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    SCARA3 scavenger receptor class A member 3 [ Homo sapiens (human) ]

    Gene ID: 51435, updated on 28-Oct-2024

    Summary

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    Official Symbol
    SCARA3provided by HGNC
    Official Full Name
    scavenger receptor class A member 3provided by HGNC
    Primary source
    HGNC:HGNC:19000
    See related
    Ensembl:ENSG00000168077 MIM:602728; AllianceGenome:HGNC:19000
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CSR; APC7; CSR1; MSLR1; MSRL1
    Summary
    This gene encodes a macrophage scavenger receptor-like protein. This protein has been shown to deplete reactive oxygen species, and thus play an important role in protecting cells from oxidative stress. The expression of this gene is induced by oxidative stress. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in endometrium (RPKM 16.5), brain (RPKM 14.0) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SCARA3 in Genome Data Viewer
    Location:
    8p21.1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (27633463..27734141)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (27910729..28013971)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (27491419..27534288)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901919 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:27450407-27450907 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:27466546-27467252 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:27467959-27468666 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:27470630-27470815 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:27471849-27472348 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19050 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:27473305-27473805 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:27474096-27474852 Neighboring gene clusterin Neighboring gene microRNA 6843 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:27491053-27491882 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:27491883-27492711 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:27508580-27509080 Neighboring gene RNA, U6 small nuclear 1086, pseudogene Neighboring gene uncharacterized LOC124901921 Neighboring gene uncharacterized LOC124901920 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:27560651-27560796 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:27562294-27562794 Neighboring gene microRNA 3622b Neighboring gene microRNA 3622a Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27154 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:27587170-27587710 Neighboring gene coiled-coil domain containing 25 Neighboring gene uncharacterized LOC107986934 Neighboring gene uncharacterized LOC124902093 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27155 Neighboring gene RNA, U6 small nuclear 1276, pseudogene Neighboring gene establishment of sister chromatid cohesion N-acetyltransferase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. CSR, a scavenger receptor-like protein with a protective role against cellular damage causedby UV irradiation and oxidative stress. Han HJ, et al. Hum Mol Genet, 1998 Jun. PMID 9580669
    2. SCARA3 inhibits cell proliferation and EMT through AKT signaling pathway in lung cancer. Kim J, et al. BMC Cancer, 2022 May 16. PMID 35578316, Free PMC Article
    3. SCARA3 mRNA is overexpressed in ovarian carcinoma compared with breast carcinoma effusions. Bock AJ, et al. Hum Pathol, 2012 May. PMID 21855113
    4. Dinucleotide repeat polymorphism in the first intron of the CSR gene. Han HJ, et al. J Hum Genet, 1998. PMID 9747040
    5. CSR1 suppresses tumor growth and metastasis of prostate cancer. Yu G, et al. Am J Pathol, 2006 Feb. PMID 16436673, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SCARA3 inhibits cell proliferation and EMT through AKT signaling pathway in lung cancer.
      Title: SCARA3 inhibits cell proliferation and EMT through AKT signaling pathway in lung cancer.
    2. DICER-AS1 functions as competing endogenous RNA that targets CSR1 by sponging microRNA-650 and suppresses gastric cancer progression.
      Title: DICER-AS1 functions as competing endogenous RNA that targets CSR1 by sponging microRNA-650 and suppresses gastric cancer progression.
    3. Identification of SCARA3 with potential roles in metabolic disorders.
      Title: Identification of SCARA3 with potential roles in metabolic disorders.
    4. Study found that SCARA3 is associated with severity of hand, foot, and mouth disease, and it may be a potential prognostic marker to predict the HFMD progression in EV71 infected patients.
      Title: Scavenger receptor class a, member 3 is associated with severity of hand, foot, and mouth disease in a case-control study.
    5. CSR1 is SUMOylated at K582 and rapid ubiquitinated and degradated in prostate cancer cells.
      Title: Sumoylation Negatively Regulates CSR1-Dependent Prostate Cancer Cell Death.
    6. demonstrated that CSR1 inhibited hepatocellular carcinoma cell proliferation, migration and invasion through inactivation of hematopoietic PBX interacting protein (HPIP) and its downstream PI3K/AKT signaling pathway.
      Title: CSR1 suppresses tumor growth and metastasis of human hepatocellular carcinoma via inhibition of HPIP.
    7. The interaction between CSR1 and SF3A3 led to migration of SF3A3 from nucleus to cytoplasm. The cytoplasmic redistribution of SF3A3 significantly reduced the splicing efficiency of epidermal growth factor receptor and platelet-derived growth factor receptor.
      Title: Cellular stress response 1 down-regulates the expression of epidermal growth factor receptor and platelet-derived growth factor receptor through inactivation of splicing factor 3A3.
    8. Suppression of CSR1 expression is a novel mechanism critical for the oncogenic activity of miR-650.
      Title: Oncogenic Activity of miR-650 in Prostate Cancer Is Mediated by Suppression of CSR1 Expression.
    9. Findings regarding the interaction of NADPH-P450 reductase (NPR) with cellular stress response (CSR) indicated function of NPR in hypoxic response.
      Title: A cellular stress response (CSR) that interacts with NADPH-P450 reductase (NPR) is a new regulator of hypoxic response.
    10. Data indicate that the clinical samples showed an inverse correlation between SCARA3 gene expression, myeloma progression, and favorable clinical prognosis.
      Title: Scavenger receptor class A member 3 (SCARA3) in disease progression and therapy resistance in multiple myeloma.
    Submit: New GeneRIF Correction See all GeneRIFs (16)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr Treatment of human primary astrocytes with HIV-1 Vpr downregulates expression of eleven genes, BNIP3, CYGB, DUOX2, DUSP1, FOXM1, GAPDH, HPRT1, MT3, MTL5, PTGS2, and SCARA3 PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables scavenger receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in UV protection TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in response to oxidative stress TAS
    Traceable Author Statement
    more info
    		 PubMed 
    NOT involved_in toll-like receptor 3 signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of collagen trimer IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    scavenger receptor class A member 3
    Names
    cellular stress response gene protein
    cellular stress response protein
    macrophage scavenger receptor-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016240.3 → NP_057324.2  scavenger receptor class A member 3 isoform 1

      See identical proteins and their annotated locations for NP_057324.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1), also known as CSR1, encodes the longer isoform (1).
      Source sequence(s)
      AC013643
      Consensus CDS
      CCDS34871.1
      UniProtKB/Swiss-Prot
      Q6AZY7, Q9UM15, Q9UM16
      Related
      ENSP00000301904.3, ENST00000301904.4
      Conserved Domains (1) summary
      pfam01391
      Location:469 → 541
      Collagen; Collagen triple helix repeat (20 copies)

    2. NM_182826.2 → NP_878185.1  scavenger receptor class A member 3 isoform 2

      See identical proteins and their annotated locations for NP_878185.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2), also known as CSR2, differs in the 3' end-region, which includes a part of the coding region, as compared to variant 1. The resulting isoform (2) has a distinct and shorter C-terminus, as compared to isoform 1.
      Source sequence(s)
      AB007830, AC013643
      Consensus CDS
      CCDS34870.1
      UniProtKB/Swiss-Prot
      Q6AZY7
      Related
      ENSP00000337985.3, ENST00000337221.8
      Conserved Domains (1) summary
      TIGR02168
      Location:128 → 374
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      27633463..27734141
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047421850.1 → XP_047277806.1  scavenger receptor class A member 3 isoform X1

      UniProtKB/Swiss-Prot
      Q6AZY7, Q9UM15, Q9UM16

    2. XM_017013535.2 → XP_016869024.1  scavenger receptor class A member 3 isoform X1

      UniProtKB/Swiss-Prot
      Q6AZY7, Q9UM15, Q9UM16
      Conserved Domains (1) summary
      pfam01391
      Location:469 → 541
      Collagen; Collagen triple helix repeat (20 copies)

    3. XM_017013536.3 → XP_016869025.1  scavenger receptor class A member 3 isoform X2

      Conserved Domains (1) summary
      TIGR02168
      Location:128 → 374
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    4. XM_017013537.2 → XP_016869026.1  scavenger receptor class A member 3 isoform X3

    RNA

    1. XR_949419.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      27910729..28013971
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054360629.1 → XP_054216604.1  scavenger receptor class A member 3 isoform X1

      UniProtKB/Swiss-Prot
      Q6AZY7, Q9UM15, Q9UM16

    2. XM_054360630.1 → XP_054216605.1  scavenger receptor class A member 3 isoform X1

      UniProtKB/Swiss-Prot
      Q6AZY7, Q9UM15, Q9UM16

    3. XM_054360631.1 → XP_054216606.1  scavenger receptor class A member 3 isoform X2

    4. XM_054360632.1 → XP_054216607.1  scavenger receptor class A member 3 isoform X3

    RNA

    1. XR_008487851.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AZY7.1 GenPept UniProtKB/Swiss-Prot:Q6AZY7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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