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    TSC2 TSC complex subunit 2 [ Microcaecilia unicolor ]

    Gene ID: 115477003, updated on 17-Mar-2024

    Summary

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    Gene symbol
    TSC2
    Gene description
    TSC complex subunit 2
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Microcaecilia unicolor
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Gymnophiona; Siphonopidae; Microcaecilia
    Orthologs
    human mouse all
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    Genomic context

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    See TSC2 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    42
    Annotation release Status Assembly Chr Location
    100 current aMicUni1.1 (GCF_901765095.1) 8 NC_044038.1 (3621318..3713388, complement)

    Chromosome 8 - NC_044038.1Genomic Context describing neighboring genes Neighboring gene RAB26, member RAS oncogene family Neighboring gene polycystin 1, transient receptor potential channel interacting Neighboring gene nth like DNA glycosylase 1 Neighboring gene NHERF family PDZ scaffold protein 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_044038.1 Chromosome 8 Reference aMicUni1.1 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of TOR signaling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of insulin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of TSC1-TSC2 complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tuberin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Microcaecilia unicolor Annotation Release 100 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference aMicUni1.1 Primary Assembly

    Genomic

    1. NC_044038.1 Reference aMicUni1.1 Primary Assembly

      Range
      3621318..3713388 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030213656.1 → XP_030069516.1  tuberin isoform X9

      UniProtKB/TrEMBL
      A0A6P7YY98
      Conserved Domains (3) summary
      pfam02145
      Location:1495 → 1681
      Rap_GAP; Rap/ran-GAP
      pfam03542
      Location:552 → 902
      Tuberin
      pfam11864
      Location:54 → 469
      DUF3384; Domain of unknown function (DUF3384)

    2. XM_030213655.1 → XP_030069515.1  tuberin isoform X8

      UniProtKB/TrEMBL
      A0A6P7Z231
      Conserved Domains (3) summary
      pfam02145
      Location:1495 → 1681
      Rap_GAP; Rap/ran-GAP
      pfam03542
      Location:552 → 902
      Tuberin
      pfam11864
      Location:54 → 469
      DUF3384; Domain of unknown function (DUF3384)

    3. XM_030213654.1 → XP_030069514.1  tuberin isoform X7

      UniProtKB/TrEMBL
      A0A6P7Z166
      Conserved Domains (3) summary
      pfam02145
      Location:1496 → 1682
      Rap_GAP; Rap/ran-GAP
      pfam03542
      Location:552 → 902
      Tuberin
      pfam11864
      Location:54 → 469
      DUF3384; Domain of unknown function (DUF3384)

    4. XM_030213651.1 → XP_030069511.1  tuberin isoform X4

      UniProtKB/TrEMBL
      A0A6P7YY94
      Conserved Domains (3) summary
      pfam02145
      Location:1539 → 1725
      Rap_GAP; Rap/ran-GAP
      pfam03542
      Location:552 → 902
      Tuberin
      pfam11864
      Location:54 → 469
      DUF3384; Domain of unknown function (DUF3384)

    5. XM_030213657.1 → XP_030069517.1  tuberin isoform X10

      UniProtKB/TrEMBL
      A0A6P7YQH9
      Conserved Domains (3) summary
      pfam02145
      Location:1562 → 1748
      Rap_GAP; Rap/ran-GAP
      pfam03542
      Location:552 → 902
      Tuberin
      pfam11864
      Location:54 → 469
      DUF3384; Domain of unknown function (DUF3384)

    6. XM_030213653.1 → XP_030069513.1  tuberin isoform X6

      UniProtKB/TrEMBL
      A0A6P7YX28
      Conserved Domains (3) summary
      pfam02145
      Location:1500 → 1686
      Rap_GAP; Rap/ran-GAP
      pfam03542
      Location:557 → 907
      Tuberin
      pfam11864
      Location:54 → 474
      DUF3384; Domain of unknown function (DUF3384)

    7. XM_030213652.1 → XP_030069512.1  tuberin isoform X5

      UniProtKB/TrEMBL
      A0A6P7YQH5
      Conserved Domains (3) summary
      pfam02145
      Location:1501 → 1687
      Rap_GAP; Rap/ran-GAP
      pfam03542
      Location:557 → 907
      Tuberin
      pfam11864
      Location:54 → 474
      DUF3384; Domain of unknown function (DUF3384)

    8. XM_030213650.1 → XP_030069510.1  tuberin isoform X3

      UniProtKB/TrEMBL
      A0A6P7Z224
      Conserved Domains (3) summary
      pfam02145
      Location:1543 → 1729
      Rap_GAP; Rap/ran-GAP
      pfam03542
      Location:557 → 907
      Tuberin
      pfam11864
      Location:54 → 474
      DUF3384; Domain of unknown function (DUF3384)

    9. XM_030213648.1 → XP_030069508.1  tuberin isoform X2

      UniProtKB/TrEMBL
      A0A6P7YX23
      Conserved Domains (3) summary
      pfam02145
      Location:1543 → 1729
      Rap_GAP; Rap/ran-GAP
      pfam03542
      Location:557 → 907
      Tuberin
      pfam11864
      Location:54 → 474
      DUF3384; Domain of unknown function (DUF3384)

    10. XM_030213647.1 → XP_030069507.1  tuberin isoform X1

      UniProtKB/TrEMBL
      A0A6P7YQH0
      Conserved Domains (3) summary
      pfam02145
      Location:1544 → 1730
      Rap_GAP; Rap/ran-GAP
      pfam03542
      Location:557 → 907
      Tuberin
      pfam11864
      Location:54 → 474
      DUF3384; Domain of unknown function (DUF3384)
    Nucleotide Protein
    Heading Accession and Version

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