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    ADD1 adducin 1 [ Homo sapiens (human) ]

    Gene ID: 118, updated on 3-Dec-2024

    Summary

    Official Symbol
    ADD1provided by HGNC
    Official Full Name
    adducin 1provided by HGNC
    Primary source
    HGNC:HGNC:243
    See related
    Ensembl:ENSG00000087274 MIM:102680; AllianceGenome:HGNC:243
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ADDA
    Summary
    Adducins are a family of cytoskeletal proteins encoded by three genes (alpha, beta, and gamma). Adducin acts as a heterodimer of the related alpha, beta, or gamma subunits. The protein encoded by this gene represents the alpha subunit. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. [provided by RefSeq, Aug 2017]
    Expression
    Ubiquitous expression in brain (RPKM 57.3), ovary (RPKM 51.1) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ADD1 in Genome Data Viewer
    Location:
    4p16.3
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (2843844..2930062)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (2842299..2928525)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (2845571..2931789)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102723763 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:2763311-2764135 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:2764939-2765507 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15181 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21183 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21184 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21185 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:2788339-2788973 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21186 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:2789609-2790243 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15182 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21188 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21189 Neighboring gene SH3 domain binding protein 2 Neighboring gene nonconserved acetylation island sequence 125 enhancer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21191 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15183 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15184 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15185 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15186 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:2821815-2822316 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:2827676-2828562 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:2828563-2829448 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21192 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21193 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:2838931-2839928 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21194 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:2844343-2844854 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15187 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15188 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15189 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15190 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21195 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21196 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15191 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21197 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:2863877-2864589 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:2864590-2865301 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:2876343-2876870 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:2876871-2877396 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21198 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:2923771-2924668 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:2924669-2925564 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:2925565-2926460 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:2927877-2928392 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21199 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21200 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21201 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21202 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:2935265-2936132 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15193 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15194 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:2937390-2938589 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21204 Neighboring gene NOP14 antisense RNA 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:2948362-2949561 Neighboring gene major facilitator superfamily domain containing 10 Neighboring gene NOP14 nucleolar protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC3339, MGC44427

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables actin binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables actin filament binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cadherin binding HDA PubMed 
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein dimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables spectrin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of F-actin capping protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in adherens junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in focal adhesion HDA PubMed 
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    is_active_in postsynaptic density IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    alpha-adducin
    Names
    adducin 1 (alpha)
    alpha-adducin 1
    erythrocyte adducin alpha subunit

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012037.1 RefSeqGene

      Range
      4988..91206
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001119.5NP_001110.2  alpha-adducin isoform a

      See identical proteins and their annotated locations for NP_001110.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) utilizes an in-frame alternate splice site in the coding region, compared to variant 2. This results in a shorter protein (isoform a), compared to isoform b. Variants 1, 6, and 7 all encode the same isoform (a).
      Source sequence(s)
      AL121750, BI460192, CR995783, CX783962, X58141
      Consensus CDS
      CCDS43205.1
      UniProtKB/Swiss-Prot
      A2A3N8, A2A3P0, B4DI79, D3DVR3, D3DVR4, D3DVR5, P35611, Q13734, Q14729, Q16156, Q86XM2, Q9UJB6
      UniProtKB/TrEMBL
      E7ENY0
      Related
      ENSP00000381197.1, ENST00000398129.5
      Conserved Domains (2) summary
      cl00214
      Location:145391
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
      cl25756
      Location:584702
      BASP1; Brain acid soluble protein 1 (BASP1 protein)
    2. NM_001286645.2NP_001273574.1  alpha-adducin isoform e

      See identical proteins and their annotated locations for NP_001273574.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and contains two additional alternate exons compared to variant 1. The resulting isoform (e) has an alternate in-frame segment and a shorter and distinct C-terminus compared to isoform a. Variants 5 and 11 both encode the same isoform (e).
      Source sequence(s)
      BC042998, BU729599
      Consensus CDS
      CCDS75094.1
      UniProtKB/TrEMBL
      E7ENY0
      Related
      ENSP00000348100.3, ENST00000355842.7
      Conserved Domains (1) summary
      cl00214
      Location:145391
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
    3. NM_001354754.2NP_001341683.1  alpha-adducin isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), as well as variants 1 and 7, encodes isoform a.
      Source sequence(s)
      AL121750, AL390065, BX465861
      Consensus CDS
      CCDS43205.1
      UniProtKB/Swiss-Prot
      A2A3N8, A2A3P0, B4DI79, D3DVR3, D3DVR4, D3DVR5, P35611, Q13734, Q14729, Q16156, Q86XM2, Q9UJB6
      UniProtKB/TrEMBL
      E7ENY0
      Conserved Domains (2) summary
      cl00214
      Location:145391
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
      cl25756
      Location:584702
      BASP1; Brain acid soluble protein 1 (BASP1 protein)
    4. NM_001354755.2NP_001341684.1  alpha-adducin isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7), as well as variants 1 and 6, encodes isoform a.
      Source sequence(s)
      AL121750, AL390065, BX465861
      Consensus CDS
      CCDS43205.1
      UniProtKB/Swiss-Prot
      A2A3N8, A2A3P0, B4DI79, D3DVR3, D3DVR4, D3DVR5, P35611, Q13734, Q14729, Q16156, Q86XM2, Q9UJB6
      UniProtKB/TrEMBL
      E7ENY0
      Conserved Domains (2) summary
      cl00214
      Location:145391
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
      cl25756
      Location:584702
      BASP1; Brain acid soluble protein 1 (BASP1 protein)
    5. NM_001354756.2NP_001341685.1  alpha-adducin isoform f

      Status: REVIEWED

      Source sequence(s)
      AL121750, AL390065, BX465861
      UniProtKB/TrEMBL
      E7ENY0
      Conserved Domains (2) summary
      cl00214
      Location:145391
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
      cl27087
      Location:624725
      SPOR; Sporulation related domain
    6. NM_001354757.2NP_001341686.1  alpha-adducin isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9), as well as variants 3 and 10, encodes isoform c.
      Source sequence(s)
      AL121750, AL390065, BX465861
      Consensus CDS
      CCDS93468.1
      UniProtKB/TrEMBL
      E7ENY0
      Conserved Domains (1) summary
      cl00214
      Location:145391
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
    7. NM_001354758.2NP_001341687.1  alpha-adducin isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10), as well as variants 3 and 9, encodes isoform c.
      Source sequence(s)
      AL121750, AL390065, BX465861
      Consensus CDS
      CCDS93468.1
      UniProtKB/TrEMBL
      E7ENY0
      Related
      ENSP00000498269.1, ENST00000651918.1
      Conserved Domains (1) summary
      cl00214
      Location:145391
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
    8. NM_001354759.2NP_001341688.1  alpha-adducin isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11), as well as variant 5, encodes isoform e.
      Source sequence(s)
      AL121750, AL390065, BX465861
      Consensus CDS
      CCDS75094.1
      UniProtKB/TrEMBL
      E7ENY0
      Conserved Domains (1) summary
      cl00214
      Location:145391
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
    9. NM_001354761.2NP_001341690.1  alpha-adducin isoform g

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12) encodes the longest isoform (g).
      Source sequence(s)
      AL121750, AL390065, BX465861
      Consensus CDS
      CCDS93469.1
      UniProtKB/TrEMBL
      A0A804HL01, E7ENY0
      Related
      ENSP00000508142.1, ENST00000683351.1
      Conserved Domains (2) summary
      cl00214
      Location:145391
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
      cl25756
      Location:646764
      BASP1; Brain acid soluble protein 1 (BASP1 protein)
    10. NM_001354762.2NP_001341691.1  alpha-adducin isoform h

      Status: REVIEWED

      Source sequence(s)
      AL121750, AL390065, BX465861
      UniProtKB/TrEMBL
      E7ENY0
      Conserved Domains (1) summary
      cl00214
      Location:145391
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
    11. NM_014189.4NP_054908.2  alpha-adducin isoform b

      See identical proteins and their annotated locations for NP_054908.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) encodes isoform b.
      Source sequence(s)
      AL121750, BI460192, CA391117, CR995783, CX783962, X58141
      Consensus CDS
      CCDS3363.1
      UniProtKB/TrEMBL
      E7ENY0
      Related
      ENSP00000264758.6, ENST00000264758.11
      Conserved Domains (2) summary
      pfam05466
      Location:615733
      BASP1; Brain acid soluble protein 1 (BASP1 protein)
      cl00214
      Location:145391
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
    12. NM_014190.4NP_054909.2  alpha-adducin isoform c

      See identical proteins and their annotated locations for NP_054909.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) includes an additional exon in the 3' coding region, which results in a frameshift, compared to variant 2. The encoded protein (isoform c) contains an early stop codon and shorter C-terminus, compared to isoform b. Variants 3, 9, and 10 all encode the same isoform (c).
      Source sequence(s)
      AL121750, BC042998, BI460192, BU729599, CR995783, X58141
      Consensus CDS
      CCDS93468.1
      UniProtKB/TrEMBL
      E7ENY0
      Related
      ENSP00000421907.2, ENST00000513328.6
      Conserved Domains (1) summary
      cl00214
      Location:145391
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
    13. NM_176801.3NP_789771.1  alpha-adducin isoform d

      See identical proteins and their annotated locations for NP_789771.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) utilizes an alternate splice site and includes an additional exon in the coding region, which results in a frameshift, compared to variant 2. The encoded protein (isoform d) contains an early stop codon and shorter C-terminus, compared to isoform b.
      Source sequence(s)
      AL121750, BC042998, BI460192, BU729599, CA391117, CR995783, X58141
      Consensus CDS
      CCDS3364.1
      UniProtKB/TrEMBL
      E7ENY0
      Related
      ENSP00000381193.1, ENST00000398125.5
      Conserved Domains (1) summary
      cl00214
      Location:145391
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      2843844..2930062
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047449580.1XP_047305536.1  alpha-adducin isoform X1

      UniProtKB/TrEMBL
      A0A804HL01, E7ENY0
    2. XM_047449581.1XP_047305537.1  alpha-adducin isoform X1

      UniProtKB/TrEMBL
      A0A804HL01, E7ENY0
    3. XM_047449579.1XP_047305535.1  alpha-adducin isoform X1

      UniProtKB/TrEMBL
      A0A804HL01, E7ENY0
    4. XM_047449582.1XP_047305538.1  alpha-adducin isoform X3

      UniProtKB/TrEMBL
      E7ENY0
    5. XM_017007703.2XP_016863192.1  alpha-adducin isoform X1

      UniProtKB/TrEMBL
      A0A804HL01, E7ENY0
      Conserved Domains (2) summary
      cl00214
      Location:145391
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
      cl25756
      Location:646764
      BASP1; Brain acid soluble protein 1 (BASP1 protein)
    6. XM_005247934.3XP_005247991.1  alpha-adducin isoform X1

      See identical proteins and their annotated locations for XP_005247991.1

      UniProtKB/TrEMBL
      A0A804HL01, E7ENY0
      Conserved Domains (2) summary
      cl00214
      Location:145391
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
      cl25756
      Location:646764
      BASP1; Brain acid soluble protein 1 (BASP1 protein)
    7. XM_024453887.2XP_024309655.1  alpha-adducin isoform X5

      UniProtKB/TrEMBL
      E7ENY0
      Conserved Domains (1) summary
      cl00214
      Location:145391
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
    8. XM_017007704.2XP_016863193.1  alpha-adducin isoform X2

      UniProtKB/TrEMBL
      E7ENY0
      Conserved Domains (2) summary
      pfam05466
      Location:615733
      BASP1; Brain acid soluble protein 1 (BASP1 protein)
      cl00214
      Location:145391
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
    9. XM_017007705.2XP_016863194.1  alpha-adducin isoform X3

      UniProtKB/TrEMBL
      E7ENY0
      Conserved Domains (2) summary
      cl00214
      Location:145391
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
      cl27087
      Location:624725
      SPOR; Sporulation related domain
    10. XM_017007709.3XP_016863198.1  alpha-adducin isoform X6

      UniProtKB/TrEMBL
      E7ENY0
      Conserved Domains (1) summary
      cl00214
      Location:145391
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
    11. XM_017007706.3XP_016863195.1  alpha-adducin isoform X4

      UniProtKB/Swiss-Prot
      A2A3N8, A2A3P0, B4DI79, D3DVR3, D3DVR4, D3DVR5, P35611, Q13734, Q14729, Q16156, Q86XM2, Q9UJB6
      UniProtKB/TrEMBL
      E7ENY0
      Conserved Domains (2) summary
      cl00214
      Location:145391
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
      cl25756
      Location:584702
      BASP1; Brain acid soluble protein 1 (BASP1 protein)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      2842299..2928525
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054348867.1XP_054204842.1  alpha-adducin isoform X1

      UniProtKB/TrEMBL
      A0A804HL01, E7ENY0
    2. XM_054348868.1XP_054204843.1  alpha-adducin isoform X1

      UniProtKB/TrEMBL
      A0A804HL01, E7ENY0
    3. XM_054348865.1XP_054204840.1  alpha-adducin isoform X1

      UniProtKB/TrEMBL
      A0A804HL01, E7ENY0
    4. XM_054348871.1XP_054204846.1  alpha-adducin isoform X3

      UniProtKB/TrEMBL
      E7ENY0
    5. XM_054348866.1XP_054204841.1  alpha-adducin isoform X1

      UniProtKB/TrEMBL
      A0A804HL01, E7ENY0
    6. XM_054348864.1XP_054204839.1  alpha-adducin isoform X1

      UniProtKB/TrEMBL
      A0A804HL01, E7ENY0
    7. XM_054348873.1XP_054204848.1  alpha-adducin isoform X5

      UniProtKB/TrEMBL
      E7ENY0
    8. XM_054348869.1XP_054204844.1  alpha-adducin isoform X2

      UniProtKB/TrEMBL
      E7ENY0
    9. XM_054348870.1XP_054204845.1  alpha-adducin isoform X3

      UniProtKB/TrEMBL
      E7ENY0
    10. XM_054348874.1XP_054204849.1  alpha-adducin isoform X6

      UniProtKB/TrEMBL
      E7ENY0
    11. XM_054348872.1XP_054204847.1  alpha-adducin isoform X4

      UniProtKB/Swiss-Prot
      A2A3N8, A2A3P0, B4DI79, D3DVR3, D3DVR4, D3DVR5, P35611, Q13734, Q14729, Q16156, Q86XM2, Q9UJB6
      UniProtKB/TrEMBL
      E7ENY0