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Links from PubChem Substance
- Official
Symbol
- CCL1provided by HGNC
- Official
Full Name
- C-C motif chemokine ligand 1provided by HGNC
- Primary source
-
HGNC:HGNC:10609
- See related
-
Ensembl:ENSG00000108702
MIM:182281;
AllianceGenome:HGNC:10609
- Gene type
- protein coding
- RefSeq status
- REVIEWED
- Organism
-
Homo sapiens
- Lineage
- Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
- Also known as
- P500; SISe; TCA3; I-309; SCYA1
- Summary
- This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, is secreted by activated T cells and displays chemotactic activity for monocytes but not for neutrophils. It binds to the chemokine (C-C motif) receptor 8. [provided by RefSeq, Sep 2014]
- Expression
- Low expression observed in reference dataset See more
- Orthologs
-
mouse
all
-
NEW
-
Try the new Gene table
Try the new Transcript table
- Exon count:
- 3
Annotation release |
Status |
Assembly |
Chr
|
Location |
RS_2024_08 |
current |
GRCh38.p14 (GCF_000001405.40) |
17 |
NC_000017.11 (34360328..34363233, complement) |
RS_2024_08 |
current |
T2T-CHM13v2.0 (GCF_009914755.1) |
17 |
NC_060941.1 (35307311..35310197, complement) |
RS_2024_09 |
previous assembly |
GRCh37.p13 (GCF_000001405.25) |
17 |
NC_000017.10 (32687347..32690252, complement) |
Chromosome 17 - NC_000017.11
- Project title: HPA RNA-seq normal tissues
HPA RNA-seq normal tissues
- Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
- BioProject: PRJEB4337
- Publication:
PMID 24309898
- Analysis date: Wed Apr 4 07:08:55 2018
-
CCL21 activation of the MALAT1/SRSF1/mTOR axis underpins the development of gastric carcinoma.
Fu Q, et al. J Transl Med, 2021 May 17. PMID 34001131, Free PMC Article
-
The utility of serum C-C chemokine ligand 1 in sarcoidosis: A comparison to IgG4-related disease.
Komatsu M, et al. Cytokine, 2020 Sep. PMID 32447247
-
Comparison of the chemokine profiles in the bronchoalveolar lavage fluid between IgG4-related respiratory disease and sarcoidosis: CC-chemokine ligand 1 might be involved in the pathogenesis of sarcoidosis.
Yamamoto H, et al. Cytokine, 2019 Aug. PMID 31063909
-
The CC chemokine ligand (CCL) 1, upregulated by the viral transactivator Tax, can be downregulated by minocycline: possible implications for long-term treatment of HTLV-1-associated myelopathy/tropical spastic paraparesis.
Saito M, et al. Virol J, 2017 Dec 4. PMID 29202792, Free PMC Article
-
Tuberculosis susceptibility genes in the chemokine cluster region of chromosome 17 in Hong Kong Chinese.
Tang NL, et al. Hong Kong Med J, 2011 Dec. PMID 22147355
See all (74) citations in PubMed
Replication interactions
Interaction |
Pubs |
HIV-1 infected clinical samples have plasma extracellular vesicles that contain elevated CCL1 (I309), IGFBP1, CCL5 (RANTES), GMCSF, ANG, ADIPOQ (ACRP30), CSF3 (GCSF), CXCL1 (GRO), ICAM1, IL2RA, IL6R, TNFRSF1A, and TIMP1 when compared to healthy donors |
PubMed
|
Protein interactions
Protein |
Gene |
Interaction |
Pubs |
Envelope surface glycoprotein gp120
|
env
|
HIV-1 IIIB Env (gp120) upregulates production of TNF (TNF-a), IL-17A, CCL2 (MCP1), CCL5 (RANTES), IL6, IL10, CXCL8 (IL8), CXCL1 (GRO-a), and CCL1 (I309) in stimulated monocyte derived macrophages |
PubMed
|
Tat
|
tat
|
HIV-1 Tat inhibits I-309 (CCL1) driven cell migration as demonstrated using Tat peptides containing CXC or CC-like sequences (Tat amino acids 25-27 and 30-31, respectively) |
PubMed
|
Vif
|
vif
|
HIV-1 Vif downregulates the expression of chemokine (C-C motif) ligand 1 (CCL1) in Vif-expression T cells |
PubMed
|
Vpr
|
vpr
|
HIV-1 Vpr downregulates the monocyte chemoattractant I-309) |
PubMed
|
Go to the HIV-1, Human Interaction Database
Products |
Interactant |
Other Gene |
Complex |
Source |
Pubs |
Description |
- Preferred Names
- C-C motif chemokine 1
- Names
- T lymphocyte-secreted protein I-309
- chemokine (C-C motif) ligand 1
- inflammatory cytokine I-309
- small inducible cytokine A1 (I-309, homologous to mouse Tca-3)
NEW
Try the new Transcript table
These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
mRNA and Protein(s)
-
NM_002981.2 → NP_002972.1 C-C motif chemokine 1 precursor
See identical proteins and their annotated locations for NP_002972.1
Status: REVIEWED
- Source sequence(s)
-
AC011193, DA620119, M57502
- Consensus CDS
-
CCDS11282.1
- UniProtKB/Swiss-Prot
- B2R5G9, P22362, Q2M309
- Related
- ENSP00000225842.3, ENST00000225842.4
- Conserved Domains (1) summary
-
- cd00272
Location:33 → 89
- Chemokine_CC; Chemokine_CC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; some members (e.g. ...
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000017.11 Reference GRCh38.p14 Primary Assembly
- Range
-
34360328..34363233 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
Alternate T2T-CHM13v2.0
Genomic
-
NC_060941.1 Alternate T2T-CHM13v2.0
- Range
-
35307311..35310197 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.
Molecular Biology Databases
- Bgee database
- BioGPS
- BioGRID Open Repository of CRISPR Screens (ORCS)
- Eukaryotic Promoter Database
- GlyGen glycoinformatics resource
- Human eFP Browser
- Ingenuity Pathways Analysis
- InnateDB
- InterMine
- Kyoto Encyclopedia of Genes and Genomes
- OMA Browser: Orthologous MAtrix
- OrthoDB catalog of orthologs
- PANTHER Classification System
- PhosphoSitePlus
- The Weizmann Institute of Science GeneCards and MalaCards databases
Research Materials
- Addgene Non-profit plasmid repository
- Bio-Techne
- Creative Biogene
- ExactAntigen/Labome
- GenScript latest version of gene cDNA ORF Clone
- GeneCopoeia Inc.
- GeneTex Inc
- Kazusa DNA Research Institute
- OriGene