U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ZNF574 zinc finger protein 574 [ Homo sapiens (human) ]

    Gene ID: 64763, updated on 28-Oct-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ZNF574provided by HGNC
    Official Full Name
    zinc finger protein 574provided by HGNC
    Primary source
    HGNC:HGNC:26166
    See related
    Ensembl:ENSG00000105732 AllianceGenome:HGNC:26166
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FP972
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in testis (RPKM 9.8), ovary (RPKM 4.8) and 25 other tissues See more
    Orthologs
    mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ZNF574 in Genome Data Viewer
    Location:
    19q13.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (42068477..42081552)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (44887841..44900921)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (42572629..42585704)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10679 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10680 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14695 Neighboring gene Rab acceptor 1 Neighboring gene ATPase Na+/K+ transporting subunit alpha 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10681 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10682 Neighboring gene glutamate ionotropic receptor kainate type subunit 5 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:42536134-42536906 Neighboring gene Sharpr-MPRA regulatory regions 411/7488 and 4104 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:42539441-42539940 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14697 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14698 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14699 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10683 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10684 Neighboring gene POU class 2 homeobox 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14700 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10685 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14701 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10686 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14702 Neighboring gene Sharpr-MPRA regulatory region 1615 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:42653684-42654184 Neighboring gene microRNA 4323 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:42654185-42654685 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:42659146-42659674 Neighboring gene long non-coding regulator of POU2F2 Neighboring gene POU2F2 antisense RNA 2

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. ZNF574 Promotes Ovarian Cancer Cell Proliferation and Migration through Regulating AKT and AMPK Signaling Pathways. Zhang J, et al. Ann Clin Lab Sci, 2022 Jul. PMID 36197766
    2. A non-proteolytic role for ubiquitin in deadenylation of MHC-I mRNA by the RNA-binding E3-ligase MEX-3C. Cano F, et al. Nat Commun, 2015 Oct 16. PMID 26471122, Free PMC Article
    3. Multidimensional Proteomics Reveals a Role of UHRF2 in the Regulation of Epithelial-Mesenchymal Transition (EMT). Lai M, et al. Mol Cell Proteomics, 2016 Jul. PMID 27114453, Free PMC Article
    4. UBE2O and USP7 co-regulate RECQL4 ubiquitinylation and homologous recombination-mediated DNA repair. Huang Q, et al. FASEB J, 2022 Jan. PMID 34921745
    5. Comparative analysis of virus-host interactomes with a mammalian high-throughput protein complementation assay based on Gaussia princeps luciferase. Neveu G, et al. Methods, 2012 Dec. PMID 22898364, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZNF574 Promotes Ovarian Cancer Cell Proliferation and Migration through Regulating AKT and AMPK Signaling Pathways.
      Title: ZNF574 Promotes Ovarian Cancer Cell Proliferation and Migration through Regulating AKT and AMPK Signaling Pathways.
    Submit: New GeneRIF Correction

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • FLJ22059

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    zinc finger protein 574

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330519.2 → NP_001317448.1  zinc finger protein 574 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AF447880, AK131369
      Consensus CDS
      CCDS82356.1
      UniProtKB/TrEMBL
      A0A0C4DFM2
      Related
      ENSP00000222339.6, ENST00000222339.7

    2. NM_022752.6 → NP_073589.4  zinc finger protein 574 isoform 1

      See identical proteins and their annotated locations for NP_073589.4

      Status: VALIDATED

      Source sequence(s)
      AF447880, BC001184, DA404303
      Consensus CDS
      CCDS12596.1
      UniProtKB/Swiss-Prot
      Q6IPE0, Q6ZN10, Q6ZN55, Q7L5Z5, Q8NCE3, Q9H6N0
      Related
      ENSP00000351939.3, ENST00000359044.5
      Conserved Domains (4) summary
      cd11674
      Location:437 → 491
      lambda-1; inner capsid protein lambda-1 or VP3
      COG5048
      Location:495 → 848
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:497 → 517
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam15909
      Location:311 → 390
      zf-C2H2_8; C2H2-type zinc ribbon

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      42068477..42081552
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011527228.4 → XP_011525530.1  zinc finger protein 574 isoform X1

      See identical proteins and their annotated locations for XP_011525530.1

      UniProtKB/Swiss-Prot
      Q6IPE0, Q6ZN10, Q6ZN55, Q7L5Z5, Q8NCE3, Q9H6N0
      Conserved Domains (4) summary
      cd11674
      Location:437 → 491
      lambda-1; inner capsid protein lambda-1 or VP3
      COG5048
      Location:495 → 848
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:497 → 517
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam15909
      Location:311 → 390
      zf-C2H2_8; C2H2-type zinc ribbon

    2. XM_011527230.4 → XP_011525532.1  zinc finger protein 574 isoform X1

      See identical proteins and their annotated locations for XP_011525532.1

      UniProtKB/Swiss-Prot
      Q6IPE0, Q6ZN10, Q6ZN55, Q7L5Z5, Q8NCE3, Q9H6N0
      Related
      ENSP00000469029.1, ENST00000600245.1
      Conserved Domains (4) summary
      cd11674
      Location:437 → 491
      lambda-1; inner capsid protein lambda-1 or VP3
      COG5048
      Location:495 → 848
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:497 → 517
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam15909
      Location:311 → 390
      zf-C2H2_8; C2H2-type zinc ribbon

    3. XM_011527229.4 → XP_011525531.1  zinc finger protein 574 isoform X1

      See identical proteins and their annotated locations for XP_011525531.1

      UniProtKB/Swiss-Prot
      Q6IPE0, Q6ZN10, Q6ZN55, Q7L5Z5, Q8NCE3, Q9H6N0
      Conserved Domains (4) summary
      cd11674
      Location:437 → 491
      lambda-1; inner capsid protein lambda-1 or VP3
      COG5048
      Location:495 → 848
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:497 → 517
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam15909
      Location:311 → 390
      zf-C2H2_8; C2H2-type zinc ribbon

    4. XM_005259159.4 → XP_005259216.1  zinc finger protein 574 isoform X1

      See identical proteins and their annotated locations for XP_005259216.1

      UniProtKB/Swiss-Prot
      Q6IPE0, Q6ZN10, Q6ZN55, Q7L5Z5, Q8NCE3, Q9H6N0
      Conserved Domains (4) summary
      cd11674
      Location:437 → 491
      lambda-1; inner capsid protein lambda-1 or VP3
      COG5048
      Location:495 → 848
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:497 → 517
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam15909
      Location:311 → 390
      zf-C2H2_8; C2H2-type zinc ribbon

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      44887841..44900921
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321781.1 → XP_054177756.1  zinc finger protein 574 isoform X1

      UniProtKB/Swiss-Prot
      Q6IPE0, Q6ZN10, Q6ZN55, Q7L5Z5, Q8NCE3, Q9H6N0

    2. XM_054321783.1 → XP_054177758.1  zinc finger protein 574 isoform X1

      UniProtKB/Swiss-Prot
      Q6IPE0, Q6ZN10, Q6ZN55, Q7L5Z5, Q8NCE3, Q9H6N0

    3. XM_054321782.1 → XP_054177757.1  zinc finger protein 574 isoform X1

      UniProtKB/Swiss-Prot
      Q6IPE0, Q6ZN10, Q6ZN55, Q7L5Z5, Q8NCE3, Q9H6N0

    4. XM_054321780.1 → XP_054177755.1  zinc finger protein 574 isoform X1

      UniProtKB/Swiss-Prot
      Q6IPE0, Q6ZN10, Q6ZN55, Q7L5Z5, Q8NCE3, Q9H6N0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZN55.2 GenPept UniProtKB/Swiss-Prot:Q6ZN55

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools