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    Mettl25 methyltransferase like 25 [ Mus musculus (house mouse) ]

    Gene ID: 216292, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Mettl25provided by MGI
    Official Full Name
    methyltransferase like 25provided by MGI
    Primary source
    MGI:MGI:3041259
    See related
    Ensembl:ENSMUSG00000036009 AllianceGenome:MGI:3041259
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable methyltransferase activity. Predicted to be involved in methylation. Is expressed in adrenal gland; ganglia; telencephalon; and testis. Orthologous to human METTL25 (methyltransferase like 25). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 2.9), whole brain E14.5 (RPKM 2.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mettl25 in Genome Data Viewer
    Location:
    10 D1; 10 55.12 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (105599052..105677246, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (105763185..105841380, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene transmembrane and tetratricopeptide repeat containing 2 Neighboring gene keratin 19 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr10:105012433-105012734 Neighboring gene predicted gene 15663 Neighboring gene STARR-seq mESC enhancer starr_27763 Neighboring gene STARR-seq mESC enhancer starr_27765 Neighboring gene STARR-positive B cell enhancer ABC_E9803 Neighboring gene STARR-positive B cell enhancer ABC_E6919 Neighboring gene coiled-coil domain containing 59 Neighboring gene STARR-seq mESC enhancer starr_27766 Neighboring gene STARR-seq mESC enhancer starr_27767 Neighboring gene predicted gene, 25342

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    2. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    probable methyltransferase-like protein 25
    Names
    methyltransferase-like protein 25

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359640.1 → NP_001346569.1  probable methyltransferase-like protein 25 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK148535, AV286383, BB345676, BC067068, CK618051
      Conserved Domains (1) summary
      cl17173
      Location:4 → 268
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    2. NM_001359642.1 → NP_001346571.1  probable methyltransferase-like protein 25 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK148535, AV286383, BC067068, CK618051
      Conserved Domains (1) summary
      cl17173
      Location:4 → 268
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    3. NM_207522.3 → NP_997405.3  probable methyltransferase-like protein 25 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC125108, AC132471
      Consensus CDS
      CCDS36049.2
      UniProtKB/TrEMBL
      A0A0R4J0G2
      Related
      ENSMUSP00000038665.11, ENSMUST00000046638.10

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      105599052..105677246 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245038.2 → XP_030100898.1  probable methyltransferase-like protein 25 isoform X6

      Conserved Domains (1) summary
      cl17173
      Location:4 → 268
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    2. XM_030245037.1 → XP_030100897.1  probable methyltransferase-like protein 25 isoform X6

      Conserved Domains (1) summary
      cl17173
      Location:4 → 268
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    3. XM_017313903.2 → XP_017169392.1  probable methyltransferase-like protein 25 isoform X3

      UniProtKB/Swiss-Prot
      Q3UMX5, Q6NXH8
      Conserved Domains (1) summary
      cl17173
      Location:149 → 385
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    4. XM_030245039.1 → XP_030100899.1  probable methyltransferase-like protein 25 isoform X7

      Conserved Domains (1) summary
      cl17173
      Location:4 → 240
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    5. XM_036155757.1 → XP_036011650.1  probable methyltransferase-like protein 25 isoform X6

      Conserved Domains (1) summary
      cl17173
      Location:4 → 268
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    6. XM_030245031.1 → XP_030100891.1  probable methyltransferase-like protein 25 isoform X4

      Conserved Domains (1) summary
      cl17173
      Location:4 → 268
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    7. XM_030245033.1 → XP_030100893.1  probable methyltransferase-like protein 25 isoform X4

      Conserved Domains (1) summary
      cl17173
      Location:4 → 268
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    8. XM_030245032.1 → XP_030100892.1  probable methyltransferase-like protein 25 isoform X4

      Conserved Domains (1) summary
      cl17173
      Location:4 → 268
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    9. XM_011243412.3 → XP_011241714.1  probable methyltransferase-like protein 25 isoform X2

      UniProtKB/Swiss-Prot
      Q3UMX5, Q6NXH8
      Conserved Domains (1) summary
      cl17173
      Location:149 → 385
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    10. XM_011243411.3 → XP_011241713.1  probable methyltransferase-like protein 25 isoform X1

      UniProtKB/Swiss-Prot
      Q3UMX5, Q6NXH8
      Conserved Domains (1) summary
      cl17173
      Location:149 → 413
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    11. XM_011243414.3 → XP_011241716.1  probable methyltransferase-like protein 25 isoform X4

      See identical proteins and their annotated locations for XP_011241716.1

      Conserved Domains (1) summary
      cl17173
      Location:4 → 268
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    12. XM_030245035.1 → XP_030100895.1  probable methyltransferase-like protein 25 isoform X5

      Conserved Domains (1) summary
      cl17173
      Location:4 → 240
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    13. XM_036155756.1 → XP_036011649.1  probable methyltransferase-like protein 25 isoform X4

      Conserved Domains (1) summary
      cl17173
      Location:4 → 268
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    14. XM_036155755.1 → XP_036011648.1  probable methyltransferase-like protein 25 isoform X4

      Conserved Domains (1) summary
      cl17173
      Location:4 → 268
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    15. XM_017313904.1 → XP_017169393.1  probable methyltransferase-like protein 25 isoform X4

      Conserved Domains (1) summary
      cl17173
      Location:4 → 268
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RNA

    1. XR_004936162.1 RNA Sequence

    2. XR_001779503.2 RNA Sequence

    3. XR_004936161.1 RNA Sequence

      Related
      ENSMUST00000176924.8

    4. XR_003948672.1 RNA Sequence

    5. XR_001779504.2 RNA Sequence

    6. XR_004936163.1 RNA Sequence

    7. XR_004936165.1 RNA Sequence

    8. XR_004936164.1 RNA Sequence

    9. XR_871710.3 RNA Sequence

    10. XR_003948673.1 RNA Sequence

    11. XR_871709.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NXH8.1 GenPept UniProtKB/Swiss-Prot:Q6NXH8

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