ATP6V0A1 ATPase H+ transporting V0 subunit a1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ATP6V0A1provided by HGNC
Official Full Name: ATPase H+ transporting V0 subunit a1provided by HGNC
Primary source: HGNC:HGNC:865
See related: Ensembl:ENSG00000033627 MIM:192130; AllianceGenome:HGNC:865
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: a1; Stv1; VPP1; Vph1; ATP6N1; DEE104; NEDEBA; ATP6N1A
Summary: This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three A subunit proteins and the encoded protein is associated with clathrin-coated vesicles. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in brain (RPKM 46.5), kidney (RPKM 12.3) and 23 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 17q21.2

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (42458878..42522579)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (43316076..43379766)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (40610896..40674597)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

V-ATPase V0a1 promotes Weibel-Palade body biogenesis through the regulation of membrane fission.
Title: V-ATPase V0a1 promotes Weibel-Palade body biogenesis through the regulation of membrane fission.
ATP6V0A1 encoding the a1-subunit of the V0 domain of vacuolar H(+)-ATPases is essential for brain development in humans and mice.
Title: ATP6V0A1 encoding the a1-subunit of the V0 domain of vacuolar H(+)-ATPases is essential for brain development in humans and mice.
The function of vacuolar ATPase (V-ATPase) a subunit isoforms in invasiveness of MCF10a and MCF10CA1a human breast cancer cells.
Title: The function of vacuolar ATPase (V-ATPase) a subunit isoforms in invasiveness of MCF10a and MCF10CA1a human breast cancer cells.
Inhibition of lysosome degradation on autophagosome formation and responses to GMI, an immunomodulatory protein from Ganoderma microsporum. ATP6V0A1 plays an important role in mediating autophagosome-lysosome fusion.
Title: Inhibition of lysosome degradation on autophagosome formation and responses to GMI, an immunomodulatory protein from Ganoderma microsporum.
a series of events whereby ATP6V0A1 3'-UTR variant T+3246C functioned: ATP6V0A1 expression probably was affected through differential micro-RNA effects, altering vacuolar pH and consequently CHGA processing and exocytotic secretion.
Title: A common genetic variant in the 3'-UTR of vacuolar H+-ATPase ATP6V0A1 creates a micro-RNA motif to alter chromogranin A processing and hypertension risk.
Observational study, meta-analysis, and genome-wide association study of gene-disease association. (HuGE Navigator)
Title: Novel loci for major depression identified by genome-wide association study of Sequenced Treatment Alternatives to Relieve Depression and meta-analysis of three studies.
The mRNA levels of POLR2F, ATP6V0A1 and PRNP were evaluated by quantitative RT-PCR in 70 colorectal carcinomas and 17 normal tissue specimens and were correlated with clinicopathological parameters.
Title: POLR2F, ATP6V0A1 and PRNP expression in colorectal cancer: new molecules with prognostic significance?

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Developmental and epileptic encephalopathy 104 MedGen: C5774183 OMIM: 619970 GeneReviews: Not available	not available
Neurodevelopmental disorder with epilepsy and brain atrophy MedGen: C5774184 OMIM: 619971 GeneReviews: Not available	not available

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of ATPase, H+ transporting, lysosomal V0 subunit a1 (ATP6V0A1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

2194 (e-PCR)
- UniSTS:9243

ATP6V0A1_708 (e-PCR)
- UniSTS:277019

RH92453 (e-PCR)
- UniSTS:91307

D17S1365E (e-PCR)
- UniSTS:37811

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATPase binding	IBA Inferred from Biological aspect of Ancestor more info
enables ATPase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables proton-transporting ATPase activity, rotational mechanism	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in endosomal lumen acidification	NAS Non-traceable Author Statement more info	PubMed
involved_in lysosomal lumen acidification	NAS Non-traceable Author Statement more info	PubMed
involved_in proton transmembrane transport	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of macroautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle lumen acidification	IEA Inferred from Electronic Annotation more info
involved_in vacuolar acidification	IBA Inferred from Biological aspect of Ancestor more info
involved_in vacuolar acidification	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info
located_in clathrin-coated vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in endosome membrane	TAS Traceable Author Statement more info
located_in extracellular exosome	HDA more info	PubMed
located_in ficolin-1-rich granule membrane	TAS Traceable Author Statement more info
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info
located_in lysosomal membrane	TAS Traceable Author Statement more info	PubMed
located_in melanosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear speck	IDA Inferred from Direct Assay more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in phagocytic vesicle membrane	TAS Traceable Author Statement more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
part_of proton-transporting V-type ATPase complex	NAS Non-traceable Author Statement more info	PubMed
located_in secretory granule membrane	TAS Traceable Author Statement more info
located_in synaptic vesicle membrane	IEA Inferred from Electronic Annotation more info
part_of vacuolar proton-transporting V-type ATPase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of vacuolar proton-transporting V-type ATPase, V0 domain	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: V-type proton ATPase 116 kDa subunit a 1

Names: ATPase, H+ transporting, lysosomal V0 subunit a1; ATPase, H+ transporting, lysosomal non-catalytic accessory protein 1 (110/116kD); H(+)-transporting two-sector ATPase, 116 kDa accessory protein A1; V-ATPase 116 kDa subunit a 1; V-ATPase 116 kDa subunit a1; V-ATPase subunit a1; V-type proton ATPase 116 kDa subunit a; V-type proton ATPase 116 kDa subunit a1; clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit; vacuolar adenosine triphosphatase subunit Ac116; vacuolar proton pump subunit 1; vacuolar proton translocating ATPase 116 kDa subunit A; vacuolar-type H(+)-ATPase 115 kDa subunit

NP_001123492.1

EC 7.1.2.2

NP_001123493.1

EC 7.1.2.2

NP_001365451.1

EC 7.1.2.2

NP_001365452.1

EC 7.1.2.2

NP_001365459.1

EC 7.1.2.2

NP_001365460.1

EC 7.1.2.2

NP_001365461.1

EC 7.1.2.2

NP_001365462.1

EC 7.1.2.2

NP_001365463.1

EC 7.1.2.2

NP_001365464.1

EC 7.1.2.2

NP_001365465.1

EC 7.1.2.2

NP_001365466.1

EC 7.1.2.2

NP_001365467.1

EC 7.1.2.2

NP_001365468.1

EC 7.1.2.2

NP_001365469.1

EC 7.1.2.2

NP_001365470.1

EC 7.1.2.2

NP_001365471.1

EC 7.1.2.2

NP_001365472.1

EC 7.1.2.2

NP_001365473.1

EC 7.1.2.2

NP_001365474.1

EC 7.1.2.2

NP_001365475.1

EC 7.1.2.2

NP_001365476.1

EC 7.1.2.2

NP_001365477.1

EC 7.1.2.2

NP_001365478.1

EC 7.1.2.2

NP_001365479.1

EC 7.1.2.2

NP_001365480.1

EC 7.1.2.2

NP_001365481.1

EC 7.1.2.2

NP_001365483.1

EC 7.1.2.2

NP_001365485.1

EC 7.1.2.2

NP_001365486.1

EC 7.1.2.2

NP_005168.2

EC 7.1.2.2

XP_047292260.1

EC 7.1.2.2

XP_047292261.1

EC 7.1.2.2

XP_054172489.1

EC 7.1.2.2

XP_054172490.1

EC 7.1.2.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_047037.1 RefSeqGene

Range

5035..68736

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001130020.3 → NP_001123492.1 V-type proton ATPase 116 kDa subunit a 1 isoform 2

See identical proteins and their annotated locations for NP_001123492.1

Status: REVIEWED

Source sequence(s)

AC067852, AC107993

Consensus CDS

CCDS45683.1

UniProtKB/TrEMBL

Q5CZH6

Related

ENSP00000264649.5, ENST00000264649.10

Conserved Domains (1) summary

pfam01496
Location:27 → 828

V_ATPase_I; V-type ATPase 116kDa subunit family
NM_001130021.3 → NP_001123493.1 V-type proton ATPase 116 kDa subunit a 1 isoform 1

See identical proteins and their annotated locations for NP_001123493.1

Status: REVIEWED

Source sequence(s)

AC067852, AC107993

Consensus CDS

CCDS45684.1

UniProtKB/Swiss-Prot

B7Z3B7, Q8N5G7, Q93050, Q9NSX0

UniProtKB/TrEMBL

Q53ET5

Related

ENSP00000342951.3, ENST00000343619.9

Conserved Domains (1) summary

pfam01496
Location:27 → 827

V_ATPase_I; V-type ATPase 116kDa subunit family
NM_001378522.1 → NP_001365451.1 V-type proton ATPase 116 kDa subunit a 1 isoform 4

Status: REVIEWED

Source sequence(s)

AC067852, AC107993

UniProtKB/TrEMBL

Q5CZH6

Related

ENSP00000515529.1, ENST00000703892.1

Conserved Domains (1) summary

pfam01496
Location:27 → 834

V_ATPase_I; V-type ATPase 116kDa subunit family
NM_001378523.1 → NP_001365452.1 V-type proton ATPase 116 kDa subunit a 1 isoform 5

Status: REVIEWED

Source sequence(s)

AC067852, AC107993

UniProtKB/TrEMBL

Q5CZH6

Conserved Domains (1) summary

pfam01496
Location:27 → 792

V_ATPase_I; V-type ATPase 116kDa subunit family
NM_001378530.1 → NP_001365459.1 V-type proton ATPase 116 kDa subunit a 1 isoform 6

Status: REVIEWED

Source sequence(s)

AC067852, AC107993

UniProtKB/TrEMBL

Q53ET5

Conserved Domains (1) summary

pfam01496
Location:27 → 893

V_ATPase_I; V-type ATPase 116kDa subunit family
NM_001378531.1 → NP_001365460.1 V-type proton ATPase 116 kDa subunit a 1 isoform 7

Status: REVIEWED

Source sequence(s)

AC067852, AC107993

UniProtKB/TrEMBL

Q5CZH6

Conserved Domains (1) summary

pfam01496
Location:27 → 875

V_ATPase_I; V-type ATPase 116kDa subunit family
NM_001378532.1 → NP_001365461.1 V-type proton ATPase 116 kDa subunit a 1 isoform 8

Status: REVIEWED

Source sequence(s)

AC067852, AC107993

Consensus CDS

CCDS92317.1

UniProtKB/TrEMBL

A0A994J3Z0, Q5CZH6

Related

ENSP00000515525.1, ENST00000703888.1

Conserved Domains (1) summary

pfam01496
Location:27 → 869

V_ATPase_I; V-type ATPase 116kDa subunit family
NM_001378533.1 → NP_001365462.1 V-type proton ATPase 116 kDa subunit a 1 isoform 9

Status: REVIEWED

Source sequence(s)

AC067852, AC107993

Consensus CDS

CCDS92318.1

UniProtKB/TrEMBL

K7EN36, Q53ET5

Related

ENSP00000466767.2, ENST00000592324.2

Conserved Domains (1) summary

pfam01496
Location:27 → 868

V_ATPase_I; V-type ATPase 116kDa subunit family
NM_001378534.1 → NP_001365463.1 V-type proton ATPase 116 kDa subunit a 1 isoform 10

Status: REVIEWED

Source sequence(s)

AC067852, AC107993

UniProtKB/TrEMBL

Q5CZH6

Related

ENSP00000515531.1, ENST00000703894.1

Conserved Domains (1) summary

pfam01496
Location:27 → 859

V_ATPase_I; V-type ATPase 116kDa subunit family
NM_001378535.1 → NP_001365464.1 V-type proton ATPase 116 kDa subunit a 1 isoform 11

Status: REVIEWED

Source sequence(s)

AC067852, AC107993

Consensus CDS

CCDS92319.1

UniProtKB/TrEMBL

K7ENA1, Q53ET5

Related

ENSP00000466852.2, ENST00000588138.2

Conserved Domains (1) summary

pfam01496
Location:27 → 852

V_ATPase_I; V-type ATPase 116kDa subunit family
NM_001378536.1 → NP_001365465.1 V-type proton ATPase 116 kDa subunit a 1 isoform 12

Status: REVIEWED

Source sequence(s)

AC067852, AC107993

Consensus CDS

CCDS92322.1

UniProtKB/TrEMBL

A0A994J3Z4, A0A994J473

Related

ENSP00000515530.1, ENST00000703893.1

Conserved Domains (1) summary

pfam01496
Location:27 → 791

V_ATPase_I; V-type ATPase 116kDa subunit family
NM_001378537.1 → NP_001365466.1 V-type proton ATPase 116 kDa subunit a 1 isoform 13

Status: REVIEWED

Source sequence(s)

AC067852, AC107993

UniProtKB/TrEMBL

Q53ET5

Conserved Domains (1) summary

pfam01496
Location:27 → 785

V_ATPase_I; V-type ATPase 116kDa subunit family
NM_001378538.1 → NP_001365467.1 V-type proton ATPase 116 kDa subunit a 1 isoform 14

Status: REVIEWED

Source sequence(s)

AC067852, AC107993

Consensus CDS

CCDS92323.1

UniProtKB/TrEMBL

A0A994J473, B7Z2A9

Related

ENSP00000466878.1, ENST00000585525.5

Conserved Domains (1) summary

pfam01496
Location:27 → 784

V_ATPase_I; V-type ATPase 116kDa subunit family
NM_001378539.1 → NP_001365468.1 V-type proton ATPase 116 kDa subunit a 1 isoform 15

Status: REVIEWED

Source sequence(s)

AC067852, AC107993

UniProtKB/TrEMBL

A0A994J6N0

Related

ENSP00000515526.1, ENST00000703889.1

Conserved Domains (1) summary

pfam01496
Location:27 → 760

V_ATPase_I; V-type ATPase 116kDa subunit family
NM_001378540.1 → NP_001365469.1 V-type proton ATPase 116 kDa subunit a 1 isoform 16

Status: REVIEWED

Source sequence(s)

AC067852, AC107993

Consensus CDS

CCDS92324.1

UniProtKB/TrEMBL

A0A994J473, B7Z641

Related

ENSP00000443991.1, ENST00000537728.5

Conserved Domains (1) summary

pfam01496
Location:27 → 778

V_ATPase_I; V-type ATPase 116kDa subunit family
NM_001378541.1 → NP_001365470.1 V-type proton ATPase 116 kDa subunit a 1 isoform 17

Status: REVIEWED

Source sequence(s)

AC067852, AC107993

UniProtKB/TrEMBL

A0A994J6N0

Conserved Domains (1) summary

pfam01496
Location:27 → 754

V_ATPase_I; V-type ATPase 116kDa subunit family
NM_001378542.1 → NP_001365471.1 V-type proton ATPase 116 kDa subunit a 1 isoform 18

Status: REVIEWED

Source sequence(s)

AC067852, AC107993

Consensus CDS

CCDS92320.1

UniProtKB/TrEMBL

A0A994J4L9, K7ERA6

Related

ENSP00000468177.2, ENST00000586201.6

Conserved Domains (1) summary

pfam01496
Location:27 → 753

V_ATPase_I; V-type ATPase 116kDa subunit family
NM_001378543.1 → NP_001365472.1 V-type proton ATPase 116 kDa subunit a 1 isoform 19

Status: REVIEWED

Source sequence(s)

AC067852, AC107993

UniProtKB/TrEMBL

Q5CZH6

Conserved Domains (1) summary

pfam01496
Location:1 → 768

V_ATPase_I; V-type ATPase 116kDa subunit family
NM_001378544.1 → NP_001365473.1 V-type proton ATPase 116 kDa subunit a 1 isoform 20

Status: REVIEWED

Source sequence(s)

AC067852, AC107993

UniProtKB/TrEMBL

A0A994J4L9

Conserved Domains (1) summary

pfam01496
Location:27 → 747

V_ATPase_I; V-type ATPase 116kDa subunit family
NM_001378545.1 → NP_001365474.1 V-type proton ATPase 116 kDa subunit a 1 isoform 21

Status: REVIEWED

Source sequence(s)

AC067852, AC107993

Consensus CDS

CCDS92321.1

UniProtKB/TrEMBL

A0A994J3Z9, A0A994J473

Related

ENSP00000515535.1, ENST00000703897.1

Conserved Domains (1) summary

pfam01496
Location:27 → 757

V_ATPase_I; V-type ATPase 116kDa subunit family
NM_001378546.1 → NP_001365475.1 V-type proton ATPase 116 kDa subunit a 1 isoform 22

Status: REVIEWED

Source sequence(s)

AC067852, AC107993

UniProtKB/TrEMBL

Q53ET5

Conserved Domains (1) summary

pfam01496
Location:27 → 756

V_ATPase_I; V-type ATPase 116kDa subunit family
NM_001378547.1 → NP_001365476.1 V-type proton ATPase 116 kDa subunit a 1 isoform 23

Status: REVIEWED

Source sequence(s)

AC067852, AC107993

UniProtKB/TrEMBL

Q53ET5

Conserved Domains (1) summary

pfam01496
Location:27 → 750

V_ATPase_I; V-type ATPase 116kDa subunit family
NM_001378548.1 → NP_001365477.1 V-type proton ATPase 116 kDa subunit a 1 isoform 24

Status: REVIEWED

Source sequence(s)

AC067852, AC107993

UniProtKB/TrEMBL

Q53ET5

Conserved Domains (1) summary

pfam01496
Location:27 → 745

V_ATPase_I; V-type ATPase 116kDa subunit family
NM_001378549.1 → NP_001365478.1 V-type proton ATPase 116 kDa subunit a 1 isoform 25

Status: REVIEWED

Source sequence(s)

AC067852, AC107993

UniProtKB/TrEMBL

Q53ET5

Conserved Domains (1) summary

pfam01496
Location:1 → 767

V_ATPase_I; V-type ATPase 116kDa subunit family
NM_001378550.1 → NP_001365479.1 V-type proton ATPase 116 kDa subunit a 1 isoform 26

Status: REVIEWED

Source sequence(s)

AC067852, AC107993

UniProtKB/TrEMBL

A0A994J473

Conserved Domains (1) summary

pfam01496
Location:28 → 785

V_ATPase_I; V-type ATPase 116kDa subunit family
NM_001378551.1 → NP_001365480.1 V-type proton ATPase 116 kDa subunit a 1 isoform 27

Status: REVIEWED

Source sequence(s)

AC067852, AC107993

UniProtKB/TrEMBL

Q53ET5

Conserved Domains (1) summary

pfam01496
Location:27 → 862

V_ATPase_I; V-type ATPase 116kDa subunit family
NM_001378552.1 → NP_001365481.1 V-type proton ATPase 116 kDa subunit a 1 isoform 28

Status: REVIEWED

Source sequence(s)

AC067852, AC107993

UniProtKB/TrEMBL

A0A994J4L9

Conserved Domains (1) summary

pfam01496
Location:27 → 788

V_ATPase_I; V-type ATPase 116kDa subunit family
NM_001378554.1 → NP_001365483.1 V-type proton ATPase 116 kDa subunit a 1 isoform 29

Status: REVIEWED

Source sequence(s)

AC067852, AC107993

UniProtKB/TrEMBL

Q53ET5

Conserved Domains (1) summary

pfam01496
Location:27 → 751

V_ATPase_I; V-type ATPase 116kDa subunit family
NM_001378556.1 → NP_001365485.1 V-type proton ATPase 116 kDa subunit a 1 isoform 30

Status: REVIEWED

Source sequence(s)

AC067852, AC107993

UniProtKB/TrEMBL

A0A994J4L9

Conserved Domains (1) summary

pfam01496
Location:28 → 711

V_ATPase_I; V-type ATPase 116kDa subunit family
NM_001378557.1 → NP_001365486.1 V-type proton ATPase 116 kDa subunit a 1 isoform 31

Status: REVIEWED

Source sequence(s)

AC067852, AC107993

UniProtKB/TrEMBL

A0A994J4L9

Conserved Domains (1) summary

pfam01496
Location:27 → 711

V_ATPase_I; V-type ATPase 116kDa subunit family
NM_005177.5 → NP_005168.2 V-type proton ATPase 116 kDa subunit a 1 isoform 3

See identical proteins and their annotated locations for NP_005168.2

Status: REVIEWED

Source sequence(s)

AC067852, AC107993

Consensus CDS

CCDS11426.1

UniProtKB/TrEMBL

Q53ET5

Related

ENSP00000377415.2, ENST00000393829.6

Conserved Domains (1) summary

pfam01496
Location:27 → 821

V_ATPase_I; V-type ATPase 116kDa subunit family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000017.11 Reference GRCh38.p14 Primary Assembly

Range

42458878..42522579

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047436305.1 → XP_047292261.1 V-type proton ATPase 116 kDa subunit a 1 isoform X2
XM_047436304.1 → XP_047292260.1 V-type proton ATPase 116 kDa subunit a 1 isoform X1

RNA

XR_007065303.1 RNA Sequence
XR_007065304.1 RNA Sequence
XR_007065306.1 RNA Sequence
XR_007065305.1 RNA Sequence
XR_007065307.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

NC_060941.1 Alternate T2T-CHM13v2.0

Range

43316076..43379766

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054316515.1 → XP_054172490.1 V-type proton ATPase 116 kDa subunit a 1 isoform X2
XM_054316514.1 → XP_054172489.1 V-type proton ATPase 116 kDa subunit a 1 isoform X1