CAV1 caveolin 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CAV1provided by HGNC
Official Full Name: caveolin 1provided by HGNC
Primary source: HGNC:HGNC:1527
See related: Ensembl:ENSG00000105974 MIM:601047; AllianceGenome:HGNC:1527
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CGL3; PPH3; BSCL3; LCCNS; VIP21; MSTP085
Summary: The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.[provided by RefSeq, Mar 2010]
Expression: Biased expression in fat (RPKM 322.1), lung (RPKM 308.8) and 13 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 7q31.2

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (116525009..116561185)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (117840041..117876175)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (116165063..116201239)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cellular prion protein acts as mediator of amyloid beta uptake by caveolin-1 causing cellular dysfunctions in vitro and in vivo.
Title: Cellular prion protein acts as mediator of amyloid beta uptake by caveolin-1 causing cellular dysfunctions in vitro and in vivo.
Dynamic remodeling of TRPC5 channel-caveolin-1-eNOS protein assembly potentiates the positive feedback interaction between Ca[2+] and NO signals.
Title: Dynamic remodeling of TRPC5 channel-caveolin-1-eNOS protein assembly potentiates the positive feedback interaction between Ca(2+) and NO signals.
Exploring the conformational dynamics and key amino acids in the CD26-caveolin-1 interaction and potential therapeutic interventions.
Title: Exploring the conformational dynamics and key amino acids in the CD26-caveolin-1 interaction and potential therapeutic interventions.
Recruitment of TNF ligands to lipid rafts is mediated by their physical association with caveolin-1.
Title: Recruitment of TNF ligands to lipid rafts is mediated by their physical association with caveolin-1.
Mediation role of body fat distribution (FD) on the relationship between CAV1 rs3807992 polymorphism and metabolic syndrome in overweight and obese women.
Title: Mediation role of body fat distribution (FD) on the relationship between CAV1 rs3807992 polymorphism and metabolic syndrome in overweight and obese women.
High Caveolin-1 mRNA expression in triple-negative breast cancer is associated with an aggressive tumor microenvironment, chemoresistance, and poor clinical outcome.
Title: High Caveolin-1 mRNA expression in triple-negative breast cancer is associated with an aggressive tumor microenvironment, chemoresistance, and poor clinical outcome.
Ago2/CAV1 interaction potentiates metastasis via controlling Ago2 localization and miRNA action.
Title: Ago2/CAV1 interaction potentiates metastasis via controlling Ago2 localization and miRNA action.
Caveolin-1's dual impact on endometrioid endometrial carcinoma: a histopathological and immunohistochemical study.
Title: Caveolin-1's dual impact on endometrioid endometrial carcinoma: a histopathological and immunohistochemical study.
Inhibition of glycolysis and Src/Akt signaling reduces Caveolin-1-enhanced metastasis.
Title: Inhibition of glycolysis and Src/Akt signaling reduces Caveolin-1-enhanced metastasis.
Scaffolds and the scaffolding domain: an alternative paradigm for caveolin-1 signaling.
Title: Scaffolds and the scaffolding domain: an alternative paradigm for caveolin-1 signaling.

Submit: New GeneRIF Correction See all GeneRIFs (926)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Congenital generalized lipodystrophy type 3 MedGen: C2675861 OMIM: 612526 GeneReviews: Berardinelli-Seip Congenital Lipodystrophy	not available
Partial lipodystrophy, congenital cataracts, and neurodegeneration syndrome MedGen: C3807567 OMIM: 606721 GeneReviews: Not available	not available
Pulmonary hypertension, primary, 3 MedGen: C3809192 OMIM: 615343 GeneReviews: Heritable Pulmonary Arterial Hypertension Overview	not available

EBI GWAS Catalog

Description
Common variants near ABCA1, AFAP1 and GMDS confer risk of primary open-angle glaucoma. EBI GWAS Catalog EBI GWAS CatalogPubMed
Common variants near CAV1 and CAV2 are associated with primary open-angle glaucoma. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genetic determinants of P wave duration and PR segment. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of electrocardiographic parameters identifies a new association for PR interval and confirms previously reported associations. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of PR interval. EBI GWAS Catalog EBI GWAS CatalogPubMed
Identification of three novel genetic variations associated with electrocardiographic traits (QRS duration and PR interval) in East Asians. EBI GWAS Catalog EBI GWAS CatalogPubMed
Meta-analysis identifies six new susceptibility loci for atrial fibrillation. EBI GWAS Catalog EBI GWAS CatalogPubMed
Novel loci associated with PR interval in a genome-wide association study of 10 African American cohorts. EBI GWAS Catalog EBI GWAS CatalogPubMed
Several common variants modulate heart rate, PR interval and QRS duration. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of caveolin 1 (CAV1) by siRNA enhances HIV-1 infection in human Langerhans cells	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Envelope transmembrane glycoprotein gp41	env	HIV-1 gp41 forms a stable complex with caveolin-1 through its amino-acid residues 623-631 in HIV-infected cells; antibodies to the caveolin-1 binding domain in gp41 inhibit virus infectivity	PubMed
	env	Amino acid residues 61-101 of caveolin 1 are involved in the binding of caveolin 1 to the N36(L8)C34 domain of gp41	PubMed
Nef	nef	HIV-1 Nef induces phosphorylation of CAV1 in endothelial cells	PubMed
	nef	HIV-1 Nef redistributes CAV1 during high density lipoprotein stimulation in human aortic endothelial cells (suggesting that HIV interferes with cholesterol efflux by high density lipoproteins)	PubMed
	nef	Cav-1 physically interacts with HIV-1 Nef and restores Nef mediated impairment of apoA-I mediated cholesterol efflux in astrocyte derived glioblastoma cells and macrophages	PubMed
Tat	tat	HIV-1 Tat co-localizes with CAV1 in the cholesterol-enriched lipid rafts of human podocytes	PubMed
	tat	Activation of p38 MAPK in HIV-infected cells mediated by Tat leads to the phosphorylation of p53 which subsequently upregulates CAV-1 expression	PubMed
	tat	Treatment with Tat activates the Ras pathway in human brain micro vascular endothelial cells (HBMECs), an effect that is markedly attenuated by caveolin-1 silencing	PubMed
Vpr	vpr	HIV-1 Vpr C-terminus (residues 52-96) entry into cells is mediated through clathrin- and caveolae/raft-dependent endocytosis	PubMed
capsid	gag	HIV-1 CA co-localizes with langerin and caveolin-1 at the cell membrane of human Langerhans cells	PubMed
reverse transcriptase	gag-pol	CAV-1 expression inhibits HIV-1 replication monitored by reverse transcriptase activity	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ECD18777 (e-PCR)
- UniSTS:299787

ECD18009 (e-PCR)
- UniSTS:299020

ECD06962 (e-PCR)
- UniSTS:288020

ECD18532 (e-PCR)
- UniSTS:299543

ECD01546 (e-PCR)
- UniSTS:282649

ECD19567 (e-PCR)
- UniSTS:300572

ECD06713 (e-PCR)
- UniSTS:287773

D7S2756 (e-PCR)
- UniSTS:80929

RH11008 (e-PCR)
- UniSTS:50979

HUEST-D29206 (e-PCR)
- UniSTS:50979

ECD14440 (e-PCR)
- UniSTS:295461

ECD14441 (e-PCR)
- UniSTS:295462

RH69535 (e-PCR)
- UniSTS:42022

ECD01055 (e-PCR)
- UniSTS:282162

ECD05966 (e-PCR)
- UniSTS:287028

ECD05195 (e-PCR)
- UniSTS:286261

ECD07255 (e-PCR)
- UniSTS:288312

ECD04428 (e-PCR)
- UniSTS:285500

ECD13690 (e-PCR)
- UniSTS:294718

ECD06753 (e-PCR)
- UniSTS:287813

ECD15500 (e-PCR)
- UniSTS:296517

REN66695 (e-PCR)
- UniSTS:391495

REN66696 (e-PCR)
- UniSTS:391496

REN66697 (e-PCR)
- UniSTS:391497

REN66698 (e-PCR)
- UniSTS:391498

REN66699 (e-PCR)
- UniSTS:391499

REN66700 (e-PCR)
- UniSTS:391500

REN66701 (e-PCR)
- UniSTS:391501

ECD13448 (e-PCR)
- UniSTS:294478

REN66702 (e-PCR)
- UniSTS:391502

REN66703 (e-PCR)
- UniSTS:391503

REN66704 (e-PCR)
- UniSTS:391504

REN66705 (e-PCR)
- UniSTS:391505

REN66706 (e-PCR)
- UniSTS:391506

REN66707 (e-PCR)
- UniSTS:391507

REN66708 (e-PCR)
- UniSTS:391508

REN66709 (e-PCR)
- UniSTS:391509

REN66710 (e-PCR)
- UniSTS:391510

REN66711 (e-PCR)
- UniSTS:391511

REN66712 (e-PCR)
- UniSTS:391512

REN66713 (e-PCR)
- UniSTS:391513

ECD14493 (e-PCR)
- UniSTS:295514

REN66714 (e-PCR)
- UniSTS:391514

REN66715 (e-PCR)
- UniSTS:391515

ECD21690 (e-PCR)
- UniSTS:302684

REN66716 (e-PCR)
- UniSTS:391516

REN66717 (e-PCR)
- UniSTS:391517

REN66718 (e-PCR)
- UniSTS:391518

ECD17066 (e-PCR)
- UniSTS:298079

REN66719 (e-PCR)
- UniSTS:391519

REN66720 (e-PCR)
- UniSTS:391520

REN66721 (e-PCR)
- UniSTS:391521

D7S2864 (e-PCR)
- UniSTS:33634

ECD22214 (e-PCR)
- UniSTS:303202

REN66722 (e-PCR)
- UniSTS:391522

REN66723 (e-PCR)
- UniSTS:391523

REN66724 (e-PCR)
- UniSTS:391524

REN66725 (e-PCR)
- UniSTS:391525

ECD21441 (e-PCR)
- UniSTS:302438

REN66726 (e-PCR)
- UniSTS:391526

REN66727 (e-PCR)
- UniSTS:391527

REN66728 (e-PCR)
- UniSTS:391528

REN66729 (e-PCR)
- UniSTS:391529

REN66730 (e-PCR)
- UniSTS:391530

REN66731 (e-PCR)
- UniSTS:391531

REN66732 (e-PCR)
- UniSTS:391532

REN66733 (e-PCR)
- UniSTS:391533

stSG597990 (e-PCR)
- UniSTS:442734

REN66734 (e-PCR)
- UniSTS:391534

REN66735 (e-PCR)
- UniSTS:391535

REN66736 (e-PCR)
- UniSTS:391536

REN66737 (e-PCR)
- UniSTS:391537

REN66738 (e-PCR)
- UniSTS:391538

ECD02409 (e-PCR)
- UniSTS:283507

REN66739 (e-PCR)
- UniSTS:391539

REN66740 (e-PCR)
- UniSTS:391540

REN66741 (e-PCR)
- UniSTS:391541

REN66742 (e-PCR)
- UniSTS:391542

REN66743 (e-PCR)
- UniSTS:391543

REN66744 (e-PCR)
- UniSTS:391544

REN66745 (e-PCR)
- UniSTS:391545

REN66746 (e-PCR)
- UniSTS:391546

REN66747 (e-PCR)
- UniSTS:391547

REN66748 (e-PCR)
- UniSTS:391548

REN66749 (e-PCR)
- UniSTS:391549

REN66750 (e-PCR)
- UniSTS:391550

REN66751 (e-PCR)
- UniSTS:391551

REN66752 (e-PCR)
- UniSTS:391552

RH91504 (e-PCR)
- UniSTS:92545

REN66753 (e-PCR)
- UniSTS:391553

ECD05272 (e-PCR)
- UniSTS:286338

REN66754 (e-PCR)
- UniSTS:391554

ECD05273 (e-PCR)
- UniSTS:286339

REN66755 (e-PCR)
- UniSTS:391555

REN66756 (e-PCR)
- UniSTS:391556

REN66757 (e-PCR)
- UniSTS:391557

REN66758 (e-PCR)
- UniSTS:391558

ECD05019 (e-PCR)
- UniSTS:286087

REN66759 (e-PCR)
- UniSTS:391559

REN66760 (e-PCR)
- UniSTS:391560

REN66761 (e-PCR)
- UniSTS:391561

REN66762 (e-PCR)
- UniSTS:391562

REN66763 (e-PCR)
- UniSTS:391563

REN66764 (e-PCR)
- UniSTS:391564

REN66765 (e-PCR)
- UniSTS:391565

REN66766 (e-PCR)
- UniSTS:391566

ECD22774 (e-PCR)
- UniSTS:303759

REN66767 (e-PCR)
- UniSTS:391567

REN66768 (e-PCR)
- UniSTS:391568

REN66769 (e-PCR)
- UniSTS:391569

REN66770 (e-PCR)
- UniSTS:391570

REN66771 (e-PCR)
- UniSTS:391571

REN66772 (e-PCR)
- UniSTS:391572

REN66773 (e-PCR)
- UniSTS:391573

REN66774 (e-PCR)
- UniSTS:391574

REN66775 (e-PCR)
- UniSTS:391575

REN66776 (e-PCR)
- UniSTS:391576

REN66777 (e-PCR)
- UniSTS:391577

REN66778 (e-PCR)
- UniSTS:391578

REN66779 (e-PCR)
- UniSTS:391579

REN66780 (e-PCR)
- UniSTS:391580

REN66781 (e-PCR)
- UniSTS:391581

REN66782 (e-PCR)
- UniSTS:391582

REN66783 (e-PCR)
- UniSTS:391583

REN66784 (e-PCR)
- UniSTS:391584

ECD05303 (e-PCR)
- UniSTS:286369

ECD18414 (e-PCR)
- UniSTS:299425

REN66785 (e-PCR)
- UniSTS:391585

REN66786 (e-PCR)
- UniSTS:391586

REN66787 (e-PCR)
- UniSTS:391587

REN66788 (e-PCR)
- UniSTS:391588

REN66789 (e-PCR)
- UniSTS:391589

REN66790 (e-PCR)
- UniSTS:391590

REN66791 (e-PCR)
- UniSTS:391591

REN66792 (e-PCR)
- UniSTS:391592

REN66793 (e-PCR)
- UniSTS:391593

REN66794 (e-PCR)
- UniSTS:391594

REN66795 (e-PCR)
- UniSTS:391595

REN66796 (e-PCR)
- UniSTS:391596

REN66797 (e-PCR)
- UniSTS:391597

REN66798 (e-PCR)
- UniSTS:391598

REN66799 (e-PCR)
- UniSTS:391599

REN66800 (e-PCR)
- UniSTS:391600

REN66801 (e-PCR)
- UniSTS:391601

REN66802 (e-PCR)
- UniSTS:391602

REN66803 (e-PCR)
- UniSTS:391603

REN66804 (e-PCR)
- UniSTS:391604

REN66805 (e-PCR)
- UniSTS:391605

REN66806 (e-PCR)
- UniSTS:391606

REN66807 (e-PCR)
- UniSTS:391607

ECD12784 (e-PCR)
- UniSTS:293816

ECD14844 (e-PCR)
- UniSTS:295864

REN66808 (e-PCR)
- UniSTS:391608

REN66809 (e-PCR)
- UniSTS:391609

REN66810 (e-PCR)
- UniSTS:391610

REN66811 (e-PCR)
- UniSTS:391611

REN66812 (e-PCR)
- UniSTS:391612

REN66813 (e-PCR)
- UniSTS:391613

REN66814 (e-PCR)
- UniSTS:391614

REN66815 (e-PCR)
- UniSTS:391615

REN66816 (e-PCR)
- UniSTS:391616

ECD18959 (e-PCR)
- UniSTS:299969

REN66817 (e-PCR)
- UniSTS:391617

REN66818 (e-PCR)
- UniSTS:391618

REN66819 (e-PCR)
- UniSTS:391619

ECD18449 (e-PCR)
- UniSTS:299460

REN66820 (e-PCR)
- UniSTS:391620

REN66821 (e-PCR)
- UniSTS:391621

REN66822 (e-PCR)
- UniSTS:391622

REN66823 (e-PCR)
- UniSTS:391623

ECD05342 (e-PCR)
- UniSTS:286408

REN66824 (e-PCR)
- UniSTS:391624

REN66825 (e-PCR)
- UniSTS:391625

REN66826 (e-PCR)
- UniSTS:391626

REN66827 (e-PCR)
- UniSTS:391627

REN66828 (e-PCR)
- UniSTS:391628

ECD05091 (e-PCR)
- UniSTS:286157

REN66829 (e-PCR)
- UniSTS:391629

ECD00439 (e-PCR)
- UniSTS:281550

ECD14093 (e-PCR)
- UniSTS:295118

REN66830 (e-PCR)
- UniSTS:391630

REN66831 (e-PCR)
- UniSTS:391631

REN66832 (e-PCR)
- UniSTS:391632

REN66833 (e-PCR)
- UniSTS:391633

REN66834 (e-PCR)
- UniSTS:391634

REN66835 (e-PCR)
- UniSTS:391635

REN66836 (e-PCR)
- UniSTS:391636

ECD08445 (e-PCR)
- UniSTS:289493

REN66837 (e-PCR)
- UniSTS:391637

REN66838 (e-PCR)
- UniSTS:391638

REN66839 (e-PCR)
- UniSTS:391639

REN66840 (e-PCR)
- UniSTS:391640

ECD20013 (e-PCR)
- UniSTS:301017

ECD02781 (e-PCR)
- UniSTS:283875

ECD05380 (e-PCR)
- UniSTS:286446

ECD06677 (e-PCR)
- UniSTS:287737

ECD08482 (e-PCR)
- UniSTS:289530

ECD08231 (e-PCR)
- UniSTS:289279

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATPase binding	IPI Inferred from Physical Interaction more info	PubMed
enables ATPase binding	ISS Inferred from Sequence or Structural Similarity more info
enables cholesterol binding	TAS Traceable Author Statement more info	PubMed
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables inward rectifier potassium channel inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables molecular adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables molecular adaptor activity	TAS Traceable Author Statement more info	PubMed
enables nitric-oxide synthase binding	IPI Inferred from Physical Interaction more info	PubMed
enables oxysterol binding	ISS Inferred from Sequence or Structural Similarity more info
enables patched binding	NAS Non-traceable Author Statement more info	PubMed
enables peptidase activator activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein sequestering activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein tyrosine kinase inhibitor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein tyrosine kinase inhibitor activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-macromolecule adaptor activity	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter binding	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in T cell costimulation	IDA Inferred from Direct Assay more info	PubMed
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in angiotensin-activated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in basement membrane organization	IEA Inferred from Electronic Annotation more info
involved_in calcium ion homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in calcium ion transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in caveola assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in caveola assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in caveola assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in caveola assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in caveolin-mediated endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to exogenous dsRNA	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to hyperoxia	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to misfolded protein	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to peptide hormone stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to starvation	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to transforming growth factor beta stimulus	IEA Inferred from Electronic Annotation more info
involved_in cholesterol homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in cholesterol homeostasis	TAS Traceable Author Statement more info	PubMed
involved_in cholesterol transport	TAS Traceable Author Statement more info	PubMed
involved_in cytokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in endothelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in establishment of localization in cell	IEA Inferred from Electronic Annotation more info
involved_in fibroblast proliferation	IEA Inferred from Electronic Annotation more info
involved_in glandular epithelial cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in insulin receptor internalization	IEA Inferred from Electronic Annotation more info
involved_in intracellular calcium ion homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular nitric oxide homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in lactation	IEA Inferred from Electronic Annotation more info
involved_in lipid storage	ISS Inferred from Sequence or Structural Similarity more info
involved_in maintenance of protein location in cell	ISS Inferred from Sequence or Structural Similarity more info
involved_in mammary gland development	ISS Inferred from Sequence or Structural Similarity more info
involved_in mammary gland involution	ISS Inferred from Sequence or Structural Similarity more info
involved_in membrane depolarization	ISS Inferred from Sequence or Structural Similarity more info
involved_in muscle cell cellular homeostasis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of BMP signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of anoikis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cytokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of endothelial cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of endothelial cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of epithelial cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of fibroblast proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of inward rectifier potassium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of necroptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of nitric oxide biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of peptidyl-serine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of pinocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of potassium ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein ubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of receptor signaling pathway via JAK-STAT	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in nitric oxide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ERAD pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of calcium ion transport into cytosol	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of canonical NF-kappaB signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell adhesion molecule production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cholesterol efflux	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of extrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gap junction assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of intrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of peptidyl-serine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein ubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of toll-like receptor 3 signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vasoconstriction	ISS Inferred from Sequence or Structural Similarity more info
involved_in post-transcriptional regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in protein localization	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to basolateral plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to plasma membrane raft	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in receptor internalization	IDA Inferred from Direct Assay more info	PubMed
involved_in receptor internalization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in receptor-mediated endocytosis of virus by host cell	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of blood coagulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cardiac muscle cell action potential involved in regulation of contraction	IC Inferred by Curator more info	PubMed
involved_in regulation of cell communication by electrical coupling involved in cardiac conduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of entry of bacterium into host cell	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of fatty acid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of heart rate by cardiac conduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of membrane repolarization during action potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of ruffle assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of smooth muscle contraction	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of the force of heart contraction by chemical signal	IEA Inferred from Electronic Annotation more info
involved_in regulation of ventricular cardiac muscle cell action potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to bacterium	IDA Inferred from Direct Assay more info	PubMed
involved_in response to calcium ion	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within response to estrogen	IDA Inferred from Direct Assay more info	PubMed
involved_in response to hypoxia	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to ischemia	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to progesterone	IDA Inferred from Direct Assay more info	PubMed
involved_in skeletal muscle tissue development	ISS Inferred from Sequence or Structural Similarity more info
involved_in triglyceride metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in vasculogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in vasoconstriction	IEA Inferred from Electronic Annotation more info
involved_in vesicle organization	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi membrane	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi membrane	TAS Traceable Author Statement more info
located_in acrosomal membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in caveola	IDA Inferred from Direct Assay more info	PubMed
located_in caveola	NAS Non-traceable Author Statement more info	PubMed
part_of caveolar macromolecular signaling complex	IEA Inferred from Electronic Annotation more info
located_in cell cortex	IEA Inferred from Electronic Annotation more info
located_in cilium	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasmic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in early endosome membrane	TAS Traceable Author Statement more info
located_in endocytic vesicle membrane	TAS Traceable Author Statement more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	TAS Traceable Author Statement more info	PubMed
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in focal adhesion	HDA more info	PubMed
colocalizes_with focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with focal adhesion	IDA Inferred from Direct Assay more info	PubMed
located_in lipid droplet	TAS Traceable Author Statement more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in membrane raft	ISS Inferred from Sequence or Structural Similarity more info
is_active_in perinuclear region of cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with sarcolemma	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: caveolin-1

Names: caveolin 1, caveolae protein, 22kDa; cell growth-inhibiting protein 32

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012051.1 RefSeqGene

Range

5252..41395

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001172895.1 → NP_001166366.1 caveolin-1 isoform beta

See identical proteins and their annotated locations for NP_001166366.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (beta) is shorter than isoform alpha. Variants 2, 3 and 4 encode the same isoform.

Source sequence(s)

AB209926, AC006159, AK290871, BC006432, BG170208, DB266251

Consensus CDS

CCDS55156.1

UniProtKB/TrEMBL

Q7Z4F3

Related

ENSP00000384348.1, ENST00000405348.6

Conserved Domains (1) summary

pfam01146
Location:14 → 144

Caveolin
NM_001172896.2 → NP_001166367.1 caveolin-1 isoform beta

See identical proteins and their annotated locations for NP_001166367.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (beta) is shorter than isoform alpha. Variants 2, 3 and 4 encode the same isoform.

Source sequence(s)

AB209926, AC006159, AF172085, AK290871, BG170208, DA943080

Consensus CDS

CCDS55156.1

UniProtKB/TrEMBL

Q7Z4F3

Related

ENSP00000377110.1, ENST00000393467.1

Conserved Domains (1) summary

pfam01146
Location:14 → 144

Caveolin
NM_001172897.2 → NP_001166368.1 caveolin-1 isoform beta

See identical proteins and their annotated locations for NP_001166368.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (beta) is shorter than isoform alpha. Variants 2, 3 and 4 encode the same isoform.

Source sequence(s)

AB209926, AC006159, AK290871, BG170208, DA477166, EF649773

Consensus CDS

CCDS55156.1

UniProtKB/TrEMBL

Q7Z4F3

Related

ENSP00000377111.1, ENST00000393468.1

Conserved Domains (1) summary

pfam01146
Location:14 → 144

Caveolin
NM_001753.5 → NP_001744.2 caveolin-1 isoform alpha

See identical proteins and their annotated locations for NP_001744.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (alpha).

Source sequence(s)

AB209926, AC006159, AK290871, BG170208

Consensus CDS

CCDS5767.1

UniProtKB/Swiss-Prot

Q03135, Q9UGP1, Q9UNG1, Q9UQH6

UniProtKB/TrEMBL

A9XTE5, Q2TNI1

Related

ENSP00000339191.2, ENST00000341049.7

Conserved Domains (1) summary

pfam01146
Location:45 → 175

Caveolin