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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
mRNA and Protein(s)
-
NM_001256834.3 → NP_001243763.1 aurora kinase B isoform 2
See identical proteins and their annotated locations for NP_001243763.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) lacks an exon in the 5' coding region, which results in translation initiation from an in-frame downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2 and 5 encode the same isoform.
- Source sequence(s)
-
AK297976, BC009751
- Consensus CDS
-
CCDS58514.1
- UniProtKB/TrEMBL
-
B2RC06
- Related
- ENSP00000443869.1, ENST00000534871.5
- Conserved Domains (2) summary
-
- smart00220
Location:36 → 286
- S_TKc; Serine/Threonine protein kinases, catalytic domain
- cl21453
Location:29 → 298
- PKc_like; Protein Kinases, catalytic domain
-
NM_001284526.2 → NP_001271455.1 aurora kinase B isoform 3
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) uses an alternate in-frame acceptor splice site in the mid-coding region compared to variant 1. The resulting isoform (3) is one amino acid longer than isoform 1.
- Source sequence(s)
-
BC009751, BC013300
- Consensus CDS
-
CCDS67162.1
- UniProtKB/TrEMBL
-
B2RC06
- Related
- ENSP00000313950.6, ENST00000316199.10
- Conserved Domains (2) summary
-
- smart00220
Location:78 → 328
- S_TKc; Serine/Threonine protein kinases, catalytic domain
- cl21453
Location:71 → 340
- PKc_like; Protein Kinases, catalytic domain
-
NM_001313950.2 → NP_001300879.1 aurora kinase B isoform 1
Status: REVIEWED
- Description
- Transcript Variant: This variant (4) uses an alternate acceptor splice site in the 5' non-coding region compared to variant 1. Variants 4 and 1 encode the same isoform (1).
- Source sequence(s)
-
BC009751, BP225027, CX781462
- Consensus CDS
-
CCDS11134.1
- UniProtKB/Swiss-Prot
- B4DNM4, C7G533, C7G534, C7G535, D3DTR4, J9JID1, O14630, O60446, O95083, Q96DV5, Q96GD4, Q9UQ46
- UniProtKB/TrEMBL
-
B2RC06
- Conserved Domains (1) summary
-
- cl21453
Location:70 → 339
- PKc_like; Protein Kinases, catalytic domain
-
NM_001313951.1 → NP_001300880.1 aurora kinase B isoform 2
Status: REVIEWED
- Description
- Transcript Variant: This variant (5) contains a novel exon in the 5' region, which results in translation initiation from an in-frame downstream start codon compared to variant 1. Variants 5 and 2 encode the same isoform (2).
- Source sequence(s)
-
BC009751, BE797606, BP225027
- Consensus CDS
-
CCDS58514.1
- UniProtKB/TrEMBL
-
B2RC06
- Conserved Domains (2) summary
-
- smart00220
Location:36 → 286
- S_TKc; Serine/Threonine protein kinases, catalytic domain
- cl21453
Location:29 → 298
- PKc_like; Protein Kinases, catalytic domain
-
NM_001313952.2 → NP_001300881.1 aurora kinase B isoform 4
Status: REVIEWED
- Description
- Transcript Variant: This variant (6) lacks an exon in the 5' coding region and uses two alternate acceptor splice sites in the mid-region compared to variant 1. The encoded isoform (4), resulting from use of an in-frame downstream start codon, has a shorter N-terminus and and an extra amino acid in the mid-region compared to isoform 1.
- Source sequence(s)
-
BC009751, BM905813, BP225027
- UniProtKB/TrEMBL
-
B2RC06
- Conserved Domains (2) summary
-
- smart00220
Location:37 → 287
- S_TKc; Serine/Threonine protein kinases, catalytic domain
- cl21453
Location:30 → 299
- PKc_like; Protein Kinases, catalytic domain
-
NM_001313953.3 → NP_001300882.1 aurora kinase B isoform 5
Status: REVIEWED
- Description
- Transcript Variant: This variant (7) uses alternate in-frame donor and acceptor splices sites in the mid-coding region compared to variant 1. The resulting isoform (5) is shorter containing a 16 aa protein segment not found in isoform 1.
- Source sequence(s)
-
AC135178, BC009751, BU153790
- Consensus CDS
-
CCDS82065.1
- UniProtKB/TrEMBL
-
B2RC06
- Related
- ENSP00000462207.1, ENST00000578549.5
- Conserved Domains (2) summary
-
- smart00220
Location:102 → 295
- S_TKc; Serine/Threonine protein kinases, catalytic domain
- cl21453
Location:70 → 307
- PKc_like; Protein Kinases, catalytic domain
-
NM_001313954.2 → NP_001300883.1 aurora kinase B isoform 6
Status: REVIEWED
- Description
- Transcript Variant: This variant (8) uses an alternate donor splice site in the mid-region compared to variant 1. It represents translation initiation at a downstream AUG compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render this transcript variant a candidate for nonsense-mediated mRNA decay (NMD). Leaky scanning may allow translation initiation at the downstream AUG, which would result in an isoform (6) that is shorter, with a distinct N-terminus compared to isoform 1.
- Source sequence(s)
-
AF004022, BC009751, BP225027, BU181480
- UniProtKB/Swiss-Prot
-
Q96GD4
- Conserved Domains (2) summary
-
- smart00220
Location:27 → 175
- S_TKc; Serine/Threonine protein kinases, catalytic domain
- cl21453
Location:21 → 187
- PKc_like; Protein Kinases, catalytic domain
-
NM_001313955.2 → NP_001300884.1 aurora kinase B isoform 7
Status: REVIEWED
- Description
- Transcript Variant: This variant (9) lacks two non-consecutive exons in the 5' and mid-region and uses an alternate donor splice site in the mid-region, compared to variant 1. It represents translation initiation at a downstream AUG compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render this transcript variant a candidate for nonsense-mediated mRNA decay (NMD). Leaky scanning may allow translation initiation at the downstream AUG, which would result in an isoform (7) that is shorter, with a distinct N-terminus compared to isoform 1.
- Source sequence(s)
-
BC009751, BI199088, BP225027
- UniProtKB/Swiss-Prot
-
Q96GD4
- Conserved Domains (2) summary
-
- smart00220
Location:10 → 159
- S_TKc; Serine/Threonine protein kinases, catalytic domain
- cl21453
Location:10 → 171
- PKc_like; Protein Kinases, catalytic domain
-
NM_004217.4 → NP_004208.2 aurora kinase B isoform 1
See identical proteins and their annotated locations for NP_004208.2
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) represents the predominant transcript and encodes the predominant isoform (1). Variants 1 and 4 encode the same isoform.
- Source sequence(s)
-
AC135178, BC000442, BC009751
- Consensus CDS
-
CCDS11134.1
- UniProtKB/Swiss-Prot
- B4DNM4, C7G533, C7G534, C7G535, D3DTR4, J9JID1, O14630, O60446, O95083, Q96DV5, Q96GD4, Q9UQ46
- UniProtKB/TrEMBL
-
B2RC06
- Related
- ENSP00000463999.1, ENST00000585124.6
- Conserved Domains (1) summary
-
- cl21453
Location:70 → 339
- PKc_like; Protein Kinases, catalytic domain
RNA
-
NR_132730.2 RNA Sequence
Status: REVIEWED
- Description
- Transcript Variant: This variant (10) uses an alternate donor splice site in the mid-region compared to variant 1. It is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders this transcript variant a candidate for nonsense-mediated mRNA decay (NMD).
- Source sequence(s)
-
BC009751, CN286704
-
NR_132731.1 RNA Sequence
Status: REVIEWED
- Description
- Transcript Variant: This variant (11) lacks an internal exon and uses an alternate acceptor splice site in the mid-region compared to variant 1. It is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders this transcript variant a candidate for nonsense-mediated mRNA decay (NMD).
- Source sequence(s)
-
AY677083, BC009751