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    DDX11 DEAD/H-box helicase 11 [ Homo sapiens (human) ]

    Gene ID: 1663, updated on 3-Nov-2024

    Summary

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    Official Symbol
    DDX11provided by HGNC
    Official Full Name
    DEAD/H-box helicase 11provided by HGNC
    Primary source
    HGNC:HGNC:2736
    See related
    Ensembl:ENSG00000013573 MIM:601150; AllianceGenome:HGNC:2736
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CHL1; KRG2; WABS; CHLR1
    Summary
    DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an enzyme that possesses both ATPase and DNA helicase activities. This gene is a homolog of the yeast CHL1 gene, and may function to maintain chromosome transmission fidelity and genome stability. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in bone marrow (RPKM 6.8), lymph node (RPKM 4.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See DDX11 in Genome Data Viewer
    Location:
    12p11.21
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (31073860..31104799)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (30948354..30979293)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (31226794..31257733)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene tetraspanin 11 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:31130578-31131412 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:31133507-31134008 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:31134009-31134508 Neighboring gene TSPAN11 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6161 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:31140539-31141040 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:31141041-31141540 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:31165500-31165701 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:31181720-31181949 Neighboring gene DDX11 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 7044 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:31226445-31226976 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:31227509-31228038 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:31232984-31233540 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:31256969-31257468 Neighboring gene MPRA-validated peak1651 silencer Neighboring gene uncharacterized LOC124902912 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:31270198-31270728 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:31270729-31271258 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:31273911-31274440 Neighboring gene alpha-2-macroglobulin like 1 pseudogene Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:31373729-31374473 Neighboring gene uncharacterized LOC107987168

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Clinical Report: Warsaw Breakage Syndrome with small radii and fibulae. Eppley S, et al. Am J Med Genet A, 2017 Nov. PMID 28960803
    2. DDX11-AS1 contributes to osteosarcoma progression via stabilizing DDX11. Zhang H, et al. Life Sci, 2020 Aug 1. PMID 32014424
    3. Warsaw Syndrome. Adam MP, et al. , 1993. PMID 31169992
    4. DDX11-AS1exacerbates bladder cancer progression by enhancing CDK6 expression via suppressing miR-499b-5p. Li Q, et al. Biomed Pharmacother, 2020 Jul. PMID 32422563
    5. Warsaw breakage syndrome, a cohesinopathy associated with mutations in the XPD helicase family member DDX11/ChlR1. van der Lelij P, et al. Am J Hum Genet, 2010 Feb 12. PMID 20137776, Free PMC Article

    See all (72) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DEAD/H-box helicase 11 is transcriptionally activated by Yin Yang-1 and accelerates oral squamous cell carcinoma progression.
      Title: DEAD/H-box helicase 11 is transcriptionally activated by Yin Yang-1 and accelerates oral squamous cell carcinoma progression.
    2. Mapping of DDX11 genetic interactions defines sister chromatid cohesion as the major dependency.
      Title: Mapping of DDX11 genetic interactions defines sister chromatid cohesion as the major dependency.
    3. Mutations in DEAD/H-box helicase 11 correlate with increased relapse risk in adults with acute myeloid leukaemia with normal cytogenetics.
      Title: Mutations in DEAD/H-box helicase 11 correlate with increased relapse risk in adults with acute myeloid leukaemia with normal cytogenetics.
    4. Finding underlying genetic mechanisms of two patients with autism spectrum disorder carrying familial apparently balanced chromosomal translocations.
      Title: Finding underlying genetic mechanisms of two patients with autism spectrum disorder carrying familial apparently balanced chromosomal translocations.
    5. Expression of DDX11 and DNM1L at the 12p11 Locus Modulates Systemic Lupus Erythematosus Susceptibility.
      Title: Expression of DDX11 and DNM1L at the 12p11 Locus Modulates Systemic Lupus Erythematosus Susceptibility.
    6. Timeless couples G-quadruplex detection with processing by DDX11 helicase during DNA replication.
      Title: Timeless couples G-quadruplex detection with processing by DDX11 helicase during DNA replication.
    7. E2F1 mediated DDX11 transcriptional activation promotes hepatocellular carcinoma progression through PI3K/AKT/mTOR pathway.
      Title: E2F1 mediated DDX11 transcriptional activation promotes hepatocellular carcinoma progression through PI3K/AKT/mTOR pathway.
    8. The long non-coding RNA DDX11-AS1 facilitates cell progression and oxaliplatin resistance via regulating miR-326/IRS1 axis in gastric cancer.
      Title: The long non-coding RNA DDX11-AS1 facilitates cell progression and oxaliplatin resistance via regulating miR-326/IRS1 axis in gastric cancer.
    9. The iron-sulfur helicase DDX11 promotes the generation of single-stranded DNA for CHK1 activation.
      Title: The iron-sulfur helicase DDX11 promotes the generation of single-stranded DNA for CHK1 activation.
    10. DDX11-AS1exacerbates bladder cancer progression by enhancing CDK6 expression via suppressing miR-499b-5p.
      Title: DDX11-AS1exacerbates bladder cancer progression by enhancing CDK6 expression via suppressing miR-499b-5p.
    Submit: New GeneRIF Correction See all GeneRIFs (36)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Warsaw breakage syndrome
    MedGen: C3150658 OMIM: 613398 GeneReviews: Warsaw Syndrome
    		Compare labs

    Variation

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    See Variation Viewer (GRCh37.p13)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat DDX11 is downregulated in HIV-1 Tat and NC cotransfection of HEK 293T cells PubMed
    nucleocapsid gag DDX11 is downregulated in HIV-1 Tat and NC cotransfection of HEK 293T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC9335, MGC133249

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 5'-3' DNA helicase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent activity, acting on DNA IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP-dependent activity, acting on DNA IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables ATP-dependent activity, acting on RNA IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA helicase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA replication origin binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables G-quadruplex DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chromatin binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables helicase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables single-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables single-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables triplex DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA duplex unwinding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA duplex unwinding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G-quadruplex DNA unwinding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to bleomycin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to cisplatin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to hydroxyurea IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of sister chromatid cohesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of protein binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleolar chromatin organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of double-strand break repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of endodeoxyribonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of sister chromatid cohesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription of nucleolar large rRNA by RNA polymerase I IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in replication fork processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sister chromatid cohesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Ctf18 RFC-like complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in midbody IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT part_of mitotic cohesin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    colocalizes_with nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle pole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ATP-dependent DNA helicase DDX11
    Names
    CHL1-like helicase homolog
    CHL1-related helicase gene-1
    CHL1-related protein 1
    DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11
    DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 (CHL1-like helicase homolog, S. cerevisiae)
    DEAD/H box protein 11
    DNA 5'-3' helicase DDX11
    KRG-2
    hCHLR1
    keratinocyte growth factor-regulated gene 2 protein
    probable ATP-dependent DNA helicase DDX11
    probable ATP-dependent RNA helicase DDX11
    NP_001244073.1
    NP_001244074.1
    NP_001400621.1
    NP_001400622.1
    NP_001400623.1
    NP_001400624.1
    NP_001400625.1
    NP_001400626.1
    NP_001400627.1
    NP_001400628.1
    NP_001400629.1
    NP_001400631.1
    NP_001400632.1
    NP_001400633.1
    NP_001400634.1
    NP_001400635.1
    NP_004390.3
    NP_085911.2
    NP_689651.1
    XP_005253388.1
    XP_005253390.1
    XP_006719113.1
    XP_011518894.1
    XP_011518897.1
    XP_011518899.2
    XP_016874408.1
    XP_016874409.2
    XP_016874410.2
    XP_016874411.1
    XP_016874414.1
    XP_016874415.2
    XP_016874416.2
    XP_016874417.2
    XP_016874418.2
    XP_016874419.2
    XP_016874424.1
    XP_016874425.1
    XP_016874426.1
    XP_016874427.2
    XP_016874428.2
    XP_047284403.1
    XP_047284404.1
    XP_047284405.1
    XP_047284407.1
    XP_047284408.1
    XP_047284409.1
    XP_047284410.1
    XP_047284411.1
    XP_047284412.1
    XP_047284413.1
    XP_047284414.1
    XP_047284415.1
    XP_047284416.1
    XP_047284417.1
    XP_047284418.1
    XP_047284419.1
    XP_047284420.1
    XP_047284421.1
    XP_054227284.1
    XP_054227285.1
    XP_054227286.1
    XP_054227287.1
    XP_054227288.1
    XP_054227289.1
    XP_054227290.1
    XP_054227291.1
    XP_054227292.1
    XP_054227293.1
    XP_054227294.1
    XP_054227295.1
    XP_054227296.1
    XP_054227297.1
    XP_054227298.1
    XP_054227299.1
    XP_054227300.1
    XP_054227301.1
    XP_054227302.1
    XP_054227303.1
    XP_054227304.1
    XP_054227305.1
    XP_054227306.1
    XP_054227307.1
    XP_054227308.1
    XP_054227309.1
    XP_054227310.1
    XP_054227311.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_023352.1 RefSeqGene

      Range
      5016..35955
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001257144.2 → NP_001244073.1  ATP-dependent DNA helicase DDX11 isoform 3

      See identical proteins and their annotated locations for NP_001244073.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 3. Variants 3, 4, 9 and 10 all encode the same isoform (3).
      Source sequence(s)
      AC008013, BC050522
      Consensus CDS
      CCDS44856.1
      UniProtKB/Swiss-Prot
      Q13333, Q86VQ4, Q86W62, Q92498, Q92770, Q92998, Q92999, Q96FC9
      UniProtKB/TrEMBL
      Q2NKM7
      Related
      ENSP00000440402.1, ENST00000545668.5
      Conserved Domains (1) summary
      cl26947
      Location:227 → 822
      HBB; Helical and beta-bridge domain

    2. NM_001257145.2 → NP_001244074.1  ATP-dependent DNA helicase DDX11 isoform 4

      See identical proteins and their annotated locations for NP_001244074.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and coding region, and uses a downstream AUG compared to variant 3. The resulting protein (isoform 4) has shorter N- and C-termini compared to isoform 3. Variants 5, 11, and 12 all encode the same isoform (4).
      Source sequence(s)
      AC008013, BC050069
      Consensus CDS
      CCDS58224.1
      UniProtKB/TrEMBL
      Q2NKM7
      Related
      ENSP00000228264.6, ENST00000228264.10
      Conserved Domains (3) summary
      smart00488
      Location:1 → 411
      DEXDc2; DEAD-like helicases superfamily
      TIGR00604
      Location:201 → 867
      rad3; DNA repair helicase (rad3)
      pfam13307
      Location:666 → 853
      Helicase_C_2; Helicase C-terminal domain

    3. NM_001413692.1 → NP_001400621.1  ATP-dependent DNA helicase DDX11 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC008013

    4. NM_001413693.1 → NP_001400622.1  ATP-dependent DNA helicase DDX11 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC008013

    5. NM_001413694.1 → NP_001400623.1  ATP-dependent DNA helicase DDX11 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC008013

    6. NM_001413695.1 → NP_001400624.1  ATP-dependent DNA helicase DDX11 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC008013
      UniProtKB/Swiss-Prot
      Q13333, Q86VQ4, Q86W62, Q92498, Q92770, Q92998, Q92999, Q96FC9

    7. NM_001413696.1 → NP_001400625.1  ATP-dependent DNA helicase DDX11 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC008013
      UniProtKB/Swiss-Prot
      Q13333, Q86VQ4, Q86W62, Q92498, Q92770, Q92998, Q92999, Q96FC9

    8. NM_001413697.1 → NP_001400626.1  ATP-dependent DNA helicase DDX11 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC008013

    9. NM_001413698.1 → NP_001400627.1  ATP-dependent DNA helicase DDX11 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC008013

    10. NM_001413699.1 → NP_001400628.1  ATP-dependent DNA helicase DDX11 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC008013

    11. NM_001413700.1 → NP_001400629.1  ATP-dependent DNA helicase DDX11 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC008013

    12. NM_001413702.1 → NP_001400631.1  ATP-dependent DNA helicase DDX11 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC008013

    13. NM_001413703.1 → NP_001400632.1  ATP-dependent DNA helicase DDX11 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC008013

    14. NM_001413704.1 → NP_001400633.1  ATP-dependent DNA helicase DDX11 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC008013

    15. NM_001413705.1 → NP_001400634.1  ATP-dependent DNA helicase DDX11 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC008013

    16. NM_001413706.1 → NP_001400635.1  ATP-dependent DNA helicase DDX11 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC008013

    17. NM_004399.3 → NP_004390.3  ATP-dependent DNA helicase DDX11 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon and uses an alternate splice junction compared to variant 3, that results in a frameshift. The resulting isoform (2) lacks an internal segment and has a distinct C-terminus compared to isoform 3.
      Source sequence(s)
      AC008013, BC011264, BC111733, X99583
      Consensus CDS
      CCDS8721.1
      UniProtKB/TrEMBL
      Q2NKM7
      Related
      ENSP00000309965.5, ENST00000350437.8
      Conserved Domains (3) summary
      smart00488
      Location:11 → 437
      DEXDc2; DEAD-like helicases superfamily
      smart00491
      Location:680 → 817
      HELICc2; helicase superfamily c-terminal domain
      TIGR00604
      Location:227 → 843
      rad3; DNA repair helicase (rad3)

    18. NM_030653.4 → NP_085911.2  ATP-dependent DNA helicase DDX11 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) uses an alternate splice junction at a coding exon compared to variant 3, that results in a frameshift. The resulting isoform (1) is shorter and has a distinct C-terminus compared to isoform 3. Variants 1 and 6-8 all encode the same isoform (1).
      Source sequence(s)
      AC008013, BC011264, BC111733
      Consensus CDS
      CCDS41767.1
      UniProtKB/TrEMBL
      Q2NKM7
      Related
      ENSP00000443426.1, ENST00000542838.6
      Conserved Domains (3) summary
      smart00488
      Location:11 → 437
      DEXDc2; DEAD-like helicases superfamily
      TIGR00604
      Location:227 → 893
      rad3; DNA repair helicase (rad3)
      pfam13307
      Location:692 → 879
      Helicase_C_2; Helicase C-terminal domain

    19. NM_152438.2 → NP_689651.1  ATP-dependent DNA helicase DDX11 isoform 3

      See identical proteins and their annotated locations for NP_689651.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) encodes the longest isoform (3). Variants 3, 4, 9 and 10 all encode the same isoform (3).
      Source sequence(s)
      AC008013, BC011264, BC111733
      Consensus CDS
      CCDS44856.1
      UniProtKB/Swiss-Prot
      Q13333, Q86VQ4, Q86W62, Q92498, Q92770, Q92998, Q92999, Q96FC9
      UniProtKB/TrEMBL
      Q2NKM7
      Conserved Domains (1) summary
      cl26947
      Location:227 → 822
      HBB; Helical and beta-bridge domain

    RNA

    1. NR_182200.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC008013

    2. NR_182201.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC008013

    3. NR_182202.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC008013
      Related
      ENST00000435753.6

    4. NR_182203.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC008013
      Related
      ENST00000539049.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      31073860..31104799
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017018922.2 → XP_016874411.1  ATP-dependent DNA helicase DDX11 isoform X5

    2. XM_017018925.2 → XP_016874414.1  ATP-dependent DNA helicase DDX11 isoform X5

    3. XM_017018919.3 → XP_016874408.1  ATP-dependent DNA helicase DDX11 isoform X1

    4. XM_006719050.5 → XP_006719113.1  ATP-dependent DNA helicase DDX11 isoform X14

      UniProtKB/TrEMBL
      Q2NKM7
      Conserved Domains (3) summary
      smart00488
      Location:47 → 473
      DEXDc2; DEAD-like helicases superfamily
      TIGR00604
      Location:263 → 929
      rad3; DNA repair helicase (rad3)
      pfam13307
      Location:728 → 915
      Helicase_C_2; Helicase C-terminal domain

    5. XM_005253333.5 → XP_005253390.1  ATP-dependent DNA helicase DDX11 isoform X16

      UniProtKB/TrEMBL
      Q2NKM7
      Conserved Domains (3) summary
      smart00488
      Location:47 → 473
      DEXDc2; DEAD-like helicases superfamily
      TIGR00604
      Location:263 → 929
      rad3; DNA repair helicase (rad3)
      pfam13307
      Location:728 → 915
      Helicase_C_2; Helicase C-terminal domain

    6. XM_011520592.4 → XP_011518894.1  ATP-dependent DNA helicase DDX11 isoform X8

      See identical proteins and their annotated locations for XP_011518894.1

      Conserved Domains (2) summary
      smart00488
      Location:47 → 473
      DEXDc2; DEAD-like helicases superfamily
      smart00491
      Location:746 → 860
      HELICc2; helicase superfamily c-terminal domain

    7. XM_005253331.5 → XP_005253388.1  ATP-dependent DNA helicase DDX11 isoform X12

      UniProtKB/TrEMBL
      Q2NKM7
      Conserved Domains (2) summary
      smart00488
      Location:47 → 473
      DEXDc2; DEAD-like helicases superfamily
      smart00491
      Location:746 → 860
      HELICc2; helicase superfamily c-terminal domain

    8. XM_011520595.4 → XP_011518897.1  ATP-dependent DNA helicase DDX11 isoform X22

      UniProtKB/TrEMBL
      Q2NKM7
      Conserved Domains (3) summary
      smart00488
      Location:47 → 473
      DEXDc2; DEAD-like helicases superfamily
      smart00491
      Location:716 → 853
      HELICc2; helicase superfamily c-terminal domain
      TIGR00604
      Location:263 → 879
      rad3; DNA repair helicase (rad3)

    9. XM_047428447.1 → XP_047284403.1  ATP-dependent DNA helicase DDX11 isoform X2

    10. XM_047428452.1 → XP_047284408.1  ATP-dependent DNA helicase DDX11 isoform X15

    11. XM_047428454.1 → XP_047284410.1  ATP-dependent DNA helicase DDX11 isoform X17

    12. XM_047428448.1 → XP_047284404.1  ATP-dependent DNA helicase DDX11 isoform X10

    13. XM_047428461.1 → XP_047284417.1  ATP-dependent DNA helicase DDX11 isoform X24

    14. XM_047428451.1 → XP_047284407.1  ATP-dependent DNA helicase DDX11 isoform X14

    15. XM_047428453.1 → XP_047284409.1  ATP-dependent DNA helicase DDX11 isoform X16

    16. XM_047428449.1 → XP_047284405.1  ATP-dependent DNA helicase DDX11 isoform X12

    17. XM_047428459.1 → XP_047284415.1  ATP-dependent DNA helicase DDX11 isoform X22

    18. XM_017018928.3 → XP_016874417.2  ATP-dependent DNA helicase DDX11 isoform X9

    19. XM_017018930.3 → XP_016874419.2  ATP-dependent DNA helicase DDX11 isoform X13

    20. XM_017018921.3 → XP_016874410.2  ATP-dependent DNA helicase DDX11 isoform X4

    21. XM_047428455.1 → XP_047284411.1  ATP-dependent DNA helicase DDX11 isoform X18

    22. XM_017018929.3 → XP_016874418.2  ATP-dependent DNA helicase DDX11 isoform X11

    23. XM_017018920.3 → XP_016874409.2  ATP-dependent DNA helicase DDX11 isoform X3

    24. XM_047428457.1 → XP_047284413.1  ATP-dependent DNA helicase DDX11 isoform X20

    25. XM_017018926.3 → XP_016874415.2  ATP-dependent DNA helicase DDX11 isoform X6

    26. XM_017018927.3 → XP_016874416.2  ATP-dependent DNA helicase DDX11 isoform X7

    27. XM_047428460.1 → XP_047284416.1  ATP-dependent DNA helicase DDX11 isoform X23

    28. XM_047428456.1 → XP_047284412.1  ATP-dependent DNA helicase DDX11 isoform X19

    29. XM_047428458.1 → XP_047284414.1  ATP-dependent DNA helicase DDX11 isoform X21

    30. XM_017018938.3 → XP_016874427.2  ATP-dependent DNA helicase DDX11 isoform X28

    31. XM_017018939.3 → XP_016874428.2  ATP-dependent DNA helicase DDX11 isoform X29

    32. XM_047428463.1 → XP_047284419.1  ATP-dependent DNA helicase DDX11 isoform X27

    33. XM_047428464.1 → XP_047284420.1  ATP-dependent DNA helicase DDX11 isoform X30

    34. XM_011520597.4 → XP_011518899.2  ATP-dependent DNA helicase DDX11 isoform X31

    35. XM_017018935.1 → XP_016874424.1  ATP-dependent DNA helicase DDX11 isoform X26

    36. XM_047428462.1 → XP_047284418.1  ATP-dependent DNA helicase DDX11 isoform X25

    37. XM_017018936.1 → XP_016874425.1  ATP-dependent DNA helicase DDX11 isoform X26

    38. XM_047428465.1 → XP_047284421.1  ATP-dependent DNA helicase DDX11 isoform X32

    39. XM_017018937.2 → XP_016874426.1  ATP-dependent DNA helicase DDX11 isoform X26

    RNA

    1. XR_001748610.3 RNA Sequence

    2. XR_007063056.1 RNA Sequence

    3. XR_007063057.1 RNA Sequence

    4. XR_007063058.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      30948354..30979293
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054371328.1 → XP_054227303.1  ATP-dependent DNA helicase DDX11 isoform X34

    2. XM_054371309.1 → XP_054227284.1  ATP-dependent DNA helicase DDX11 isoform X8

    3. XM_054371311.1 → XP_054227286.1  ATP-dependent DNA helicase DDX11 isoform X10

    4. XM_054371310.1 → XP_054227285.1  ATP-dependent DNA helicase DDX11 isoform X8

    5. XM_054371317.1 → XP_054227292.1  ATP-dependent DNA helicase DDX11 isoform X14

    6. XM_054371319.1 → XP_054227294.1  ATP-dependent DNA helicase DDX11 isoform X15

    7. XM_054371325.1 → XP_054227300.1  ATP-dependent DNA helicase DDX11 isoform X24

    8. XM_054371318.1 → XP_054227293.1  ATP-dependent DNA helicase DDX11 isoform X14

    9. XM_054371313.1 → XP_054227288.1  ATP-dependent DNA helicase DDX11 isoform X12

    10. XM_054371314.1 → XP_054227289.1  ATP-dependent DNA helicase DDX11 isoform X12

    11. XM_054371321.1 → XP_054227296.1  ATP-dependent DNA helicase DDX11 isoform X16

    12. XM_054371323.1 → XP_054227298.1  ATP-dependent DNA helicase DDX11 isoform X17

    13. XM_054371322.1 → XP_054227297.1  ATP-dependent DNA helicase DDX11 isoform X16

    14. XM_054371315.1 → XP_054227290.1  ATP-dependent DNA helicase DDX11 isoform X34

    15. XM_054371330.1 → XP_054227305.1  ATP-dependent DNA helicase DDX11 isoform X41

    16. XM_054371320.1 → XP_054227295.1  ATP-dependent DNA helicase DDX11 isoform X36

    17. XM_054371312.1 → XP_054227287.1  ATP-dependent DNA helicase DDX11 isoform X33

    18. XM_054371316.1 → XP_054227291.1  ATP-dependent DNA helicase DDX11 isoform X35

    19. XM_054371331.1 → XP_054227306.1  ATP-dependent DNA helicase DDX11 isoform X42

    20. XM_054371324.1 → XP_054227299.1  ATP-dependent DNA helicase DDX11 isoform X37

    21. XM_054371326.1 → XP_054227301.1  ATP-dependent DNA helicase DDX11 isoform X38

    22. XM_054371327.1 → XP_054227302.1  ATP-dependent DNA helicase DDX11 isoform X39

    23. XM_054371335.1 → XP_054227310.1  ATP-dependent DNA helicase DDX11 isoform X44

    24. XM_054371332.1 → XP_054227307.1  ATP-dependent DNA helicase DDX11 isoform X43

    25. XM_054371329.1 → XP_054227304.1  ATP-dependent DNA helicase DDX11 isoform X40

    26. XM_054371336.1 → XP_054227311.1  ATP-dependent DNA helicase DDX11 isoform X32

    27. XM_054371334.1 → XP_054227309.1  ATP-dependent DNA helicase DDX11 isoform X43

    28. XM_054371333.1 → XP_054227308.1  ATP-dependent DNA helicase DDX11 isoform X43

    RNA

    1. XR_008488549.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_030655.2: Suppressed sequence

      Description
      NM_030655.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96FC9.1 GenPept UniProtKB/Swiss-Prot:Q96FC9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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