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    PDK1 pyruvate dehydrogenase kinase 1 [ Homo sapiens (human) ]

    Gene ID: 5163, updated on 2-Nov-2024

    Summary

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    Official Symbol
    PDK1provided by HGNC
    Official Full Name
    pyruvate dehydrogenase kinase 1provided by HGNC
    Primary source
    HGNC:HGNC:8809
    See related
    Ensembl:ENSG00000152256 MIM:602524; AllianceGenome:HGNC:8809
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2013]
    Annotation information
    Note: PDK1 (Gene ID: 5163) and PDPK1 (Gene ID: 5170) share the PDK1 symbol/alias in common. PDK1 is a widely used alternative name for 3-phosphoinositide dependent protein kinase 1 (PDPK1). [01 Jun 2018]
    Expression
    Ubiquitous expression in heart (RPKM 4.7), adrenal (RPKM 4.3) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PDK1 in Genome Data Viewer
    Location:
    2q31.1
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (172555373..172724312)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (173041625..173210788)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (173420101..173490351)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985960 Neighboring gene uncharacterized LOC105373742 Neighboring gene Sharpr-MPRA regulatory region 14975 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:173245267-173245776 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:173245777-173246288 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_55951 Neighboring gene NANOG hESC enhancer GRCh37_chr2:173280388-173280889 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12110 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:173293126-173293626 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:173295051-173296250 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:173299510-173300010 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:173318135-173318864 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_56026 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_56072 Neighboring gene ITGA6 and PDK1 antisense RNA 1 Neighboring gene integrin subunit alpha 6 Neighboring gene Sharpr-MPRA regulatory region 994 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:173399678-173400178 Neighboring gene PDK1 and ITGA6 antisense RNA 1 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:173413559-173414301 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:173414302-173415043 Neighboring gene Sharpr-MPRA regulatory region 4236 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16763 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12111 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:173456666-173456873 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_56189 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_56221 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_56231 Neighboring gene Sharpr-MPRA regulatory region 7042 Neighboring gene small nucleolar RNA U13 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_56260 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_56279 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_56293 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:173577807-173578364 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:173590766-173591266 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:173591267-173591767 Neighboring gene RAPGEF4 antisense RNA 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:173607526-173608725 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:173668092-173668282 Neighboring gene Rap guanine nucleotide exchange factor 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:173770903-173771408 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:173771409-173771912 Neighboring gene aldehyde dehydrogenase 7 family member A1 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12112 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12113 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_56377 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_56397 Neighboring gene mitogen-activated protein kinase kinase kinase 20 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:174056283-174056864 Neighboring gene MAP3K20 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16764 Neighboring gene VISTA enhancer hs242 Neighboring gene NANOG hESC enhancer GRCh37_chr2:174129200-174129707

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. PDK1 regulates the progression of esophageal squamous cell carcinoma through metabolic reprogramming. Ma Y, et al. Mol Carcinog, 2023 Jun. PMID 36988347
    2. The Glycolytic Gatekeeper PDK1 defines different metabolic states between genetically distinct subtypes of human acute myeloid leukemia. Erdem A, et al. Nat Commun, 2022 Mar 1. PMID 35232995, Free PMC Article
    3. PDK-1 mediated Hippo-YAP-IRS2 signaling pathway and involved in the apoptosis of non-small cell lung cancer cells. Wang G, et al. Biosci Rep, 2019 May 31. PMID 30988063, Free PMC Article
    4. Synthetic Essentiality of Metabolic Regulator PDHK1 in PTEN-Deficient Cells and Cancers. Chatterjee N, et al. Cell Rep, 2019 Aug 27. PMID 31461649, Free PMC Article
    5. Induction of Pyruvate Dehydrogenase Kinase 1 by Hypoxia Alters Cellular Metabolism and Inhibits Apoptosis in Endometriotic Stromal Cells. Lee HC, et al. Reprod Sci, 2019 Jun. PMID 30092712

    See all (158) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Inhibition of the ubiquitin-proteasome system reduces the abundance of pyruvate dehydrogenase kinase 1 in cultured myotubes.
      Title: Inhibition of the ubiquitin-proteasome system reduces the abundance of pyruvate dehydrogenase kinase 1 in cultured myotubes.
    2. Long non-coding RNA NEAT1 promotes aerobic glycolysis and progression of cervical cancer through WNT/beta-catenin/PDK1 axis.
      Title: Long non-coding RNA NEAT1 promotes aerobic glycolysis and progression of cervical cancer through WNT/β-catenin/PDK1 axis.
    3. Glutaminase potentiates the glycolysis in esophageal squamous cell carcinoma by interacting with PDK1.
      Title: Glutaminase potentiates the glycolysis in esophageal squamous cell carcinoma by interacting with PDK1.
    4. Circadian modulation of glucose utilization via CRY1-mediated repression of Pdk1 expression.
      Title: Circadian modulation of glucose utilization via CRY1-mediated repression of Pdk1 expression.
    5. RP11-495P10.1 promotes HCC cell proliferation by regulating reprogramming of glucose metabolism and acetylation of the NR4A3 promoter via the PDK1/PDH axis.
      Title: RP11-495P10.1 promotes HCC cell proliferation by regulating reprogramming of glucose metabolism and acetylation of the NR4A3 promoter via the PDK1/PDH axis.
    6. Combined inhibition of pyruvate dehydrogenase kinase 1 and lactate dehydrogenase a induces metabolic and signaling reprogramming and enhances lung adenocarcinoma cell killing.
      Title: Combined inhibition of pyruvate dehydrogenase kinase 1 and lactate dehydrogenase a induces metabolic and signaling reprogramming and enhances lung adenocarcinoma cell killing.
    7. Pyruvate dehydrogenase kinase 1 regulates the function of human decidual natural killer cells.
      Title: Pyruvate dehydrogenase kinase 1 regulates the function of human decidual natural killer cells.
    8. Circ_0000284 facilitates the growth, metastasis and glycolysis of intrahepatic cholangiocarcinoma through miR-152-3p-mediated PDK1 expression.
      Title: Circ_0000284 facilitates the growth, metastasis and glycolysis of intrahepatic cholangiocarcinoma through miR-152-3p-mediated PDK1 expression.
    9. Pyruvate dehydrogenase kinase regulates vascular inflammation in atherosclerosis and increases cardiovascular risk.
      Title: Pyruvate dehydrogenase kinase regulates vascular inflammation in atherosclerosis and increases cardiovascular risk.
    10. PDK1-stabilized LncRNA SPRY4-IT1 promotes breast cancer progression via activating NF-kappaB signaling pathway.
      Title: PDK1-stabilized LncRNA SPRY4-IT1 promotes breast cancer progression via activating NF-κB signaling pathway.
    Submit: New GeneRIF Correction See all GeneRIFs (72)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians.
    EBI GWAS Catalog
    Pilot genome-wide association search identifies potential loci for risk of erectile dysfunction in type 1 diabetes using the DCCT/EDIC study cohort.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat induces phosphorylation of PDK1 in Tat-expressing cells and HIV-1-infected cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pyruvate dehydrogenase (acetyl-transferring) kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyruvate dehydrogenase (acetyl-transferring) kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pyruvate dehydrogenase (acetyl-transferring) kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glucose metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in hypoxia-inducible factor-1alpha signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intrinsic apoptotic signaling pathway in response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of acetyl-CoA biosynthetic process from pyruvate IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of acetyl-CoA biosynthetic process from pyruvate IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of glucose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of glucose metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial matrix TAS
    Traceable Author Statement
    more info
    		  
    located_in mitochondrion HTP PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of pyruvate dehydrogenase complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial; pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial
    Names
    PDH kinase 1
    mitochondrial pyruvate dehydrogenase, lipoamide, kinase isoenzyme 1
    pyruvate dehydrogenase kinase, isoenzyme 1
    NP_001265478.1
    NP_002601.1
    XP_006712657.1
    XP_011509645.1
    XP_011509646.1
    XP_011509647.1
    XP_011509649.1
    XP_047300692.1
    XP_047300693.1
    XP_047300694.1
    XP_047300695.1
    XP_047300696.1
    XP_054198508.1
    XP_054198509.1
    XP_054198510.1
    XP_054198511.1
    XP_054198512.1
    XP_054198513.1
    XP_054198514.1
    XP_054198515.1
    XP_054198516.1
    XP_054198517.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001278549.2 → NP_001265478.1  [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC018712, AK304388, BQ023252, DC322401
      Consensus CDS
      CCDS63059.1
      UniProtKB/TrEMBL
      Q53R49
      Related
      ENSP00000376352.2, ENST00000392571.6
      Conserved Domains (3) summary
      smart00387
      Location:290 → 410
      HATPase_c; Histidine kinase-like ATPases
      COG0642
      Location:244 → 418
      BaeS; Signal transduction histidine kinase [Signal transduction mechanisms]
      pfam10436
      Location:56 → 240
      BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase

    2. NM_002610.5 → NP_002601.1  [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial isoform 2 precursor

      See identical proteins and their annotated locations for NP_002601.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AC018712, AK312700, BQ023252
      Consensus CDS
      CCDS2250.1
      UniProtKB/Swiss-Prot
      B2R6T1, B7Z937, D3DPD8, E9PD65, Q15118, Q308M4
      UniProtKB/TrEMBL
      Q53R49
      Related
      ENSP00000282077.3, ENST00000282077.8
      Conserved Domains (2) summary
      smart00387
      Location:270 → 390
      HATPase_c; Histidine kinase-like ATPases
      pfam10436
      Location:56 → 220
      BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase

    RNA

    1. NR_103729.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an internal exon and has a split 3' exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC018712, BC039158, BQ023252, DC322401

    2. NR_103731.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains alternate 5' and 3' sequences and lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC093818, AK302321, BX485353

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      172555373..172724312
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011511343.3 → XP_011509645.1  pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_011509645.1

      UniProtKB/TrEMBL
      Q53R49
      Conserved Domains (3) summary
      smart00387
      Location:214 → 334
      HATPase_c; Histidine kinase-like ATPases
      COG0642
      Location:168 → 342
      BaeS; Signal transduction histidine kinase [Signal transduction mechanisms]
      pfam10436
      Location:2 → 164
      BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase

    2. XM_011511345.4 → XP_011509647.1  pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial isoform X2

      See identical proteins and their annotated locations for XP_011509647.1

      UniProtKB/TrEMBL
      B7Z7N6, Q53R49
      Conserved Domains (3) summary
      smart00387
      Location:194 → 314
      HATPase_c; Histidine kinase-like ATPases
      COG0642
      Location:148 → 322
      BaeS; Signal transduction histidine kinase [Signal transduction mechanisms]
      pfam10436
      Location:2 → 144
      BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase

    3. XM_047444737.1 → XP_047300693.1  pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial isoform X3

    4. XM_047444738.1 → XP_047300694.1  pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial isoform X4

    5. XM_006712594.3 → XP_006712657.1  pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial isoform X6

      Conserved Domains (1) summary
      pfam10436
      Location:56 → 240
      BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase

    6. XM_047444740.1 → XP_047300696.1  pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial isoform X7

    7. XM_011511344.3 → XP_011509646.1  pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_011509646.1

      UniProtKB/TrEMBL
      Q53R49
      Conserved Domains (3) summary
      smart00387
      Location:214 → 334
      HATPase_c; Histidine kinase-like ATPases
      COG0642
      Location:168 → 342
      BaeS; Signal transduction histidine kinase [Signal transduction mechanisms]
      pfam10436
      Location:2 → 164
      BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase

    8. XM_047444736.1 → XP_047300692.1  pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial isoform X2

      UniProtKB/TrEMBL
      B7Z7N6

    9. XM_011511347.3 → XP_011509649.1  pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_011509649.1

      UniProtKB/TrEMBL
      Q53R49
      Conserved Domains (3) summary
      smart00387
      Location:214 → 334
      HATPase_c; Histidine kinase-like ATPases
      COG0642
      Location:168 → 342
      BaeS; Signal transduction histidine kinase [Signal transduction mechanisms]
      pfam10436
      Location:2 → 164
      BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase

    10. XM_047444739.1 → XP_047300695.1  pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial isoform X5

      UniProtKB/TrEMBL
      B7Z207

    RNA

    1. XR_007076395.1 RNA Sequence

    2. XR_007076402.1 RNA Sequence

    3. XR_007076394.1 RNA Sequence

    4. XR_922944.3 RNA Sequence

    5. XR_001738772.3 RNA Sequence

    6. XR_001738774.3 RNA Sequence

    7. XR_001738771.2 RNA Sequence

    8. XR_007076391.1 RNA Sequence

    9. XR_007076393.1 RNA Sequence

    10. XR_007076392.1 RNA Sequence

    11. XR_922942.2 RNA Sequence

    12. XR_922943.2 RNA Sequence

    13. XR_007076398.1 RNA Sequence

    14. XR_007076396.1 RNA Sequence

    15. XR_007076401.1 RNA Sequence

    16. XR_007076403.1 RNA Sequence

    17. XR_007076399.1 RNA Sequence

    18. XR_007076400.1 RNA Sequence

    19. XR_007076397.1 RNA Sequence

    20. XR_922945.1 RNA Sequence

    21. XR_001738775.3 RNA Sequence

    22. XR_427093.4 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      173041625..173210788
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054342534.1 → XP_054198509.1  pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial isoform X1

    2. XM_054342536.1 → XP_054198511.1  pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial isoform X2

      UniProtKB/TrEMBL
      B7Z7N6

    3. XM_054342538.1 → XP_054198513.1  pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial isoform X3

    4. XM_054342539.1 → XP_054198514.1  pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial isoform X4

    5. XM_054342541.1 → XP_054198516.1  pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial isoform X6

    6. XM_054342542.1 → XP_054198517.1  pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial isoform X7

    7. XM_054342533.1 → XP_054198508.1  pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial isoform X1

    8. XM_054342537.1 → XP_054198512.1  pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial isoform X2

      UniProtKB/TrEMBL
      B7Z7N6

    9. XM_054342535.1 → XP_054198510.1  pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial isoform X1

    10. XM_054342540.1 → XP_054198515.1  pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial isoform X5

      UniProtKB/TrEMBL
      B7Z207

    RNA

    1. XR_008486404.1 RNA Sequence

    2. XR_008486405.1 RNA Sequence

    3. XR_008486414.1 RNA Sequence

    4. XR_008486401.1 RNA Sequence

    5. XR_008486411.1 RNA Sequence

    6. XR_008486396.1 RNA Sequence

    7. XR_008486399.1 RNA Sequence

    8. XR_008486403.1 RNA Sequence

    9. XR_008486402.1 RNA Sequence

    10. XR_008486397.1 RNA Sequence

    11. XR_008486398.1 RNA Sequence

    12. XR_008486409.1 RNA Sequence

    13. XR_008486407.1 RNA Sequence

    14. XR_008486413.1 RNA Sequence

    15. XR_008486415.1 RNA Sequence

    16. XR_008486410.1 RNA Sequence

    17. XR_008486412.1 RNA Sequence

    18. XR_008486408.1 RNA Sequence

    19. XR_008486400.1 RNA Sequence

    20. XR_008486406.1 RNA Sequence

    21. XR_008486395.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q15118.1 GenPept UniProtKB/Swiss-Prot:Q15118

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