
      UniProtKB/Swiss-Prot
      Q5JVG2
      Conserved Domains (3) summary
      COG5048
      Location:374775
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:658678
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl02581
      Location:131
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    5. NM_001354536.2NP_001341465.1  zinc finger protein 484 isoform b

      Status: VALIDATED

      Source sequence(s)
      AL136981
      Consensus CDS
      CCDS35067.1
      Conserved Domains (3) summary
      COG5048
      Location:374775
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:658678
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl02581
      Location:131
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    6. NM_001354537.2NP_001341466.1  zinc finger protein 484 isoform d

      Status: VALIDATED

      Source sequence(s)
      AL136981
      Conserved Domains (4) summary
      smart00349
      Location:2584
      KRAB; krueppel associated box
      COG5048
      Location:427828
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:711731
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:387412
      zf-H2C2_2; Zinc-finger double domain
    7. NM_031486.4NP_113674.1  zinc finger protein 484 isoform a

      See identical proteins and their annotated locations for NP_113674.1

      Status: VALIDATED

      Source sequence(s)
      AL136981
      Consensus CDS
      CCDS35066.1
      UniProtKB/Swiss-Prot
      B1AL89, B4DRI2, Q5JVG2
      Related
      ENSP00000364645.3, ENST00000375495.8
      Conserved Domains (3) summary
      smart00349
      Location:867
      KRAB; krueppel associated box
      COG5048
      Location:410811
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:694714
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      92844182..92878038 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006717299.4XP_006717362.1  zinc finger protein 484 isoform X5

      See identical proteins and their annotated locations for XP_006717362.1

      Conserved Domains (5) summary
      smart00349
      Location:131
      KRAB; krueppel associated box
      COG5048
      Location:389790
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:673693
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:699721
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:713736
      zf-H2C2_2; Zinc-finger double domain
    2. XM_011519075.3XP_011517377.1  zinc finger protein 484 isoform X4

      Conserved Domains (6) summary
      smart00349
      Location:867
      KRAB; krueppel associated box
      COG5048
      Location:425826
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:709729
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:735757
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:847
      KRAB; KRAB box
      pfam13465
      Location:749772
      zf-H2C2_2; Zinc-finger double domain
    3. XM_017015178.2XP_016870667.1  zinc finger protein 484 isoform X5

      Conserved Domains (5) summary
      smart00349
      Location:131
      KRAB; krueppel associated box
      COG5048
      Location:389790
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:673693
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:699721
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:713736
      zf-H2C2_2; Zinc-finger double domain
    4. XM_011519074.3XP_011517376.1  zinc finger protein 484 isoform X3

      Conserved Domains (6) summary
      smart00349
      Location:1069
      KRAB; krueppel associated box
      COG5048
      Location:427828
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:711731
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:737759
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:1049
      KRAB; KRAB box
      pfam13465
      Location:751774
      zf-H2C2_2; Zinc-finger double domain
    5. XM_011519073.3XP_011517375.1  zinc finger protein 484 isoform X1

      Conserved Domains (6) summary
      smart00349
      Location:2584
      KRAB; krueppel associated box
      COG5048
      Location:442843
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:726746
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:752774
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:2564
      KRAB; KRAB box
      pfam13465
      Location:766789
      zf-H2C2_2; Zinc-finger double domain
    6. XM_017015179.2XP_016870668.1  zinc finger protein 484 isoform X5

      Conserved Domains (5) summary
      smart00349
      Location:131
      KRAB; krueppel associated box
      COG5048
      Location:389790
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:673693
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:699721
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:713736
      zf-H2C2_2; Zinc-finger double domain
    7. XM_047423945.1XP_047279901.1  zinc finger protein 484 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      105004630..105044436 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054363927.1XP_054219902.1  zinc finger protein 484 isoform X2

    2. XM_054363930.1XP_054219905.1  zinc finger protein 484 isoform X5

    3. XM_054363929.1XP_054219904.1  zinc finger protein 484 isoform X4

    4. XM_054363931.1XP_054219906.1  zinc finger protein 484 isoform X5

    5. XM_054363928.1XP_054219903.1  zinc finger protein 484 isoform X3

    6. XM_054363926.1XP_054219901.1  zinc finger protein 484 isoform X1

    7. XM_054363932.1XP_054219907.1  zinc finger protein 484 isoform X5