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    CD300A CD300a molecule [ Homo sapiens (human) ]

    Gene ID: 11314, updated on 10-Dec-2024

    Summary

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    Official Symbol
    CD300Aprovided by HGNC
    Official Full Name
    CD300a moleculeprovided by HGNC
    Primary source
    HGNC:HGNC:19319
    See related
    Ensembl:ENSG00000167851 MIM:606790; AllianceGenome:HGNC:19319
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IRC1; IRC2; CLM-8; IRp60; IGSF12; CMRF35H; CMRF-35H; CMRF35-H; CMRF35H9; CMRF35-H9; IRC1/IRC2; CMRF-35-H9
    Summary
    This gene encodes a member of the CD300 glycoprotein family of cell surface proteins found on leukocytes involved in immune response signaling pathways. This gene is located on chromosome 17 in a cluster with all but one of the other family members. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
    Expression
    Broad expression in spleen (RPKM 24.5), appendix (RPKM 12.1) and 14 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CD300A in Genome Data Viewer
    Location:
    17q25.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (74466373..74484798)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (75356904..75375324)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (72462512..72480937)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene RNA, 5S ribosomal pseudogene 448 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72420638-72421138 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72422872-72423636 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8932 Neighboring gene G protein-coupled receptor class C group 5 member C Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12705 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72440360-72440904 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72440905-72441448 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72448210-72449201 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72449202-72450192 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:72450947-72451617 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12706 Neighboring gene uncharacterized LOC124904056 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8934 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8935 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12707 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12708 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12709 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12710 Neighboring gene uncharacterized LOC107985074 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12711 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12712 Neighboring gene CD300 molecule like family member b Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72535116-72535616 Neighboring gene CD300c molecule

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CD300a and CD300f molecules regulate the function of leukocytes.
      Title: CD300a and CD300f molecules regulate the function of leukocytes.
    2. CD300 molecules participate in the mechanisms that viruses employ to develop immune evasion strategies and to infect host cells [Review].
      Title: CD300 receptor family in viral infections.
    3. Results provide an insight into the novel set of paired receptors CD300a and CD300c that are distinctively expressed on CD56(bright) natural killers (NK) cells with varied effector functions and show there differential binding to their ligands phosphatidylethanolamine and phosphatidylserine (PS) resulting in their differential ability to affect CD56(bright) NK cell functions.
      Title: CD300c is uniquely expressed on CD56 bright Natural Killer Cells and differs from CD300a upon ligand recognition.
    4. High CD300A expression is associated with diffuse large B-cell lymphoma.
      Title: Suppression of CD300A inhibits the growth of diffuse large B-cell lymphoma.
    5. US3 protein kinase of pseudorabies virus triggers the binding of the inhibitory natural killer cell receptor CD300a to the surface of the infected cell, and protects of virus infected cells against natural killer cell-mediated lysis.
      Title: Pseudorabies Virus US3 Protein Kinase Protects Infected Cells from NK Cell-Mediated Lysis via Increased Binding of the Inhibitory NK Cell Receptor CD300a.
    6. Overall, these data indicate that CD300a is a novel Dengue virus binding receptor that recognizes phosphatidylethanolamine and phosphatidylserine present on virions and enhance infection.
      Title: The Phosphatidylserine and Phosphatidylethanolamine Receptor CD300a Binds Dengue Virus and Enhances Infection.
    7. Data show that peroxisome proliferator activator receptor delta (PPARdelta/beta) directly regulates CD300a protein in macrophages.
      Title: PPARβ/δ activation of CD300a controls intestinal immunity.
    8. CD300a induction by the hypoxic environment represents a mechanism of regulation of monocyte/macrophage pro-inflammatory responses at pathologic sites
      Title: Identification of CD300a as a new hypoxia-inducible gene and a regulator of CCL20 and VEGF production by human monocytes and macrophages.
    9. interaction with phosphatidylserines inhibits IgE/FcepsilonRI-dependent anaphylactic basophil degranulation
      Title: Mechanism of phosphatidylserine inhibition of IgE/FcεRI-dependent anaphylactic human basophil degranulation via CD300a.
    10. The inhibitory receptor CD300a is regulator of monocytes transendothelial migration.
      Title: Transcriptional profiling of human monocytes identifies the inhibitory receptor CD300a as regulator of transendothelial migration.
    Submit: New GeneRIF Correction See all GeneRIFs (25)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV-1 Vif downregulates the expression of CD300a molecule (CD300A) in Vif-expression T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables phosphatidylethanolamine binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylserine binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in immune system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of B cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of B cell receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of MAP kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of MyD88-dependent toll-like receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of NK T cell activation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of eosinophil activation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of eosinophil migration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of fibroblast proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of mast cell activation involved in immune response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of mast cell degranulation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of neutrophil activation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of phagocytosis, engulfment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of T cell receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular exosome HDA PubMed 
    located_in ficolin-1-rich granule membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in tertiary granule membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    CMRF35-like molecule 8
    Names
    CD300 antigen-like family member A
    CD300a antigen
    CMRF35H leukocyte immunoglobulin-like receptor
    NK inhibitory receptor
    immunoglobulin superfamily member 12
    inhibitory receptor protein 60
    leukocyte membrane antigen

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256841.2 → NP_001243770.1  CMRF35-like molecule 8 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001243770.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 5' coding region compared to variant 1. The resulting protein (isoform 2), also referred to as IRC1c, is shorter compared to isoform 1.
      Source sequence(s)
      AC079325, AJ010102, BF059016
      Consensus CDS
      CCDS58590.1
      UniProtKB/Swiss-Prot
      Q9UGN4
      Related
      ENSP00000308188.5, ENST00000310828.10
      Conserved Domains (1) summary
      pfam15330
      Location:86 → 160
      SIT; SHP2-interacting transmembrane adaptor protein, SIT

    2. NM_001330456.1 → NP_001317385.1  CMRF35-like molecule 8 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC079325
      Consensus CDS
      CCDS82197.1
      UniProtKB/TrEMBL
      J3QKQ4
      Related
      ENSP00000497133.1, ENST00000648095.1

    3. NM_001330457.2 → NP_001317386.1  CMRF35-like molecule 8 isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AC079325
      Consensus CDS
      CCDS82196.1
      UniProtKB/Swiss-Prot
      Q9UGN4
      Related
      ENSP00000376401.3, ENST00000392625.7

    4. NM_007261.4 → NP_009192.2  CMRF35-like molecule 8 isoform 1 precursor

      See identical proteins and their annotated locations for NP_009192.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1), also referred to as IRC1a.
      Source sequence(s)
      BC032352
      Consensus CDS
      CCDS32720.1
      UniProtKB/Swiss-Prot
      A8MW96, O95100, Q9HD97, Q9P0F3, Q9UBK4, Q9UGN4, Q9UMS9, Q9UMT0
      Related
      ENSP00000353259.3, ENST00000360141.8
      Conserved Domains (3) summary
      cd05716
      Location:23 → 117
      Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
      smart00410
      Location:22 → 105
      IG_like; Immunoglobulin like
      pfam15330
      Location:199 → 273
      SIT; SHP2-interacting transmembrane adaptor protein, SIT

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      74466373..74484798
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005256990.4 → XP_005257047.1  CMRF35-like molecule 8 isoform X1

      Conserved Domains (2) summary
      cd05716
      Location:23 → 117
      Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
      smart00410
      Location:22 → 105
      IG_like; Immunoglobulin like

    2. XM_005256991.6 → XP_005257048.1  CMRF35-like molecule 8 isoform X2

      Conserved Domains (2) summary
      cd05716
      Location:23 → 117
      Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
      smart00410
      Location:22 → 105
      IG_like; Immunoglobulin like

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791806.1 Reference GRCh38.p14 PATCHES

      Range
      42821..61246
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054333228.1 → XP_054189203.1  CMRF35-like molecule 8 isoform X1

    2. XM_054333229.1 → XP_054189204.1  CMRF35-like molecule 8 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      75356904..75375324
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054314909.1 → XP_054170884.1  CMRF35-like molecule 8 isoform X1

    2. XM_054314910.1 → XP_054170885.1  CMRF35-like molecule 8 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UGN4.2 GenPept UniProtKB/Swiss-Prot:Q9UGN4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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