PGRMC2 progesterone receptor membrane component 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PGRMC2provided by HGNC
Official Full Name: progesterone receptor membrane component 2provided by HGNC
Primary source: HGNC:HGNC:16089
See related: Ensembl:ENSG00000164040 MIM:607735; AllianceGenome:HGNC:16089
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: DG6; PMBP
Summary: Enables heme binding activity. Involved in adipose tissue development. Located in endoplasmic reticulum and nuclear envelope. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in fat (RPKM 36.7), small intestine (RPKM 30.1) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 4q28.2

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	4	NC_000004.12 (128269242..128287813, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	4	NC_060928.1 (131573342..131591912, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	4	NC_000004.11 (129190397..129208968, complement)

Chromosome 4 - NC_000004.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deciphering the role of PGRMC2 in the human endometrium during the menstrual cycle and in vitro decidualization using an in vitro approach.
Title: Deciphering the role of PGRMC2 in the human endometrium during the menstrual cycle and in vitro decidualization using an in vitro approach.
Progesterone receptor membrane component 2 is critical for human placental extravillous trophoblast invasion.
Title: Progesterone receptor membrane component 2 is critical for human placental extravillous trophoblast invasion.
The role of progesterone receptor membrane component (PGRMC) in the endometrium.
Title: The role of progesterone receptor membrane component (PGRMC) in the endometrium.
show that progesterone receptor membrane component 2 (PGRMC2) is required for delivery of labile, or signalling haem, to the nucleus
Title: PGRMC2 is an intracellular haem chaperone critical for adipocyte function.
Results found PGRMC2 to be targeted by miR-3687. Further data indicate that PGRMC2 mRNA expression in oesophageal squamous cell carcinoma (ESCC) may be related to cell proliferation and local progression.
Title: Differential miRNA Expression in Basaloid Squamous Cell Carcinoma of the Oesophagus: miR-3687 Targets PGRMC2.
Demonstrate a change in myometriumPGRMC1 expression and changes in PGRMC1 and PGRMC2 cell localisation in association with parturition.
Title: Changes in myometrial expression of progesterone receptor membrane components 1 and 2 are associated with human parturition at term.
It deserves further examination as data point to a role of PGRMC2 as tumor suppressor, migration inhibitor and regulator of cytochrome P450 proteins.
Title: PGRMC2, a yet uncharacterized protein with potential as tumor suppressor, migration inhibitor, and regulator of cytochrome P450 enzyme activity.
In secretory phase endometrium from women with advanced stage endometriosis, PGRMC-2 expression is downregulated.
Title: Expression patterns of progesterone receptor membrane components 1 and 2 in endometria from women with and without endometriosis.
Reversely, in the HO-8910 cells treated with CDDP alone, levels of both PGRMC1 and PGR were increased while the level of PGRMC2 was decreased
Title: Progesterone protects ovarian cancer cells from cisplatin-induced inhibitory effects through progesterone receptor membrane component 1/2 as well as AKT signaling.
PGRMC2 inhibits migration of SKOV-3 ovarian cancer cells in vitro.
Title: In vitro inhibition of SKOV-3 cell migration as a distinctive feature of progesterone receptor membrane component type 2 versus type 1.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of progesterone receptor membrane component 2 (PGRMC2) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Vpr	vpr	A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of progesterone receptor membrane component 2 (PGRMC2) expression by HIV-1 Vpr in Vpr transduced macrophages	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH91160 (e-PCR)
- UniSTS:88387

G19722 (e-PCR)
- UniSTS:56735

A001W34 (e-PCR)
- UniSTS:56736

D4S3304 (e-PCR)
- UniSTS:75983

SHGC-50187 (e-PCR)
- UniSTS:76774

STS-Z41404 (e-PCR)
- UniSTS:23289

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables heme binding	IDA Inferred from Direct Assay more info	PubMed
enables heme transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables nuclear steroid receptor activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables steroid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in adipose tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heme transport	IEA Inferred from Electronic Annotation more info
involved_in steroid hormone receptor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in membrane	HDA more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	TAS Traceable Author Statement more info
located_in nucleoplasm	TAS Traceable Author Statement more info

General protein information

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Preferred Names: membrane-associated progesterone receptor component 2

Names: progesterone membrane binding protein; steroid receptor protein DG6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.