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    ZBTB11 zinc finger and BTB domain containing 11 [ Homo sapiens (human) ]

    Gene ID: 27107, updated on 3-Dec-2024

    Summary

    Official Symbol
    ZBTB11provided by HGNC
    Official Full Name
    zinc finger and BTB domain containing 11provided by HGNC
    Primary source
    HGNC:HGNC:16740
    See related
    Ensembl:ENSG00000066422 MIM:618181; AllianceGenome:HGNC:16740
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MRT69; ZNF913; ZNF-U69274
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Located in nucleoplasm. Implicated in autosomal recessive intellectual developmental disorder 69. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bone marrow (RPKM 8.1), testis (RPKM 5.9) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See ZBTB11 in Genome Data Viewer
    Location:
    3q12.3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (101648889..101677132, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (104361496..104389742, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (101367733..101395976, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L32 pseudogene 7 Neighboring gene RNA, U6 small nuclear 1256, pseudogene Neighboring gene RNY1 pseudogene 12 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:101392720-101393220 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:101395114-101395668 Neighboring gene endogenous retrovirus group K member 5 Gag polyprotein Neighboring gene ZBTB11 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20172 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20173 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:101405139-101406338 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:101406769-101407322 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:101407323-101407876 Neighboring gene ribosomal protein L24 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr3:101418343-101419102 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:101419863-101420622 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:101420623-101421381 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr3:101421445-101422644 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:101422701-101423652 Neighboring gene uncharacterized LOC124909402

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ13426, MGC133303

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    zinc finger and BTB domain-containing protein 11

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014415.4NP_055230.2  zinc finger and BTB domain-containing protein 11

      See identical proteins and their annotated locations for NP_055230.2

      Status: VALIDATED

      Source sequence(s)
      AB208862, AC084198, AI636025, AK312859, BC028062, DA907277
      Consensus CDS
      CCDS2943.1
      UniProtKB/Swiss-Prot
      O95625, Q2NKP9
      UniProtKB/TrEMBL
      A0A994J7A5
      Related
      ENSP00000326200.4, ENST00000312938.5
      Conserved Domains (4) summary
      smart00225
      Location:215306
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:681701
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:204305
      BTB; BTB/POZ domain
      pfam13465
      Location:900923
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      101648889..101677132 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011512689.3XP_011510991.1  zinc finger and BTB domain-containing protein 11 isoform X1

      UniProtKB/TrEMBL
      A0A8I5KRR0
      Related
      ENSP00000510736.1, ENST00000688910.1
      Conserved Domains (4) summary
      smart00225
      Location:150241
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:616636
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:139240
      BTB; BTB/POZ domain
      pfam13465
      Location:835858
      zf-H2C2_2; Zinc-finger double domain
    2. XM_011512690.3XP_011510992.1  zinc finger and BTB domain-containing protein 11 isoform X2

      UniProtKB/TrEMBL
      Q59H97
      Conserved Domains (2) summary
      sd00017
      Location:397417
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:616639
      zf-H2C2_2; Zinc-finger double domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      104361496..104389742 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054346169.1XP_054202144.1  zinc finger and BTB domain-containing protein 11 isoform X1

      UniProtKB/TrEMBL
      A0A8I5KRR0
    2. XM_054346170.1XP_054202145.1  zinc finger and BTB domain-containing protein 11 isoform X2

      UniProtKB/TrEMBL
      Q59H97