CDK7 cyclin dependent kinase 7 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CDK7provided by HGNC
Official Full Name: cyclin dependent kinase 7provided by HGNC
Primary source: HGNC:HGNC:1778
See related: Ensembl:ENSG00000134058 MIM:601955; AllianceGenome:HGNC:1778
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CAK; CAK1; HCAK; MO15; STK1; CDKN7; p39MO15
Summary: The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in testis (RPKM 18.1), placenta (RPKM 14.9) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 5q13.2

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (69234795..69277430)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (70060554..70103173)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (68530622..68573257)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Activation of the CDK7 Gene, Coding for the Catalytic Subunit of the Cyclin-Dependent Kinase (CDK)-Activating Kinase (CAK) and General Transcription Factor II H, by the Trans-Activator Protein Tax of Human T-Cell Leukemia Virus Type-1.
Title: Activation of the CDK7 Gene, Coding for the Catalytic Subunit of the Cyclin-Dependent Kinase (CDK)-Activating Kinase (CAK) and General Transcription Factor II H, by the Trans-Activator Protein Tax of Human T-Cell Leukemia Virus Type-1.
Structural basis of Cdk7 activation by dual T-loop phosphorylation.
Title: Structural basis of Cdk7 activation by dual T-loop phosphorylation.
CDK7 kinase activity promotes RNA polymerase II promoter escape by facilitating initiation factor release.
Title: CDK7 kinase activity promotes RNA polymerase II promoter escape by facilitating initiation factor release.
CDK7 in breast cancer: mechanisms of action and therapeutic potential.
Title: CDK7 in breast cancer: mechanisms of action and therapeutic potential.
CDK7 and CDK9 inhibition interferes with transcription, translation, and stemness, and induces cytotoxicity in GBM irrespective of temozolomide sensitivity.
Title: CDK7 and CDK9 inhibition interferes with transcription, translation, and stemness, and induces cytotoxicity in GBM irrespective of temozolomide sensitivity.
Cytomegalovirus cyclin-dependent kinase ortholog vCDK/pUL97 undergoes regulatory interaction with human cyclin H and CDK7 to codetermine viral replication efficiency.
Title: Cytomegalovirus cyclin-dependent kinase ortholog vCDK/pUL97 undergoes regulatory interaction with human cyclin H and CDK7 to codetermine viral replication efficiency.
Disruption of CDK7 signaling leads to catastrophic chromosomal instability coupled with a loss of condensin-mediated chromatin compaction.
Title: Disruption of CDK7 signaling leads to catastrophic chromosomal instability coupled with a loss of condensin-mediated chromatin compaction.
Castration-resistant prostate cancer cells are dependent on the high activity of CDK7.
Title: Castration-resistant prostate cancer cells are dependent on the high activity of CDK7.
Super-enhancer-driven lncRNA LIMD1-AS1 activated by CDK7 promotes glioma progression.
Title: Super-enhancer-driven lncRNA LIMD1-AS1 activated by CDK7 promotes glioma progression.
CDK7/GRP78 signaling axis contributes to tumor growth and metastasis in osteosarcoma.
Title: CDK7/GRP78 signaling axis contributes to tumor growth and metastasis in osteosarcoma.

Submit: New GeneRIF Correction See all GeneRIFs (65)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	HIV-1 Tat interacts with the RNA polymerase II holoenzyme and transcription preinitiation complexes, which include TFIIH, during Tat-mediated transactivation of the HIV-1 LTR	PubMed
	tat	TFIIH subunits CDK7 and cyclin H have been identified as two components associated with the Tat-associated CTD kinase (TTK) that binds to HIV-1 Tat	PubMed
	tat	Phosphorylation of CDK7 by CDK2 is involved in the interaction of HIV-1 Tat with CDK7 and subsequent activation of HIV-1 transactivation of the HIV-1 LTR promoter	PubMed
	tat	TFIIH synergizes with HIV-1 Tat to induce transcription elongation from the HIV-1 LTR promoter	PubMed
	tat	Interaction of HIV-1 Tat with TFIIH stimulates phosphorylation of Ser-5 of the RNA polymerase II C-terminal domain (CTD), which in turn also stimulates co-transcriptional capping of HIV-1 mRNA	PubMed
	tat	TFIIH interacts with HIV-1 Tat as a component of the HIV-1 transcription preinitiation complex, but is released from the elongation complex which includes P-TEFb	PubMed
	tat	CAK/TFIIH is required for HIV-1 Tat-mediated transactivation of the HIV-1 LTR promoter	PubMed
	tat	Amino acids 1-48 of HIV-1 Tat, which includes the Tat activation domain, mediate the binding of Tat to CAK and the TFIIH complex through a direct interaction with CDK7 and possibly other TFIIH subunits, including p62 and ERCC3	PubMed
Vpr	vpr	As a component of the TFIIH transcription complex, CDK7 inhibits HIV-1 Vpr cell cycle-arresting function	PubMed
	vpr	As a component of the TFIIH transcription complex, CDK7 enhances the synergistic activation of glucocorticoid receptor by HIV-1 Vpr and p300	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D5S1414 (e-PCR)
- UniSTS:149791

RH70920 (e-PCR)
- UniSTS:69983

SHGC-12862 (e-PCR)
- UniSTS:72869

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP-dependent activity, acting on DNA	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II CTD heptapeptide repeat S2 kinase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S5 kinase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S7 kinase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat T4 kinase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat Y1 kinase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II CTD heptapeptide repeat kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables cyclin-dependent protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	TAS Traceable Author Statement more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	TAS Traceable Author Statement more info

Process	Evidence Code	Pubs
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in protein stabilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of G1/S transition of mitotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell cycle	TAS Traceable Author Statement more info	PubMed
involved_in snRNA transcription by RNA polymerase II	TAS Traceable Author Statement more info
involved_in transcription by RNA polymerase II	TAS Traceable Author Statement more info
involved_in transcription initiation at RNA polymerase II promoter	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of CAK-ERCC2 complex	IDA Inferred from Direct Assay more info	PubMed
part_of cyclin-dependent protein kinase holoenzyme complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in fibrillar center	IDA Inferred from Direct Assay more info
located_in male germ cell nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info
part_of transcription factor TFIIH core complex	IDA Inferred from Direct Assay more info	PubMed
part_of transcription factor TFIIH holo complex	IDA Inferred from Direct Assay more info	PubMed
part_of transcription factor TFIIK complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription factor TFIIK complex	IDA Inferred from Direct Assay more info	PubMed
part_of transcription factor TFIIK complex	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: cyclin-dependent kinase 7

Names: 39 KDa protein kinase; CDK-activating kinase 1; TFIIH basal transcription factor complex kinase subunit; cell division protein kinase 7; cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase); homolog of Xenopus MO15 Cdk-activating kinase; kinase subunit of CAK; serine/threonine kinase stk1; serine/threonine protein kinase 1; serine/threonine protein kinase MO15

NP_001310998.1

EC 2.7.11.22

EC 2.7.11.23

NP_001310999.1

EC 2.7.11.22

EC 2.7.11.23

NP_001311000.1

EC 2.7.11.22

EC 2.7.11.23

NP_001311001.1

EC 2.7.11.22

EC 2.7.11.23

NP_001311003.1

EC 2.7.11.22

EC 2.7.11.23

NP_001311004.1

EC 2.7.11.22

EC 2.7.11.23

NP_001311006.1

EC 2.7.11.22

EC 2.7.11.23

NP_001311007.1

EC 2.7.11.22

EC 2.7.11.23

NP_001790.1

EC 2.7.11.22

EC 2.7.11.23

XP_011541396.1

EC 2.7.11.22

EC 2.7.11.23

XP_047272565.1

EC 2.7.11.22

EC 2.7.11.23

XP_054185464.1

EC 2.7.11.22

EC 2.7.11.23

XP_054207386.1

EC 2.7.11.22

EC 2.7.11.23

XP_054207387.1

EC 2.7.11.22

EC 2.7.11.23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001324069.2 → NP_001310998.1 cyclin-dependent kinase 7 isoform 2

Status: VALIDATED

Source sequence(s)

BC005298, BI520184, CA437275, L20320

UniProtKB/TrEMBL

D6RAD4

Conserved Domains (1) summary

cd07841
Location:2 → 267

STKc_CDK7; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 7
NM_001324070.2 → NP_001310999.1 cyclin-dependent kinase 7 isoform 3

Status: VALIDATED

Source sequence(s)

AK308493, BC000834, CA437275

UniProtKB/Swiss-Prot

P50613

Conserved Domains (1) summary

cd07841
Location:11 → 251

STKc_CDK7; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 7
NM_001324071.2 → NP_001311000.1 cyclin-dependent kinase 7 isoform 5

Status: VALIDATED

Source sequence(s)

AC145132, BC000834, BC005298, CA437275

UniProtKB/Swiss-Prot

P50613

Conserved Domains (1) summary

cl21453
Location:43 → 251

PKc_like; Protein Kinases, catalytic domain
NM_001324072.1 → NP_001311001.1 cyclin-dependent kinase 7 isoform 4

Status: VALIDATED

Source sequence(s)

AC145132

Consensus CDS

CCDS83002.1

UniProtKB/TrEMBL

D6R9G1

Conserved Domains (1) summary

cd07841
Location:1 → 215

STKc_CDK7; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 7
NM_001324074.2 → NP_001311003.1 cyclin-dependent kinase 7 isoform 4

Status: VALIDATED

Source sequence(s)

AC145132

Consensus CDS

CCDS83002.1

UniProtKB/TrEMBL

D6R9G1

Conserved Domains (1) summary

cd07841
Location:1 → 215

STKc_CDK7; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 7
NM_001324075.2 → NP_001311004.1 cyclin-dependent kinase 7 isoform 4

Status: VALIDATED

Source sequence(s)

AC145132

Consensus CDS

CCDS83002.1

UniProtKB/TrEMBL

D6R9G1

Conserved Domains (1) summary

cd07841
Location:1 → 215

STKc_CDK7; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 7
NM_001324077.1 → NP_001311006.1 cyclin-dependent kinase 7 isoform 4

Status: VALIDATED

Source sequence(s)

BC005298, BI520184, BU660651, CA305960, CA437275

Consensus CDS

CCDS83002.1

UniProtKB/TrEMBL

D6R9G1

Related

ENSP00000422121.1, ENST00000502604.5

Conserved Domains (1) summary

cd07841
Location:1 → 215

STKc_CDK7; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 7
NM_001324078.2 → NP_001311007.1 cyclin-dependent kinase 7 isoform 4

Status: VALIDATED

Source sequence(s)

BI520184, CA437275, KU177971

Consensus CDS

CCDS83002.1

UniProtKB/TrEMBL

D6R9G1

Conserved Domains (1) summary

cd07841
Location:1 → 215

STKc_CDK7; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 7
NM_001799.4 → NP_001790.1 cyclin-dependent kinase 7 isoform 1

See identical proteins and their annotated locations for NP_001790.1

Status: VALIDATED

Source sequence(s)

BC000834, BC005298, BI520184, CA437275

Consensus CDS

CCDS3999.1

UniProtKB/Swiss-Prot

P50613, Q9BS60, Q9UE19

UniProtKB/TrEMBL

A0A0S2Z3F9, D6RAD4

Related

ENSP00000256443.3, ENST00000256443.8

Conserved Domains (1) summary

cd07841
Location:11 → 308

STKc_CDK7; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 7

RNA

NR_136690.2 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC145132

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000005.10 Reference GRCh38.p14 Primary Assembly

Range

69234795..69277430

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047416609.1 → XP_047272565.1 cyclin-dependent kinase 7 isoform X1
XM_011543094.3 → XP_011541396.1 cyclin-dependent kinase 7 isoform X2

Conserved Domains (1) summary

cl21453
Location:1 → 191

PKc_like; Protein Kinases, catalytic domain