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    BCL2L11 BCL2 like 11 [ Homo sapiens (human) ]

    Gene ID: 10018, updated on 3-Dec-2024

    Summary

    Official Symbol
    BCL2L11provided by HGNC
    Official Full Name
    BCL2 like 11provided by HGNC
    Primary source
    HGNC:HGNC:994
    See related
    Ensembl:ENSG00000153094 MIM:603827; AllianceGenome:HGNC:994
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BAM; BIM; BOD
    Summary
    The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jun 2013]
    Expression
    Ubiquitous expression in lymph node (RPKM 7.9), thyroid (RPKM 7.1) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See BCL2L11 in Genome Data Viewer
    Location:
    2q13
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (111120914..111168445)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (111543978..111591507)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (111878491..111926022)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene acyl-CoA oxidase like Neighboring gene uncharacterized LOC124907866 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16377 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16378 Neighboring gene Sharpr-MPRA regulatory region 7769 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16379 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16380 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16381 Neighboring gene Sharpr-MPRA regulatory region 8028 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11865 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11866 Neighboring gene ACOXL antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:111923374-111923874 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16383 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16384 Neighboring gene uncharacterized LOC124907868 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11867 Neighboring gene Sharpr-MPRA regulatory region 6991 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16385 Neighboring gene MIR4435-2 host gene Neighboring gene periaxin-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Copy number response

    Description
    Copy number response
    Haploinsufficency

    No evidence available (Last evaluated 2018-06-21)

    ClinGen Genome Curation Page
    Triplosensitivity

    No evidence available (Last evaluated 2018-06-21)

    ClinGen Genome Curation Page

    EBI GWAS Catalog

    Description
    A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia.
    EBI GWAS Catalog
    A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia.
    EBI GWAS Catalog
    Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms.
    EBI GWAS Catalog
    Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci.
    EBI GWAS Catalog
    Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat upregulates BIM expression in Tat-infected Jurkat T cells PubMed
    tat HIV-1 Tat acetylation at position K28 stimulates its activity to induce the translocation of Bim, a pro-apoptotic protein of the Bcl-2 family, from microtubules to mitochondria PubMed
    tat HIV-1 Tat (amino acids 36-39) binds tubulin alpha/beta dimers and polymerized microtubules leading to the alteration of microtubule dynamics and activation of a mitochondria-dependent apoptotic pathway that is facilitated by the Bcl-2 relative Bim PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    contributes_to microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in B cell homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in T cell homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in apoptotic process involved in embryonic digit morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to glucocorticoid stimulus TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in developmental pigmentation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ear development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in extrinsic apoptotic signaling pathway in absence of ligand IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in kidney development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in male gonad development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mammary gland development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in meiosis I IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in myeloid cell homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in odontogenesis of dentin-containing tooth IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of IRE1-mediated unfolded protein response TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of T cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cysteine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of fibroblast apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of mitochondrial membrane permeability involved in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein-containing complex assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein-containing complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of release of cytochrome c from mitochondria IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of release of cytochrome c from mitochondria IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in post-embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of developmental pigmentation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of organ growth IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to endoplasmic reticulum stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in spleen development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in thymocyte apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in thymus development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in tube formation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of BIM-BCL-2 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of BIM-BCL-xl complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of Bcl-2 family protein complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial outer membrane TAS
    Traceable Author Statement
    more info
     
    located_in mitochondrion HTP PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    bcl-2-like protein 11
    Names
    BCL2-like 11 (apoptosis facilitator)
    bcl-2 interacting mediator of cell death
    bcl-2 interacting protein Bim
    bcl-2-related ovarian death agonist

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029006.1 RefSeqGene

      Range
      5001..52532
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_620

    mRNA and Protein(s)

    1. NM_001204106.2NP_001191035.1  bcl-2-like protein 11 isoform 11

      See identical proteins and their annotated locations for NP_001191035.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11, also known as BimS) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The resulting isoform (11) is shorter, compared to isoform 1.
      Source sequence(s)
      AC096670, AI268146, AK290377, AY305714
      UniProtKB/Swiss-Prot
      O43521
      Conserved Domains (2) summary
      pfam06773
      Location:440
      Bim_N; Bim protein N-terminus
      pfam08945
      Location:4676
      Bclx_interact; Bcl-x interacting, BH3 domain
    2. NM_001204107.1NP_001191036.1  bcl-2-like protein 11 isoform 12

      See identical proteins and their annotated locations for NP_001191036.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12) uses an alternate in-frame splice site in the 5' coding region, contains two alternate internal exons, and differs in the 3' coding region and UTR, compared to variant 1. The resulting isoform (12) is shorter and has a distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.
      Source sequence(s)
      AC096670, AI268146, AK290377, AY423442
      Consensus CDS
      CCDS56132.1
      UniProtKB/Swiss-Prot
      O43521
      Related
      ENSP00000411137.1, ENST00000439718.1
      Conserved Domains (2) summary
      pfam06773
      Location:440
      Bim_N; Bim protein N-terminus
      pfam08945
      Location:4673
      Bclx_interact; Bcl-x interacting, BH3 domain
    3. NM_001204108.1NP_001191037.1  bcl-2-like protein 11 isoform 13

      See identical proteins and their annotated locations for NP_001191037.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13) contains an alternate internal exon, and differs in the 3' coding region and UTR, compared to variant 1. The resulting isoform (13) has a shorter and distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.
      Source sequence(s)
      AC096670, AI268146, AK290377, AY423443
      Consensus CDS
      CCDS56135.1
      UniProtKB/Swiss-Prot
      O43521
      Conserved Domains (2) summary
      pfam06773
      Location:440
      Bim_N; Bim protein N-terminus
      pfam08945
      Location:132163
      Bclx_interact; Bcl-x interacting, BH3 domain
    4. NM_001204109.2NP_001191038.1  bcl-2-like protein 11 isoform 14

      See identical proteins and their annotated locations for NP_001191038.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14) lacks an internal exon, contains an alternate internal exon, and differs in the 3' coding region and UTR, compared to variant 1. The resulting isoform (14) has a shorter and distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.
      Source sequence(s)
      AC096670, AI268146, AK290377, AY428962
      Consensus CDS
      CCDS56136.1
      UniProtKB/TrEMBL
      C9J417
      Related
      ENSP00000403727.1, ENST00000436733.5
      Conserved Domains (1) summary
      pfam06773
      Location:440
      Bim_N; Bim protein N-terminus
    5. NM_001204110.2NP_001191039.1  bcl-2-like protein 11 isoform 15

      See identical proteins and their annotated locations for NP_001191039.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15) uses an alternate in-frame splice site in the 5' coding region, contains an alternate internal exon, and differs in the 3' coding region and UTR, compared to variant 1. The resulting isoform (15) is shorter and has a distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.
      Source sequence(s)
      AC096670, AI268146, AK290377, DQ849200
      Consensus CDS
      CCDS56133.1
      UniProtKB/Swiss-Prot
      O43521
      Related
      ENSP00000391292.1, ENST00000452231.5
      Conserved Domains (2) summary
      pfam06773
      Location:440
      Bim_N; Bim protein N-terminus
      pfam08945
      Location:4673
      Bclx_interact; Bcl-x interacting, BH3 domain
    6. NM_001204111.2NP_001191040.1  bcl-2-like protein 11 isoform 16

      See identical proteins and their annotated locations for NP_001191040.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16) lacks an in-frame segment in the 5' coding region, and lacks an exon in the 3' coding region which results in a frameshift, compared to variant 1. The resulting isoform (16) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC096670, AI268146, AK290377, DQ849201
      UniProtKB/Swiss-Prot
      O43521
      Conserved Domains (1) summary
      pfam06773
      Location:440
      Bim_N; Bim protein N-terminus
    7. NM_001204112.2NP_001191041.1  bcl-2-like protein 11 isoform 17

      See identical proteins and their annotated locations for NP_001191041.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17) lacks an alternate in-frame segment in the 5' coding region, lacks an internal exon, and contains an alternate internal exon, compared to variant 1. The resulting isoform (17) is shorter and has a distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.
      Source sequence(s)
      AC096670, AI268146, AK290377, DQ849202
      Consensus CDS
      CCDS56131.1
      UniProtKB/Swiss-Prot
      O43521
      Related
      ENSP00000393781.1, ENST00000415458.5
      Conserved Domains (1) summary
      pfam06773
      Location:440
      Bim_N; Bim protein N-terminus
    8. NM_001204113.1NP_001191042.1  bcl-2-like protein 11 isoform 18

      See identical proteins and their annotated locations for NP_001191042.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (18) lacks an alternate in-frame segment and differs in the 3' UTR and coding sequence, compared to variant 1. The resulting isoform (18) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC096670, AK290377, AW629314
      Consensus CDS
      CCDS74559.1
      UniProtKB/TrEMBL
      H7BZE5
      Related
      ENSP00000389225.2, ENST00000438054.2
      Conserved Domains (1) summary
      pfam06773
      Location:440
      Bim_N; Bim protein N-terminus
    9. NM_006538.5NP_006529.1  bcl-2-like protein 11 isoform 6

      See identical proteins and their annotated locations for NP_006529.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6, also known as BimL) lacks an in-frame segment in the 5' coding coding region, compared to variant 1. The resulting isoform (6) is shorter, compared to isoform 1.
      Source sequence(s)
      AC096670, AF032458, AI268146, AK290377, BC033694
      Consensus CDS
      CCDS42731.1
      UniProtKB/Swiss-Prot
      O43521
      Related
      ENSP00000309226.8, ENST00000308659.12
      Conserved Domains (2) summary
      pfam06773
      Location:440
      Bim_N; Bim protein N-terminus
      pfam08945
      Location:70106
      Bclx_interact; Bcl-x interacting, BH3 domain
    10. NM_138621.5NP_619527.1  bcl-2-like protein 11 isoform 1

      See identical proteins and their annotated locations for NP_619527.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1, also known as BimEL) encodes the longest isoform (1).
      Source sequence(s)
      AC096670, AI268146, BC033694
      Consensus CDS
      CCDS2089.1
      UniProtKB/Swiss-Prot
      A8K2W2, O43521, O43522, Q0MSE7, Q0MSE8, Q0MSE9, Q53R28, Q6JTU6, Q6T851, Q6TE14, Q6TE15, Q6TE16, Q6V402, Q8WYL6, Q8WYL7, Q8WYL8, Q8WYL9, Q8WYM0, Q8WYM1
      Related
      ENSP00000376943.2, ENST00000393256.8
      Conserved Domains (2) summary
      pfam06773
      Location:440
      Bim_N; Bim protein N-terminus
      pfam08945
      Location:130166
      Bclx_interact; Bcl-x interacting, BH3 domain
    11. NM_138622.4NP_619528.1  bcl-2-like protein 11 isoform 2

      See identical proteins and their annotated locations for NP_619528.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2, also known as Bim-alpha1) contains an alternate internal exon and differs in the 3' coding region and UTR, compared to variant 1. The resulting isoform (2) contains a shorter and distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.
      Source sequence(s)
      AB071195, AC096670, AI268146, AK290377
      Consensus CDS
      CCDS74560.1
      UniProtKB/Swiss-Prot
      O43521
      Conserved Domains (2) summary
      pfam06773
      Location:440
      Bim_N; Bim protein N-terminus
      pfam08945
      Location:132163
      Bclx_interact; Bcl-x interacting, BH3 domain
    12. NM_138623.4NP_619529.1  bcl-2-like protein 11 isoform 3

      See identical proteins and their annotated locations for NP_619529.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3, also known as Bim-ACD and Bim-alpha2) lacks a 5' segment, contains an alternate internal exon, and differs in the 3' coding region and UTR, compared to variant 1. The resulting isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.
      Source sequence(s)
      AB071196, AC096670, AI268146, AK290377
      UniProtKB/Swiss-Prot
      O43521
      Conserved Domains (2) summary
      pfam06773
      Location:440
      Bim_N; Bim protein N-terminus
      pfam08945
      Location:76103
      Bclx_interact; Bcl-x interacting, BH3 domain
    13. NM_138624.4NP_619530.1  bcl-2-like protein 11 isoform 4

      See identical proteins and their annotated locations for NP_619530.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4, also known as Bim-beta1) contains an alternate internal exon, and differs in the 3' coding region and UTR, compared to variant 1. The resulting isoform (4) has a shorter and distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.
      Source sequence(s)
      AB071197, AC096670, AI268146, AK290377
      Consensus CDS
      CCDS56134.1
      UniProtKB/TrEMBL
      C9J417
      Conserved Domains (1) summary
      pfam06773
      Location:440
      Bim_N; Bim protein N-terminus
    14. NM_138625.4NP_619531.1  bcl-2-like protein 11 isoform 5

      See identical proteins and their annotated locations for NP_619531.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5, also known as Bim-beta3) uses an alternate splice site in the 5' coding region, contains an alternate internal exon, and differs in the 3' coding region and UTR, compared to variant 1. The resulting isoform (5) is shorter and has a distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.
      Source sequence(s)
      AB071199, AC096670, AI268146, AK290377
      UniProtKB/TrEMBL
      A0A0C4DH20
      Related
      ENSP00000354879.6, ENST00000361493.10
      Conserved Domains (1) summary
      pfam06773
      Location:440
      Bim_N; Bim protein N-terminus
    15. NM_138626.4NP_619532.1  bcl-2-like protein 11 isoform 7

      See identical proteins and their annotated locations for NP_619532.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7, also known as Bim-ABC and Bim-beta2) lacks an exon in the 3' coding region which results in a frameshift, compared to variant 1. The resulting isoform (7) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AB071198, AC096670, AI268146, AK290377
      Consensus CDS
      CCDS74561.1
      UniProtKB/TrEMBL
      C9J417
      Conserved Domains (1) summary
      pfam06773
      Location:440
      Bim_N; Bim protein N-terminus
    16. NM_138627.4NP_619533.1  bcl-2-like protein 11 isoform 8

      See identical proteins and their annotated locations for NP_619533.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8, also known as Bim-A and Bim-beta4) uses an alternate splice site in the 5' coding region, and lacks an exon in the 3' coding region which results in a frameshift, compared to variant 1. The resulting isoform (8) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AB071200, AC096670, AI268146, AK290377
      UniProtKB/Swiss-Prot
      O43521
      Conserved Domains (1) summary
      pfam06773
      Location:440
      Bim_N; Bim protein N-terminus
    17. NM_207002.3NP_996885.1  bcl-2-like protein 11 isoform 9

      See identical proteins and their annotated locations for NP_996885.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9, also known as Bim-gamma) lacks several exons and includes an alternate 3' terminal exon, compared to variant 1. The resulting isoform (9) has a distinct and shorter C-terminus, compared to isoform 1.
      Source sequence(s)
      AA890664, AC096670, AK290377, AY352518
      Consensus CDS
      CCDS2092.1
      UniProtKB/Swiss-Prot
      O43521
      Related
      ENSP00000384641.1, ENST00000405953.6
      Conserved Domains (1) summary
      pfam06773
      Location:440
      Bim_N; Bim protein N-terminus
    18. NM_207003.3NP_996886.1  bcl-2-like protein 11 isoform 10

      See identical proteins and their annotated locations for NP_996886.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10, also known as Bim-alpha3) uses an alternate splice site in the 5' coding region, contains an alternate internal exon, and differs in the 3' coding region and UTR, compared to variant 1. The resulting isoform (10) is shorter and has a distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.
      Source sequence(s)
      AC096670, AI268146, AK290377, AY305715
      UniProtKB/Swiss-Prot
      O43521
      Conserved Domains (2) summary
      pfam06773
      Location:440
      Bim_N; Bim protein N-terminus
      pfam08945
      Location:4273
      Bclx_interact; Bcl-x interacting, BH3 domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      111120914..111168445
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047442102.1XP_047298058.1  bcl-2-like protein 11 isoform X6

    2. XM_005263556.4XP_005263613.1  bcl-2-like protein 11 isoform X8

      See identical proteins and their annotated locations for XP_005263613.1

      Conserved Domains (2) summary
      pfam06773
      Location:440
      Bim_N; Bim protein N-terminus
      pfam08945
      Location:132163
      Bclx_interact; Bcl-x interacting, BH3 domain
    3. XM_005263553.4XP_005263610.1  bcl-2-like protein 11 isoform X4

      UniProtKB/TrEMBL
      A0AA75IMJ6
      Conserved Domains (2) summary
      pfam06773
      Location:98134
      Bim_N; Bim protein N-terminus
      pfam08945
      Location:166197
      Bclx_interact; Bcl-x interacting, BH3 domain
    4. XM_017003101.3XP_016858590.1  bcl-2-like protein 11 isoform X12

      UniProtKB/TrEMBL
      A0AA75IMJ6
    5. XM_005263552.5XP_005263609.1  bcl-2-like protein 11 isoform X3

      Conserved Domains (2) summary
      pfam06773
      Location:98134
      Bim_N; Bim protein N-terminus
      pfam08945
      Location:166197
      Bclx_interact; Bcl-x interacting, BH3 domain
    6. XM_047442104.1XP_047298060.1  bcl-2-like protein 11 isoform X11

      UniProtKB/TrEMBL
      A0AA75IMJ6
    7. XM_011510464.4XP_011508766.1  bcl-2-like protein 11 isoform X9

      Conserved Domains (1) summary
      pfam06773
      Location:98134
      Bim_N; Bim protein N-terminus
    8. XM_005263559.4XP_005263616.2  bcl-2-like protein 11 isoform X10

    9. XM_047442099.1XP_047298055.1  bcl-2-like protein 11 isoform X2

      Related
      ENSP00000412892.1, ENST00000437029.5
    10. XM_005263555.5XP_005263612.2  bcl-2-like protein 11 isoform X7

    11. XM_047442101.1XP_047298057.1  bcl-2-like protein 11 isoform X5

      UniProtKB/TrEMBL
      C9J417
      Related
      ENSP00000394640.1, ENST00000431217.1
    12. XM_011510461.4XP_011508763.2  bcl-2-like protein 11 isoform X1

    13. XM_005263557.5XP_005263614.1  bcl-2-like protein 11 isoform X8

      See identical proteins and their annotated locations for XP_005263614.1

      Conserved Domains (2) summary
      pfam06773
      Location:440
      Bim_N; Bim protein N-terminus
      pfam08945
      Location:132163
      Bclx_interact; Bcl-x interacting, BH3 domain

    RNA

    1. XR_007068189.1 RNA Sequence

    2. XR_007068187.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      111543978..111591507
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054340063.1XP_054196038.1  bcl-2-like protein 11 isoform X6

    2. XM_054340070.1XP_054196045.1  bcl-2-like protein 11 isoform X8

    3. XM_054340055.1XP_054196030.1  bcl-2-like protein 11 isoform X14

      UniProtKB/TrEMBL
      E9PAM9
    4. XM_054340061.1XP_054196036.1  bcl-2-like protein 11 isoform X18

    5. XM_054340060.1XP_054196035.1  bcl-2-like protein 11 isoform X4

      UniProtKB/TrEMBL
      A0AA75IMJ6
    6. XM_054340069.1XP_054196044.1  bcl-2-like protein 11 isoform X12

      UniProtKB/TrEMBL
      A0AA75IMJ6
    7. XM_054340067.1XP_054196042.1  bcl-2-like protein 11 isoform X21

    8. XM_054340057.1XP_054196032.1  bcl-2-like protein 11 isoform X16

    9. XM_054340054.1XP_054196029.1  bcl-2-like protein 11 isoform X13

    10. XM_054340059.1XP_054196034.1  bcl-2-like protein 11 isoform X3

    11. XM_054340064.1XP_054196039.1  bcl-2-like protein 11 isoform X20

    12. XM_054340062.1XP_054196037.1  bcl-2-like protein 11 isoform X19

    13. XM_054340058.1XP_054196033.1  bcl-2-like protein 11 isoform X17

    14. XM_054340068.1XP_054196043.1  bcl-2-like protein 11 isoform X11

      UniProtKB/TrEMBL
      A0AA75IMJ6
    15. XM_054340056.1XP_054196031.1  bcl-2-like protein 11 isoform X15

    16. XM_054340066.1XP_054196041.1  bcl-2-like protein 11 isoform X9

    17. XM_054340065.1XP_054196040.1  bcl-2-like protein 11 isoform X8

    RNA

    1. XR_008486241.1 RNA Sequence

    2. XR_008486242.1 RNA Sequence

    3. XR_008486243.1 RNA Sequence