CD69 CD69 molecule [Homo sapiens (human)] - Gene

Summary

Official Symbol: CD69provided by HGNC
Official Full Name: CD69 moleculeprovided by HGNC
Primary source: HGNC:HGNC:1694
See related: Ensembl:ENSG00000110848 MIM:107273; AllianceGenome:HGNC:1694
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: AIM; EA1; MLR-3; CLEC2C; GP32/28; BL-AC/P26
Summary: This gene encodes a member of the calcium dependent lectin superfamily of type II transmembrane receptors. Expression of the encoded protein is induced upon activation of T lymphocytes, and may play a role in proliferation. Furthermore, the protein may act to transmit signals in natural killer cells and platelets. [provided by RefSeq, Aug 2011]
Expression: Biased expression in bone marrow (RPKM 55.9), lymph node (RPKM 41.3) and 13 other tissues See more
Orthologs: all
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Genomic context

Location:: 12p13.31

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (9752486..9760901, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (9638644..9647057, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (9905082..9913497, complement)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The heterogeneity of tumour immune microenvironment revealing the CRABP2/CD69 signature discriminates distinct clinical outcomes in breast cancer.
Title: The heterogeneity of tumour immune microenvironment revealing the CRABP2/CD69 signature discriminates distinct clinical outcomes in breast cancer.
Cancer cell-derived CD69 induced under lipid and oxygen starvation promotes ovarian cancer progression through fibronectin.
Title: Cancer cell-derived CD69 induced under lipid and oxygen starvation promotes ovarian cancer progression through fibronectin.
CD69 serves as a potential diagnostic and prognostic biomarker for hepatocellular carcinoma.
Title: CD69 serves as a potential diagnostic and prognostic biomarker for hepatocellular carcinoma.
Machine learning links different gene patterns of viral infection to immunosuppression and immune-related biomarkers in severe burns.
Title: Machine learning links different gene patterns of viral infection to immunosuppression and immune-related biomarkers in severe burns.
Combined assessment of S- and N-specific IL-2 and IL-13 secretion and CD69 neo-expression for discrimination of post-infection and post-vaccination cellular SARS-CoV-2-specific immune response.
Title: Combined assessment of S- and N-specific IL-2 and IL-13 secretion and CD69 neo-expression for discrimination of post-infection and post-vaccination cellular SARS-CoV-2-specific immune response.
CD4+ T cells in inflammatory diseases: pathogenic T-helper cells and the CD69-Myl9 system.
Title: CD4+ T cells in inflammatory diseases: pathogenic T-helper cells and the CD69-Myl9 system.
Apoptosis inhibitor of macrophage as a biomarker for disease activity in Japanese children with IgA nephropathy and Henoch-Schonlein purpura nephritis.
Title: Apoptosis inhibitor of macrophage as a biomarker for disease activity in Japanese children with IgA nephropathy and Henoch-Schönlein purpura nephritis.
Prognostic Relevance of Concordant Expression CD69 and CD56 in Response to Bortezomib Combination Therapy in Multiple Myeloma Patients.
Title: Prognostic Relevance of Concordant Expression CD69 and CD56 in Response to Bortezomib Combination Therapy in Multiple Myeloma Patients.
T cells selectively filter oscillatory signals on the minutes timescale.
Title: T cells selectively filter oscillatory signals on the minutes timescale.
Increased CD69 expression on activated eosinophils in eosinophilic chronic rhinosinusitis correlates with clinical findings.
Title: Increased CD69 expression on activated eosinophils in eosinophilic chronic rhinosinusitis correlates with clinical findings.

Submit: New GeneRIF Correction See all GeneRIFs (61)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 significantly inhibits CD69 expression in phytohemagglutinin-stimulated T cells in vitro and may also affect T-cell activation in vivo	PubMed
Nef	nef	Cells expressing HIV-1 Nef from long-term non-progressors and progressive infection patients induce higher surface levels of CD69 and CD25 than cells producing HIV-2 or SIV Nef	PubMed
	nef	HIV-1 Nef protein with an intact SH3-binding domain expressed in the productively infected monocyte-derived macrophages is required for the enhanced expression of CD69 on the cell surface	PubMed
	nef	Functional Nef is required for the activation of resting CD4+ T cells by upregulating CD69 expression on cell surface	PubMed
	nef	HIV-1 Nef downregulates CD69 in Jurkat cells in a concentration-dependent manner	PubMed
	nef	HIV-1 Nef blocks a receptor-proximal event in CD3 signaling by downregulating CD69 expression on the cell surface; mutations at amino acid residues P72, P75, R105 and R106 in Nef disrupts the ability of Nef to block CD3 signaling	PubMed
Tat	tat	HIV-1 Tat binds to a cell surface receptor and activates a cell surface-mediated signal pathway in K562 cells, leading to the activation of NF-kappa B and the induction of CD69	PubMed
Vpr	vpr	Human endothelial cell (EC)-stimulated virus-producing cells (p24(high) T cells) are activated to sometimes express CD69 (but not CD25, HLA-DR, VLA-1, or effector cytokines) in the presence of HIV-1 Vpr	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

CD69_506 (e-PCR)
- UniSTS:277077

GDB:384725 (e-PCR)
- UniSTS:157088

STS-Z22576 (e-PCR)
- UniSTS:432

WI-9214 (e-PCR)
- UniSTS:55732

RH68090 (e-PCR)
- UniSTS:2038

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables molecular sequestering activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane signaling receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of T cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of T-helper 17 cell lineage commitment	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: early activation antigen CD69

Names: C-type lectin domain family 2, member C; CD69 antigen (p60, early T-cell activation antigen); activation inducer molecule (AIM/CD69); early T-cell activation antigen p60; early lymphocyte activation antigen; leukocyte surface antigen Leu-23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001781.2 → NP_001772.1 early activation antigen CD69

See identical proteins and their annotated locations for NP_001772.1

Status: REVIEWED

Source sequence(s)

AC007068, Z22576

Consensus CDS

CCDS8604.1

UniProtKB/Swiss-Prot

Q07108

UniProtKB/TrEMBL

B4E009, Q53ZX0

Related

ENSP00000228434.3, ENST00000228434.7

Conserved Domains (1) summary

cd03593
Location:85 → 196

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000012.12 Reference GRCh38.p14 Primary Assembly

Range

9752486..9760901 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

NC_060936.1 Alternate T2T-CHM13v2.0

Range

9638644..9647057 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NR_026671.1: Suppressed sequence

Description

NR_026671.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
NR_026672.1: Suppressed sequence

Description

NR_026672.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.