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    mbl muscleblind [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36945, updated on 2-Nov-2024

    Summary

    Official Symbol
    mblprovided by FlyBase
    Official Full Name
    muscleblindprovided by FlyBase
    Primary source
    FLYBASE:FBgn0265487
    Locus tag
    Dmel_CG33197
    See related
    AllianceGenome:FB:FBgn0265487
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BG01127; CG10941; CG14477; CG33197; chaste; chst; cht; Dmel\CG33197; l(2)01038; l(2)k01212; l(2)k05507; mb1; Mbl; MBL; mbn; mm; n(2)k07110
    Summary
    Predicted to enable RNA binding activity. Involved in several processes, including muscle cell cellular homeostasis; regulation of alternative mRNA splicing, via spliceosome; and rhabdomere development. Located in nucleus; perinuclear region of cytoplasm; and sarcomere. Is expressed in several structures, including Y chromosome loop; brain; imaginal disc; somatic muscle cell; and visual system neurons. Used to study dilated cardiomyopathy; myotonic dystrophy type 1; and myotonic dystrophy type 2. Orthologous to human MBNL1 (muscleblind like splicing regulator 1); MBNL2 (muscleblind like splicing regulator 2); and MBNL3 (muscleblind like splicing regulator 3). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See mbl in Genome Data Viewer
    Location:
    54A3-54B5; 2-82 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17216549..17379376)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (13104054..13266881)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46235 Neighboring gene long non-coding RNA:CR43660 Neighboring gene long non-coding RNA:CR45997 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43661 Neighboring gene transfer RNA:Alanine-TGC 1-1 Neighboring gene long non-coding RNA:CR44344

    Genomic regions, transcripts, and products

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    mobile_element

    • Loc: 17236564-17241709 mobile_element_type = transposon:copia{}840
    • Loc: 17277272-17277615 mobile_element_type = transposon:jockey{}841

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleic acid binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in H zone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Z disc IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    muscleblind
    Names
    BG01127
    CG33197-PA
    CG33197-PB
    CG33197-PD
    CG33197-PH
    CG33197-PJ
    CG33197-PK
    CG33197-PM
    CG33197-PN
    CG33197-PO
    CG33197-PP
    CG33197-PR
    CG33197-PS
    CG33197-PT
    CG33197-PU
    CG33197-PV
    CG33197-PW
    CG33197-PX
    CG33197-PY
    CG33197-PZ
    MUSCLEBLIND
    chaste
    mbl-PA
    mbl-PB
    mbl-PD
    mbl-PH
    mbl-PJ
    mbl-PK
    mbl-PM
    mbl-PN
    mbl-PO
    mbl-PP
    mbl-PR
    mbl-PS
    mbl-PT
    mbl-PU
    mbl-PV
    mbl-PW
    mbl-PX
    mbl-PY
    mbl-PZ
    mindmelt

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      17216549..17379376
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274115.1NP_001261044.1  muscleblind, isoform P [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261044.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KG51
    2. NM_001414081.1NP_001401011.1  muscleblind, isoform U [Drosophila melanogaster]

      Status: REVIEWED

    3. NM_176210.2NP_788390.1  muscleblind, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788390.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O16011
      Related
      FBpp0086146
    4. NM_001274114.1NP_001261043.1  muscleblind, isoform O [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261043.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KF98
    5. NM_001144217.2NP_001137689.2  muscleblind, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137689.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZI9
    6. NM_001274117.1NP_001261046.1  muscleblind, isoform R [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261046.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      I7AEJ0, I7BCJ6
      Conserved Domains (1) summary
      smart00356
      Location:175201
      ZnF_C3H1; zinc finger
    7. NM_001274119.1NP_001261048.1  muscleblind, isoform T [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261048.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFA2, I7AEJ0
      Conserved Domains (1) summary
      smart00356
      Location:175201
      ZnF_C3H1; zinc finger
    8. NM_001274118.1NP_001261047.1  muscleblind, isoform S [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261047.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KET3, I7AEJ0
      Conserved Domains (1) summary
      smart00356
      Location:175201
      ZnF_C3H1; zinc finger
    9. NM_001259464.2NP_001246393.1  muscleblind, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246393.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K835, I7BCJ2
    10. NM_001144216.3NP_001137688.2  muscleblind, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137688.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZJ0, I7BCJ2
    11. NM_001259462.2NP_001246391.1  muscleblind, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246391.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K7U4, I7AEJ0
      Conserved Domains (1) summary
      smart00356
      Location:175201
      ZnF_C3H1; zinc finger
    12. NM_001259466.2NP_001246395.1  muscleblind, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246395.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K782, I7BCJ2
    13. NM_176211.2NP_788391.1  muscleblind, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788391.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O16008, O16009, O16010, O16011, Q86BE8, Q9V803, Q9V804
      Related
      FBpp0086144
    14. NM_176212.2NP_788392.1  muscleblind, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788392.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      L7Z877
      Related
      FBpp0086143
    15. NM_001426710.1NP_001413638.1  muscleblind, isoform Z [Drosophila melanogaster]

      Status: REVIEWED

    16. NM_001414085.1NP_001401015.1  muscleblind, isoform Y [Drosophila melanogaster]

      Status: REVIEWED

    17. NM_001414083.1NP_001401013.1  muscleblind, isoform W [Drosophila melanogaster]

      Status: REVIEWED

    18. NM_001414084.1NP_001401014.1  muscleblind, isoform X [Drosophila melanogaster]

      Status: REVIEWED

    19. NM_001414082.1NP_001401012.1  muscleblind, isoform V [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8E779